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The map label for this gene is galK

Identifier: 116494212

GI number: 116494212

Start: 667140

End: 668306

Strand: Direct

Name: galK

Synonym: LSEI_0664

Alternate gene names: 116494212

Gene position: 667140-668306 (Clockwise)

Preceding gene: 116494208

Following gene: 116494213

Centisome position: 23.04

GC content: 48.67

Gene sequence:

>1167_bases
GTGAACAGTACAGATGTCACAAAAGGTTTTACGGAACAATTTGGCAAGCAGGCGGAGCACACTTTCTTCGCACCAGGACG
CATTAATTTAATTGGTGAACACACCGATTACAATGGTGGCCACGTTTTCCCATGCGCCATTTCGTTGGGCACTTATGCAG
CGGTTGGCACCAATGAGGACAACGCTTTTCGGTTATACTCGGCCAACTTCCCAAAGGTTGGCATTATTGACATCCCATTT
TCAGATCTTTTCCAAGATAAGCGCGGCTTGTGGACAGATTACTTCCAAGGTATGGCGCGGGTGATGAAGACGGCGGGTGC
GAACTTCACGCATGGCCTCAATGTCTACATCAACGGCAACTTACCTGATGGCGCTGGGTTATCAAGTTCTGCTTCTCTGG
AAATGCTGGTCGGAACGATTCTGAACAATCTTTTTGATGGCGGCTTTGAACCGTTGGAGCTGGTTCAGTTCGGCGTTAAA
GTCGAAAACGACTATATCGGCGTGAACTCCGGTGTGATGGATCAGTTCGCGATTGAAATGGGTCGCGCAAATCAAGCAAC
GCTGCTGGATACAAACACGATGAAATACGAGTACCTGCCAGTTGAGATGGGCGATAACGTGATTGTCATCATGAATACCA
ACAAGCGTCGTGAGTTGGCTGATTCCAAGTACAACGAACGCCGCAGTGAATGCGAAAAAGCACTGGCAATGCTACAAAAG
GGCATTGAAGTCAAAAGTCTGGGTCAACTGAGTGAAGACGAATTCGACGAGAATACTTATCTCATTTACGATCCAATCCT
GATCAAACGCGCGCGCCACGCCGTCTTTGAAAATCAGCGGACATTGAAGGCTTCGAAAGCACTGCAAGATGGCGATTTGA
AGACCTTTGGCAAACTAGTCTCTGCTTCTGGGGTTTCGTTGGCTTTTGACTACGAAGTCACTGGCATCGAGCTTGATACC
CTTGTGACCAATGCCTTGAAGCAACGGGGTGTGCTTGGCGCTCGCATGACCGGTGCCGGTTTTGGCGGTTGCGCCATTGC
GATTGTGAACAGCGCTGATGTTGAAGACTTTATTGACAACGTTGGTAAGGCCTATCGAGAAAAGATTGGCTATGACGCCC
ATTTCTATGTGGCCGATATTGCCGATGGTGCTAGGCAACTGAACTAA

Upstream 100 bases:

>100_bases
TATAGCGCTTCCAATCCGTCATTATTTTTAGTAAAATAAAAACGGTTACAAAAATCAGCAGCGGATAAATAAGCTTAACT
TCAATTAGGAGGTATTGACG

Downstream 100 bases:

>100_bases
CTCTGCTAAAATAGAAAAAGTGTTATAAAGTAGAGCGTGAGCCAGACCGATTTCTAGTCTGACGAACACGTTTTAAAAAA
GGGAGATATTTTATTATGAC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNSTDVTKGFTEQFGKQAEHTFFAPGRINLIGEHTDYNGGHVFPCAISLGTYAAVGTNEDNAFRLYSANFPKVGIIDIPF
SDLFQDKRGLWTDYFQGMARVMKTAGANFTHGLNVYINGNLPDGAGLSSSASLEMLVGTILNNLFDGGFEPLELVQFGVK
VENDYIGVNSGVMDQFAIEMGRANQATLLDTNTMKYEYLPVEMGDNVIVIMNTNKRRELADSKYNERRSECEKALAMLQK
GIEVKSLGQLSEDEFDENTYLIYDPILIKRARHAVFENQRTLKASKALQDGDLKTFGKLVSASGVSLAFDYEVTGIELDT
LVTNALKQRGVLGARMTGAGFGGCAIAIVNSADVEDFIDNVGKAYREKIGYDAHFYVADIADGARQLN

Sequences:

>Translated_388_residues
MNSTDVTKGFTEQFGKQAEHTFFAPGRINLIGEHTDYNGGHVFPCAISLGTYAAVGTNEDNAFRLYSANFPKVGIIDIPF
SDLFQDKRGLWTDYFQGMARVMKTAGANFTHGLNVYINGNLPDGAGLSSSASLEMLVGTILNNLFDGGFEPLELVQFGVK
VENDYIGVNSGVMDQFAIEMGRANQATLLDTNTMKYEYLPVEMGDNVIVIMNTNKRRELADSKYNERRSECEKALAMLQK
GIEVKSLGQLSEDEFDENTYLIYDPILIKRARHAVFENQRTLKASKALQDGDLKTFGKLVSASGVSLAFDYEVTGIELDT
LVTNALKQRGVLGARMTGAGFGGCAIAIVNSADVEDFIDNVGKAYREKIGYDAHFYVADIADGARQLN
>Mature_388_residues
MNSTDVTKGFTEQFGKQAEHTFFAPGRINLIGEHTDYNGGHVFPCAISLGTYAAVGTNEDNAFRLYSANFPKVGIIDIPF
SDLFQDKRGLWTDYFQGMARVMKTAGANFTHGLNVYINGNLPDGAGLSSSASLEMLVGTILNNLFDGGFEPLELVQFGVK
VENDYIGVNSGVMDQFAIEMGRANQATLLDTNTMKYEYLPVEMGDNVIVIMNTNKRRELADSKYNERRSECEKALAMLQK
GIEVKSLGQLSEDEFDENTYLIYDPILIKRARHAVFENQRTLKASKALQDGDLKTFGKLVSASGVSLAFDYEVTGIELDT
LVTNALKQRGVLGARMTGAGFGGCAIAIVNSADVEDFIDNVGKAYREKIGYDAHFYVADIADGARQLN

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=388, Percent_Identity=34.5360824742268, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI48527957, Length=411, Percent_Identity=26.7639902676399, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI4503897, Length=409, Percent_Identity=27.1393643031785, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI1786972, Length=384, Percent_Identity=36.4583333333333, Blast_Score=245, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71989053, Length=419, Percent_Identity=26.491646778043, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320212, Length=476, Percent_Identity=25, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319494, Length=259, Percent_Identity=28.957528957529, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24661292, Length=420, Percent_Identity=26.4285714285714, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21355577, Length=420, Percent_Identity=26.4285714285714, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24661285, Length=420, Percent_Identity=26.4285714285714, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_LACC3 (Q03BB8)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_805946.1
- ProteinModelPortal:   Q03BB8
- SMR:   Q03BB8
- STRING:   Q03BB8
- GeneID:   4419612
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_0664
- eggNOG:   COG0153
- HOGENOM:   HBG725121
- OMA:   KENSWID
- PhylomeDB:   Q03BB8
- ProtClustDB:   CLSK2317747
- BioCyc:   LCAS321967:LSEI_0664-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00473
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00131

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 42562; Mature: 42562

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTDVTKGFTEQFGKQAEHTFFAPGRINLIGEHTDYNGGHVFPCAISLGTYAAVGTNED
CCCCCCCCHHHHHHCCCCCCEEECCCEEEEEECCCCCCCCEEEEEEEECCCEEEECCCCC
NAFRLYSANFPKVGIIDIPFSDLFQDKRGLWTDYFQGMARVMKTAGANFTHGLNVYINGN
CEEEEEECCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
LPDGAGLSSSASLEMLVGTILNNLFDGGFEPLELVQFGVKVENDYIGVNSGVMDQFAIEM
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCEECCCEEECCCCHHHHHHHHH
GRANQATLLDTNTMKYEYLPVEMGDNVIVIMNTNKRRELADSKYNERRSECEKALAMLQK
CCCCCEEEEECCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GIEVKSLGQLSEDEFDENTYLIYDPILIKRARHAVFENQRTLKASKALQDGDLKTFGKLV
CCCHHHHCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHH
SASGVSLAFDYEVTGIELDTLVTNALKQRGVLGARMTGAGFGGCAIAIVNSADVEDFIDN
HCCCCEEEEEEEEECEEHHHHHHHHHHHCCCCCEEECCCCCCCEEEEEECCCCHHHHHHH
VGKAYREKIGYDAHFYVADIADGARQLN
HHHHHHHHCCCCCEEEEEECCCHHHCCC
>Mature Secondary Structure
MNSTDVTKGFTEQFGKQAEHTFFAPGRINLIGEHTDYNGGHVFPCAISLGTYAAVGTNED
CCCCCCCCHHHHHHCCCCCCEEECCCEEEEEECCCCCCCCEEEEEEEECCCEEEECCCCC
NAFRLYSANFPKVGIIDIPFSDLFQDKRGLWTDYFQGMARVMKTAGANFTHGLNVYINGN
CEEEEEECCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
LPDGAGLSSSASLEMLVGTILNNLFDGGFEPLELVQFGVKVENDYIGVNSGVMDQFAIEM
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCEECCCEEECCCCHHHHHHHHH
GRANQATLLDTNTMKYEYLPVEMGDNVIVIMNTNKRRELADSKYNERRSECEKALAMLQK
CCCCCEEEEECCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GIEVKSLGQLSEDEFDENTYLIYDPILIKRARHAVFENQRTLKASKALQDGDLKTFGKLV
CCCHHHHCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHH
SASGVSLAFDYEVTGIELDTLVTNALKQRGVLGARMTGAGFGGCAIAIVNSADVEDFIDN
HCCCCEEEEEEEEECEEHHHHHHHHHHHCCCCCEEECCCCCCCEEEEEECCCCHHHHHHH
VGKAYREKIGYDAHFYVADIADGARQLN
HHHHHHHHCCCCCEEEEEECCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA