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The map label for this gene is phoR [H]

Identifier: 116492235

GI number: 116492235

Start: 482676

End: 484061

Strand: Direct

Name: phoR [H]

Synonym: PEPE_0432

Alternate gene names: 116492235

Gene position: 482676-484061 (Clockwise)

Preceding gene: 116492234

Following gene: 116492236

Centisome position: 26.34

GC content: 36.87

Gene sequence:

>1386_bases
ATGAGTTCGTCTCGAAAAAAGGCGATTAAGCGTACCGTGCAATTTGGTTTTGCTAGTCTAATCGGAAATGCCTTTATGGC
TTTTCTGGTGTATAAATTAATTGTAAAAGAAAATCCACGAGTAACTAAGGTAGATATGTCACTGTTAATCGCCGTGATTT
TATTAATTACGGTTATTGAAATAATTGTATTTTGGAGTAATCAAAAGAAAATTATTGAGCGTCAAAAGTTATTCAGAAAG
AACTTAGAAGAAGTTATTAAAGGTAACCATGTTCCCAAGATTCAATTGGATCCAGAAGATCCATTTTATAAATTATCTAA
AGTTGTTAATGAAATTGGTACCCATGAGCGTCATCAAATTCACGTTTTGAGAAATCAACAAAGTGAATTAACCGCCATTA
TGGATAATTTGCCAGTAGGAGTGCTAGTTATTAATCGGCACCGTGAACTACAAGTGGCTAACACGTACGCTATTAACCAC
TTAGGGATTACTGGACTCGACGTTCCTCACCCATATACCATGGATATTCGGGATCATGAATTAAGTGAATTGGTGGATAA
CGTGTTTAGAACACGTCAGAGTACTACCAAAACAATTAAACTAGATGGGGACCAGCCATATATTTATGAAACAACGGTTG
TTTACAGTCCCAAAGTGCACCATAAATTTGAAATTATTGTGCTACTTTACGATGCAACGGAAACGGTGCGCTCTAAACAA
ATTGAACGTGACTTTGTTAACAATGCTTCGCACGAACTTCGTACACCAATTACATCGATTGCGGGCTTCGCAGATACGTT
ACTAAACGGAGCCAAGGACGATCCAGAAACCTTGGATAATTTCTTACGTATTATTAAGGCTGAAAGTGATAAGTTAGTGC
AATTAACGGACGATATTTTAACCATGTCGCGCGTTAAGAGTGGTGAACGAGAACGTAAAGAAATTAATTTACATAAGTAT
GTGGATCAACAACTTAAGTTAGTAGAAAGTAACATCAGTAGCATGAATCTACATGTGGAAAACAATATTCCAGCAGATGT
TAATGAAGAAGTGATTGAAAATGATTTATTCCAAATCGTCAAGAATTTGATTACTAATGCGATTAGTTACAATCGAAAAG
GTGGAAAAATCAAGATTGATTACGGATCACATCATGACCGTTGGAAGCTCGTAGTGAGTGATACTGGTATTGGAATTCCT
TTAGGTCAGACGGACCGCGTTTTTGAACGTTTTTATCGGGTGAATAACGCTACTAAAGGTGGTACTGGATTAGGTTTAGC
CATTGTTAAAGAAGCGGTTGACGATATGAATGGTAGCGTTCGAATCGAATCAGATGAAGATAGCGGAACCACGGTGATCG
TAAAATTCAAGCGTGATATTAATTAA

Upstream 100 bases:

>100_bases
CAGACCCGTATTGTAGATATCCACATCAGTCATTTGAGGGATAAACTGGAAAATGATCCCAAACATCCACAGTTGATCAA
AACCATTAGGGGGTTTGGAT

Downstream 100 bases:

>100_bases
ATATTGTGGAATAAAGTTGAATTTTAATTCGGCTTTATTTTTTTTACACTTTTTACTATTTTAAAATTCTTTACATAATC
TTTACATACCTCATATTTAA

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSSSRKKAIKRTVQFGFASLIGNAFMAFLVYKLIVKENPRVTKVDMSLLIAVILLITVIEIIVFWSNQKKIIERQKLFRK
NLEEVIKGNHVPKIQLDPEDPFYKLSKVVNEIGTHERHQIHVLRNQQSELTAIMDNLPVGVLVINRHRELQVANTYAINH
LGITGLDVPHPYTMDIRDHELSELVDNVFRTRQSTTKTIKLDGDQPYIYETTVVYSPKVHHKFEIIVLLYDATETVRSKQ
IERDFVNNASHELRTPITSIAGFADTLLNGAKDDPETLDNFLRIIKAESDKLVQLTDDILTMSRVKSGERERKEINLHKY
VDQQLKLVESNISSMNLHVENNIPADVNEEVIENDLFQIVKNLITNAISYNRKGGKIKIDYGSHHDRWKLVVSDTGIGIP
LGQTDRVFERFYRVNNATKGGTGLGLAIVKEAVDDMNGSVRIESDEDSGTTVIVKFKRDIN

Sequences:

>Translated_461_residues
MSSSRKKAIKRTVQFGFASLIGNAFMAFLVYKLIVKENPRVTKVDMSLLIAVILLITVIEIIVFWSNQKKIIERQKLFRK
NLEEVIKGNHVPKIQLDPEDPFYKLSKVVNEIGTHERHQIHVLRNQQSELTAIMDNLPVGVLVINRHRELQVANTYAINH
LGITGLDVPHPYTMDIRDHELSELVDNVFRTRQSTTKTIKLDGDQPYIYETTVVYSPKVHHKFEIIVLLYDATETVRSKQ
IERDFVNNASHELRTPITSIAGFADTLLNGAKDDPETLDNFLRIIKAESDKLVQLTDDILTMSRVKSGERERKEINLHKY
VDQQLKLVESNISSMNLHVENNIPADVNEEVIENDLFQIVKNLITNAISYNRKGGKIKIDYGSHHDRWKLVVSDTGIGIP
LGQTDRVFERFYRVNNATKGGTGLGLAIVKEAVDDMNGSVRIESDEDSGTTVIVKFKRDIN
>Mature_460_residues
SSSRKKAIKRTVQFGFASLIGNAFMAFLVYKLIVKENPRVTKVDMSLLIAVILLITVIEIIVFWSNQKKIIERQKLFRKN
LEEVIKGNHVPKIQLDPEDPFYKLSKVVNEIGTHERHQIHVLRNQQSELTAIMDNLPVGVLVINRHRELQVANTYAINHL
GITGLDVPHPYTMDIRDHELSELVDNVFRTRQSTTKTIKLDGDQPYIYETTVVYSPKVHHKFEIIVLLYDATETVRSKQI
ERDFVNNASHELRTPITSIAGFADTLLNGAKDDPETLDNFLRIIKAESDKLVQLTDDILTMSRVKSGERERKEINLHKYV
DQQLKLVESNISSMNLHVENNIPADVNEEVIENDLFQIVKNLITNAISYNRKGGKIKIDYGSHHDRWKLVVSDTGIGIPL
GQTDRVFERFYRVNNATKGGTGLGLAIVKEAVDDMNGSVRIESDEDSGTTVIVKFKRDIN

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=238, Percent_Identity=27.7310924369748, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994928, Length=373, Percent_Identity=26.8096514745308, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=29.3617021276596, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786600, Length=238, Percent_Identity=26.890756302521, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693157, Length=233, Percent_Identity=28.3261802575107, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=26.5873015873016, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=245, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=27.8008298755187, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081816, Length=235, Percent_Identity=24.6808510638298, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=25.7261410788382, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788549, Length=343, Percent_Identity=24.7813411078717, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=222, Percent_Identity=26.5765765765766, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790300, Length=214, Percent_Identity=28.0373831775701, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=26.9058295964126, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789403, Length=192, Percent_Identity=27.6041666666667, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082128, Length=213, Percent_Identity=25.8215962441315, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52517; Mature: 52386

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSRKKAIKRTVQFGFASLIGNAFMAFLVYKLIVKENPRVTKVDMSLLIAVILLITVIE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
IIVFWSNQKKIIERQKLFRKNLEEVIKGNHVPKIQLDPEDPFYKLSKVVNEIGTHERHQI
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEE
HVLRNQQSELTAIMDNLPVGVLVINRHRELQVANTYAINHLGITGLDVPHPYTMDIRDHE
EEECCCHHHHHHHHHCCCEEEEEEECCCEEEEEEEEEEEECCCCCCCCCCCEEECCCCCH
LSELVDNVFRTRQSTTKTIKLDGDQPYIYETTVVYSPKVHHKFEIIVLLYDATETVRSKQ
HHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCEEEEEEEEECCHHHHHHHH
IERDFVNNASHELRTPITSIAGFADTLLNGAKDDPETLDNFLRIIKAESDKLVQLTDDIL
HHHHHHCCCCHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHH
TMSRVKSGERERKEINLHKYVDQQLKLVESNISSMNLHVENNIPADVNEEVIENDLFQIV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
KNLITNAISYNRKGGKIKIDYGSHHDRWKLVVSDTGIGIPLGQTDRVFERFYRVNNATKG
HHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCC
GTGLGLAIVKEAVDDMNGSVRIESDEDSGTTVIVKFKRDIN
CCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCC
>Mature Secondary Structure 
SSSRKKAIKRTVQFGFASLIGNAFMAFLVYKLIVKENPRVTKVDMSLLIAVILLITVIE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
IIVFWSNQKKIIERQKLFRKNLEEVIKGNHVPKIQLDPEDPFYKLSKVVNEIGTHERHQI
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEE
HVLRNQQSELTAIMDNLPVGVLVINRHRELQVANTYAINHLGITGLDVPHPYTMDIRDHE
EEECCCHHHHHHHHHCCCEEEEEEECCCEEEEEEEEEEEECCCCCCCCCCCEEECCCCCH
LSELVDNVFRTRQSTTKTIKLDGDQPYIYETTVVYSPKVHHKFEIIVLLYDATETVRSKQ
HHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCEEEEEEEEECCHHHHHHHH
IERDFVNNASHELRTPITSIAGFADTLLNGAKDDPETLDNFLRIIKAESDKLVQLTDDIL
HHHHHHCCCCHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHH
TMSRVKSGERERKEINLHKYVDQQLKLVESNISSMNLHVENNIPADVNEEVIENDLFQIV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
KNLITNAISYNRKGGKIKIDYGSHHDRWKLVVSDTGIGIPLGQTDRVFERFYRVNNATKG
HHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCC
GTGLGLAIVKEAVDDMNGSVRIESDEDSGTTVIVKFKRDIN
CCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]