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The map label for this gene is guaA

Identifier: 116492215

GI number: 116492215

Start: 459253

End: 460806

Strand: Direct

Name: guaA

Synonym: PEPE_0412

Alternate gene names: 116492215

Gene position: 459253-460806 (Clockwise)

Preceding gene: 116492214

Following gene: 116492217

Centisome position: 25.06

GC content: 40.93

Gene sequence:

>1554_bases
TTGGCGAACGCAGATTTATCAAATTTTGATAAAATCATTGTTTTGGATTTCGGTAGTCAATACAACCAATTGATTACACG
TAGAATCCGTGAATTCGGTATTTACTCTGAGCTTCTTTCTCATAAGATTACTGCTGAAGAAATCAAAAAGATTAATCCTA
AAGGAATTATCTTCTCTGGTGGACCTAACAGTGTTTATGATAAAGATGCCTTTCGAATTGACCCAGAAATTTATAAGTTA
GGTATTCCAATTTTAGGTATTTGTTACGGAATGCAATTAATGACTTATAACTTAGGCGGACGAGTTGAACCAGCTGATAA
CCGTGAATACGGTCATGCTGATATTGATGTGACTGATGATCAAGCGGTTATGTTTAAAGAGCTTCCTGCTAAACAAACAG
TTTGGATGAGCCATGGTGATTTGGTTCGTGAAGTCCCTGAAGGATTTAAGACCGTTGCAACTAGCGCAAACTGTCCGATT
GCCTCAATGGCTGATGATGCTCGTAAGTTCTACGGGGTTCAATTCCATGCTGAAGTACGTAATACTCAATATGGTAACGA
AATTCTCCGGCACTTTGCATTTGACGTTTGTGAAGCTAAAGCTAACTGGTCCATGAACGACTTTATCGACATGCAAGTAC
AACAAATCCGTGAAACTGTGGGAGACCGTAAAGTATTGCTTGGTCTTTCTGGTGGAGTGGATTCTAGCGTGGTTGGGGTA
TTACTCAATAAAGCAATCGGTGACCAATTAGTATGTATCTTCGTAGATCACGGTTTACTCCGCAAGGGCGAAGCAAAGCA
AGTTATGGATAGTCTAGAAGGTAAGTTTGGTTTGAACATTATCAAAGTGGATGCTCAAGATCGCTTCTTGAGTAAGCTTG
CTGGTGTTTCAGAACCTGAACAAAAACGTAAGATTATTGGTAACGAGTTTATTCAAGTATTTAATGATGAAGCACAAAAA
CTTAAAGGAATTGACTTCCTAGCTCAAGGTACGCTTTACACTGATGTAATCGAAAGTGGAACAGATACTGCTCAAACGAT
TAAGTCACATCATAATGTGGGTGGACTTCCAGAAGACATGCACTTTGAATTGATTGAACCACTTCGTACTTTATTTAAAG
ACGAAGCTCGTGACCTTGGTGAAAAATTGGGAATGCCAGAAGATCTCGTTTGGCGTCAACCATTCCCAGGTCCTGGTTTG
GGAATTCGTGTAATCGGTGAAATCACCGAAGACAAACTTCAAATTGTGCGTGACAGTGACTTGATTCTTCGCGAAGAAAT
CAAGAAGGCTGGTCTCGACCGTGATATCTGGCAATACTTTACTGTTTTACCTGGTATCCGTAGTGTTGGTGTTATGGGTG
ACGGCCGCACTTACGATTACACAGTAGGTATCCGGGCTGTTAACTCAATCGACGGTATGACTGCCGACTTTGCTCGTATC
CCATGGGATGTCTTGCAAAAGATTTCGGTACGTATCGTAAATGAAGTGGACCATGTTAACCGCATCGTCTATGACATTAC
TTCTAAGCCACCGGCAACTGTGGAATGGGAATAA

Upstream 100 bases:

>100_bases
ATAGCCTTTTCATCGATTGTGAGGCAAGCTTAGGGGCTATGGTTTTTCCCGTTTTTACTGTATGATAGATGAGTAAGAAT
AAAAGAATGAGGTGAAGGAC

Downstream 100 bases:

>100_bases
AAGTAATATAAAATTTAAAATAAGAATCGCATAACTACGGGCTTTTAAGAGTGTTTAATGGGACGGAAAACAATAAAAAT
TGATATGGTTCCCTACAATT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MANADLSNFDKIIVLDFGSQYNQLITRRIREFGIYSELLSHKITAEEIKKINPKGIIFSGGPNSVYDKDAFRIDPEIYKL
GIPILGICYGMQLMTYNLGGRVEPADNREYGHADIDVTDDQAVMFKELPAKQTVWMSHGDLVREVPEGFKTVATSANCPI
ASMADDARKFYGVQFHAEVRNTQYGNEILRHFAFDVCEAKANWSMNDFIDMQVQQIRETVGDRKVLLGLSGGVDSSVVGV
LLNKAIGDQLVCIFVDHGLLRKGEAKQVMDSLEGKFGLNIIKVDAQDRFLSKLAGVSEPEQKRKIIGNEFIQVFNDEAQK
LKGIDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMHFELIEPLRTLFKDEARDLGEKLGMPEDLVWRQPFPGPGL
GIRVIGEITEDKLQIVRDSDLILREEIKKAGLDRDIWQYFTVLPGIRSVGVMGDGRTYDYTVGIRAVNSIDGMTADFARI
PWDVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE

Sequences:

>Translated_517_residues
MANADLSNFDKIIVLDFGSQYNQLITRRIREFGIYSELLSHKITAEEIKKINPKGIIFSGGPNSVYDKDAFRIDPEIYKL
GIPILGICYGMQLMTYNLGGRVEPADNREYGHADIDVTDDQAVMFKELPAKQTVWMSHGDLVREVPEGFKTVATSANCPI
ASMADDARKFYGVQFHAEVRNTQYGNEILRHFAFDVCEAKANWSMNDFIDMQVQQIRETVGDRKVLLGLSGGVDSSVVGV
LLNKAIGDQLVCIFVDHGLLRKGEAKQVMDSLEGKFGLNIIKVDAQDRFLSKLAGVSEPEQKRKIIGNEFIQVFNDEAQK
LKGIDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMHFELIEPLRTLFKDEARDLGEKLGMPEDLVWRQPFPGPGL
GIRVIGEITEDKLQIVRDSDLILREEIKKAGLDRDIWQYFTVLPGIRSVGVMGDGRTYDYTVGIRAVNSIDGMTADFARI
PWDVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE
>Mature_516_residues
ANADLSNFDKIIVLDFGSQYNQLITRRIREFGIYSELLSHKITAEEIKKINPKGIIFSGGPNSVYDKDAFRIDPEIYKLG
IPILGICYGMQLMTYNLGGRVEPADNREYGHADIDVTDDQAVMFKELPAKQTVWMSHGDLVREVPEGFKTVATSANCPIA
SMADDARKFYGVQFHAEVRNTQYGNEILRHFAFDVCEAKANWSMNDFIDMQVQQIRETVGDRKVLLGLSGGVDSSVVGVL
LNKAIGDQLVCIFVDHGLLRKGEAKQVMDSLEGKFGLNIIKVDAQDRFLSKLAGVSEPEQKRKIIGNEFIQVFNDEAQKL
KGIDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMHFELIEPLRTLFKDEARDLGEKLGMPEDLVWRQPFPGPGLG
IRVIGEITEDKLQIVRDSDLILREEIKKAGLDRDIWQYFTVLPGIRSVGVMGDGRTYDYTVGIRAVNSIDGMTADFARIP
WDVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=548, Percent_Identity=37.043795620438, Blast_Score=314, Evalue=1e-85,
Organism=Escherichia coli, GI1788854, Length=517, Percent_Identity=51.8375241779497, Blast_Score=563, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71992710, Length=574, Percent_Identity=35.3658536585366, Blast_Score=298, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI71992717, Length=574, Percent_Identity=35.3658536585366, Blast_Score=298, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=574, Percent_Identity=35.3658536585366, Blast_Score=297, Evalue=8e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=525, Percent_Identity=53.3333333333333, Blast_Score=545, Evalue=1e-156,
Organism=Drosophila melanogaster, GI281365319, Length=548, Percent_Identity=37.956204379562, Blast_Score=315, Evalue=5e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_PEDPA (Q03H14)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_803950.1
- ProteinModelPortal:   Q03H14
- SMR:   Q03H14
- STRING:   Q03H14
- GeneID:   4418413
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0412
- NMPDR:   fig|278197.10.peg.384
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   VVNAAHS
- PhylomeDB:   Q03H14
- ProtClustDB:   PRK00074
- BioCyc:   PPEN278197:PEPE_0412-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57977; Mature: 57846

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 88-88 ACT_SITE 176-176 ACT_SITE 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANADLSNFDKIIVLDFGSQYNQLITRRIREFGIYSELLSHKITAEEIKKINPKGIIFSG
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEECC
GPNSVYDKDAFRIDPEIYKLGIPILGICYGMQLMTYNLGGRVEPADNREYGHADIDVTDD
CCCCCCCCCCEEECHHHHHHCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCEECCC
QAVMFKELPAKQTVWMSHGDLVREVPEGFKTVATSANCPIASMADDARKFYGVQFHAEVR
CHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCEEEEEHHH
NTQYGNEILRHFAFDVCEAKANWSMNDFIDMQVQQIRETVGDRKVLLGLSGGVDSSVVGV
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHH
LLNKAIGDQLVCIFVDHGLLRKGEAKQVMDSLEGKFGLNIIKVDAQDRFLSKLAGVSEPE
HHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCH
QKRKIIGNEFIQVFNDEAQKLKGIDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDM
HHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCH
HFELIEPLRTLFKDEARDLGEKLGMPEDLVWRQPFPGPGLGIRVIGEITEDKLQIVRDSD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCEEEEEHHCHHHHHHHCCCC
LILREEIKKAGLDRDIWQYFTVLPGIRSVGVMGDGRTYDYTVGIRAVNSIDGMTADFARI
HHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCEEEEEEEEEEECCCCCCCHHHHHC
PWDVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE
CHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure 
ANADLSNFDKIIVLDFGSQYNQLITRRIREFGIYSELLSHKITAEEIKKINPKGIIFSG
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEECC
GPNSVYDKDAFRIDPEIYKLGIPILGICYGMQLMTYNLGGRVEPADNREYGHADIDVTDD
CCCCCCCCCCEEECHHHHHHCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCEECCC
QAVMFKELPAKQTVWMSHGDLVREVPEGFKTVATSANCPIASMADDARKFYGVQFHAEVR
CHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCEEEEEHHH
NTQYGNEILRHFAFDVCEAKANWSMNDFIDMQVQQIRETVGDRKVLLGLSGGVDSSVVGV
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHH
LLNKAIGDQLVCIFVDHGLLRKGEAKQVMDSLEGKFGLNIIKVDAQDRFLSKLAGVSEPE
HHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCH
QKRKIIGNEFIQVFNDEAQKLKGIDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDM
HHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCH
HFELIEPLRTLFKDEARDLGEKLGMPEDLVWRQPFPGPGLGIRVIGEITEDKLQIVRDSD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCEEEEEHHCHHHHHHHCCCC
LILREEIKKAGLDRDIWQYFTVLPGIRSVGVMGDGRTYDYTVGIRAVNSIDGMTADFARI
HHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCEEEEEEEEEEECCCCCCCHHHHHC
PWDVLQKISVRIVNEVDHVNRIVYDITSKPPATVEWE
CHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA