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The map label for this gene is pyrE [H]

Identifier: 116327704

GI number: 116327704

Start: 1098387

End: 1098950

Strand: Direct

Name: pyrE [H]

Synonym: LBL_0950

Alternate gene names: 116327704

Gene position: 1098387-1098950 (Clockwise)

Preceding gene: 116327702

Following gene: 116327705

Centisome position: 30.39

GC content: 43.26

Gene sequence:

>564_bases
ATGAAACAGAAACTTTTAGAACTCATTCTGACTCATGCATACCGTTATTCGGAACAACCTTTTACCCTCGCTTCCGGAAA
AAAGTCCAGACATTATTTTAACTGTAAGGAAATTACGCTTGTTCCGGATCGTTTGGAACTTCTTTGTAAATTTATCGTAG
AACGGCATTTAGACGAATCAGGGATTTTAAAACCGCAGGCTTTCGGCGGTCTTACAATGGGGGCCGATCCGATCTGTTAC
GGAATCAGTTTGGAATTTAGAAAACAAGATAAGAACATATATCCTTTGATCGTTCGCAAATTTTCCAAGGATCACGGAAC
GAACAAATTGGTGGAAGGTGCGGTGCACGAAGTAAAAAGCTGTGTGATCGTGGACGACGTAATTACGACCGGGGGATCCA
CGATTCAAGCGATCCGTAGTATGCGTGATTCCGGAATCGTGGTCGTTCAAGGAGTCTGCATCTTGGATCGCCAGGAAGGC
GGAATGGATGCGATCCTTGCGGAAGGGGTCCAAATGTTTCCTATATTCAAAAAAAGTGATTTTGGAAATTTGGAACATGA
GTGA

Upstream 100 bases:

>100_bases
GATAGAATGATGGGCTTTTCGATTTTTCCGAAATTGAAAACGGGTTTTCGGATTCTTTCCTGAAAATTCACTGGTTAAAA
ACGTGTAAAAAAGAATTTCG

Downstream 100 bases:

>100_bases
ATTTCCCTACGATTTCGGTAAGTTTCGAAGAAATCTGATTTTTCGCTCGATTGCCGTGGTTCTTCTTTATTTCGTATTTA
TTGTCTGGAATTTTCTTAAG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MKQKLLELILTHAYRYSEQPFTLASGKKSRHYFNCKEITLVPDRLELLCKFIVERHLDESGILKPQAFGGLTMGADPICY
GISLEFRKQDKNIYPLIVRKFSKDHGTNKLVEGAVHEVKSCVIVDDVITTGGSTIQAIRSMRDSGIVVVQGVCILDRQEG
GMDAILAEGVQMFPIFKKSDFGNLEHE

Sequences:

>Translated_187_residues
MKQKLLELILTHAYRYSEQPFTLASGKKSRHYFNCKEITLVPDRLELLCKFIVERHLDESGILKPQAFGGLTMGADPICY
GISLEFRKQDKNIYPLIVRKFSKDHGTNKLVEGAVHEVKSCVIVDDVITTGGSTIQAIRSMRDSGIVVVQGVCILDRQEG
GMDAILAEGVQMFPIFKKSDFGNLEHE
>Mature_187_residues
MKQKLLELILTHAYRYSEQPFTLASGKKSRHYFNCKEITLVPDRLELLCKFIVERHLDESGILKPQAFGGLTMGADPICY
GISLEFRKQDKNIYPLIVRKFSKDHGTNKLVEGAVHEVKSCVIVDDVITTGGSTIQAIRSMRDSGIVVVQGVCILDRQEG
GMDAILAEGVQMFPIFKKSDFGNLEHE

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=164, Percent_Identity=26.8292682926829, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554964, Length=181, Percent_Identity=28.1767955801105, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17933654, Length=187, Percent_Identity=31.0160427807487, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 20974; Mature: 20974

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKLLELILTHAYRYSEQPFTLASGKKSRHYFNCKEITLVPDRLELLCKFIVERHLDES
CHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEECCEEEEECHHHHHHHHHHHHHHCCCCC
GILKPQAFGGLTMGADPICYGISLEFRKQDKNIYPLIVRKFSKDHGTNKLVEGAVHEVKS
CCCCCCCCCCCCCCCCCEEEECEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVIVDDVITTGGSTIQAIRSMRDSGIVVVQGVCILDRQEGGMDAILAEGVQMFPIFKKSD
HEEEHHHHHCCCHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHCCCCEEEEEECCC
FGNLEHE
CCCCCCC
>Mature Secondary Structure
MKQKLLELILTHAYRYSEQPFTLASGKKSRHYFNCKEITLVPDRLELLCKFIVERHLDES
CHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEECCEEEEECHHHHHHHHHHHHHHCCCCC
GILKPQAFGGLTMGADPICYGISLEFRKQDKNIYPLIVRKFSKDHGTNKLVEGAVHEVKS
CCCCCCCCCCCCCCCCCEEEECEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVIVDDVITTGGSTIQAIRSMRDSGIVVVQGVCILDRQEGGMDAILAEGVQMFPIFKKSD
HEEEHHHHHCCCHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHCCCCEEEEEECCC
FGNLEHE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA