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The map label for this gene is rmlA [H]

Identifier: 116327949

GI number: 116327949

Start: 1456474

End: 1457358

Strand: Direct

Name: rmlA [H]

Synonym: LBL_1238

Alternate gene names: 116327949

Gene position: 1456474-1457358 (Clockwise)

Preceding gene: 116327948

Following gene: 116327950

Centisome position: 40.3

GC content: 40.11

Gene sequence:

>885_bases
ATGAAATCGAGAAAAGGGATTATACTCGCAGGCGGTTCTGGAACAAGGCTTTATCCGGTTACGTACGTCGTTTCCAAACA
ACTTTTGCCGGTTTACGATAAACCGATGATTTATTACCCACTAACAACGCTTATGCTAGCGGGAATTAAAGAAATACTTT
TGATTTCCACGCCCCAAGCGACTCCTATGTATAAAGAACTGTTAGGAGACGGAAAACAATGGGGAATTTCTATCGAATAT
GCGGTTCAGCCCGAACCGGGAGGATTGGCGCAAGCATATTGGATCGGAGAAAATTTCGTCAACGGGCATCCGTCCGTATT
GATTCTTGGAGATAATATTTATTTCGGTCATAATCTTGCTGTTCTTTTAGAGAACGCTTCTAAAAAAACTAAGGGTTCTA
CCGTGTTCGCGTATCCGGTTCATGATCCGGAGCGGTATGGAGTGGTGGAATTTGATTCGGAAAGACGTGCGGTTTCGATC
GAAGAAAAACCTTCTAAGCCGAAGTCCAATTACGCAGTCACTGGATTATATTTTTATGATGAAGAAGTTGTGAGTATAGC
CAAGTCCATTAAACCTTCTGCAAGAGGAGAATTGGAAATTACGGACGTAAATAGGATTTATTTAGAAAGAGGAATTTTAA
ACGTTCAAGTGATGGGACGAGGATACGCTTGGTTGGATACTGGGACTCACGAATCTCTTTTAGAGGCGTCTGTATTTATA
GAAACGATTGAAAAAAGACAGGGACTTAAAGTTGCCTGCCCGGAGGAAATCGCATTTAGAAAAGGTTTTATAGATGGGTC
TCAATTAGAAAAATTGATAGTTCCTCTTAAAAAAACAGGTTATGGAGAATATCTTGTGAAAATACTTCAAGAAAAGATTT
ACTAA

Upstream 100 bases:

>100_bases
AGAGACGGTCCGGTGGTATTTAGACAACGAGTCTTGGTGGAAGGAAATTCTTTCCGGTCAATATAAAGAATATTACCAAA
ATCAGTATGAGAAACATTAG

Downstream 100 bases:

>100_bases
ATTCCATAGAGGTTTTACATTTTTAAACTATTTGTTTTTTGATTCTGCTATCAGTATATCGTTTTTTGGTTATTGTCTGA
TCGTATAATAAGTGTTTACC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKSRKGIILAGGSGTRLYPVTYVVSKQLLPVYDKPMIYYPLTTLMLAGIKEILLISTPQATPMYKELLGDGKQWGISIEY
AVQPEPGGLAQAYWIGENFVNGHPSVLILGDNIYFGHNLAVLLENASKKTKGSTVFAYPVHDPERYGVVEFDSERRAVSI
EEKPSKPKSNYAVTGLYFYDEEVVSIAKSIKPSARGELEITDVNRIYLERGILNVQVMGRGYAWLDTGTHESLLEASVFI
ETIEKRQGLKVACPEEIAFRKGFIDGSQLEKLIVPLKKTGYGEYLVKILQEKIY

Sequences:

>Translated_294_residues
MKSRKGIILAGGSGTRLYPVTYVVSKQLLPVYDKPMIYYPLTTLMLAGIKEILLISTPQATPMYKELLGDGKQWGISIEY
AVQPEPGGLAQAYWIGENFVNGHPSVLILGDNIYFGHNLAVLLENASKKTKGSTVFAYPVHDPERYGVVEFDSERRAVSI
EEKPSKPKSNYAVTGLYFYDEEVVSIAKSIKPSARGELEITDVNRIYLERGILNVQVMGRGYAWLDTGTHESLLEASVFI
ETIEKRQGLKVACPEEIAFRKGFIDGSQLEKLIVPLKKTGYGEYLVKILQEKIY
>Mature_294_residues
MKSRKGIILAGGSGTRLYPVTYVVSKQLLPVYDKPMIYYPLTTLMLAGIKEILLISTPQATPMYKELLGDGKQWGISIEY
AVQPEPGGLAQAYWIGENFVNGHPSVLILGDNIYFGHNLAVLLENASKKTKGSTVFAYPVHDPERYGVVEFDSERRAVSI
EEKPSKPKSNYAVTGLYFYDEEVVSIAKSIKPSARGELEITDVNRIYLERGILNVQVMGRGYAWLDTGTHESLLEASVFI
ETIEKRQGLKVACPEEIAFRKGFIDGSQLEKLIVPLKKTGYGEYLVKILQEKIY

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=267, Percent_Identity=22.4719101123595, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI11761619, Length=267, Percent_Identity=22.4719101123595, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788351, Length=291, Percent_Identity=70.7903780068729, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1790224, Length=288, Percent_Identity=62.1527777777778, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI133931050, Length=197, Percent_Identity=25.8883248730964, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=252, Percent_Identity=27.3809523809524, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=24.3027888446215, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=24.3027888446215, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32834; Mature: 32834

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRKGIILAGGSGTRLYPVTYVVSKQLLPVYDKPMIYYPLTTLMLAGIKEILLISTPQA
CCCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCCEEEECHHHHHHHCHHEEEEEECCCC
TPMYKELLGDGKQWGISIEYAVQPEPGGLAQAYWIGENFVNGHPSVLILGDNIYFGHNLA
CHHHHHHHCCCCHHCEEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCEEECCCEE
VLLENASKKTKGSTVFAYPVHDPERYGVVEFDSERRAVSIEEKPSKPKSNYAVTGLYFYD
EEEECCCCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
EEVVSIAKSIKPSARGELEITDVNRIYLERGILNVQVMGRGYAWLDTGTHESLLEASVFI
HHHHHHHHHCCCCCCCEEEEEECCEEEECCCEEEEEEECCCEEEEECCCHHHHHHHHHHH
ETIEKRQGLKVACPEEIAFRKGFIDGSQLEKLIVPLKKTGYGEYLVKILQEKIY
HHHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSRKGIILAGGSGTRLYPVTYVVSKQLLPVYDKPMIYYPLTTLMLAGIKEILLISTPQA
CCCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCCEEEECHHHHHHHCHHEEEEEECCCC
TPMYKELLGDGKQWGISIEYAVQPEPGGLAQAYWIGENFVNGHPSVLILGDNIYFGHNLA
CHHHHHHHCCCCHHCEEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCEEECCCEE
VLLENASKKTKGSTVFAYPVHDPERYGVVEFDSERRAVSIEEKPSKPKSNYAVTGLYFYD
EEEECCCCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
EEVVSIAKSIKPSARGELEITDVNRIYLERGILNVQVMGRGYAWLDTGTHESLLEASVFI
HHHHHHHHHCCCCCCCEEEEEECCEEEECCCEEEEEEECCCEEEEECCCHHHHHHHHHHH
ETIEKRQGLKVACPEEIAFRKGFIDGSQLEKLIVPLKKTGYGEYLVKILQEKIY
HHHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]