Click here to switch to the map view.

The map label for this gene is lrp [H]

Identifier: 116249271

GI number: 116249271

Start: 658224

End: 658766

Strand: Direct

Name: lrp [H]

Synonym: pRL120606

Alternate gene names: 116249271

Gene position: 658224-658766 (Clockwise)

Preceding gene: 116249269

Following gene: 116249283

Centisome position: 75.66

GC content: 54.33

Gene sequence:

>543_bases
ATGCCAGAAAGTAGCAGCATAATATGCTGTGTGATTGGCGATCTCGAGCAAGTGAGGGCGTGTGGGATGAAACTCGACCG
GATCGACGTAAAAATTCTCTACGAACTGCAGAAGAACGGCCGCGTCACCAATGTGGAACTCGCCGAACTGGTCAATCTCT
CGCCGAGCCCCTGCTTGATGCGGGTGAAGAAGCTGCAGTCGGAGGGTTATATCGAAGGTTATTCGGCCCAGATCAACGTC
AGCAAACTGGGGCAGACGCTGACGGTGTTCACCGAGATTACCCTGAAAAACCACCGGCAGATCGACTTCGCCCGCTTCCT
GGCGGCGATCGAGAAGGTCGACCAGGTGATCGAATGCCATCTGGTTTCGGGCGGCTACGATTATCTGCTGAAATTCGTCA
CCGCCGGGATCGACGAATACCAGACGATCATGGAGCGCCTCACCGATATGGACGTCGGCATCGACAAGTATTTCAGCTTC
GTCGTCCTGAAATCGCCGATCATCAAAGCCCACATGCCGCTAACCACCTTGTTTCCGCATTAG

Upstream 100 bases:

>100_bases
TGGCAGCAGAAGATTCCGTGTTGGGAGGACGCCAGCAGCCGTTTGTGCTTCGGCCTGTCTCGTAACGCGATCGACAGGCC
AGCATCCTGTGTTAAGGTTG

Downstream 100 bases:

>100_bases
CCGGCGAGAGGACCGCAGCCGGGCACCCGCTCAAACGCAAGATTTCGGGGTTCCAGACCGACCTCACCCCGTTGTCTTTC
CCCGATCCAACCGGTCCTAA

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MPESSSIICCVIGDLEQVRACGMKLDRIDVKILYELQKNGRVTNVELAELVNLSPSPCLMRVKKLQSEGYIEGYSAQINV
SKLGQTLTVFTEITLKNHRQIDFARFLAAIEKVDQVIECHLVSGGYDYLLKFVTAGIDEYQTIMERLTDMDVGIDKYFSF
VVLKSPIIKAHMPLTTLFPH

Sequences:

>Translated_180_residues
MPESSSIICCVIGDLEQVRACGMKLDRIDVKILYELQKNGRVTNVELAELVNLSPSPCLMRVKKLQSEGYIEGYSAQINV
SKLGQTLTVFTEITLKNHRQIDFARFLAAIEKVDQVIECHLVSGGYDYLLKFVTAGIDEYQTIMERLTDMDVGIDKYFSF
VVLKSPIIKAHMPLTTLFPH
>Mature_179_residues
PESSSIICCVIGDLEQVRACGMKLDRIDVKILYELQKNGRVTNVELAELVNLSPSPCLMRVKKLQSEGYIEGYSAQINVS
KLGQTLTVFTEITLKNHRQIDFARFLAAIEKVDQVIECHLVSGGYDYLLKFVTAGIDEYQTIMERLTDMDVGIDKYFSFV
VLKSPIIKAHMPLTTLFPH

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=143, Percent_Identity=43.3566433566434, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=29.3333333333333, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1790182, Length=150, Percent_Identity=29.3333333333333, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 20320; Mature: 20189

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESSSIICCVIGDLEQVRACGMKLDRIDVKILYELQKNGRVTNVELAELVNLSPSPCLM
CCCCCCEEEEEECCHHHHHHHCCEEHHHHHHHEEEEHHCCCCCEEEHHHHHCCCCCHHHH
RVKKLQSEGYIEGYSAQINVSKLGQTLTVFTEITLKNHRQIDFARFLAAIEKVDQVIECH
HHHHHHCCCCEECCCCEEEHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LVSGGYDYLLKFVTAGIDEYQTIMERLTDMDVGIDKYFSFVVLKSPIIKAHMPLTTLFPH
EECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCCHHCCCC
>Mature Secondary Structure 
PESSSIICCVIGDLEQVRACGMKLDRIDVKILYELQKNGRVTNVELAELVNLSPSPCLM
CCCCCEEEEEECCHHHHHHHCCEEHHHHHHHEEEEHHCCCCCEEEHHHHHCCCCCHHHH
RVKKLQSEGYIEGYSAQINVSKLGQTLTVFTEITLKNHRQIDFARFLAAIEKVDQVIECH
HHHHHHCCCCEECCCCEEEHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LVSGGYDYLLKFVTAGIDEYQTIMERLTDMDVGIDKYFSFVVLKSPIIKAHMPLTTLFPH
EECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]