Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 116326861

GI number: 116326861

Start: 11368

End: 13866

Strand: Direct

Name: gyrA [H]

Synonym: LBL_0009

Alternate gene names: 116326861

Gene position: 11368-13866 (Clockwise)

Preceding gene: 116326860

Following gene: 116326862

Centisome position: 0.31

GC content: 40.22

Gene sequence:

>2499_bases
ATGAGTCAAGAGAATGAAACAAAAGTCCTAAACTATAATATCGCCGGAAAGCCCGATATTGCGGATGCTCTTAAAAACGG
CATTAGAGTAATTCCCGTGGAAATCGAAGATCAGATGAAAGAAGCGTATCTTGGTTACGCGATGTCCGTCATTGTAGGTC
GGGCGCTTCCGGATGTGAGAGATGGATTAAAACCGGTTCATAGAAGAATCCTTCATGCCATGAACGAACGAGCGTGGAGA
AGCGATCGTCCTTATGTGAAATGCGCTAAGATTGTGGGGGAAGTGATTGGTAATTATCACCCGCACGGAGATGCGTCTGT
TTATGAAGCTCTTGTAAGAATGGTTCAGGATTTTTCCCTGCGCGTTCCATTGATTGATGGGCAAGGAAATTTCGGTTCTA
TAGACGGCGATAACCCTGCGGCTTATCGGTACACCGAAGCAAGACTTGAAAAAGTCGCGGAAGAATTGTTACGCGACATT
GAAAAAGAGACCGTTAGTTTCTCGCCTAATTACGATGATACAAAACAACAACCGGACGTATTACCCGCAAATTTTCCGAA
TTTACTCGTAAATGGATCTTCCGGAATCGCGGTGGGAATGGCGACGAATATTCCTCCTCATAATCTGAAAGAAACGATCG
ATGCAGTAATTGCCGTGATTCGAAATCCGGAAATTACAATTCCGGAAATTCTCAGAATTATTCCCGGTCCCGATTTTCCG
ACTTCCGGAATTATCATCGGTGGAGAAGGTCTTATCTCTGCATATACAACCGGAAAAGGATCGATACGAATTCGCTCCAA
AGTGGAGATTGAAGAAAAGAAAAACGGAAGAGAAGTAATTGTGGTCACCGAAATTCCCTATCAGGTGAACAAGAAAGTTC
TTTTGGAAAAAATCGGAGACATAGTTAACGAAAAACAAATCGAAGGAATTTCTGAAATCCTCGATCTTTCGGATCGAAAA
GGGATTCGAATAGAAATTCATATTAAAAAAGATGCGAATGCTCAGGTTATTTTAAACCAACTTTATAAAATGACTCAACT
TCAAGTGAGTTATGGAATCACGATGCTCGCGATTCTGGACAATAAACCAAAAATTTTTAATATTAAGGAAATATTAACTG
CCTATTCTGCACACAGAAGAGATGTGATCGTAAAAAGAACTCAGTTCGATTTAGATAAGGCCGAAAAACGCGCTCATATC
TTGGAAGGATTAAAGATTGCCTTAGAAAACATCGAGGACGTGATTAAAGTCATTCGGGCTTCCAAAAATCCTCCCGAGGC
AAAGCAACAATTAATGGTTCGTTTTAGTCTTTCCGAGGTTCAATCGGATGCCATTTTAGAAATGAGATTGCAAAGGCTTA
CTTCTCTCGAAGTTCAAAAGATCATTGATGAGTTGGAAGAGGTCAGAAAACTCATCGTGGATCTAAAGGATATTCTCGCA
AAACCTTCTCGCATAAACGATATTGTTTGTACAGAACTTCAAGAAGTGGGAGATAAATACGGAACAAAAAGAAAGACCGA
AATTTCCATCGAAAGTATAGAAAGTTCTTCTTTTAATGCGGAAGATTTGATCGCGGACGAAGAAATGGTAATCCAAATCA
CATACGATCAATTTATCAAGCGTCTTCCGATCGATACTTTCAAAAGACAAAAACGGGGTGGAAAAGGAATTCAAGGTCTT
TCTCAGAAACGTGATGATGTGATTAAAATTATGAAAGCCGCAATGACTCACGATAGTATCATGTTTTTTTCTAATATAGG
AAAAGTTTACGTGATGAAGGCTTATGAATTGCCAATCGCATCCAAAGAAGCGCGTGGGAAATCCTTAAAGGCAATCATCA
ATTTGAGGGAAGATGAATATGTTTCTTCTATCTTTACTTTCAGGGGACAAGATATGGATAAGGATCTCCTCTTGGTCACT
AAACGCGGATTTATCAAACGGATTCAACTTAAGGAATTTGGAAACGTAAAAAAATCTGGAATCATAGCGATCGGACTCAG
AGAAGGGGATGAGCTGATTAAAGTGGAAGCTATAGAGGATAAGGATGAAGTTATGATCTTTTCTAAGAAAGGGTTGGCTC
TTCGGATCGAAGGAAATATTATCAGAGCTCAAGGAAGAACGGCGAGTGGTGTTACCGGAATGCGGCTTGCGGAAGATGAC
ACAATTGTAGGCTTGAGTAAATACAAAGAGGGAGAGGATATATTTGTAGTTTCGGAAGAAGGTTATGGAAAACGTCTCGG
TTTTGAGGAATTTGCCGCGAAAGGCAGAGGCGGAAAAGGAATGGCCTACTTAAAAGTGACTGAAAAAAACGGATTTTCCG
TAGGAACGGGTTCCGTTGGGAGTGAAGATGAAGTCATTCTCATCACTCAACAAGGAATGACGATTCGAATTAATGCATTC
GATATTTCTAAACTAGGCAGAACCGCAGTCGGAGTTCGTATTGTGGATTTAAAAGATAACGATAAGGTACAGGATTTTAC
TGTTTTGGGAGAAAATTGA

Upstream 100 bases:

>100_bases
CATCCTTATGGGTGATGAAGTTCAACCTAGAAAACAATTCATCGAAATTAATGCCGCCAAGGTTGCAAACTTGGATCTTT
GATCCTAGGGGAATTCTAAA

Downstream 100 bases:

>100_bases
TCCGAATCGGGAGCGTAATAATTCCGGGGAGAATTTCACTTTCTCCAATGGCGGGGATTTCAGATTCTCCCACTCGAAGA
ATTTGTAGAAAATTCGGAGC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 832; Mature: 831

Protein sequence:

>832_residues
MSQENETKVLNYNIAGKPDIADALKNGIRVIPVEIEDQMKEAYLGYAMSVIVGRALPDVRDGLKPVHRRILHAMNERAWR
SDRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQDFSLRVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLRDI
EKETVSFSPNYDDTKQQPDVLPANFPNLLVNGSSGIAVGMATNIPPHNLKETIDAVIAVIRNPEITIPEILRIIPGPDFP
TSGIIIGGEGLISAYTTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKIGDIVNEKQIEGISEILDLSDRK
GIRIEIHIKKDANAQVILNQLYKMTQLQVSYGITMLAILDNKPKIFNIKEILTAYSAHRRDVIVKRTQFDLDKAEKRAHI
LEGLKIALENIEDVIKVIRASKNPPEAKQQLMVRFSLSEVQSDAILEMRLQRLTSLEVQKIIDELEEVRKLIVDLKDILA
KPSRINDIVCTELQEVGDKYGTKRKTEISIESIESSSFNAEDLIADEEMVIQITYDQFIKRLPIDTFKRQKRGGKGIQGL
SQKRDDVIKIMKAAMTHDSIMFFSNIGKVYVMKAYELPIASKEARGKSLKAIINLREDEYVSSIFTFRGQDMDKDLLLVT
KRGFIKRIQLKEFGNVKKSGIIAIGLREGDELIKVEAIEDKDEVMIFSKKGLALRIEGNIIRAQGRTASGVTGMRLAEDD
TIVGLSKYKEGEDIFVVSEEGYGKRLGFEEFAAKGRGGKGMAYLKVTEKNGFSVGTGSVGSEDEVILITQQGMTIRINAF
DISKLGRTAVGVRIVDLKDNDKVQDFTVLGEN

Sequences:

>Translated_832_residues
MSQENETKVLNYNIAGKPDIADALKNGIRVIPVEIEDQMKEAYLGYAMSVIVGRALPDVRDGLKPVHRRILHAMNERAWR
SDRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQDFSLRVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLRDI
EKETVSFSPNYDDTKQQPDVLPANFPNLLVNGSSGIAVGMATNIPPHNLKETIDAVIAVIRNPEITIPEILRIIPGPDFP
TSGIIIGGEGLISAYTTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKIGDIVNEKQIEGISEILDLSDRK
GIRIEIHIKKDANAQVILNQLYKMTQLQVSYGITMLAILDNKPKIFNIKEILTAYSAHRRDVIVKRTQFDLDKAEKRAHI
LEGLKIALENIEDVIKVIRASKNPPEAKQQLMVRFSLSEVQSDAILEMRLQRLTSLEVQKIIDELEEVRKLIVDLKDILA
KPSRINDIVCTELQEVGDKYGTKRKTEISIESIESSSFNAEDLIADEEMVIQITYDQFIKRLPIDTFKRQKRGGKGIQGL
SQKRDDVIKIMKAAMTHDSIMFFSNIGKVYVMKAYELPIASKEARGKSLKAIINLREDEYVSSIFTFRGQDMDKDLLLVT
KRGFIKRIQLKEFGNVKKSGIIAIGLREGDELIKVEAIEDKDEVMIFSKKGLALRIEGNIIRAQGRTASGVTGMRLAEDD
TIVGLSKYKEGEDIFVVSEEGYGKRLGFEEFAAKGRGGKGMAYLKVTEKNGFSVGTGSVGSEDEVILITQQGMTIRINAF
DISKLGRTAVGVRIVDLKDNDKVQDFTVLGEN
>Mature_831_residues
SQENETKVLNYNIAGKPDIADALKNGIRVIPVEIEDQMKEAYLGYAMSVIVGRALPDVRDGLKPVHRRILHAMNERAWRS
DRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQDFSLRVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLRDIE
KETVSFSPNYDDTKQQPDVLPANFPNLLVNGSSGIAVGMATNIPPHNLKETIDAVIAVIRNPEITIPEILRIIPGPDFPT
SGIIIGGEGLISAYTTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKIGDIVNEKQIEGISEILDLSDRKG
IRIEIHIKKDANAQVILNQLYKMTQLQVSYGITMLAILDNKPKIFNIKEILTAYSAHRRDVIVKRTQFDLDKAEKRAHIL
EGLKIALENIEDVIKVIRASKNPPEAKQQLMVRFSLSEVQSDAILEMRLQRLTSLEVQKIIDELEEVRKLIVDLKDILAK
PSRINDIVCTELQEVGDKYGTKRKTEISIESIESSSFNAEDLIADEEMVIQITYDQFIKRLPIDTFKRQKRGGKGIQGLS
QKRDDVIKIMKAAMTHDSIMFFSNIGKVYVMKAYELPIASKEARGKSLKAIINLREDEYVSSIFTFRGQDMDKDLLLVTK
RGFIKRIQLKEFGNVKKSGIIAIGLREGDELIKVEAIEDKDEVMIFSKKGLALRIEGNIIRAQGRTASGVTGMRLAEDDT
IVGLSKYKEGEDIFVVSEEGYGKRLGFEEFAAKGRGGKGMAYLKVTEKNGFSVGTGSVGSEDEVILITQQGMTIRINAFD
ISKLGRTAVGVRIVDLKDNDKVQDFTVLGEN

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=469, Percent_Identity=22.3880597014925, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI19913406, Length=319, Percent_Identity=23.5109717868339, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1788562, Length=829, Percent_Identity=45.4764776839566, Blast_Score=731, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=654, Percent_Identity=36.085626911315, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=32.183908045977, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=174, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=501, Percent_Identity=23.3532934131737, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=176, Percent_Identity=28.9772727272727, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93000; Mature: 92869

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQENETKVLNYNIAGKPDIADALKNGIRVIPVEIEDQMKEAYLGYAMSVIVGRALPDVR
CCCCCCCEEEEEECCCCCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHH
DGLKPVHRRILHAMNERAWRSDRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQDFSL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCE
RVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLRDIEKETVSFSPNYDDTKQQPDV
EEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCC
LPANFPNLLVNGSSGIAVGMATNIPPHNLKETIDAVIAVIRNPEITIPEILRIIPGPDFP
CCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
TSGIIIGGEGLISAYTTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKIGD
CCCEEECCCCEEEEEECCCCCEEEEEEEEEHHCCCCCEEEEEEECCCHHHHHHHHHHHHH
IVNEKQIEGISEILDLSDRKGIRIEIHIKKDANAQVILNQLYKMTQLQVSYGITMLAILD
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEEC
NKPKIFNIKEILTAYSAHRRDVIVKRTQFDLDKAEKRAHILEGLKIALENIEDVIKVIRA
CCCCEEEHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SKNPPEAKQQLMVRFSLSEVQSDAILEMRLQRLTSLEVQKIIDELEEVRKLIVDLKDILA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KPSRINDIVCTELQEVGDKYGTKRKTEISIESIESSSFNAEDLIADEEMVIQITYDQFIK
CCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHCCCCEEEEEEEHHHHHH
RLPIDTFKRQKRGGKGIQGLSQKRDDVIKIMKAAMTHDSIMFFSNIGKVYVMKAYELPIA
HCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHCCCEEEEEEEEECCCC
SKEARGKSLKAIINLREDEYVSSIFTFRGQDMDKDLLLVTKRGFIKRIQLKEFGNVKKSG
CCCCCCCCEEEHEECCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHEEHHHHCCCCCCCC
IIAIGLREGDELIKVEAIEDKDEVMIFSKKGLALRIEGNIIRAQGRTASGVTGMRLAEDD
EEEEEECCCCCEEEEEEECCCCCEEEEECCCEEEEEECCEEEECCCCCCCCCCCEECCCC
TIVGLSKYKEGEDIFVVSEEGYGKRLGFEEFAAKGRGGKGMAYLKVTEKNGFSVGTGSVG
CEEEHHHCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCCCEECCCCCC
SEDEVILITQQGMTIRINAFDISKLGRTAVGVRIVDLKDNDKVQDFTVLGEN
CCCCEEEEEECCCEEEEEEEEHHHCCCHHHCEEEEEECCCCCCEEEEEECCC
>Mature Secondary Structure 
SQENETKVLNYNIAGKPDIADALKNGIRVIPVEIEDQMKEAYLGYAMSVIVGRALPDVR
CCCCCCEEEEEECCCCCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHH
DGLKPVHRRILHAMNERAWRSDRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQDFSL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCE
RVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLRDIEKETVSFSPNYDDTKQQPDV
EEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCC
LPANFPNLLVNGSSGIAVGMATNIPPHNLKETIDAVIAVIRNPEITIPEILRIIPGPDFP
CCCCCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
TSGIIIGGEGLISAYTTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKIGD
CCCEEECCCCEEEEEECCCCCEEEEEEEEEHHCCCCCEEEEEEECCCHHHHHHHHHHHHH
IVNEKQIEGISEILDLSDRKGIRIEIHIKKDANAQVILNQLYKMTQLQVSYGITMLAILD
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEEC
NKPKIFNIKEILTAYSAHRRDVIVKRTQFDLDKAEKRAHILEGLKIALENIEDVIKVIRA
CCCCEEEHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SKNPPEAKQQLMVRFSLSEVQSDAILEMRLQRLTSLEVQKIIDELEEVRKLIVDLKDILA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KPSRINDIVCTELQEVGDKYGTKRKTEISIESIESSSFNAEDLIADEEMVIQITYDQFIK
CCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHCCCCEEEEEEEHHHHHH
RLPIDTFKRQKRGGKGIQGLSQKRDDVIKIMKAAMTHDSIMFFSNIGKVYVMKAYELPIA
HCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHCCCEEEEEEEEECCCC
SKEARGKSLKAIINLREDEYVSSIFTFRGQDMDKDLLLVTKRGFIKRIQLKEFGNVKKSG
CCCCCCCCEEEHEECCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHEEHHHHCCCCCCCC
IIAIGLREGDELIKVEAIEDKDEVMIFSKKGLALRIEGNIIRAQGRTASGVTGMRLAEDD
EEEEEECCCCCEEEEEEECCCCCEEEEECCCEEEEEECCEEEECCCCCCCCCCCEECCCC
TIVGLSKYKEGEDIFVVSEEGYGKRLGFEEFAAKGRGGKGMAYLKVTEKNGFSVGTGSVG
CEEEHHHCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCCCEECCCCCC
SEDEVILITQQGMTIRINAFDISKLGRTAVGVRIVDLKDNDKVQDFTVLGEN
CCCCEEEEEECCCEEEEEEEEHHHCCCHHHCEEEEEECCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]