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The map label for this gene is nuoF [H]

Identifier: 116515042

GI number: 116515042

Start: 114701

End: 116017

Strand: Direct

Name: nuoF [H]

Synonym: BCc_101

Alternate gene names: 116515042

Gene position: 114701-116017 (Clockwise)

Preceding gene: 116515041

Following gene: 116515043

Centisome position: 27.55

GC content: 26.65

Gene sequence:

>1317_bases
ATGATATATATGTTAAAAACATCTGAAACTCATCCTTTAACATGGAGAATAGATAAATATTCTTCTAATAAATCTATTGG
AATACATGAGTACTGTCACACTGGCGGTTATCAATCTTTAAAAAAATCTTTAAAAAAATTATGTCCAGAAGATATAATAT
TATTAATTAAAGAATCAGGTTTAAGAGGAAGAGGAGGAGCTGGATTTCCTACCGGAATAAAATGGAATTTAATGTTAAAA
AGTAATATTAAAGAAAAAATAAGATACTTAATTTGTAATGCGGATGAAATGGAGCCTGGAACATATAAAGATAGATTTTT
AATGGAAAGATTACCACATCAATTAATTGAAGGTATTATTATATGTGCTTTTACATTACATATTAGTTGTGCTTACATTT
TTTTACGTGGTGATTATTATGTAGCAGAAAAAATTTTAAATAAATCAATTGATGAAGCATATCAATTAGGTTATTTAGGA
AAAAATATATTAAATAGTGGATTTAATTTTAATTTGTTTCTACATACAGGAGCTGGTCGTTATATTTGTGGTGAAGAAAC
AGCTTTAATTAATTCATTAGAAGGATTAAGAGCTAATCCACGATTTAAACCACCATTTCCTGCTAATTATGGTCTTTGGG
GTAAACCTACATGTATTAATAATGTTGAAACATTATCAAATATTCCTGCAATTATTCAACATGGTTCAGAATGGTATAAG
AATTTATCTAAAGGAAAAGATTCTGGAACTAAATTATTAGGATTTTCAGGTAAAGTAAAAAATCCTGGTTTATGGGAGTT
ACCATTAGGAATTACTGCAAGAGAAGTATTAGAAGATTATGCTGGAGGAATGAAAAAAAATTTATTTTTAAAAGCTTGGC
AACCAGGTGGTGCTGGAACTGATATATTATCACATAAAGATATTGATATAAAAATGGATTTTACTAGTTTTCAAGAAATA
GGTAGTCGATTAGGAACTGGAATTTCTATGGCGATTGATAATAATATCAATATTATTTCTTTACTTATTAATATTGAAAT
TTTTTTTTCTCGAGAATCATGTGGATTTTGTACTCCGTGTCGAGAAGGATTACCATGGATTGTTAAGTTATTAAAAAATT
TAGAAAAAAAAAATGGAAAAAAAGAAGATATTAAAATATTAGATGAATTGTGTATATCTTTAGGTCCTGGAAAAACTTTT
TGTGCTCATGCTCCAGGAGCAATATCTCCATTAAAAAGTGCTTTAAAATTATTTCGTAATGAGTTTGAAAATAGCATTTA
TAAAAATAAAAAAAATATAAATATTGTTTCTTTATAA

Upstream 100 bases:

>100_bases
GTTTAGGAGCTTGTGATAAAGGTCCTGTAATGCTAGTTAATAAAACTTTATATACTAGACTTACTTCAAAAATGTTAATT
AATATATTGGATAAATATAA

Downstream 100 bases:

>100_bases
GAAATAATAAAAATATATATTTTAATTTAATTAAATATAATAATTTGTATGTTAATATTATTTTTTTTAAAAAAATTTTA
ATATAATAAAATATTAGTAA

Product: NADH dehydrogenase I chain F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MIYMLKTSETHPLTWRIDKYSSNKSIGIHEYCHTGGYQSLKKSLKKLCPEDIILLIKESGLRGRGGAGFPTGIKWNLMLK
SNIKEKIRYLICNADEMEPGTYKDRFLMERLPHQLIEGIIICAFTLHISCAYIFLRGDYYVAEKILNKSIDEAYQLGYLG
KNILNSGFNFNLFLHTGAGRYICGEETALINSLEGLRANPRFKPPFPANYGLWGKPTCINNVETLSNIPAIIQHGSEWYK
NLSKGKDSGTKLLGFSGKVKNPGLWELPLGITAREVLEDYAGGMKKNLFLKAWQPGGAGTDILSHKDIDIKMDFTSFQEI
GSRLGTGISMAIDNNINIISLLINIEIFFSRESCGFCTPCREGLPWIVKLLKNLEKKNGKKEDIKILDELCISLGPGKTF
CAHAPGAISPLKSALKLFRNEFENSIYKNKKNINIVSL

Sequences:

>Translated_438_residues
MIYMLKTSETHPLTWRIDKYSSNKSIGIHEYCHTGGYQSLKKSLKKLCPEDIILLIKESGLRGRGGAGFPTGIKWNLMLK
SNIKEKIRYLICNADEMEPGTYKDRFLMERLPHQLIEGIIICAFTLHISCAYIFLRGDYYVAEKILNKSIDEAYQLGYLG
KNILNSGFNFNLFLHTGAGRYICGEETALINSLEGLRANPRFKPPFPANYGLWGKPTCINNVETLSNIPAIIQHGSEWYK
NLSKGKDSGTKLLGFSGKVKNPGLWELPLGITAREVLEDYAGGMKKNLFLKAWQPGGAGTDILSHKDIDIKMDFTSFQEI
GSRLGTGISMAIDNNINIISLLINIEIFFSRESCGFCTPCREGLPWIVKLLKNLEKKNGKKEDIKILDELCISLGPGKTF
CAHAPGAISPLKSALKLFRNEFENSIYKNKKNINIVSL
>Mature_438_residues
MIYMLKTSETHPLTWRIDKYSSNKSIGIHEYCHTGGYQSLKKSLKKLCPEDIILLIKESGLRGRGGAGFPTGIKWNLMLK
SNIKEKIRYLICNADEMEPGTYKDRFLMERLPHQLIEGIIICAFTLHISCAYIFLRGDYYVAEKILNKSIDEAYQLGYLG
KNILNSGFNFNLFLHTGAGRYICGEETALINSLEGLRANPRFKPPFPANYGLWGKPTCINNVETLSNIPAIIQHGSEWYK
NLSKGKDSGTKLLGFSGKVKNPGLWELPLGITAREVLEDYAGGMKKNLFLKAWQPGGAGTDILSHKDIDIKMDFTSFQEI
GSRLGTGISMAIDNNINIISLLINIEIFFSRESCGFCTPCREGLPWIVKLLKNLEKKNGKKEDIKILDELCISLGPGKTF
CAHAPGAISPLKSALKLFRNEFENSIYKNKKNINIVSL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=382, Percent_Identity=39.7905759162304, Blast_Score=298, Evalue=8e-81,
Organism=Homo sapiens, GI260656005, Length=382, Percent_Identity=39.7905759162304, Blast_Score=298, Evalue=9e-81,
Organism=Escherichia coli, GI1788620, Length=437, Percent_Identity=60.4118993135012, Blast_Score=568, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17531727, Length=384, Percent_Identity=40.8854166666667, Blast_Score=308, Evalue=4e-84,
Organism=Drosophila melanogaster, GI19920794, Length=386, Percent_Identity=40.6735751295337, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI45550452, Length=381, Percent_Identity=40.9448818897638, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24653819, Length=406, Percent_Identity=31.7733990147783, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24653817, Length=360, Percent_Identity=30.2777777777778, Blast_Score=200, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 49089; Mature: 49089

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2 ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYMLKTSETHPLTWRIDKYSSNKSIGIHEYCHTGGYQSLKKSLKKLCPEDIILLIKESG
CEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCHHEEEEEECCC
LRGRGGAGFPTGIKWNLMLKSNIKEKIRYLICNADEMEPGTYKDRFLMERLPHQLIEGII
CCCCCCCCCCCCCEEEEEECCCHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
ICAFTLHISCAYIFLRGDYYVAEKILNKSIDEAYQLGYLGKNILNSGFNFNLFLHTGAGR
HHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
YICGEETALINSLEGLRANPRFKPPFPANYGLWGKPTCINNVETLSNIPAIIQHGSEWYK
EEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHCCHHHHH
NLSKGKDSGTKLLGFSGKVKNPGLWELPLGITAREVLEDYAGGMKKNLFLKAWQPGGAGT
HHHCCCCCCCEEEECCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCC
DILSHKDIDIKMDFTSFQEIGSRLGTGISMAIDNNINIISLLINIEIFFSRESCGFCTPC
CCCCCCCCEEEECHHHHHHHHHHHCCCEEEEECCCCEEEEEEEEEEEEEECCCCCCCCHH
REGLPWIVKLLKNLEKKNGKKEDIKILDELCISLGPGKTFCAHAPGAISPLKSALKLFRN
HCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHH
EFENSIYKNKKNINIVSL
HHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MIYMLKTSETHPLTWRIDKYSSNKSIGIHEYCHTGGYQSLKKSLKKLCPEDIILLIKESG
CEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCHHEEEEEECCC
LRGRGGAGFPTGIKWNLMLKSNIKEKIRYLICNADEMEPGTYKDRFLMERLPHQLIEGII
CCCCCCCCCCCCCEEEEEECCCHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
ICAFTLHISCAYIFLRGDYYVAEKILNKSIDEAYQLGYLGKNILNSGFNFNLFLHTGAGR
HHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
YICGEETALINSLEGLRANPRFKPPFPANYGLWGKPTCINNVETLSNIPAIIQHGSEWYK
EEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHCCHHHHH
NLSKGKDSGTKLLGFSGKVKNPGLWELPLGITAREVLEDYAGGMKKNLFLKAWQPGGAGT
HHHCCCCCCCEEEECCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCC
DILSHKDIDIKMDFTSFQEIGSRLGTGISMAIDNNINIISLLINIEIFFSRESCGFCTPC
CCCCCCCCEEEECHHHHHHHHHHHCCCEEEEECCCCEEEEEEEEEEEEEECCCCCCCCHH
REGLPWIVKLLKNLEKKNGKKEDIKILDELCISLGPGKTFCAHAPGAISPLKSALKLFRN
HCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHH
EFENSIYKNKKNINIVSL
HHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]