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The map label for this gene is yngG [H]

Identifier: 114800467

GI number: 114800467

Start: 3519321

End: 3520220

Strand: Reverse

Name: yngG [H]

Synonym: HNE_3374

Alternate gene names: 114800467

Gene position: 3520220-3519321 (Counterclockwise)

Preceding gene: 114797855

Following gene: 114797835

Centisome position: 95.01

GC content: 67.33

Gene sequence:

>900_bases
ATGACCCGCCGTATCGATATTGTTGAAGTTGGCCCGCGCGACGGGTTGCAGAATGATCCGGCCAATCTGAGCGTGGATCA
GAAGCTGGAATTCATTGCGCGGCTGGAAGCGGCGGGCGTGCGCCGCATGGAATCGGGTAGTTTCGTCAGCCCCAAGGCGG
TGCCGAAGATGGCCGATTCCCCGGCCGTCTTTGCCGGGCTCGACCGGACGAAGCCGACCCGCCATATCGCGCTGGCGCTG
AATGAGACGGGCGTGCGCCGCGCGATCGAGGCGAAGGCGGACGAGATCAATTTCGTGCTGGTGGCGGGCGAGGCGTTCGG
GCGGCGCAATCAGGGCATGAGCCCGCAGGAGAGCGCTGATATGCTCAGCCATTGCGCGCCGCTTATCCTTGAGGCGGGCA
TCCCGCTTTCGGCGACCATCTCGGTGGCGTTTGGCGATCCGTATACGGGGGACGTGGATATAGCCGTCGTCGGCGGCCTT
GCCGCGCAGGCACAGAGAGCCGGGGTGGCGGAGCTGGCGCTCGGCGATACGATCGGCGCGGCCACGCCCTGGGATGTGCG
CAAGCGGATCGACCGGGTGCGGATGGAAGCGCCCGACGTGTTCCTGCGGATGCATTTCCACGATACGCGCGGGGCAGGGC
TGGCGAATGTGTTTGCGGCGGTCGAAGCGGGCGTGGATGTGATCGATGCCAGCTGCGGCGGAATTGGCGGATGCCCCTTC
GCCCCGGCGGCGACGGGCAATGTGGCGACCGAAGATGTCGTCTGGATGCTGGAGCGGGCAGGCTTTGAGACGGGGCTCGA
TCTGGCGCGCCTGATCGAGACGGCGAAATGGCTGGAGGGCGCGCTCGGCCATCCGGTGGCCTCGGCGCTGAGCCGGGCGG
GGGCGTTTCCGGCGGGCTGA

Upstream 100 bases:

>100_bases
GCCGAGATGGAAGGCAGCTTCGCCACGCATGATTTCAAGGAAGGCGTCGCCAGTTTCGTTGAGCGCCGCGCGCCGGCCTT
TACCGGCAAATAGGAGCCTC

Downstream 100 bases:

>100_bases
TGGCGTGTTTCCATACGGCTGTATCCGGACTGGCGGTTTCCATCCGGGGTCTGAGCAGTTCGGGTGGCTCCGCGAGGTGG
AGCCTCGTGCGCGGCGGGCG

Product: putative hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTRRIDIVEVGPRDGLQNDPANLSVDQKLEFIARLEAAGVRRMESGSFVSPKAVPKMADSPAVFAGLDRTKPTRHIALAL
NETGVRRAIEAKADEINFVLVAGEAFGRRNQGMSPQESADMLSHCAPLILEAGIPLSATISVAFGDPYTGDVDIAVVGGL
AAQAQRAGVAELALGDTIGAATPWDVRKRIDRVRMEAPDVFLRMHFHDTRGAGLANVFAAVEAGVDVIDASCGGIGGCPF
APAATGNVATEDVVWMLERAGFETGLDLARLIETAKWLEGALGHPVASALSRAGAFPAG

Sequences:

>Translated_299_residues
MTRRIDIVEVGPRDGLQNDPANLSVDQKLEFIARLEAAGVRRMESGSFVSPKAVPKMADSPAVFAGLDRTKPTRHIALAL
NETGVRRAIEAKADEINFVLVAGEAFGRRNQGMSPQESADMLSHCAPLILEAGIPLSATISVAFGDPYTGDVDIAVVGGL
AAQAQRAGVAELALGDTIGAATPWDVRKRIDRVRMEAPDVFLRMHFHDTRGAGLANVFAAVEAGVDVIDASCGGIGGCPF
APAATGNVATEDVVWMLERAGFETGLDLARLIETAKWLEGALGHPVASALSRAGAFPAG
>Mature_298_residues
TRRIDIVEVGPRDGLQNDPANLSVDQKLEFIARLEAAGVRRMESGSFVSPKAVPKMADSPAVFAGLDRTKPTRHIALALN
ETGVRRAIEAKADEINFVLVAGEAFGRRNQGMSPQESADMLSHCAPLILEAGIPLSATISVAFGDPYTGDVDIAVVGGLA
AQAQRAGVAELALGDTIGAATPWDVRKRIDRVRMEAPDVFLRMHFHDTRGAGLANVFAAVEAGVDVIDASCGGIGGCPFA
PAATGNVATEDVVWMLERAGFETGLDLARLIETAKWLEGALGHPVASALSRAGAFPAG

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150422, Length=289, Percent_Identity=37.0242214532872, Blast_Score=206, Evalue=1e-53,
Organism=Homo sapiens, GI109150427, Length=289, Percent_Identity=37.0242214532872, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI62198232, Length=293, Percent_Identity=37.8839590443686, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI260654708, Length=126, Percent_Identity=43.6507936507937, Blast_Score=118, Evalue=7e-27,
Organism=Escherichia coli, GI1786261, Length=315, Percent_Identity=25.7142857142857, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510563, Length=294, Percent_Identity=38.4353741496599, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24582381, Length=294, Percent_Identity=36.3945578231293, Blast_Score=200, Evalue=7e-52,
Organism=Drosophila melanogaster, GI281363050, Length=151, Percent_Identity=29.8013245033113, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652224, Length=151, Percent_Identity=29.8013245033113, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652222, Length=151, Percent_Identity=29.8013245033113, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652220, Length=151, Percent_Identity=29.8013245033113, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652218, Length=151, Percent_Identity=29.8013245033113, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652212, Length=151, Percent_Identity=29.8013245033113, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652210, Length=151, Percent_Identity=29.8013245033113, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652214, Length=151, Percent_Identity=29.8013245033113, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921944, Length=151, Percent_Identity=29.8013245033113, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652216, Length=151, Percent_Identity=29.8013245033113, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 31320; Mature: 31189

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRIDIVEVGPRDGLQNDPANLSVDQKLEFIARLEAAGVRRMESGSFVSPKAVPKMADS
CCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCC
PAVFAGLDRTKPTRHIALALNETGVRRAIEAKADEINFVLVAGEAFGRRNQGMSPQESAD
CCEEECCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEEECHHHCCCCCCCCCHHHHH
MLSHCAPLILEAGIPLSATISVAFGDPYTGDVDIAVVGGLAAQAQRAGVAELALGDTIGA
HHHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEECCHHHHHHHCCHHHHHHCCCCCC
ATPWDVRKRIDRVRMEAPDVFLRMHFHDTRGAGLANVFAAVEAGVDVIDASCGGIGGCPF
CCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCC
APAATGNVATEDVVWMLERAGFETGLDLARLIETAKWLEGALGHPVASALSRAGAFPAG
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TRRIDIVEVGPRDGLQNDPANLSVDQKLEFIARLEAAGVRRMESGSFVSPKAVPKMADS
CCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCC
PAVFAGLDRTKPTRHIALALNETGVRRAIEAKADEINFVLVAGEAFGRRNQGMSPQESAD
CCEEECCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEEECHHHCCCCCCCCCHHHHH
MLSHCAPLILEAGIPLSATISVAFGDPYTGDVDIAVVGGLAAQAQRAGVAELALGDTIGA
HHHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEECCHHHHHHHCCHHHHHHCCCCCC
ATPWDVRKRIDRVRMEAPDVFLRMHFHDTRGAGLANVFAAVEAGVDVIDASCGGIGGCPF
CCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCC
APAATGNVATEDVVWMLERAGFETGLDLARLIETAKWLEGALGHPVASALSRAGAFPAG
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]