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The map label for this gene is relA [H]

Identifier: 116492882

GI number: 116492882

Start: 1118861

End: 1121092

Strand: Reverse

Name: relA [H]

Synonym: PEPE_1120

Alternate gene names: 116492882

Gene position: 1121092-1118861 (Counterclockwise)

Preceding gene: 116492883

Following gene: 116492881

Centisome position: 61.18

GC content: 38.49

Gene sequence:

>2232_bases
ATGTCTAAAGAACCAGTGTTAACGGCAAATGAAGTAATTAAAATGTGCCAGGAGTACATGAACGAAGAACATGCGGCATT
TGTTCAAAAAGCCTGTGATTTTGCGTCATATGTCCATAAGGAACAATATCGTCAATCGGGCGAACCATATATTATGCATC
CGATTCAAGTTGCAGGGATTTTAGCCAATCTAAAAATGGATCCTGAAACGGTTGCAGCTGGATTTTTACATGACACAGTC
GAAGATACACTGATTACCTTAGGTGATATCGAAGAACTTTTTGGTAAAGATGTGGCAGTAATTGTCGATGGTGTTTCTAA
AATCAGTAAAATCAAATATAAATCAAATCAAGAACAGTTAGCTGAAAATCATCGGAAGTTGCTTTTAGCTATGTCACAAG
ATATCCGAGTTATTATTGTTAAGCTTGCAGATCGCTTGCATAACATGCGAACTCTACAACACTTGCGCCCTGATAAACAA
CGACGAATATCAAATGAAACGTTGGAAATTTACGCACCACTAGCCGAACGCTTAGGGATTAGCACAATTAAATGGGAACT
TGAAGATATTTCACTGCGGTATCTAAATCCTCAACAATATTATCGAATTGTTCATTTAATGAATTCAAGGCGAAATCAAC
GTGAAGAATACATTGATTCCGCGATTTCAGAACTAAAATCAGCGGTCGAAGATTTACAATTAAAGCATACTGAAATTTAT
GGAAGACCAAAACACATCTATTCTATCTACCGTAAGATGGTCGATCAGCACAAGCAATTTAGTCAAATTTATGACTTACT
AGCAATTCGAGTAATTACGGTGTCAGTTCGTGATTGTTACGCTGTGTTGGGTGCTATCCATGCTAAATGGAAACCAATCC
CAGGTCGTTTTAAAGACTATATTGCAATGCCTAAGGCTAATATGTACCAATCTTTGCATACGACGGTGGTAGGGCCAGAA
GGGCGACCATTGGAGATCCAAATTCGTACTCAAGCGATGCATCGTGTTGCCGAGTATGGGGTTGCTGCTCATTGGGCTTA
TAAAGAAGGCATTAAAGATGAGTTGGCTCAAAATACAACAGATGCGAAGTTAAACTGGTTTAAAGAAATTGTCGAACTTC
AAGATGAAAGTAATGATGCAGCCGATTTTATGGAAGGTGTTAAAGGGGATCTGTTTGGTGATCGCGTTTATGCATTTACG
CCTAAGGGGGATGTGTATGAGTTACCAAAGGGAGCTGGTCCACTAGACCTGGCTTATATCATCCATACTGAAGTTGGTAA
TCATGCTACCGGAGCTAAAGTTAATGGCAAAATCGTTCCTTTAGATTACACCATTAAAAATGGTGATATTGTTGAAATTT
TAACTTCCAAAAATTCTGCTGGGCCGAGTCGTGACTGGATTAATCTAGTTTCTACTCGACGTGGACGGAATAAGATTAAA
CAATTTTTCCGCCAAGTTGATCACGAAGAAAATGTTGAAAAAGGACGGGACATCCTTGCTAAGCAATTGGAACAAACAGG
GTACGATGTTTCTGATTTGATGGACGATGAACATTTAAAAGATGTTGCTAACCAAATGAACTTCTCCCAAATTAATGATT
TGTTTGCTGCAGTTGGATTTGGTGATTTAGCTCCGGCGGGAATTGCTAATCGGTTAACCAAGGATTTACGTAAGCAAGCA
GAAGAAGATCGCCAACGAGAAGAACAAAAACAATTGTTAGAAAGTCATCAAACAATCTCTAATGAAAGTAATGACGATCG
TAAGAAAAAGAAATCTTCTTCTGAAGGCATTGTAATTGAGGGTGCGGATAATTTATTAGTTCGCTTAAGCCACTGTTGTA
GTCCAGTTCCTGGGGATGAAATCGTGGGATATATTACTAAGGGACGAGGAGTTTCCGTTCATCGGGTCGAATGTCCCAAC
GTCCGTCAAGCTGAAGAAAATGGTGAACGCATTATTGAAGTTAGTTGGGAAAATCCTAATGATGAATCAGGAAATTACTC
TGCTGACTTGGAAGTAGAAGGCTACAACCGTAATGGCATGTTAAATGATGTTTTGAAATCAGTTAATAACTCTACTAGAA
ATCTTTCATCAGTGAATGGAAAATTAGATCATAATCGGATGGTAGTAATCAGTATGACTATCGGAGTGCGAAATTTATTA
CATTTACAACGAGTTATGGAAAGCTTAAAAAATGTTAAGGACGTTTATGTGGTTAAACGTCCAACCCATTAG

Upstream 100 bases:

>100_bases
AATTTATTATCAATAAACGTATACTTAATTCAATAAAAGCGAAGCACGTAGTCATTTGATTCCGTGCTTTTATTGTATTT
TGAGGTTGGTGGTGATATTA

Downstream 100 bases:

>100_bases
GAGTAATGTATGAGAGTTGTAATTCAGAGAGTATCAAAAGCAAGCGTTACAATTGAAGAGAATGTAGTTGGAAAGGTCGG
GCCGGGATTCATGCTATTAG

Product: guanosine polyphosphate pyrophosphohydrolase/synthetase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MSKEPVLTANEVIKMCQEYMNEEHAAFVQKACDFASYVHKEQYRQSGEPYIMHPIQVAGILANLKMDPETVAAGFLHDTV
EDTLITLGDIEELFGKDVAVIVDGVSKISKIKYKSNQEQLAENHRKLLLAMSQDIRVIIVKLADRLHNMRTLQHLRPDKQ
RRISNETLEIYAPLAERLGISTIKWELEDISLRYLNPQQYYRIVHLMNSRRNQREEYIDSAISELKSAVEDLQLKHTEIY
GRPKHIYSIYRKMVDQHKQFSQIYDLLAIRVITVSVRDCYAVLGAIHAKWKPIPGRFKDYIAMPKANMYQSLHTTVVGPE
GRPLEIQIRTQAMHRVAEYGVAAHWAYKEGIKDELAQNTTDAKLNWFKEIVELQDESNDAADFMEGVKGDLFGDRVYAFT
PKGDVYELPKGAGPLDLAYIIHTEVGNHATGAKVNGKIVPLDYTIKNGDIVEILTSKNSAGPSRDWINLVSTRRGRNKIK
QFFRQVDHEENVEKGRDILAKQLEQTGYDVSDLMDDEHLKDVANQMNFSQINDLFAAVGFGDLAPAGIANRLTKDLRKQA
EEDRQREEQKQLLESHQTISNESNDDRKKKKSSSEGIVIEGADNLLVRLSHCCSPVPGDEIVGYITKGRGVSVHRVECPN
VRQAEENGERIIEVSWENPNDESGNYSADLEVEGYNRNGMLNDVLKSVNNSTRNLSSVNGKLDHNRMVVISMTIGVRNLL
HLQRVMESLKNVKDVYVVKRPTH

Sequences:

>Translated_743_residues
MSKEPVLTANEVIKMCQEYMNEEHAAFVQKACDFASYVHKEQYRQSGEPYIMHPIQVAGILANLKMDPETVAAGFLHDTV
EDTLITLGDIEELFGKDVAVIVDGVSKISKIKYKSNQEQLAENHRKLLLAMSQDIRVIIVKLADRLHNMRTLQHLRPDKQ
RRISNETLEIYAPLAERLGISTIKWELEDISLRYLNPQQYYRIVHLMNSRRNQREEYIDSAISELKSAVEDLQLKHTEIY
GRPKHIYSIYRKMVDQHKQFSQIYDLLAIRVITVSVRDCYAVLGAIHAKWKPIPGRFKDYIAMPKANMYQSLHTTVVGPE
GRPLEIQIRTQAMHRVAEYGVAAHWAYKEGIKDELAQNTTDAKLNWFKEIVELQDESNDAADFMEGVKGDLFGDRVYAFT
PKGDVYELPKGAGPLDLAYIIHTEVGNHATGAKVNGKIVPLDYTIKNGDIVEILTSKNSAGPSRDWINLVSTRRGRNKIK
QFFRQVDHEENVEKGRDILAKQLEQTGYDVSDLMDDEHLKDVANQMNFSQINDLFAAVGFGDLAPAGIANRLTKDLRKQA
EEDRQREEQKQLLESHQTISNESNDDRKKKKSSSEGIVIEGADNLLVRLSHCCSPVPGDEIVGYITKGRGVSVHRVECPN
VRQAEENGERIIEVSWENPNDESGNYSADLEVEGYNRNGMLNDVLKSVNNSTRNLSSVNGKLDHNRMVVISMTIGVRNLL
HLQRVMESLKNVKDVYVVKRPTH
>Mature_742_residues
SKEPVLTANEVIKMCQEYMNEEHAAFVQKACDFASYVHKEQYRQSGEPYIMHPIQVAGILANLKMDPETVAAGFLHDTVE
DTLITLGDIEELFGKDVAVIVDGVSKISKIKYKSNQEQLAENHRKLLLAMSQDIRVIIVKLADRLHNMRTLQHLRPDKQR
RISNETLEIYAPLAERLGISTIKWELEDISLRYLNPQQYYRIVHLMNSRRNQREEYIDSAISELKSAVEDLQLKHTEIYG
RPKHIYSIYRKMVDQHKQFSQIYDLLAIRVITVSVRDCYAVLGAIHAKWKPIPGRFKDYIAMPKANMYQSLHTTVVGPEG
RPLEIQIRTQAMHRVAEYGVAAHWAYKEGIKDELAQNTTDAKLNWFKEIVELQDESNDAADFMEGVKGDLFGDRVYAFTP
KGDVYELPKGAGPLDLAYIIHTEVGNHATGAKVNGKIVPLDYTIKNGDIVEILTSKNSAGPSRDWINLVSTRRGRNKIKQ
FFRQVDHEENVEKGRDILAKQLEQTGYDVSDLMDDEHLKDVANQMNFSQINDLFAAVGFGDLAPAGIANRLTKDLRKQAE
EDRQREEQKQLLESHQTISNESNDDRKKKKSSSEGIVIEGADNLLVRLSHCCSPVPGDEIVGYITKGRGVSVHRVECPNV
RQAEENGERIIEVSWENPNDESGNYSADLEVEGYNRNGMLNDVLKSVNNSTRNLSSVNGKLDHNRMVVISMTIGVRNLLH
LQRVMESLKNVKDVYVVKRPTH

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=141, Percent_Identity=36.8794326241135, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1790082, Length=731, Percent_Identity=38.7140902872777, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1789147, Length=729, Percent_Identity=37.5857338820302, Blast_Score=512, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI25143118, Length=162, Percent_Identity=34.5679012345679, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650996, Length=124, Percent_Identity=33.8709677419355, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84499; Mature: 84368

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEPVLTANEVIKMCQEYMNEEHAAFVQKACDFASYVHKEQYRQSGEPYIMHPIQVAGI
CCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHH
LANLKMDPETVAAGFLHDTVEDTLITLGDIEELFGKDVAVIVDGVSKISKIKYKSNQEQL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCHHHH
AENHRKLLLAMSQDIRVIIVKLADRLHNMRTLQHLRPDKQRRISNETLEIYAPLAERLGI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHCCHHHHCCC
STIKWELEDISLRYLNPQQYYRIVHLMNSRRNQREEYIDSAISELKSAVEDLQLKHTEIY
CEEEEEEEECEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRPKHIYSIYRKMVDQHKQFSQIYDLLAIRVITVSVRDCYAVLGAIHAKWKPIPGRFKDY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IAMPKANMYQSLHTTVVGPEGRPLEIQIRTQAMHRVAEYGVAAHWAYKEGIKDELAQNTT
HCCCCHHHHHHHHHEEECCCCCEEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCC
DAKLNWFKEIVELQDESNDAADFMEGVKGDLFGDRVYAFTPKGDVYELPKGAGPLDLAYI
CHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCCCCEEEEE
IHTEVGNHATGAKVNGKIVPLDYTIKNGDIVEILTSKNSAGPSRDWINLVSTRRGRNKIK
EEECCCCCCCCCEECCEEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHH
QFFRQVDHEENVEKGRDILAKQLEQTGYDVSDLMDDEHLKDVANQMNFSQINDLFAAVGF
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCC
GDLAPAGIANRLTKDLRKQAEEDRQREEQKQLLESHQTISNESNDDRKKKKSSSEGIVIE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEE
GADNLLVRLSHCCSPVPGDEIVGYITKGRGVSVHRVECPNVRQAEENGERIIEVSWENPN
CCCHHHHHHHHHCCCCCCHHHEEEEECCCCCEEEEECCCCCCCHHCCCCEEEEEECCCCC
DESGNYSADLEVEGYNRNGMLNDVLKSVNNSTRNLSSVNGKLDHNRMVVISMTIGVRNLL
CCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCHHHCCCCCCCCCEEEEEEHHHHHHHH
HLQRVMESLKNVKDVYVVKRPTH
HHHHHHHHHHCCHHEEEEECCCC
>Mature Secondary Structure 
SKEPVLTANEVIKMCQEYMNEEHAAFVQKACDFASYVHKEQYRQSGEPYIMHPIQVAGI
CCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHH
LANLKMDPETVAAGFLHDTVEDTLITLGDIEELFGKDVAVIVDGVSKISKIKYKSNQEQL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCHHHH
AENHRKLLLAMSQDIRVIIVKLADRLHNMRTLQHLRPDKQRRISNETLEIYAPLAERLGI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHCCHHHHCCC
STIKWELEDISLRYLNPQQYYRIVHLMNSRRNQREEYIDSAISELKSAVEDLQLKHTEIY
CEEEEEEEECEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRPKHIYSIYRKMVDQHKQFSQIYDLLAIRVITVSVRDCYAVLGAIHAKWKPIPGRFKDY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
IAMPKANMYQSLHTTVVGPEGRPLEIQIRTQAMHRVAEYGVAAHWAYKEGIKDELAQNTT
HCCCCHHHHHHHHHEEECCCCCEEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCC
DAKLNWFKEIVELQDESNDAADFMEGVKGDLFGDRVYAFTPKGDVYELPKGAGPLDLAYI
CHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCCCCEEEEE
IHTEVGNHATGAKVNGKIVPLDYTIKNGDIVEILTSKNSAGPSRDWINLVSTRRGRNKIK
EEECCCCCCCCCEECCEEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCHHHHH
QFFRQVDHEENVEKGRDILAKQLEQTGYDVSDLMDDEHLKDVANQMNFSQINDLFAAVGF
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCC
GDLAPAGIANRLTKDLRKQAEEDRQREEQKQLLESHQTISNESNDDRKKKKSSSEGIVIE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEE
GADNLLVRLSHCCSPVPGDEIVGYITKGRGVSVHRVECPNVRQAEENGERIIEVSWENPN
CCCHHHHHHHHHCCCCCCHHHEEEEECCCCCEEEEECCCCCCCHHCCCCEEEEEECCCCC
DESGNYSADLEVEGYNRNGMLNDVLKSVNNSTRNLSSVNGKLDHNRMVVISMTIGVRNLL
CCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCHHHCCCCCCCCCEEEEEEHHHHHHHH
HLQRVMESLKNVKDVYVVKRPTH
HHHHHHHHHHCCHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]