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The map label for this gene is adk

Identifier: 116327285

GI number: 116327285

Start: 524530

End: 525093

Strand: Direct

Name: adk

Synonym: LBL_0474

Alternate gene names: 116327285

Gene position: 524530-525093 (Clockwise)

Preceding gene: 116327284

Following gene: 116327286

Centisome position: 14.51

GC content: 44.5

Gene sequence:

>564_bases
GTGAAGAACATCATCTTCATGGGGCCTCCCGGGGCTGGAAAAGGCACGCAAGCGAAGATTCTTTGTGCAAGGCTTTCTAT
CCCTCAGATTTCCACGGGAGATATTTTACGTGAGGCCGTAAAAAATCAAACTCCGATGGGAATAGAAGCAAAACGTTATA
TGGATGCGGGAGATTTGGTGCCTGATTCTGTCGTGATCGGAATCATCAAAGACCGTATTCGAGAAGCGGATTGCAAGAAC
GGATTTTTATTGGATGGATTCCCGAGAACCGTAGAACAAGCGGACGCTCTGGATGCTCTTCTGAAAAACGAAGGTAAATC
CATCGATAAAGCGATTAATCTTGAAGTTCCAGACGGAGAACTTTTGAAACGATTGCTCGGTCGTGCGGAAATCGAAGGCC
GTGCGGATGATAACGAAGCGACGATCAAAAATCGTCTGGATAATTACAATAAAAAGACTTTACCTCTTTTGGATTTTTAC
GCGGCACAAAAGAAACTTTCTCAAGTGAATGGCGTCGGAACCCTCGAAGAAGTAACTTCTTTGATTCAAAGGGAGCTTGT
GTAA

Upstream 100 bases:

>100_bases
GCGCTCGAGACTCTGAAACAGATCGAGTCTCAACTTTTGATGAGAAATTATGAAGGCTTCATGAAGAAGTCTAAAATTAA
GGGAAGGTCTTAATTTTTCT

Downstream 100 bases:

>100_bases
GAGTGGCAAAGGAAGAAGCGATCACAGTCGATGGTACCGTACTGGAGCCTCTGCCCAACGCGATGTTCCGAGTAGAACTG
GAAAACGGTCATAAGGTGTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MKNIIFMGPPGAGKGTQAKILCARLSIPQISTGDILREAVKNQTPMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKN
GFLLDGFPRTVEQADALDALLKNEGKSIDKAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY
AAQKKLSQVNGVGTLEEVTSLIQRELV

Sequences:

>Translated_187_residues
MKNIIFMGPPGAGKGTQAKILCARLSIPQISTGDILREAVKNQTPMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKN
GFLLDGFPRTVEQADALDALLKNEGKSIDKAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY
AAQKKLSQVNGVGTLEEVTSLIQRELV
>Mature_187_residues
MKNIIFMGPPGAGKGTQAKILCARLSIPQISTGDILREAVKNQTPMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKN
GFLLDGFPRTVEQADALDALLKNEGKSIDKAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY
AAQKKLSQVNGVGTLEEVTSLIQRELV

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=36.5853658536585, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=36.5853658536585, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI4502011, Length=188, Percent_Identity=34.5744680851064, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI28144897, Length=182, Percent_Identity=31.3186813186813, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI28144899, Length=182, Percent_Identity=31.3186813186813, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=30.9644670050761, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI7706497, Length=181, Percent_Identity=28.7292817679558, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI22749187, Length=126, Percent_Identity=30.1587301587302, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1786680, Length=215, Percent_Identity=40, Blast_Score=155, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17552384, Length=205, Percent_Identity=34.6341463414634, Blast_Score=129, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17567503, Length=181, Percent_Identity=36.4640883977901, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17533833, Length=163, Percent_Identity=30.0613496932515, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=182, Percent_Identity=29.6703296703297, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=220, Percent_Identity=25.4545454545455, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=185, Percent_Identity=40.5405405405405, Blast_Score=139, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=35.0253807106599, Blast_Score=104, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=31.1475409836066, Blast_Score=96, Evalue=2e-21,
Organism=Drosophila melanogaster, GI22026816, Length=207, Percent_Identity=37.1980676328502, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=30.6532663316583, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=30.6532663316583, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221459597, Length=190, Percent_Identity=31.5789473684211, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21356893, Length=190, Percent_Identity=31.5789473684211, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24663208, Length=160, Percent_Identity=31.875, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647141, Length=160, Percent_Identity=31.875, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_LEPBJ (Q04PV9)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801819.1
- ProteinModelPortal:   Q04PV9
- SMR:   Q04PV9
- STRING:   Q04PV9
- GeneID:   4411359
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_2638
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK14528
- BioCyc:   LBOR355277:LBJ_2638-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20489; Mature: 20489

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIIFMGPPGAGKGTQAKILCARLSIPQISTGDILREAVKNQTPMGIEAKRYMDAGDLV
CCCEEEECCCCCCCCCCHHEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
PDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQADALDALLKNEGKSIDKAINLEVPDGE
CHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHEEEEECCCHH
LLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVNGVGTLEEVTS
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
LIQRELV
HHHHHCC
>Mature Secondary Structure
MKNIIFMGPPGAGKGTQAKILCARLSIPQISTGDILREAVKNQTPMGIEAKRYMDAGDLV
CCCEEEECCCCCCCCCCHHEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
PDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQADALDALLKNEGKSIDKAINLEVPDGE
CHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHEEEEECCCHH
LLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVNGVGTLEEVTS
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
LIQRELV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA