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The map label for this gene is caiT [H]

Identifier: 116493367

GI number: 116493367

Start: 1622680

End: 1624248

Strand: Reverse

Name: caiT [H]

Synonym: PEPE_1639

Alternate gene names: 116493367

Gene position: 1624248-1622680 (Counterclockwise)

Preceding gene: 116493368

Following gene: 116493366

Centisome position: 88.64

GC content: 37.79

Gene sequence:

>1569_bases
ATGGTGTTATTTGGGGTTGTATCAATCATCCTCATCACAGGCGGCCCAGCCGTTCAGCAATTAATGAACGCGTTGTTGTC
ATTCGTTACAAGCAAATATGAGTGGTTGTATATCTCAATTTATGTCATCAATTTCATGTTTTTTATCGTTTTGATTTTTA
GTAAATACGGTAAAATCAGATTCGGAAAGGCTGATCCAGCTAAAGACTATAGTGGTTTTCAATGGGGAAGCATGGTTTTT
GCAACTGCAATTGATGCAAGTATTTTGATGTTAAGTGCAACTGATCCATTGCAATACCTTCAGCACCCGGCATTTGGCGC
GAAGCCATTATCGACCCAAGCGTTTGCCTATGCTAACGTAGTGGGCGAGTTTAATTGGGGGCCGATGGCATGGATGATGT
TTGCAACTGCCACCATTGCTATTGCTTATACAATGTATGTAAAAAAAATTCCAGTAATGCGATTAAGTACTGTAATTCCC
CTCTTGAAGGGCGATCAATTATACAAAAAAGTTTTACGTCAACTAATTGATTTCTTAGTCGTTTTTGGGATCATGGGCGG
AATTGGTTCTTCGATTGGAATGGAAATTCCCGTGATTGCACGTGTTTTAAGTATTATCGTAGGTATTAAAGATACGATTT
ATTTAAAACTATTTTTATTCTTTATTTTATTGATTTTATTTACGTTAACCGTGTATGCAGGTTTAAATAAGGGAATTAAA
AAACTATCAGCATGGCACATTTATTTGGCAATTATTTTCTTAGCAATTGTTTTAGTAGCTGGTCCAACTAAATTTTTAGT
GGGCTCAGAAGGTCAAACCTTGAAATTAATGGCGCAACATTTTACTGCGCTTTCCTTTAATAAAGCTAATGCTGGCACCA
ATGGTTTTGCTCAACATCAAACCCTGTTTTATTGGGGTTGGTGGTTAGCCTACATGCCGGTAATGGGGTTATTTATTGCC
CGGATCTCGCATGGTAAGACGATTCGCCAAGTTGTTTTAGGGATGATGACTTATGGAGTCGGTGGCTGTATTTCATTTTA
TGCAGTTTTAGGGGGCTATGCTCTATGGCTTCAACAATCAGGTACTTTAAACATCGTGCACATTTTGAATACACAAGGAC
AAGCAGCAGTTCAAGCAGCATTGATTACAACTTTGCCGATGAATAAATTGATGCTAATTCTTTTCTGTGTTTCATGTTTT
ATCTTCTTAGCAACGACGATTTCTTCTTCTGCATTTATTGTTTCATCATTCACCAGTCTAGACTTGTCGCATGGTCGCCA
ACCTAGCCGATGGAATCGAATGGCTTGGGTCATCGTGTTTATTATTTTCTCGTTAGGAATTGTTATAGTAGGTGGATTTG
AGGTCGTTCAAGCAATCTGTACGGTTGCAGGATTTCCGCTAATTTTTGTATGTATTTTGTTATTATATTCTATCTATCAA
GATGTAACTGGACGTGAATTTAATCGGGTTAGAATGCCTAGTTACCTCCCCGTTGTTAATCTCCGTCCTTTGCAAAAAAT
GATGGTTAGTTATCATTTGATGCATAACATTAGTCAGGACGATTTTTAA

Upstream 100 bases:

>100_bases
CCAATGGTGTTGCTTTTTTTGTACCAATTTTTTGAAAATATGGGAGGAATTTTTTATCTTACACAGTAAGAATGTCGATC
GAGCTGTCTTTTTACCAACA

Downstream 100 bases:

>100_bases
ATGAATTTTTTAATTTATATCAGGATCGAGTTGGTCTAAAATAGGACATAGATACCGATGAATAGGGGGATGTTTTTATG
GCAAAAGTAGAAAGCTTTGA

Product: choline-glycine betaine transporter

Products: Proton [Cytoplasm]; L-carnitine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MVLFGVVSIILITGGPAVQQLMNALLSFVTSKYEWLYISIYVINFMFFIVLIFSKYGKIRFGKADPAKDYSGFQWGSMVF
ATAIDASILMLSATDPLQYLQHPAFGAKPLSTQAFAYANVVGEFNWGPMAWMMFATATIAIAYTMYVKKIPVMRLSTVIP
LLKGDQLYKKVLRQLIDFLVVFGIMGGIGSSIGMEIPVIARVLSIIVGIKDTIYLKLFLFFILLILFTLTVYAGLNKGIK
KLSAWHIYLAIIFLAIVLVAGPTKFLVGSEGQTLKLMAQHFTALSFNKANAGTNGFAQHQTLFYWGWWLAYMPVMGLFIA
RISHGKTIRQVVLGMMTYGVGGCISFYAVLGGYALWLQQSGTLNIVHILNTQGQAAVQAALITTLPMNKLMLILFCVSCF
IFLATTISSSAFIVSSFTSLDLSHGRQPSRWNRMAWVIVFIIFSLGIVIVGGFEVVQAICTVAGFPLIFVCILLLYSIYQ
DVTGREFNRVRMPSYLPVVNLRPLQKMMVSYHLMHNISQDDF

Sequences:

>Translated_522_residues
MVLFGVVSIILITGGPAVQQLMNALLSFVTSKYEWLYISIYVINFMFFIVLIFSKYGKIRFGKADPAKDYSGFQWGSMVF
ATAIDASILMLSATDPLQYLQHPAFGAKPLSTQAFAYANVVGEFNWGPMAWMMFATATIAIAYTMYVKKIPVMRLSTVIP
LLKGDQLYKKVLRQLIDFLVVFGIMGGIGSSIGMEIPVIARVLSIIVGIKDTIYLKLFLFFILLILFTLTVYAGLNKGIK
KLSAWHIYLAIIFLAIVLVAGPTKFLVGSEGQTLKLMAQHFTALSFNKANAGTNGFAQHQTLFYWGWWLAYMPVMGLFIA
RISHGKTIRQVVLGMMTYGVGGCISFYAVLGGYALWLQQSGTLNIVHILNTQGQAAVQAALITTLPMNKLMLILFCVSCF
IFLATTISSSAFIVSSFTSLDLSHGRQPSRWNRMAWVIVFIIFSLGIVIVGGFEVVQAICTVAGFPLIFVCILLLYSIYQ
DVTGREFNRVRMPSYLPVVNLRPLQKMMVSYHLMHNISQDDF
>Mature_522_residues
MVLFGVVSIILITGGPAVQQLMNALLSFVTSKYEWLYISIYVINFMFFIVLIFSKYGKIRFGKADPAKDYSGFQWGSMVF
ATAIDASILMLSATDPLQYLQHPAFGAKPLSTQAFAYANVVGEFNWGPMAWMMFATATIAIAYTMYVKKIPVMRLSTVIP
LLKGDQLYKKVLRQLIDFLVVFGIMGGIGSSIGMEIPVIARVLSIIVGIKDTIYLKLFLFFILLILFTLTVYAGLNKGIK
KLSAWHIYLAIIFLAIVLVAGPTKFLVGSEGQTLKLMAQHFTALSFNKANAGTNGFAQHQTLFYWGWWLAYMPVMGLFIA
RISHGKTIRQVVLGMMTYGVGGCISFYAVLGGYALWLQQSGTLNIVHILNTQGQAAVQAALITTLPMNKLMLILFCVSCF
IFLATTISSSAFIVSSFTSLDLSHGRQPSRWNRMAWVIVFIIFSLGIVIVGGFEVVQAICTVAGFPLIFVCILLLYSIYQ
DVTGREFNRVRMPSYLPVVNLRPLQKMMVSYHLMHNISQDDF

Specific function: Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786224, Length=481, Percent_Identity=25.987525987526, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1788102, Length=472, Percent_Identity=28.1779661016949, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI1786506, Length=479, Percent_Identity=25.4697286012526, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 58086; Mature: 58086

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLFGVVSIILITGGPAVQQLMNALLSFVTSKYEWLYISIYVINFMFFIVLIFSKYGKIR
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCEE
FGKADPAKDYSGFQWGSMVFATAIDASILMLSATDPLQYLQHPAFGAKPLSTQAFAYANV
ECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCHHHHHCCCCCCCCCCCHHHHHHHHH
VGEFNWGPMAWMMFATATIAIAYTMYVKKIPVMRLSTVIPLLKGDQLYKKVLRQLIDFLV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VFGIMGGIGSSIGMEIPVIARVLSIIVGIKDTIYLKLFLFFILLILFTLTVYAGLNKGIK
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLSAWHIYLAIIFLAIVLVAGPTKFLVGSEGQTLKLMAQHFTALSFNKANAGTNGFAQHQ
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCC
TLFYWGWWLAYMPVMGLFIARISHGKTIRQVVLGMMTYGVGGCISFYAVLGGYALWLQQS
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHEEECC
GTLNIVHILNTQGQAAVQAALITTLPMNKLMLILFCVSCFIFLATTISSSAFIVSSFTSL
CCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DLSHGRQPSRWNRMAWVIVFIIFSLGIVIVGGFEVVQAICTVAGFPLIFVCILLLYSIYQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
DVTGREFNRVRMPSYLPVVNLRPLQKMMVSYHLMHNISQDDF
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVLFGVVSIILITGGPAVQQLMNALLSFVTSKYEWLYISIYVINFMFFIVLIFSKYGKIR
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCEE
FGKADPAKDYSGFQWGSMVFATAIDASILMLSATDPLQYLQHPAFGAKPLSTQAFAYANV
ECCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCHHHHHCCCCCCCCCCCHHHHHHHHH
VGEFNWGPMAWMMFATATIAIAYTMYVKKIPVMRLSTVIPLLKGDQLYKKVLRQLIDFLV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VFGIMGGIGSSIGMEIPVIARVLSIIVGIKDTIYLKLFLFFILLILFTLTVYAGLNKGIK
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLSAWHIYLAIIFLAIVLVAGPTKFLVGSEGQTLKLMAQHFTALSFNKANAGTNGFAQHQ
HHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCC
TLFYWGWWLAYMPVMGLFIARISHGKTIRQVVLGMMTYGVGGCISFYAVLGGYALWLQQS
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHEEECC
GTLNIVHILNTQGQAAVQAALITTLPMNKLMLILFCVSCFIFLATTISSSAFIVSSFTSL
CCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DLSHGRQPSRWNRMAWVIVFIIFSLGIVIVGGFEVVQAICTVAGFPLIFVCILLLYSIYQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
DVTGREFNRVRMPSYLPVVNLRPLQKMMVSYHLMHNISQDDF
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-carnitine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-carnitine [Periplasm] = Proton [Cytoplasm] + L-carnitine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA