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The map label for this gene is caiA-4 [H]

Identifier: 116327431

GI number: 116327431

Start: 717491

End: 718666

Strand: Direct

Name: caiA-4 [H]

Synonym: LBL_0645

Alternate gene names: 116327431

Gene position: 717491-718666 (Clockwise)

Preceding gene: 116327427

Following gene: 116327432

Centisome position: 19.85

GC content: 47.02

Gene sequence:

>1176_bases
ATGGATTTTACGATACCTAAACAAGTCGAAGAAGTTAAAAAAAGAATTCGAGACTTCGTGGAAAATTACGCGATTCCGGC
GGAAGTTCATTATGACTACGATCATGGTAGGATGCCTGAAAAAATTACCGAAGAACTCAGAAAAAGAGTGAAAGAACTAG
GGCTTTGGACTCCGCATCTTCCTAAATCCGAAGGTGGCCTCGGACTTGATATGGTTGGAACGGCGATCATATTTTCCGAG
CTCGGGCGTTCTCCGATCGCTCCTTATCTTTGTAACTGCGATGCGCCTGACGAAGGGAATATGCATCTCCTTCATATTGC
GGCAAATAAAGAGCAAAAAGAAAAATACTATGATCCGCTGATTCAAGGGAAAATTCGTTCCGCTTTTGCGATGACGGAAC
TTCCGCCGGGAGCAGGGGCTGATCCTCAAACTCTTACTACCAACGCGATAAAAGACGGAAACGAATACGTAATCAATGGG
CGCAAATGGTATTGTACGGGTGCAAACGGTGCGAGCTTTTTAATCGTAATGTCTAAGGTGGCCGATTCTTTTCGAAGAAC
CACGATGTTTCTCGTGCCTACGGATGCGCCCGGTTATACGATGGTGAGAGAAATCGGAGTGATGGGTTCTCATGGTCCTG
GAGGACATTGCGAATTAAAATTCGAAAACGTTCGGGTTCCCGAGTCCGCAATATTGGGAAGAGTGGGCGAAGGATTCAAA
TGGTCTCAAGAACGTCTCGGTCCCGCAAGACTCACACATTGTATGAGATGGATCGGACTCGCAAGAAGATCCATGGAGAT
CGCAAGAGAATACGCACTCAAACGGGAAGTGTTCGGACAAAAACTTGCGGATCATCAGGGAATTCAGTGGATGTTCGCGG
AGTCCGCACTTGAAATTGAATCGGGTTATATGCTTACCTTGAAAGCCGCGCATACTTTGAGAGCGGGAGAAGATGCAAGA
CAGATCATATCGATGGCCAAATGGCAAGTCTCCGAAACTCTTTGTAAAACGGTCGATCGTGCGATTCAGATCTGCGGTTC
GCACGGATATGGAAGAGACATGAAACTCGAATTGTTCTACAGAGACGCAAGGGCGGCCAGGATCGCGGACGGGCCGACCG
AAGTCCATAAGATGGTGATCGGAAGAAATCTGATCAGCGGAAAAAGCGATTTTTAA

Upstream 100 bases:

>100_bases
ATCGTATCGGGAATACAAACTGGATCTCTGAGATGATCGAAAAAATACTCGAAGAAAAAAATATCCCGTAAAGCTCAAGC
TTTCTGGGGAAGGAAAGAAT

Downstream 100 bases:

>100_bases
TATTATAATTAGAGAATGTCATGAACGATACGGAATTAAAGAACGTTCTGGAAAGATATCTTTCCGAAAGATTAAAGGGA
AAAACCGAGATACATTCCAT

Product: Acyl-CoA dehydrogenase, carnitine metabolism

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MDFTIPKQVEEVKKRIRDFVENYAIPAEVHYDYDHGRMPEKITEELRKRVKELGLWTPHLPKSEGGLGLDMVGTAIIFSE
LGRSPIAPYLCNCDAPDEGNMHLLHIAANKEQKEKYYDPLIQGKIRSAFAMTELPPGAGADPQTLTTNAIKDGNEYVING
RKWYCTGANGASFLIVMSKVADSFRRTTMFLVPTDAPGYTMVREIGVMGSHGPGGHCELKFENVRVPESAILGRVGEGFK
WSQERLGPARLTHCMRWIGLARRSMEIAREYALKREVFGQKLADHQGIQWMFAESALEIESGYMLTLKAAHTLRAGEDAR
QIISMAKWQVSETLCKTVDRAIQICGSHGYGRDMKLELFYRDARAARIADGPTEVHKMVIGRNLISGKSDF

Sequences:

>Translated_391_residues
MDFTIPKQVEEVKKRIRDFVENYAIPAEVHYDYDHGRMPEKITEELRKRVKELGLWTPHLPKSEGGLGLDMVGTAIIFSE
LGRSPIAPYLCNCDAPDEGNMHLLHIAANKEQKEKYYDPLIQGKIRSAFAMTELPPGAGADPQTLTTNAIKDGNEYVING
RKWYCTGANGASFLIVMSKVADSFRRTTMFLVPTDAPGYTMVREIGVMGSHGPGGHCELKFENVRVPESAILGRVGEGFK
WSQERLGPARLTHCMRWIGLARRSMEIAREYALKREVFGQKLADHQGIQWMFAESALEIESGYMLTLKAAHTLRAGEDAR
QIISMAKWQVSETLCKTVDRAIQICGSHGYGRDMKLELFYRDARAARIADGPTEVHKMVIGRNLISGKSDF
>Mature_391_residues
MDFTIPKQVEEVKKRIRDFVENYAIPAEVHYDYDHGRMPEKITEELRKRVKELGLWTPHLPKSEGGLGLDMVGTAIIFSE
LGRSPIAPYLCNCDAPDEGNMHLLHIAANKEQKEKYYDPLIQGKIRSAFAMTELPPGAGADPQTLTTNAIKDGNEYVING
RKWYCTGANGASFLIVMSKVADSFRRTTMFLVPTDAPGYTMVREIGVMGSHGPGGHCELKFENVRVPESAILGRVGEGFK
WSQERLGPARLTHCMRWIGLARRSMEIAREYALKREVFGQKLADHQGIQWMFAESALEIESGYMLTLKAAHTLRAGEDAR
QIISMAKWQVSETLCKTVDRAIQICGSHGYGRDMKLELFYRDARAARIADGPTEVHKMVIGRNLISGKSDF

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI38505218, Length=397, Percent_Identity=36.272040302267, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI211971008, Length=391, Percent_Identity=36.5728900255754, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI48976061, Length=391, Percent_Identity=36.5728900255754, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI4557231, Length=395, Percent_Identity=30.126582278481, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI187960098, Length=395, Percent_Identity=30.126582278481, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI4557233, Length=388, Percent_Identity=30.4123711340206, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=29.6, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI21361497, Length=358, Percent_Identity=31.8435754189944, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI7656849, Length=387, Percent_Identity=25.5813953488372, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI226958414, Length=349, Percent_Identity=28.9398280802292, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI226958412, Length=382, Percent_Identity=27.2251308900524, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4501857, Length=385, Percent_Identity=26.7532467532467, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI76496475, Length=384, Percent_Identity=26.5625, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI4557235, Length=384, Percent_Identity=26.5625, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI87081958, Length=394, Percent_Identity=27.4111675126904, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786223, Length=393, Percent_Identity=27.735368956743, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17562446, Length=387, Percent_Identity=36.9509043927649, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17570075, Length=397, Percent_Identity=31.4861460957179, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17569725, Length=397, Percent_Identity=29.2191435768262, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17534899, Length=397, Percent_Identity=30.2267002518892, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17508101, Length=334, Percent_Identity=29.3413173652695, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17506239, Length=345, Percent_Identity=29.8550724637681, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17538396, Length=389, Percent_Identity=28.7917737789203, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17533517, Length=393, Percent_Identity=25.4452926208651, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71990804, Length=285, Percent_Identity=31.2280701754386, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=25.8666666666667, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17551932, Length=351, Percent_Identity=26.7806267806268, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=31.3304721030043, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71982178, Length=282, Percent_Identity=27.3049645390071, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71985184, Length=281, Percent_Identity=28.4697508896797, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=26.25, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17534353, Length=372, Percent_Identity=23.6559139784946, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71985192, Length=241, Percent_Identity=26.9709543568465, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=31.2169312169312, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24660351, Length=388, Percent_Identity=30.1546391752577, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=30.952380952381, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=30.2387267904509, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=27.7620396600567, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21355753, Length=343, Percent_Identity=28.2798833819242, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19920834, Length=404, Percent_Identity=25.7425742574257, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 43853; Mature: 43853

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFTIPKQVEEVKKRIRDFVENYAIPAEVHYDYDHGRMPEKITEELRKRVKELGLWTPHL
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PKSEGGLGLDMVGTAIIFSELGRSPIAPYLCNCDAPDEGNMHLLHIAANKEQKEKYYDPL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEECCCHHHHHHHCHH
IQGKIRSAFAMTELPPGAGADPQTLTTNAIKDGNEYVINGRKWYCTGANGASFLIVMSKV
HHHHHHHHHHHHCCCCCCCCCCCCEEHHHHCCCCEEEEECEEEEEECCCCCEEEEEHHHH
ADSFRRTTMFLVPTDAPGYTMVREIGVMGSHGPGGHCELKFENVRVPESAILGRVGEGFK
HHHHHHEEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCC
WSQERLGPARLTHCMRWIGLARRSMEIAREYALKREVFGQKLADHQGIQWMFAESALEIE
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHEEC
SGYMLTLKAAHTLRAGEDARQIISMAKWQVSETLCKTVDRAIQICGSHGYGRDMKLELFY
CCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
RDARAARIADGPTEVHKMVIGRNLISGKSDF
ECCCHHHCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDFTIPKQVEEVKKRIRDFVENYAIPAEVHYDYDHGRMPEKITEELRKRVKELGLWTPHL
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PKSEGGLGLDMVGTAIIFSELGRSPIAPYLCNCDAPDEGNMHLLHIAANKEQKEKYYDPL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEECCCHHHHHHHCHH
IQGKIRSAFAMTELPPGAGADPQTLTTNAIKDGNEYVINGRKWYCTGANGASFLIVMSKV
HHHHHHHHHHHHCCCCCCCCCCCCEEHHHHCCCCEEEEECEEEEEECCCCCEEEEEHHHH
ADSFRRTTMFLVPTDAPGYTMVREIGVMGSHGPGGHCELKFENVRVPESAILGRVGEGFK
HHHHHHEEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCC
WSQERLGPARLTHCMRWIGLARRSMEIAREYALKREVFGQKLADHQGIQWMFAESALEIE
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHEEC
SGYMLTLKAAHTLRAGEDARQIISMAKWQVSETLCKTVDRAIQICGSHGYGRDMKLELFY
CCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
RDARAARIADGPTEVHKMVIGRNLISGKSDF
ECCCHHHCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]