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The map label for this gene is ubiE [C]

Identifier: 114800446

GI number: 114800446

Start: 478908

End: 479534

Strand: Direct

Name: ubiE [C]

Synonym: HNE_0486

Alternate gene names: 114800446

Gene position: 478908-479534 (Clockwise)

Preceding gene: 114799227

Following gene: 114797122

Centisome position: 12.93

GC content: 62.2

Gene sequence:

>627_bases
ATGAATCCCTGGGAACGCTACGTCGTACCAAATCTTGTTTCGTGCGCATGCTCGACAAAGCCGATCATGAAACAGCGGGC
GAAGGTTGTGCCGAAGGCGGAAGGCGTTGTGCTGGAACTGGGCTGTGGATCGGGCACCAACTTTGCGATGTATGACGGGG
CGAAGGTGGATCACCTTTATGCGCTGGAGCCGTCTCCGGGGATGGTCGTGAAAGCCAGGCGCACGGCAAGCGAGCTGGGC
ATCGGCAAGAGCATCGATTTTCTGGAGACCGGCGCGGAAGCCATTCCGCTGGCGAACAATTCGGTCGATACCGCCGTGAT
TACCTTTGTGCTGTGTACCATCCCTGACTGGAAATCTGCGCTGGCCGAGACGAAACGCGTGCTGAAACCTGGCGGCAAGA
TCCTCTTCACCGAGCATGGGCTGGCGCCCGACGAAGGCGTGGCCAAATGGCAGCGCCGGGTCGAGCCTGTGTGGAAGGCT
TTGGCGGGTGGGTGTCACCTGACGCGCGATACGCAGGCGATGCTGCGCGAGGCGGGGTTTGAGCCGGAGGGCGCGGAGAC
GATGTACCTTCCGGGCACGCCGAAGATTGCCGGCTTTGTCAGCTGGGGCGCGGCGCGGCTCGCCTGA

Upstream 100 bases:

>100_bases
TTACGCAGGACGCACTGATCGCGCGGCCGACCGAGGCGACGCGGACGCTGATCCAGTCGAATTCCTATCCGGGTTTCATT
CCTTCAAAGCAGGCAGACTG

Downstream 100 bases:

>100_bases
CGCCGGCCTGACGATGCGCCGGCCGCCTTATCTTCCTTTTTTGAGTGGTCCCTTGAGCCTGGCGCCGGGGCTGAAGCCGA
TTGCGCCGGAGGCGTGGCTG

Product: UbiE/COQ5 family methlytransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: Methyltransferase; Ubiquinone/Menaquinone Biosynthesis Methyltransferase; Methyltransferase UbiE/COQ5 Family; SAM-Dependent Methyltransferase; UbiE/COQ5 Family Methlytransferase; Phosphatidylethanolamine N-Methyltransferase; Methyltransferase Domain Family; Phospholipid Methyltransferase; Sam Dependent Methyltransferase; Ubiquinone/Menaquinone Biosynthesis Methyltransferase UbiE; Methylase Involved In Ubiquinone/Menaquinone Biosynthesis; UbiE Ubiquinone/Menaquinone Biosynthesis Methyltransferase; Generic Methyltransferase; SAM-Dependent Methyltransferase UbiE/COQ5 Family; Ubiquinone/Menaquinone Biosynthesis Methyl Transferase; Methyltransferase Domain Family Protein; UbiE/COQ5 Methyltransferase; Response Regulator Receiver Protein

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNPWERYVVPNLVSCACSTKPIMKQRAKVVPKAEGVVLELGCGSGTNFAMYDGAKVDHLYALEPSPGMVVKARRTASELG
IGKSIDFLETGAEAIPLANNSVDTAVITFVLCTIPDWKSALAETKRVLKPGGKILFTEHGLAPDEGVAKWQRRVEPVWKA
LAGGCHLTRDTQAMLREAGFEPEGAETMYLPGTPKIAGFVSWGAARLA

Sequences:

>Translated_208_residues
MNPWERYVVPNLVSCACSTKPIMKQRAKVVPKAEGVVLELGCGSGTNFAMYDGAKVDHLYALEPSPGMVVKARRTASELG
IGKSIDFLETGAEAIPLANNSVDTAVITFVLCTIPDWKSALAETKRVLKPGGKILFTEHGLAPDEGVAKWQRRVEPVWKA
LAGGCHLTRDTQAMLREAGFEPEGAETMYLPGTPKIAGFVSWGAARLA
>Mature_208_residues
MNPWERYVVPNLVSCACSTKPIMKQRAKVVPKAEGVVLELGCGSGTNFAMYDGAKVDHLYALEPSPGMVVKARRTASELG
IGKSIDFLETGAEAIPLANNSVDTAVITFVLCTIPDWKSALAETKRVLKPGGKILFTEHGLAPDEGVAKWQRRVEPVWKA
LAGGCHLTRDTQAMLREAGFEPEGAETMYLPGTPKIAGFVSWGAARLA

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI164663805, Length=170, Percent_Identity=35.8823529411765, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI89145417, Length=179, Percent_Identity=30.7262569832402, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.- [C]

Molecular weight: Translated: 22355; Mature: 22355

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPWERYVVPNLVSCACSTKPIMKQRAKVVPKAEGVVLELGCGSGTNFAMYDGAKVDHLY
CCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCEEE
ALEPSPGMVVKARRTASELGIGKSIDFLETGAEAIPLANNSVDTAVITFVLCTIPDWKSA
EECCCCCEEEEECHHHHHHCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
LAETKRVLKPGGKILFTEHGLAPDEGVAKWQRRVEPVWKALAGGCHLTRDTQAMLREAGF
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
EPEGAETMYLPGTPKIAGFVSWGAARLA
CCCCCCEEECCCCCCHHHHHHCCHHHCC
>Mature Secondary Structure
MNPWERYVVPNLVSCACSTKPIMKQRAKVVPKAEGVVLELGCGSGTNFAMYDGAKVDHLY
CCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCEEE
ALEPSPGMVVKARRTASELGIGKSIDFLETGAEAIPLANNSVDTAVITFVLCTIPDWKSA
EECCCCCEEEEECHHHHHHCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
LAETKRVLKPGGKILFTEHGLAPDEGVAKWQRRVEPVWKALAGGCHLTRDTQAMLREAGF
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
EPEGAETMYLPGTPKIAGFVSWGAARLA
CCCCCCEEECCCCCCHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA