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The map label for this gene is degP [H]

Identifier: 114799653

GI number: 114799653

Start: 464464

End: 465915

Strand: Direct

Name: degP [H]

Synonym: HNE_0472

Alternate gene names: 114799653

Gene position: 464464-465915 (Clockwise)

Preceding gene: 114800434

Following gene: 114800182

Centisome position: 12.54

GC content: 63.36

Gene sequence:

>1452_bases
ATGAACCGGACCGCCGTTGCGGTATTCGCCCTGATGGCATGTATGGCCCCCACAGCGCTCGCACAGGCGGGTGGAAGCCT
GTCGCGTCCCGGAGCGCCGGTAGATGCGAAGACCGCGCCGCAAAGCTTCAGTGCGCTCTCCAAACGTCTCATGCCGGCCG
TGGTGAACATCTCCACGTCACAGGTTGTGGCCAGCCGCCTGCCAACCTTTCCGGAAGGCTCGCCCGCAGAACGCTTCAAC
GAATACTTTGGCCGCAATGATGACGGCTTCCAGCGGCAGGGCTCGCTGGGTTCCGGCTTCGTCATCAGCGCCGACGGCTA
CATCGTCACCAACAATCACGTCATCGAAAAGGCTGACACGATCGAGGTCACCTTCTCCGATGGCCGCACGATGGACGCCA
AGATTATCGGCCGCGACCGGGATTCCGACATTGCCGTCCTGAAAGTCACCGCGCGGGGCGCGCTGCCTTTTGTGGACCTT
GCCGACAGCGACCGGGCAGAAGTCGGTGACTGGGTGATCGCGATCGGTAACCCGCTGGGCTTTGGCGGCTCGGTATCTGC
CGGGATCATCTCGGCCACGGGCCGCGACCTCAACACTGGGCGGTCTGACAATTTCATCCAGACCGATGCGGCCATCAACC
AGGGTAACTCCGGTGGTCCGCTGTTCAATCTGAATGGCCAGGTCGTTGGCGTGAACACGGCGATCATTTCCCAGTCGGGC
GGGTCCATTGGCCTGGGCTTTTCGGTGCCTTCCAACACGGTGAAGCGCATCTCGGCGCAGCTCATCAAGGATGGCCGGGT
GAACCGGCCCTGGCTGGGCGTAAATGTGCAGGATGCGGACGAGTCCCTGATCAAGGCCTATAAGGCCAAAGGTTCGGCGG
GCACCATCGTGACCCGCGTGACGGATGCGAGCCCGGCAGCGAAAGCCAAGCTCGAAGTCGGCGATCTGATCCTCTCCATC
GATGGGCGCGCCGTGGCGGGGGTGCGTGACATGACGCGCCAGCTTTCCGAAAAGCCCATCGGTAAGGCGATCACGCTGAG
CATCGTCAGGGATGGCCGCGCGCGGGATGTCGCCGTCACGCTGGGCGAACTGCCCGATGAGGACGAACCCGCGACAGCGG
CGCCATCCGAAGCCGTCGGCATGTCGAACGATCTGGGCGCAGACCTCGTGGCACTCGACGATGACGTTCGCCGCCGCTTC
GGCGCGCCGCGGGATATGAACGGCGTGGCGGTTACGGGTGTCAGCACGCGCGGGCGGGCCTACAACAAGCTGCGCAAGGG
CGATGTGATCGTGGAGGTGAACTTCCAGTCCGTCAGCGCCGTGGCCGATGTCATCAAGCGTCTTGATACCGCGATGCAGA
CGCCAAATCAGCCCATCCTGATCCGCGTCAAACGGCGGGGAGAGACGGGAGGCTGGTTCGACCAGTTCGTATCGGTCGAC
ATCAAGAAGTAG

Upstream 100 bases:

>100_bases
CGCTGTTGCAACTGACGGCCAAAGCGCCATAGTCAGACTTCAAGAAAACAGCGGGCGTGCTGGCGCCTGAGAAACGACCG
TGAAGGGAGTCTTCTCCACA

Downstream 100 bases:

>100_bases
GCGAATTCCCCAGCGTTTCCGGCGACTTGGGCGGATTACGCCGCGTCACATGCCTGTCAAACATTACGGAAAATATGCCG
AATTGGCTCGCCAAGGGCGC

Product: Do family protease

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNRTAVAVFALMACMAPTALAQAGGSLSRPGAPVDAKTAPQSFSALSKRLMPAVVNISTSQVVASRLPTFPEGSPAERFN
EYFGRNDDGFQRQGSLGSGFVISADGYIVTNNHVIEKADTIEVTFSDGRTMDAKIIGRDRDSDIAVLKVTARGALPFVDL
ADSDRAEVGDWVIAIGNPLGFGGSVSAGIISATGRDLNTGRSDNFIQTDAAINQGNSGGPLFNLNGQVVGVNTAIISQSG
GSIGLGFSVPSNTVKRISAQLIKDGRVNRPWLGVNVQDADESLIKAYKAKGSAGTIVTRVTDASPAAKAKLEVGDLILSI
DGRAVAGVRDMTRQLSEKPIGKAITLSIVRDGRARDVAVTLGELPDEDEPATAAPSEAVGMSNDLGADLVALDDDVRRRF
GAPRDMNGVAVTGVSTRGRAYNKLRKGDVIVEVNFQSVSAVADVIKRLDTAMQTPNQPILIRVKRRGETGGWFDQFVSVD
IKK

Sequences:

>Translated_483_residues
MNRTAVAVFALMACMAPTALAQAGGSLSRPGAPVDAKTAPQSFSALSKRLMPAVVNISTSQVVASRLPTFPEGSPAERFN
EYFGRNDDGFQRQGSLGSGFVISADGYIVTNNHVIEKADTIEVTFSDGRTMDAKIIGRDRDSDIAVLKVTARGALPFVDL
ADSDRAEVGDWVIAIGNPLGFGGSVSAGIISATGRDLNTGRSDNFIQTDAAINQGNSGGPLFNLNGQVVGVNTAIISQSG
GSIGLGFSVPSNTVKRISAQLIKDGRVNRPWLGVNVQDADESLIKAYKAKGSAGTIVTRVTDASPAAKAKLEVGDLILSI
DGRAVAGVRDMTRQLSEKPIGKAITLSIVRDGRARDVAVTLGELPDEDEPATAAPSEAVGMSNDLGADLVALDDDVRRRF
GAPRDMNGVAVTGVSTRGRAYNKLRKGDVIVEVNFQSVSAVADVIKRLDTAMQTPNQPILIRVKRRGETGGWFDQFVSVD
IKK
>Mature_483_residues
MNRTAVAVFALMACMAPTALAQAGGSLSRPGAPVDAKTAPQSFSALSKRLMPAVVNISTSQVVASRLPTFPEGSPAERFN
EYFGRNDDGFQRQGSLGSGFVISADGYIVTNNHVIEKADTIEVTFSDGRTMDAKIIGRDRDSDIAVLKVTARGALPFVDL
ADSDRAEVGDWVIAIGNPLGFGGSVSAGIISATGRDLNTGRSDNFIQTDAAINQGNSGGPLFNLNGQVVGVNTAIISQSG
GSIGLGFSVPSNTVKRISAQLIKDGRVNRPWLGVNVQDADESLIKAYKAKGSAGTIVTRVTDASPAAKAKLEVGDLILSI
DGRAVAGVRDMTRQLSEKPIGKAITLSIVRDGRARDVAVTLGELPDEDEPATAAPSEAVGMSNDLGADLVALDDDVRRRF
GAPRDMNGVAVTGVSTRGRAYNKLRKGDVIVEVNFQSVSAVADVIKRLDTAMQTPNQPILIRVKRRGETGGWFDQFVSVD
IKK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=289, Percent_Identity=33.5640138408304, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI22129776, Length=282, Percent_Identity=32.9787234042553, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI24308541, Length=263, Percent_Identity=31.5589353612167, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI7019477, Length=251, Percent_Identity=33.0677290836653, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1786356, Length=447, Percent_Identity=37.8076062639821, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1789629, Length=453, Percent_Identity=35.0993377483444, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI1789630, Length=335, Percent_Identity=35.5223880597015, Blast_Score=189, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24646839, Length=301, Percent_Identity=32.2259136212625, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 50783; Mature: 50783

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTAVAVFALMACMAPTALAQAGGSLSRPGAPVDAKTAPQSFSALSKRLMPAVVNISTS
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCHH
QVVASRLPTFPEGSPAERFNEYFGRNDDGFQRQGSLGSGFVISADGYIVTNNHVIEKADT
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEEECCEEEECCCE
IEVTFSDGRTMDAKIIGRDRDSDIAVLKVTARGALPFVDLADSDRAEVGDWVIAIGNPLG
EEEEECCCCEEEEEEEECCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCEEEEECCCCC
FGGSVSAGIISATGRDLNTGRSDNFIQTDAAINQGNSGGPLFNLNGQVVGVNTAIISQSG
CCCCCCCCEEEECCCCCCCCCCCCEEEECHHHCCCCCCCCEEECCCEEEEEEEEEEECCC
GSIGLGFSVPSNTVKRISAQLIKDGRVNRPWLGVNVQDADESLIKAYKAKGSAGTIVTRV
CCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCEEEEEE
TDASPAAKAKLEVGDLILSIDGRAVAGVRDMTRQLSEKPIGKAITLSIVRDGRARDVAVT
ECCCCCHHEEEEECEEEEEECCCEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEE
LGELPDEDEPATAAPSEAVGMSNDLGADLVALDDDVRRRFGAPRDMNGVAVTGVSTRGRA
ECCCCCCCCCCCCCCHHHCCCCCCCCCEEEEECHHHHHHCCCCCCCCCEEEEECCCCCHH
YNKLRKGDVIVEVNFQSVSAVADVIKRLDTAMQTPNQPILIRVKRRGETGGWFDQFVSVD
HHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHEEEE
IKK
ECC
>Mature Secondary Structure
MNRTAVAVFALMACMAPTALAQAGGSLSRPGAPVDAKTAPQSFSALSKRLMPAVVNISTS
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCHH
QVVASRLPTFPEGSPAERFNEYFGRNDDGFQRQGSLGSGFVISADGYIVTNNHVIEKADT
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEEECCEEEECCCE
IEVTFSDGRTMDAKIIGRDRDSDIAVLKVTARGALPFVDLADSDRAEVGDWVIAIGNPLG
EEEEECCCCEEEEEEEECCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCEEEEECCCCC
FGGSVSAGIISATGRDLNTGRSDNFIQTDAAINQGNSGGPLFNLNGQVVGVNTAIISQSG
CCCCCCCCEEEECCCCCCCCCCCCEEEECHHHCCCCCCCCEEECCCEEEEEEEEEEECCC
GSIGLGFSVPSNTVKRISAQLIKDGRVNRPWLGVNVQDADESLIKAYKAKGSAGTIVTRV
CCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCEEEEEE
TDASPAAKAKLEVGDLILSIDGRAVAGVRDMTRQLSEKPIGKAITLSIVRDGRARDVAVT
ECCCCCHHEEEEECEEEEEECCCEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEE
LGELPDEDEPATAAPSEAVGMSNDLGADLVALDDDVRRRFGAPRDMNGVAVTGVSTRGRA
ECCCCCCCCCCCCCCHHHCCCCCCCCCEEEEECHHHHHHCCCCCCCCCEEEEECCCCCHH
YNKLRKGDVIVEVNFQSVSAVADVIKRLDTAMQTPNQPILIRVKRRGETGGWFDQFVSVD
HHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHEEEE
IKK
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]