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The map label for this gene is glmS [H]

Identifier: 116492280

GI number: 116492280

Start: 529906

End: 531723

Strand: Direct

Name: glmS [H]

Synonym: PEPE_0478

Alternate gene names: 116492280

Gene position: 529906-531723 (Clockwise)

Preceding gene: 116492279

Following gene: 116492281

Centisome position: 28.92

GC content: 39.49

Gene sequence:

>1818_bases
ATGTGTGGAATTGTAGGAGTTACTGGAAGAGCTGATACAACCAATCTATTAGTAAATGGACTTAAAAAACTTGAATATCG
TGGATATGATTCTGCGGGAATTTATGTCAGCAATGCTAATGGTGAAGATCATCTGGTTAAAGCTCAAGGTAAGATTAAAA
ATCTTGAGGAAAAAATTACGGATGATGTCATGGGAACCACAGGAATTGGCCACACACGCTGGGCAACACATGGAGTACCA
AGTATTGAAAATGCTCACCCTCATTTTTCAGAAGACCACCGTTTTTACTTAGTTCACAACGGGGTAATTCAAAATTTCAA
AGAACTTAAAAAAGACTATTTATCTGAAGTTACTTTCCAAAGCGATACGGATACGGAGGTTGTGGTTCAACTTATCGATC
GTTTTGCTAAAGCAGGGATGGATACGGAACAAGCTTTTAAAAAAGCAATTAGTTTATTAAAAGATTCATCATATGCCTTT
GTTTTGATGGACCGTCAATTACCAGAAACCTTATTCGTAGCTAAGAACAAGAGTCCTTTGTTAATCGGAGTGGGCGAAGA
TTTCAATGTAGTTTGCAGTGATGCATTGGCAATGATTAACGTGACTAACCAATTTGTTGAATTACACGACGGGGAGGTAG
TTAAGATTACGCCTCAAAGCATTTCAATTAGTAATCTAGCCGGCGAAAGGATCGACCGTGCTCCTTTCACTGTTGATATT
GATCAAGCTGACGCGGATAAAGGAACTTACCCATACTACATGCTTAAAGAAGTTGATGAACAACCTGCTGTAATCCGTCG
TATCGAAGCTAAATATTTAGATCACGCCGGCAATATTCACTTTGATCAAGCTTTGTTAGATCAAATTAATCAAGCTTCTA
AACTTTACATCGTTGGGGCTGGAACCAGTTATCATGCTGGATTAGTGGGTAAGAAGTTATTTGAGAAGTTTACCAAAACT
CCTACGGAAGTGGTATTAGCTTCTGAATTTGCTTACGACGATCCTATCATTGAAGATCAAGCCTTCTTTATCTTCTTGAG
TCAAAGTGGAGAGACTGCTGATAGTCGTCAAGTTTTAGTTCGAGTAAACGATGAATGGCAAAAACCCAGCCTAACAATTA
CTAACGTTGCTAACTCAACATTGGCTCGTGAAGCGGACTTCTCAGCTACGCTGGAAGCGGGTCCTGAAATTGCCGTTGCT
TCAACTAAAGCATATACAGCGCAAATCGCAGTAGAAGCTTTATTGGCAGTAGCAATGGGACGTGAAAAGACTAATGCTAC
AGCTGTCAATTTTGATATTACGGGACAATTGAGTAAGGTTGCTAATGCCATTCAAACCGTGGTCGATGAGAAGGGTAAGA
TTGAAGAGTTAGCTCTAGCAACTTTACGAAAAACGCGCAATGCGTTTTATATTGGACGAGGCTTGGATTATAATGTTGCC
TTGGAATCTTCTTTGAAACTAAAAGAAATTTCTTATATCCAAGCTGAAGGTTTTGCTTCTGGTGAATTAAAGCATGGTAC
GATTGCTTTGATTGAAGATGGAACGCCGGTAATTGGAATTATTACGCAATCTAAGACGGCGGATCATACGCGTAGTAATC
TTCAAGAAGTTCTTTCTCGTGGTGCTAACGTCATCACCATGGTTAGTGAAGATTTGGCTAATTCTACAGATGATATCTTA
CTTCCAGTAGTGGACGAAATGTTGATGCCATTGGTTAGTGTGATAGCTGCTCAATTGTTAGCTTATTATGCTAGTTTGCA
GCGTGGATATAACGTAGACCAACCACGTAATTTAGCTAAGAGTGTCACGGTCGAATAA

Upstream 100 bases:

>100_bases
TATTAGCGTTTGACAATTCTATAAAGCCGTTATATATTAATAATCGTTCTATATACCAATTTTAAAAATTTAAATATATT
AATTTAGAGGTGCAAGTAGT

Downstream 100 bases:

>100_bases
AAGTTAATATCTAAAATAAGCGGTACAGGTGCTAAACTGTATCGCTATTTTTTTGGATAAATTGCTAAACAGTATTGACA
CTCATAGTTGTAAGCGTTAT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MCGIVGVTGRADTTNLLVNGLKKLEYRGYDSAGIYVSNANGEDHLVKAQGKIKNLEEKITDDVMGTTGIGHTRWATHGVP
SIENAHPHFSEDHRFYLVHNGVIQNFKELKKDYLSEVTFQSDTDTEVVVQLIDRFAKAGMDTEQAFKKAISLLKDSSYAF
VLMDRQLPETLFVAKNKSPLLIGVGEDFNVVCSDALAMINVTNQFVELHDGEVVKITPQSISISNLAGERIDRAPFTVDI
DQADADKGTYPYYMLKEVDEQPAVIRRIEAKYLDHAGNIHFDQALLDQINQASKLYIVGAGTSYHAGLVGKKLFEKFTKT
PTEVVLASEFAYDDPIIEDQAFFIFLSQSGETADSRQVLVRVNDEWQKPSLTITNVANSTLAREADFSATLEAGPEIAVA
STKAYTAQIAVEALLAVAMGREKTNATAVNFDITGQLSKVANAIQTVVDEKGKIEELALATLRKTRNAFYIGRGLDYNVA
LESSLKLKEISYIQAEGFASGELKHGTIALIEDGTPVIGIITQSKTADHTRSNLQEVLSRGANVITMVSEDLANSTDDIL
LPVVDEMLMPLVSVIAAQLLAYYASLQRGYNVDQPRNLAKSVTVE

Sequences:

>Translated_605_residues
MCGIVGVTGRADTTNLLVNGLKKLEYRGYDSAGIYVSNANGEDHLVKAQGKIKNLEEKITDDVMGTTGIGHTRWATHGVP
SIENAHPHFSEDHRFYLVHNGVIQNFKELKKDYLSEVTFQSDTDTEVVVQLIDRFAKAGMDTEQAFKKAISLLKDSSYAF
VLMDRQLPETLFVAKNKSPLLIGVGEDFNVVCSDALAMINVTNQFVELHDGEVVKITPQSISISNLAGERIDRAPFTVDI
DQADADKGTYPYYMLKEVDEQPAVIRRIEAKYLDHAGNIHFDQALLDQINQASKLYIVGAGTSYHAGLVGKKLFEKFTKT
PTEVVLASEFAYDDPIIEDQAFFIFLSQSGETADSRQVLVRVNDEWQKPSLTITNVANSTLAREADFSATLEAGPEIAVA
STKAYTAQIAVEALLAVAMGREKTNATAVNFDITGQLSKVANAIQTVVDEKGKIEELALATLRKTRNAFYIGRGLDYNVA
LESSLKLKEISYIQAEGFASGELKHGTIALIEDGTPVIGIITQSKTADHTRSNLQEVLSRGANVITMVSEDLANSTDDIL
LPVVDEMLMPLVSVIAAQLLAYYASLQRGYNVDQPRNLAKSVTVE
>Mature_605_residues
MCGIVGVTGRADTTNLLVNGLKKLEYRGYDSAGIYVSNANGEDHLVKAQGKIKNLEEKITDDVMGTTGIGHTRWATHGVP
SIENAHPHFSEDHRFYLVHNGVIQNFKELKKDYLSEVTFQSDTDTEVVVQLIDRFAKAGMDTEQAFKKAISLLKDSSYAF
VLMDRQLPETLFVAKNKSPLLIGVGEDFNVVCSDALAMINVTNQFVELHDGEVVKITPQSISISNLAGERIDRAPFTVDI
DQADADKGTYPYYMLKEVDEQPAVIRRIEAKYLDHAGNIHFDQALLDQINQASKLYIVGAGTSYHAGLVGKKLFEKFTKT
PTEVVLASEFAYDDPIIEDQAFFIFLSQSGETADSRQVLVRVNDEWQKPSLTITNVANSTLAREADFSATLEAGPEIAVA
STKAYTAQIAVEALLAVAMGREKTNATAVNFDITGQLSKVANAIQTVVDEKGKIEELALATLRKTRNAFYIGRGLDYNVA
LESSLKLKEISYIQAEGFASGELKHGTIALIEDGTPVIGIITQSKTADHTRSNLQEVLSRGANVITMVSEDLANSTDDIL
LPVVDEMLMPLVSVIAAQLLAYYASLQRGYNVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=34.061135371179, Blast_Score=338, Evalue=9e-93,
Organism=Homo sapiens, GI4826742, Length=695, Percent_Identity=33.5251798561151, Blast_Score=334, Evalue=2e-91,
Organism=Escherichia coli, GI1790167, Length=617, Percent_Identity=39.2220421393841, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1788651, Length=173, Percent_Identity=31.2138728323699, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532899, Length=433, Percent_Identity=32.5635103926097, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17539970, Length=439, Percent_Identity=32.3462414578588, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17532897, Length=433, Percent_Identity=32.5635103926097, Blast_Score=212, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6322745, Length=457, Percent_Identity=31.2910284463895, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323731, Length=425, Percent_Identity=25.4117647058824, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=33.8164251207729, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21357745, Length=697, Percent_Identity=33.142037302726, Blast_Score=334, Evalue=9e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66284; Mature: 66284

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGVTGRADTTNLLVNGLKKLEYRGYDSAGIYVSNANGEDHLVKAQGKIKNLEEKIT
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEECCCHHHHHHHHHH
DDVMGTTGIGHTRWATHGVPSIENAHPHFSEDHRFYLVHNGVIQNFKELKKDYLSEVTFQ
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCC
SDTDTEVVVQLIDRFAKAGMDTEQAFKKAISLLKDSSYAFVLMDRQLPETLFVAKNKSPL
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCE
LIGVGEDFNVVCSDALAMINVTNQFVELHDGEVVKITPQSISISNLAGERIDRAPFTVDI
EEECCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEECCCCEEHHHHCCHHHCCCCCEEEC
DQADADKGTYPYYMLKEVDEQPAVIRRIEAKYLDHAGNIHFDQALLDQINQASKLYIVGA
CCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEC
GTSYHAGLVGKKLFEKFTKTPTEVVLASEFAYDDPIIEDQAFFIFLSQSGETADSRQVLV
CCCCCHHHHHHHHHHHHHCCCHHEEEEHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEE
RVNDEWQKPSLTITNVANSTLAREADFSATLEAGPEIAVASTKAYTAQIAVEALLAVAMG
EECCCCCCCCEEEEECCCCHHHHCCCCCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHC
REKTNATAVNFDITGQLSKVANAIQTVVDEKGKIEELALATLRKTRNAFYIGRGLDYNVA
CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEE
LESSLKLKEISYIQAEGFASGELKHGTIALIEDGTPVIGIITQSKTADHTRSNLQEVLSR
ECCCCCCHHHHEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHC
GANVITMVSEDLANSTDDILLPVVDEMLMPLVSVIAAQLLAYYASLQRGYNVDQPRNLAK
CCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SVTVE
HCCCC
>Mature Secondary Structure
MCGIVGVTGRADTTNLLVNGLKKLEYRGYDSAGIYVSNANGEDHLVKAQGKIKNLEEKIT
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEECCCHHHHHHHHHH
DDVMGTTGIGHTRWATHGVPSIENAHPHFSEDHRFYLVHNGVIQNFKELKKDYLSEVTFQ
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCC
SDTDTEVVVQLIDRFAKAGMDTEQAFKKAISLLKDSSYAFVLMDRQLPETLFVAKNKSPL
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCE
LIGVGEDFNVVCSDALAMINVTNQFVELHDGEVVKITPQSISISNLAGERIDRAPFTVDI
EEECCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEECCCCEEHHHHCCHHHCCCCCEEEC
DQADADKGTYPYYMLKEVDEQPAVIRRIEAKYLDHAGNIHFDQALLDQINQASKLYIVGA
CCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEC
GTSYHAGLVGKKLFEKFTKTPTEVVLASEFAYDDPIIEDQAFFIFLSQSGETADSRQVLV
CCCCCHHHHHHHHHHHHHCCCHHEEEEHHHCCCCCCCCCCEEEEEEECCCCCCCCCEEEE
RVNDEWQKPSLTITNVANSTLAREADFSATLEAGPEIAVASTKAYTAQIAVEALLAVAMG
EECCCCCCCCEEEEECCCCHHHHCCCCCEECCCCCCEEEECCCHHHHHHHHHHHHHHHHC
REKTNATAVNFDITGQLSKVANAIQTVVDEKGKIEELALATLRKTRNAFYIGRGLDYNVA
CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEE
LESSLKLKEISYIQAEGFASGELKHGTIALIEDGTPVIGIITQSKTADHTRSNLQEVLSR
ECCCCCCHHHHEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHC
GANVITMVSEDLANSTDDILLPVVDEMLMPLVSVIAAQLLAYYASLQRGYNVDQPRNLAK
CCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SVTVE
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]