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The map label for this gene is eryA [H]

Identifier: 116249035

GI number: 116249035

Start: 394862

End: 395842

Strand: Reverse

Name: eryA [H]

Synonym: pRL120366

Alternate gene names: 116249035

Gene position: 395842-394862 (Counterclockwise)

Preceding gene: 116249042

Following gene: 116249034

Centisome position: 45.5

GC content: 63.61

Gene sequence:

>981_bases
GTGGGGGATGCAATGCAATATCAGGCGGTCGTGCGAAAATTCGGCCCGGCCCAGGAGGTTGTCGAGCTCGAGCGGGCGGC
GCTGCCGCCGCTGCGGCGCGACCAGGTGAGGGTGCGCCTGCTGGCGCGGGCGATCAACCCGTCCGATATCATCACCATAT
CAGGAGCCTATAGCGGACGCACGACGTTGCCCTTCATTCCCGGCTTCGAAGCGTTCGGCGTGGTCGAACAGTGCGGCGAG
GAGGTTCATGGGCTTTCCCCGGGAACACGCGTGCTGCCGGTGCGCAGCGCCGGTGGCTGGCAGGAATTCAAGGATACCGA
TCCCGGCTGGTGCCTTCGTGTTCCAGACGCGCTCACCGACTTCGAAGCTGCGACGAGCTACGTCAATCCGATGACGGCCT
GGTTGATGCTGCATGCCAAGATCGGACTGAGGCCGGGCATGCGTATCGCCATCAATGCCGCCGCCTCTTCGATCGGAGCG
ATATTGATCGGTCTCGCCAATGCCGCAGGCGTGGAGCCGGTCGCCATCGTCCGCAGCGAAGGATCGCTTGAGCGCCTGCG
CGGCCGGGTCGAGGCTATCATCATCGATAGGGAGGAAAGCGATCTGGTTGCCGGGCTCGCCGGCCGGCATGGGGTCGACG
CGGTGCTTGATTGCGTCGGAGGTGCGCGCGCCGCGACCCTCGCCGATGCGCTGAAGCCCGGCGGGCATTTCGTGCATTAC
GGCCTGCTTTCGGGCCAAAGCATTCCGGCTTCCTTCTGGGCCTCCCATCCCGATATTGCCTTTTCCTATTGTCACCTGCG
GGAATGGGTTCATTCGCAAGCCATGGGAGATGTCCAACAGGCCTATTCCGAGATCGCGGCGCAGATCGTTTCGAAGGTTA
TCGCGACCGAGGTGCGGGAGGTATTCCCCTTGGAAAATGTCCGGCAAGCCCTGCACTCCGCTCTTCCCTTCCGAGCGGGC
GGCAAAGTTCTGCTGGCCTGA

Upstream 100 bases:

>100_bases
ATGTCAATGTCTCGCATCGAGACCCGGAACGATGCTAAAGGCCTGTCATCAACGCTCATTCGATCACCGAAAATTCGACG
GGGTGATCTAACCGCAGTGT

Downstream 100 bases:

>100_bases
CGAACATCCGTGGGCCGCGAGGTAGCTTTGACGGCTAATCGGGATCGGGAGTAGCATCCATGCGGCAGCGGCAAGGTGGT
CAAAGCGGCCGGCCCGATGG

Product: putative oxidoreductase

Products: NA

Alternate protein names: 6-deoxyerythronolide B synthase II; DEBS 2; ORF 2 [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MGDAMQYQAVVRKFGPAQEVVELERAALPPLRRDQVRVRLLARAINPSDIITISGAYSGRTTLPFIPGFEAFGVVEQCGE
EVHGLSPGTRVLPVRSAGGWQEFKDTDPGWCLRVPDALTDFEAATSYVNPMTAWLMLHAKIGLRPGMRIAINAAASSIGA
ILIGLANAAGVEPVAIVRSEGSLERLRGRVEAIIIDREESDLVAGLAGRHGVDAVLDCVGGARAATLADALKPGGHFVHY
GLLSGQSIPASFWASHPDIAFSYCHLREWVHSQAMGDVQQAYSEIAAQIVSKVIATEVREVFPLENVRQALHSALPFRAG
GKVLLA

Sequences:

>Translated_326_residues
MGDAMQYQAVVRKFGPAQEVVELERAALPPLRRDQVRVRLLARAINPSDIITISGAYSGRTTLPFIPGFEAFGVVEQCGE
EVHGLSPGTRVLPVRSAGGWQEFKDTDPGWCLRVPDALTDFEAATSYVNPMTAWLMLHAKIGLRPGMRIAINAAASSIGA
ILIGLANAAGVEPVAIVRSEGSLERLRGRVEAIIIDREESDLVAGLAGRHGVDAVLDCVGGARAATLADALKPGGHFVHY
GLLSGQSIPASFWASHPDIAFSYCHLREWVHSQAMGDVQQAYSEIAAQIVSKVIATEVREVFPLENVRQALHSALPFRAG
GKVLLA
>Mature_325_residues
GDAMQYQAVVRKFGPAQEVVELERAALPPLRRDQVRVRLLARAINPSDIITISGAYSGRTTLPFIPGFEAFGVVEQCGEE
VHGLSPGTRVLPVRSAGGWQEFKDTDPGWCLRVPDALTDFEAATSYVNPMTAWLMLHAKIGLRPGMRIAINAAASSIGAI
LIGLANAAGVEPVAIVRSEGSLERLRGRVEAIIIDREESDLVAGLAGRHGVDAVLDCVGGARAATLADALKPGGHFVHYG
LLSGQSIPASFWASHPDIAFSYCHLREWVHSQAMGDVQQAYSEIAAQIVSKVIATEVREVFPLENVRQALHSALPFRAGG
KVLLA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI67078404, Length=320, Percent_Identity=28.75, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI24308257, Length=263, Percent_Identity=28.5171102661597, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI67078406, Length=295, Percent_Identity=27.7966101694915, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI18379349, Length=313, Percent_Identity=28.7539936102236, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI22538446, Length=242, Percent_Identity=26.0330578512397, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI22538444, Length=242, Percent_Identity=26.0330578512397, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI194239674, Length=249, Percent_Identity=23.6947791164659, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI13236495, Length=249, Percent_Identity=23.6947791164659, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790485, Length=304, Percent_Identity=26.6447368421053, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17536829, Length=293, Percent_Identity=32.4232081911263, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17556000, Length=256, Percent_Identity=29.6875, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=171, Percent_Identity=32.1637426900585, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71987554, Length=187, Percent_Identity=28.8770053475936, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=315, Percent_Identity=23.1746031746032, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45550423, Length=326, Percent_Identity=30.0613496932515, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR002198
- InterPro:   IPR015357
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR020806
- InterPro:   IPR015083
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00106 adh_short; PF00107 ADH_zinc_N; PF08990 Docking; PF09277 Erythro-docking; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF00550 PP-binding [H]

EC number: =2.3.1.94 [H]

Molecular weight: Translated: 34900; Mature: 34769

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDAMQYQAVVRKFGPAQEVVELERAALPPLRRDQVRVRLLARAINPSDIITISGAYSGR
CCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
TTLPFIPGFEAFGVVEQCGEEVHGLSPGTRVLPVRSAGGWQEFKDTDPGWCLRVPDALTD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCCCEEEECCHHHHH
FEAATSYVNPMTAWLMLHAKIGLRPGMRIAINAAASSIGAILIGLANAAGVEPVAIVRSE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCEEEEECC
GSLERLRGRVEAIIIDREESDLVAGLAGRHGVDAVLDCVGGARAATLADALKPGGHFVHY
CCHHHHCCCEEEEEEECCCCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCEEEE
GLLSGQSIPASFWASHPDIAFSYCHLREWVHSQAMGDVQQAYSEIAAQIVSKVIATEVRE
EEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFPLENVRQALHSALPFRAGGKVLLA
HCCHHHHHHHHHHHCCCCCCCCEEEC
>Mature Secondary Structure 
GDAMQYQAVVRKFGPAQEVVELERAALPPLRRDQVRVRLLARAINPSDIITISGAYSGR
CCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
TTLPFIPGFEAFGVVEQCGEEVHGLSPGTRVLPVRSAGGWQEFKDTDPGWCLRVPDALTD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCCCEEEECCHHHHH
FEAATSYVNPMTAWLMLHAKIGLRPGMRIAINAAASSIGAILIGLANAAGVEPVAIVRSE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCEEEEECC
GSLERLRGRVEAIIIDREESDLVAGLAGRHGVDAVLDCVGGARAATLADALKPGGHFVHY
CCHHHHCCCEEEEEEECCCCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCEEEE
GLLSGQSIPASFWASHPDIAFSYCHLREWVHSQAMGDVQQAYSEIAAQIVSKVIATEVRE
EEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFPLENVRQALHSALPFRAGGKVLLA
HCCHHHHHHHHHHHCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2024119; 1740151 [H]