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The map label for this gene is nagB

Identifier: 116492138

GI number: 116492138

Start: 383043

End: 383753

Strand: Direct

Name: nagB

Synonym: PEPE_0335

Alternate gene names: 116492138

Gene position: 383043-383753 (Clockwise)

Preceding gene: 116492132

Following gene: 116492139

Centisome position: 20.9

GC content: 37.83

Gene sequence:

>711_bases
ATGAAGGTTATTATTGTTAAAGATAACGTAGAAGGCGGAAAAGAAGGATACAAACTATTTGCTGATGCAAAGAAAAATGG
AGCAACAACATTTGGGTTAGCTACTGGTAGTACACCGATTACCACTTATCAAGAAATTATTAAGAGTGATCTAGATTTTA
CGGACTCAATCTCAATCAATTTAGATGAATATGTTGGTTTGCCAGAAGATAGTGACCAAAGTTATGATTACTTTATGCAC
GAAAACCTCTTCAATGCTAAACCATTCAAGCACTCATACTTACCAAATGGTCGTGCAGCAGATCTTGAAGCCGAAGCCAA
GCACTATGACCAAATTATCGAAGATAACCCAATTGATTTACAAATCCTTGGTATCGGACGTAATGGTCACATTGGTTTTA
ACGAACCAGGTACACCTGCAGACAGTACAACTCACAAAGTGTCACTAACTCAATCAACAATTGATGCTAACGCTCGTTTC
TTCGAACATGAAGAAGACGTTCCACGTTATGCTATTTCAATGGGACTTGCTTCAATTATGAAGAGTAAGCATATTTTGAT
CGAAGCTTACGGCGAAGACAAAGCTGATGCAATCAAAGGTATGATCGAAGGTCCTGTCACAACTGACTTACCAGCTAGTG
TTCTTCAAAACCATGATAACGTTACTGTTATTATTGATGAAGCAGCTGCTAGCAAGCTTTCAAACAAATAA

Upstream 100 bases:

>100_bases
AAGAGAAAGTTATTTTTAATTTTTTAGGATAAATCCTTGCATTTTGGTTTAGACCATTTTATAATTGGACTATACCAAAA
ACGAAAAAGGAGATTTGATC

Downstream 100 bases:

>100_bases
TTTAAAATATTCAGCCTAACATAAAGTCTTTGTGTTAGGCTTTTTTTATTGCAGTCAAAATGTAAAATTTGTTGATAGTT
GAAAACGTTTACGCAAAGAG

Product: glucosamine-6-phosphate isomerase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKVIIVKDNVEGGKEGYKLFADAKKNGATTFGLATGSTPITTYQEIIKSDLDFTDSISINLDEYVGLPEDSDQSYDYFMH
ENLFNAKPFKHSYLPNGRAADLEAEAKHYDQIIEDNPIDLQILGIGRNGHIGFNEPGTPADSTTHKVSLTQSTIDANARF
FEHEEDVPRYAISMGLASIMKSKHILIEAYGEDKADAIKGMIEGPVTTDLPASVLQNHDNVTVIIDEAAASKLSNK

Sequences:

>Translated_236_residues
MKVIIVKDNVEGGKEGYKLFADAKKNGATTFGLATGSTPITTYQEIIKSDLDFTDSISINLDEYVGLPEDSDQSYDYFMH
ENLFNAKPFKHSYLPNGRAADLEAEAKHYDQIIEDNPIDLQILGIGRNGHIGFNEPGTPADSTTHKVSLTQSTIDANARF
FEHEEDVPRYAISMGLASIMKSKHILIEAYGEDKADAIKGMIEGPVTTDLPASVLQNHDNVTVIIDEAAASKLSNK
>Mature_236_residues
MKVIIVKDNVEGGKEGYKLFADAKKNGATTFGLATGSTPITTYQEIIKSDLDFTDSISINLDEYVGLPEDSDQSYDYFMH
ENLFNAKPFKHSYLPNGRAADLEAEAKHYDQIIEDNPIDLQILGIGRNGHIGFNEPGTPADSTTHKVSLTQSTIDANARF
FEHEEDVPRYAISMGLASIMKSKHILIEAYGEDKADAIKGMIEGPVTTDLPASVLQNHDNVTVIIDEAAASKLSNK

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily

Homologues:

Organism=Homo sapiens, GI13027378, Length=216, Percent_Identity=37.962962962963, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI19923881, Length=216, Percent_Identity=36.5740740740741, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1786893, Length=215, Percent_Identity=35.8139534883721, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1789530, Length=217, Percent_Identity=28.110599078341, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI48994958, Length=231, Percent_Identity=26.8398268398268, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17554876, Length=247, Percent_Identity=34.412955465587, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24581960, Length=216, Percent_Identity=40.7407407407407, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19920764, Length=216, Percent_Identity=40.7407407407407, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGB_PEDPA (Q03H91)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_803873.1
- ProteinModelPortal:   Q03H91
- SMR:   Q03H91
- STRING:   Q03H91
- GeneID:   4418476
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0335
- NMPDR:   fig|278197.10.peg.309
- eggNOG:   COG0363
- HOGENOM:   HBG725991
- OMA:   IIAEHPI
- PhylomeDB:   Q03H91
- ProtClustDB:   CLSK2304935
- BioCyc:   PPEN278197:PEPE_0335-MONOMER
- HAMAP:   MF_01241
- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321
- PANTHER:   PTHR11280
- TIGRFAMs:   TIGR00502

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.5.99.6

Molecular weight: Translated: 25867; Mature: 25867

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: ACT_SITE 62-62 ACT_SITE 128-128 ACT_SITE 130-130 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIIVKDNVEGGKEGYKLFADAKKNGATTFGLATGSTPITTYQEIIKSDLDFTDSISIN
CEEEEEECCCCCCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEE
LDEYVGLPEDSDQSYDYFMHENLFNAKPFKHSYLPNGRAADLEAEAKHYDQIIEDNPIDL
HHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEE
QILGIGRNGHIGFNEPGTPADSTTHKVSLTQSTIDANARFFEHEEDVPRYAISMGLASIM
EEEEECCCCCCCCCCCCCCCCCCEEEEEEEHHHHCCCCCEECCCCCCHHHHHHHHHHHHH
KSKHILIEAYGEDKADAIKGMIEGPVTTDLPASVLQNHDNVTVIIDEAAASKLSNK
CCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEECHHHHHCCCC
>Mature Secondary Structure
MKVIIVKDNVEGGKEGYKLFADAKKNGATTFGLATGSTPITTYQEIIKSDLDFTDSISIN
CEEEEEECCCCCCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEE
LDEYVGLPEDSDQSYDYFMHENLFNAKPFKHSYLPNGRAADLEAEAKHYDQIIEDNPIDL
HHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEE
QILGIGRNGHIGFNEPGTPADSTTHKVSLTQSTIDANARFFEHEEDVPRYAISMGLASIM
EEEEECCCCCCCCCCCCCCCCCCEEEEEEEHHHHCCCCCEECCCCCCHHHHHHHHHHHHH
KSKHILIEAYGEDKADAIKGMIEGPVTTDLPASVLQNHDNVTVIIDEAAASKLSNK
CCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEECHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA