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The map label for this gene is rnc [H]

Identifier: 116327694

GI number: 116327694

Start: 1088661

End: 1089404

Strand: Direct

Name: rnc [H]

Synonym: LBL_0940

Alternate gene names: 116327694

Gene position: 1088661-1089404 (Clockwise)

Preceding gene: 116327693

Following gene: 116327695

Centisome position: 30.12

GC content: 39.52

Gene sequence:

>744_bases
TTGGTCTTTAAGAAAACACAACCTTCCCCTTCGTTGAAAAATCCGGAACGGATCCAAAGTTTTAAAAAGCTTTCCAAAAA
AATCGGAATCAAGTTTTCAAAAATAGAATATTATAATACCGCATTTATCCATAGTTCTTATAAAAACGAAAATCCGGAGA
TCTTAGAAGACAACGAACGACTTGAATTTTTAGGTGATTCGGTATTGGGTCTTGTGGCTGCTCGTTCTCTTTTTCAAAAA
TATCCGAAAGCCAGCGAAGGAGAATTGTCTAGAATCAAATCTAAAATCGTTTCCACTCCTATTTTAAATTCCATCGCGGA
AAAGTTGAATCTCGGTGAATATCTTCTTTTGGGAAAGGGTGAGAAAAATTCTCAAGGGAAAGGTCGTCGTAAAATTGCGG
CGAATCTTTTTGAATCTCTTGTGGGGGCGATTTATTTGGATCGAGGATTCGAGGTCGCGGAAAAATTCATCGTTCAGCAT
TTGTTGGAATTTGCAGAGAATCCGGACATGGAGGAGTCTGTTAGGGATTATAAAACACAGCTCCAGGAATATTCTCAAAA
ACATTTTAAAACTCTCCCTGTCTATCGCATGAAGGGAGAATCGGGACCAGACCATTCAAAGATGTTTCAAGTTTCCGTTC
GGATCCGGGATCAATGGGAAGCAAGTGGTTATGGAGCCAGCAAAAAAATTGCGGAACAAAACGCGGCAAAGGAGCTTTAC
ATTCGAATTCGTAGAGGGTTTTAG

Upstream 100 bases:

>100_bases
AACTGTCGGGGACGTAACTAAGTTCATCGACAACCTCAAGTCCTAATCGTTTGAGACTTTCCGGGTTCTTCACGGGACTC
GGAATTCTTTTTTCCTTCCT

Downstream 100 bases:

>100_bases
AAACTCTGCATTCTATTTAAAAATGCGAAGCCTTGGGATTTTCTCGAATGATCTATTGTTAGGAGCTGTAGGGGATACAT
TATTGTTCGATTGAAAGAAG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MVFKKTQPSPSLKNPERIQSFKKLSKKIGIKFSKIEYYNTAFIHSSYKNENPEILEDNERLEFLGDSVLGLVAARSLFQK
YPKASEGELSRIKSKIVSTPILNSIAEKLNLGEYLLLGKGEKNSQGKGRRKIAANLFESLVGAIYLDRGFEVAEKFIVQH
LLEFAENPDMEESVRDYKTQLQEYSQKHFKTLPVYRMKGESGPDHSKMFQVSVRIRDQWEASGYGASKKIAEQNAAKELY
IRIRRGF

Sequences:

>Translated_247_residues
MVFKKTQPSPSLKNPERIQSFKKLSKKIGIKFSKIEYYNTAFIHSSYKNENPEILEDNERLEFLGDSVLGLVAARSLFQK
YPKASEGELSRIKSKIVSTPILNSIAEKLNLGEYLLLGKGEKNSQGKGRRKIAANLFESLVGAIYLDRGFEVAEKFIVQH
LLEFAENPDMEESVRDYKTQLQEYSQKHFKTLPVYRMKGESGPDHSKMFQVSVRIRDQWEASGYGASKKIAEQNAAKELY
IRIRRGF
>Mature_247_residues
MVFKKTQPSPSLKNPERIQSFKKLSKKIGIKFSKIEYYNTAFIHSSYKNENPEILEDNERLEFLGDSVLGLVAARSLFQK
YPKASEGELSRIKSKIVSTPILNSIAEKLNLGEYLLLGKGEKNSQGKGRRKIAANLFESLVGAIYLDRGFEVAEKFIVQH
LLEFAENPDMEESVRDYKTQLQEYSQKHFKTLPVYRMKGESGPDHSKMFQVSVRIRDQWEASGYGASKKIAEQNAAKELY
IRIRRGF

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=230, Percent_Identity=29.5652173913043, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI155030236, Length=230, Percent_Identity=29.5652173913043, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788920, Length=210, Percent_Identity=32.8571428571429, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=27.3127753303965, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=27.3127753303965, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17137682, Length=228, Percent_Identity=29.8245614035088, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28309; Mature: 28309

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFKKTQPSPSLKNPERIQSFKKLSKKIGIKFSKIEYYNTAFIHSSYKNENPEILEDNER
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHHHHHEEECCCCCCCCCEECCCCH
LEFLGDSVLGLVAARSLFQKYPKASEGELSRIKSKIVSTPILNSIAEKLNLGEYLLLGKG
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
EKNSQGKGRRKIAANLFESLVGAIYLDRGFEVAEKFIVQHLLEFAENPDMEESVRDYKTQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LQEYSQKHFKTLPVYRMKGESGPDHSKMFQVSVRIRDQWEASGYGASKKIAEQNAAKELY
HHHHHHHHHHCCCCEEECCCCCCCHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
IRIRRGF
HHHHCCC
>Mature Secondary Structure
MVFKKTQPSPSLKNPERIQSFKKLSKKIGIKFSKIEYYNTAFIHSSYKNENPEILEDNER
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHHHHHEEECCCCCCCCCEECCCCH
LEFLGDSVLGLVAARSLFQKYPKASEGELSRIKSKIVSTPILNSIAEKLNLGEYLLLGKG
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
EKNSQGKGRRKIAANLFESLVGAIYLDRGFEVAEKFIVQHLLEFAENPDMEESVRDYKTQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LQEYSQKHFKTLPVYRMKGESGPDHSKMFQVSVRIRDQWEASGYGASKKIAEQNAAKELY
HHHHHHHHHHCCCCEEECCCCCCCHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
IRIRRGF
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA