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The map label for this gene is trxA [H]

Identifier: 116492176

GI number: 116492176

Start: 419777

End: 420106

Strand: Direct

Name: trxA [H]

Synonym: PEPE_0373

Alternate gene names: 116492176

Gene position: 419777-420106 (Clockwise)

Preceding gene: 116492175

Following gene: 116492177

Centisome position: 22.91

GC content: 36.06

Gene sequence:

>330_bases
ATGGCCGTTACAATTAATCAAGATAACTTAACTGACGTGACACAATCTGGACTAACCATTGTGGACTTTTGGGCTCCTTG
GTGTGGTCCTTGTAAAATGATGGAACCAGCCTTAGAGAGTTTGGAAAAAACTTATGGAGATCAAATCCAGTTTGCCAAAA
TGAATGTGGATAACAATCAAGCAGTAGCAGAATCTTTTAAAATTATGAGCATTCCAGCATTGGTTTTGTTTAAAGATGGA
AAAGCCATTGAAAAAGTGACGGGGTATTATCCTGAAGCAAAATTAGCCAAATACTTAGAAAAGAAGATATCAGAAAATGA
ACCAAAGTAA

Upstream 100 bases:

>100_bases
CTTAGCCTTTTTAATTACAATTGGAATTCACTACGCCAAAAGACCGGCAAAAAAACAATGATATAATTTATGGTAACAAG
TTAGTAAAAAGGAGACAGAA

Downstream 100 bases:

>100_bases
AACAGCGATTGTGATTGATAGTTCAGCCAATATAGCTCCGGAAATCGTGCGTAAGTATCATTTTACGATCGTTAATCAAC
CGGTTATGTTTGGTAAACAT

Product: Thiol-disulfide isomerase and thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MAVTINQDNLTDVTQSGLTIVDFWAPWCGPCKMMEPALESLEKTYGDQIQFAKMNVDNNQAVAESFKIMSIPALVLFKDG
KAIEKVTGYYPEAKLAKYLEKKISENEPK

Sequences:

>Translated_109_residues
MAVTINQDNLTDVTQSGLTIVDFWAPWCGPCKMMEPALESLEKTYGDQIQFAKMNVDNNQAVAESFKIMSIPALVLFKDG
KAIEKVTGYYPEAKLAKYLEKKISENEPK
>Mature_108_residues
AVTINQDNLTDVTQSGLTIVDFWAPWCGPCKMMEPALESLEKTYGDQIQFAKMNVDNNQAVAESFKIMSIPALVLFKDGK
AIEKVTGYYPEAKLAKYLEKKISENEPK

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=85, Percent_Identity=31.7647058823529, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082331, Length=95, Percent_Identity=37.8947368421053, Blast_Score=82, Evalue=9e-18,
Organism=Escherichia coli, GI1788936, Length=85, Percent_Identity=31.7647058823529, Blast_Score=78, Evalue=1e-16,
Organism=Escherichia coli, GI87081747, Length=108, Percent_Identity=31.4814814814815, Blast_Score=65, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=37.1134020618557, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=43.2098765432099, Blast_Score=75, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=101, Percent_Identity=39.6039603960396, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=76, Percent_Identity=42.1052631578947, Blast_Score=73, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24639826, Length=100, Percent_Identity=36, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17648013, Length=89, Percent_Identity=37.0786516853933, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583090, Length=89, Percent_Identity=37.0786516853933, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573567, Length=91, Percent_Identity=29.6703296703297, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17530795, Length=71, Percent_Identity=33.8028169014084, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12222; Mature: 12091

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTINQDNLTDVTQSGLTIVDFWAPWCGPCKMMEPALESLEKTYGDQIQFAKMNVDNNQ
CEEEECCCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
AVAESFKIMSIPALVLFKDGKAIEKVTGYYPEAKLAKYLEKKISENEPK
HHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AVTINQDNLTDVTQSGLTIVDFWAPWCGPCKMMEPALESLEKTYGDQIQFAKMNVDNNQ
EEEECCCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
AVAESFKIMSIPALVLFKDGKAIEKVTGYYPEAKLAKYLEKKISENEPK
HHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA