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The map label for this gene is pepV [H]

Identifier: 116492042

GI number: 116492042

Start: 274447

End: 275844

Strand: Direct

Name: pepV [H]

Synonym: PEPE_0234

Alternate gene names: 116492042

Gene position: 274447-275844 (Clockwise)

Preceding gene: 116492041

Following gene: 116492043

Centisome position: 14.98

GC content: 38.7

Gene sequence:

>1398_bases
ATGACAATTGATTGGAATGCTGAAGTACAAAGTCGTAAAGACGTTATGTTAGAACGCTTAATGGAATTACTTAAGATTGA
TAGCTCACGTGATACAGAACATGCAACCAAAGATGCTCCACTTGGACCTGGTCCCCGTAAAGCTTTGGAAACGATGTTGG
CTTTTGCCAAAGAAGATGGATTTGTAACGAAGAACATCGATAACGTTGCAGGTCATATTGAATACGGAGATGGCGAAGAA
ATTTTCGGAATTCTCGGTCATATGGACGAAGTGCCCGCTGGGGAAGGTTGGGAAACTAACCCATTTGAACCAGTAGAAAA
AAATGGACGAATTTATGCACGTGGAATTAGTGATGATAAGGGCCCTTCAATGGCTGCTTATTTAGCATTACAAATCATTA
AAGAATTGAAGTTGCCCGTTTCTAAAAAAATCCGTTTAATCTTTGGAACCGATGAAGAGAGCGAATGGGTTGGTATGAAT
CGTTATCTTGAAGTTGAAAAAACTCCTGATTTTGGTTTTTCTCCAGATGCTGAATTCCCAATTATTAATGGTGAAAAAGG
GATTGCTTCCTTCAAAATTGAACTTCCTCAATCAGATGGACAAGGCGATTTAGTTTTGAAATCATTTACTAGTGGTATTA
AAGAAAATATGATTCCACGGGATGCAACAGCAATCGCAATTGCTGATAATGTTGACGTTGAAGAACTTAAAACCGAATTT
GATACATTTTTAGCTGAAAATGGATTGACGGGAGAATTTACCGTTGATGGAAATGAATTGAAATTTTTCTTGATTGGAAA
ATCAGCACATGCGCTAGAACCGAAAGCAGGATTGAATGCTGCTACCTTTTTAGCAACTTTCTTAAATACTAAAGTAGCCA
GCAACTATTTGAAGATGATTGCCGAACAAATGCATTTAGATTCACGTGGTCATAAGTTAGGAATTAATTCGATTGATGCT
AAGATGGGTGACTTAACGGTCACACCGGACTTATTTAATTACGAATTCGGTAAGACTAATCACGTTATTATTAACGTTCG
TTACCCTCAATCAACGAATGCGGATGAAATTATCGAAAAGGCAACTGAGGCCCTTTCGGATTTTGAAGCAAAAGTTGAAA
TTCATGGACACGCCCAAGTACCACATTATGTATCCGGTGAAGACCCATTGGTTAAAACACTTCTTTCAGTTTACGAAGAA
CATACTGGTGAAAAGGGTGAAGAAACGGTCATTGGTGGTGGAACTTACGGTCGAATTTTAGATCGCGGTGTTGCCTTTGG
GGCCCAGTTCCCAGGCCGTGAAAATGTCATGCATCAAGCTAATGAATACATGGAAATTGATGATATTATCAACGCTGCTG
TTATCTACGCCCATGCAATTTATGAGTTAGCTAAATAA

Upstream 100 bases:

>100_bases
TAACCTTCTAAAAGGTGGAACTCCACATCCTTATCTTTTTTCTGTATAATCTACCGTATAGAAAAAATGTATATGAATAA
AAATAAAGGTGGTATCCCAG

Downstream 100 bases:

>100_bases
GGTTGACAGTCGTTTTGAATATCCGTAAAATTGTAACCAATAACGAAGCTTTGAAGTAGCATAGTAGGTTATTAAGCAAG
CAAACAGAAATCTGGTGGGG

Product: dipeptidase PepV

Products: succinate; LL-2,6-diaminoheptanedioate

Alternate protein names: Beta-Ala-His dipeptidase; Peptidase V [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTIDWNAEVQSRKDVMLERLMELLKIDSSRDTEHATKDAPLGPGPRKALETMLAFAKEDGFVTKNIDNVAGHIEYGDGEE
IFGILGHMDEVPAGEGWETNPFEPVEKNGRIYARGISDDKGPSMAAYLALQIIKELKLPVSKKIRLIFGTDEESEWVGMN
RYLEVEKTPDFGFSPDAEFPIINGEKGIASFKIELPQSDGQGDLVLKSFTSGIKENMIPRDATAIAIADNVDVEELKTEF
DTFLAENGLTGEFTVDGNELKFFLIGKSAHALEPKAGLNAATFLATFLNTKVASNYLKMIAEQMHLDSRGHKLGINSIDA
KMGDLTVTPDLFNYEFGKTNHVIINVRYPQSTNADEIIEKATEALSDFEAKVEIHGHAQVPHYVSGEDPLVKTLLSVYEE
HTGEKGEETVIGGGTYGRILDRGVAFGAQFPGRENVMHQANEYMEIDDIINAAVIYAHAIYELAK

Sequences:

>Translated_465_residues
MTIDWNAEVQSRKDVMLERLMELLKIDSSRDTEHATKDAPLGPGPRKALETMLAFAKEDGFVTKNIDNVAGHIEYGDGEE
IFGILGHMDEVPAGEGWETNPFEPVEKNGRIYARGISDDKGPSMAAYLALQIIKELKLPVSKKIRLIFGTDEESEWVGMN
RYLEVEKTPDFGFSPDAEFPIINGEKGIASFKIELPQSDGQGDLVLKSFTSGIKENMIPRDATAIAIADNVDVEELKTEF
DTFLAENGLTGEFTVDGNELKFFLIGKSAHALEPKAGLNAATFLATFLNTKVASNYLKMIAEQMHLDSRGHKLGINSIDA
KMGDLTVTPDLFNYEFGKTNHVIINVRYPQSTNADEIIEKATEALSDFEAKVEIHGHAQVPHYVSGEDPLVKTLLSVYEE
HTGEKGEETVIGGGTYGRILDRGVAFGAQFPGRENVMHQANEYMEIDDIINAAVIYAHAIYELAK
>Mature_464_residues
TIDWNAEVQSRKDVMLERLMELLKIDSSRDTEHATKDAPLGPGPRKALETMLAFAKEDGFVTKNIDNVAGHIEYGDGEEI
FGILGHMDEVPAGEGWETNPFEPVEKNGRIYARGISDDKGPSMAAYLALQIIKELKLPVSKKIRLIFGTDEESEWVGMNR
YLEVEKTPDFGFSPDAEFPIINGEKGIASFKIELPQSDGQGDLVLKSFTSGIKENMIPRDATAIAIADNVDVEELKTEFD
TFLAENGLTGEFTVDGNELKFFLIGKSAHALEPKAGLNAATFLATFLNTKVASNYLKMIAEQMHLDSRGHKLGINSIDAK
MGDLTVTPDLFNYEFGKTNHVIINVRYPQSTNADEIIEKATEALSDFEAKVEIHGHAQVPHYVSGEDPLVKTLLSVYEEH
TGEKGEETVIGGGTYGRILDRGVAFGAQFPGRENVMHQANEYMEIDDIINAAVIYAHAIYELAK

Specific function: Is a relatively unspecific dipeptidase cleaving a variety of dipeptides, notably those with an N-terminal beta-Ala or D-Ala residue, e.g. carnosine (beta-Ala-His). To a lesser extent, also shows aminopeptidase activity, since it is able to catalyze the re

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17563146, Length=127, Percent_Identity=37.007874015748, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193211059, Length=95, Percent_Identity=37.8947368421053, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR011291
- InterPro:   IPR010964
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF01546 Peptidase_M20 [H]

EC number: 3.5.1.18

Molecular weight: Translated: 51320; Mature: 51189

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDWNAEVQSRKDVMLERLMELLKIDSSRDTEHATKDAPLGPGPRKALETMLAFAKEDG
CEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
FVTKNIDNVAGHIEYGDGEEIFGILGHMDEVPAGEGWETNPFEPVEKNGRIYARGISDDK
CEECCCHHHCCEEECCCCHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
GPSMAAYLALQIIKELKLPVSKKIRLIFGTDEESEWVGMNRYLEVEKTPDFGFSPDAEFP
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCEEEEEECCCCCCCCCCCCCC
IINGEKGIASFKIELPQSDGQGDLVLKSFTSGIKENMIPRDATAIAIADNVDVEELKTEF
EECCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHH
DTFLAENGLTGEFTVDGNELKFFLIGKSAHALEPKAGLNAATFLATFLNTKVASNYLKMI
HHHHHCCCCCEEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AEQMHLDSRGHKLGINSIDAKMGDLTVTPDLFNYEFGKTNHVIINVRYPQSTNADEIIEK
HHHHHCCCCCCEECCCHHCCCCCCEEECCHHHCCCCCCCCEEEEEEECCCCCCHHHHHHH
ATEALSDFEAKVEIHGHAQVPHYVSGEDPLVKTLLSVYEEHTGEKGEETVIGGGTYGRIL
HHHHHHCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHH
DRGVAFGAQFPGRENVMHQANEYMEIDDIINAAVIYAHAIYELAK
HHHHHCCCCCCCHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIDWNAEVQSRKDVMLERLMELLKIDSSRDTEHATKDAPLGPGPRKALETMLAFAKEDG
EECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
FVTKNIDNVAGHIEYGDGEEIFGILGHMDEVPAGEGWETNPFEPVEKNGRIYARGISDDK
CEECCCHHHCCEEECCCCHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCC
GPSMAAYLALQIIKELKLPVSKKIRLIFGTDEESEWVGMNRYLEVEKTPDFGFSPDAEFP
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCEEEEEECCCCCCCCCCCCCC
IINGEKGIASFKIELPQSDGQGDLVLKSFTSGIKENMIPRDATAIAIADNVDVEELKTEF
EECCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHH
DTFLAENGLTGEFTVDGNELKFFLIGKSAHALEPKAGLNAATFLATFLNTKVASNYLKMI
HHHHHCCCCCEEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AEQMHLDSRGHKLGINSIDAKMGDLTVTPDLFNYEFGKTNHVIINVRYPQSTNADEIIEK
HHHHHCCCCCCEECCCHHCCCCCCEEECCHHHCCCCCCCCEEEEEEECCCCCCHHHHHHH
ATEALSDFEAKVEIHGHAQVPHYVSGEDPLVKTLLSVYEEHTGEKGEETVIGGGTYGRIL
HHHHHHCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHH
DRGVAFGAQFPGRENVMHQANEYMEIDDIINAAVIYAHAIYELAK
HHHHHCCCCCCCHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-LL-2,6-diaminoheptanedioate; H2O

Specific reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7528082 [H]