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The map label for this gene is hemN [H]

Identifier: 114800144

GI number: 114800144

Start: 552736

End: 554088

Strand: Direct

Name: hemN [H]

Synonym: HNE_0554

Alternate gene names: 114800144

Gene position: 552736-554088 (Clockwise)

Preceding gene: 114800057

Following gene: 114798029

Centisome position: 14.92

GC content: 65.04

Gene sequence:

>1353_bases
ATGAAAGACGCCTGGATCCCCTTCGCCGCCCGCGCGGTGCCCCGTTATACCAGTTATCCGACAGCGGCAGACTTCTCGCC
TGAAACGGGAGAAGCCCAGCTGCGGGCGTGGATGGCCGCGGTAGCGCCCGGAGAGCCGGTTTCGGCCTATCTGCACATCC
CGTTCTGCGAAAAGCTCTGCTGGTATTGCGGCTGTGCCACCAGCGTTCCCAATGGTTACCGGCGGGTGGGCGAGTATACA
GACCTTCTGCTCAAGGAAATTTCCCTGAAAGCGGACGCGATGGGGCCGCATGGGGGGCTTGCCCATCTGCATTTCGGGGG
CGGATCACCCAATATCCTCAGCCCGGCTGATTTTCTGGAGCTTGCCGATGCGATGCGGCGCAGCTTCGGCCTTCGGGAGG
GCGCCGAGATAGCCGTGGAGCTGGACCCGCGCACGATGCAGGCCGGGCAGGTGGCCGCCTTTGCGCGGGCGGGCGTTAAC
CGGGCGAGCCTGGGCGTGCAGACACTGGCCGATGATGTGCAGCAAGCCATCAACCGGGTCCAGCCGCGTGAAATGGTGGT
GGCGCTGATCGAGGACCTGCGCGGGGTGGGCATCGGCGCGATCAATATGGATCTGATGTATGGCCTGCCTTACCAGACAA
CACAGCATGTGGCGCAAGCCGCGCAGTTTGCCGCCGAGATGGGCGCCGCGCGGGTTTCAGTCTTCGGCTACGCGCATGTG
CCCTGGTTTGCCAAGCATCAGCGCGCGATTAATGAAAACACCCTTGCCGGCATACGGGAGCGGTTCACCCAGGCGCGGGT
GGCGGCGATGACGCTGGAGGCGGCGGGATATGTTGCCATCGGGCTGGATCACTATGCCCGCGCCGATGACGCACTGGCGA
TTGCCGCGCGCGCGGGGCGCCTGCGCCGGAATTTTCAAGGGTATACGGATGACCCCTGCGCGACCCTGATCGGCCTGGGG
GCGACGGCCATATCGCAGTTCCGGGAAGGCTTCAGCCAGAATTGCAAGGACCGCAAAGCCTGGGCCGGGGCAATCCAGGC
CGGACGGCTGCCGTCCGAGCGCGGCATTGCTCTGACGGCGGAAGATCGCCTGAGGGCGCATGCCATCGAAACACTGATGT
GCCAGCTTGAAGTGGATGTGACGGCGGTTTGCGCGGCGATGGGCGTTGCCGATGACAGCCTTGATGACGCGCTGGAGAGC
GCCCGCGCCCTGGAAGCGGTGGGGCTTTGCTACGTTTCCGGATCAGTGATCACCGTGCCCGAAGAGGCGCGCATAATGCT
GCGCACGGTGGGGCAATGTTTTGATGCGCGCTCGCCCGCGCTCGCGCAGCAGCGCCACGCGAAGGCGGTCTAG

Upstream 100 bases:

>100_bases
GGTGCCCAATGGCACGAAAACAGCGTTGCGGCTATGGCAGAGCGCCACATACGGGAGAATACTTACAGTGAACATCCTTA
GGCAATGATAATCCGGCGCC

Downstream 100 bases:

>100_bases
GCTTTCAGCGCCTTGGCATGGTGGGCGATATGTTCGTCCATGAAGGTGGCGATGAAGTAATAGTCGTGGCCATAGCCTTC
GCGCAGGCGGTAATCGAGGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKDAWIPFAARAVPRYTSYPTAADFSPETGEAQLRAWMAAVAPGEPVSAYLHIPFCEKLCWYCGCATSVPNGYRRVGEYT
DLLLKEISLKADAMGPHGGLAHLHFGGGSPNILSPADFLELADAMRRSFGLREGAEIAVELDPRTMQAGQVAAFARAGVN
RASLGVQTLADDVQQAINRVQPREMVVALIEDLRGVGIGAINMDLMYGLPYQTTQHVAQAAQFAAEMGAARVSVFGYAHV
PWFAKHQRAINENTLAGIRERFTQARVAAMTLEAAGYVAIGLDHYARADDALAIAARAGRLRRNFQGYTDDPCATLIGLG
ATAISQFREGFSQNCKDRKAWAGAIQAGRLPSERGIALTAEDRLRAHAIETLMCQLEVDVTAVCAAMGVADDSLDDALES
ARALEAVGLCYVSGSVITVPEEARIMLRTVGQCFDARSPALAQQRHAKAV

Sequences:

>Translated_450_residues
MKDAWIPFAARAVPRYTSYPTAADFSPETGEAQLRAWMAAVAPGEPVSAYLHIPFCEKLCWYCGCATSVPNGYRRVGEYT
DLLLKEISLKADAMGPHGGLAHLHFGGGSPNILSPADFLELADAMRRSFGLREGAEIAVELDPRTMQAGQVAAFARAGVN
RASLGVQTLADDVQQAINRVQPREMVVALIEDLRGVGIGAINMDLMYGLPYQTTQHVAQAAQFAAEMGAARVSVFGYAHV
PWFAKHQRAINENTLAGIRERFTQARVAAMTLEAAGYVAIGLDHYARADDALAIAARAGRLRRNFQGYTDDPCATLIGLG
ATAISQFREGFSQNCKDRKAWAGAIQAGRLPSERGIALTAEDRLRAHAIETLMCQLEVDVTAVCAAMGVADDSLDDALES
ARALEAVGLCYVSGSVITVPEEARIMLRTVGQCFDARSPALAQQRHAKAV
>Mature_450_residues
MKDAWIPFAARAVPRYTSYPTAADFSPETGEAQLRAWMAAVAPGEPVSAYLHIPFCEKLCWYCGCATSVPNGYRRVGEYT
DLLLKEISLKADAMGPHGGLAHLHFGGGSPNILSPADFLELADAMRRSFGLREGAEIAVELDPRTMQAGQVAAFARAGVN
RASLGVQTLADDVQQAINRVQPREMVVALIEDLRGVGIGAINMDLMYGLPYQTTQHVAQAAQFAAEMGAARVSVFGYAHV
PWFAKHQRAINENTLAGIRERFTQARVAAMTLEAAGYVAIGLDHYARADDALAIAARAGRLRRNFQGYTDDPCATLIGLG
ATAISQFREGFSQNCKDRKAWAGAIQAGRLPSERGIALTAEDRLRAHAIETLMCQLEVDVTAVCAAMGVADDSLDDALES
ARALEAVGLCYVSGSVITVPEEARIMLRTVGQCFDARSPALAQQRHAKAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=172, Percent_Identity=29.6511627906977, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI87082341, Length=437, Percent_Identity=37.2997711670481, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1789325, Length=397, Percent_Identity=25.1889168765743, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 48356; Mature: 48356

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDAWIPFAARAVPRYTSYPTAADFSPETGEAQLRAWMAAVAPGEPVSAYLHIPFCEKLC
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHH
WYCGCATSVPNGYRRVGEYTDLLLKEISLKADAMGPHGGLAHLHFGGGSPNILSPADFLE
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHH
LADAMRRSFGLREGAEIAVELDPRTMQAGQVAAFARAGVNRASLGVQTLADDVQQAINRV
HHHHHHHHCCCCCCCEEEEEECCCHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
QPREMVVALIEDLRGVGIGAINMDLMYGLPYQTTQHVAQAAQFAAEMGAARVSVFGYAHV
CHHHHHHHHHHHHHCCCCEEEEEHHEECCCCHHHHHHHHHHHHHHHHCCHHEEEEEEECC
PWFAKHQRAINENTLAGIRERFTQARVAAMTLEAAGYVAIGLDHYARADDALAIAARAGR
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHCCCCHHHHHHHHHHH
LRRNFQGYTDDPCATLIGLGATAISQFREGFSQNCKDRKAWAGAIQAGRLPSERGIALTA
HHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEH
EDRLRAHAIETLMCQLEVDVTAVCAAMGVADDSLDDALESARALEAVGLCYVSGSVITVP
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCCEEECC
EEARIMLRTVGQCFDARSPALAQQRHAKAV
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MKDAWIPFAARAVPRYTSYPTAADFSPETGEAQLRAWMAAVAPGEPVSAYLHIPFCEKLC
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHH
WYCGCATSVPNGYRRVGEYTDLLLKEISLKADAMGPHGGLAHLHFGGGSPNILSPADFLE
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHH
LADAMRRSFGLREGAEIAVELDPRTMQAGQVAAFARAGVNRASLGVQTLADDVQQAINRV
HHHHHHHHCCCCCCCEEEEEECCCHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
QPREMVVALIEDLRGVGIGAINMDLMYGLPYQTTQHVAQAAQFAAEMGAARVSVFGYAHV
CHHHHHHHHHHHHHCCCCEEEEEHHEECCCCHHHHHHHHHHHHHHHHCCHHEEEEEEECC
PWFAKHQRAINENTLAGIRERFTQARVAAMTLEAAGYVAIGLDHYARADDALAIAARAGR
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHCCCCHHHHHHHHHHH
LRRNFQGYTDDPCATLIGLGATAISQFREGFSQNCKDRKAWAGAIQAGRLPSERGIALTA
HHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEH
EDRLRAHAIETLMCQLEVDVTAVCAAMGVADDSLDDALESARALEAVGLCYVSGSVITVP
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCCEEECC
EEARIMLRTVGQCFDARSPALAQQRHAKAV
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]