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The map label for this gene is moaB1 [H]

Identifier: 114799410

GI number: 114799410

Start: 1073574

End: 1074104

Strand: Reverse

Name: moaB1 [H]

Synonym: HNE_1066

Alternate gene names: 114799410

Gene position: 1074104-1073574 (Counterclockwise)

Preceding gene: 114800184

Following gene: 114798606

Centisome position: 28.99

GC content: 63.09

Gene sequence:

>531_bases
ATGCACGGCATCAATGAAAGCCTTCCCTTCAAGCCGGTCCGGATCTCCATCCTGATCGTCAGCGATACGCGCACGGAAGA
AACCGACACCTCCGGCCACACCCTGTCAGAGCGCATCCGCGCCGCCGGTCACGAGGTCGCTCACCACCTCATCGTGCCCG
ACGACAAAGCCGCCATCCGCAACACCGTGTCAGCCTGGATCGCCGCGCCGGATGTCGATGTCGTCATCACCAGCGGCGGC
ACCGGCCTCACAGGCCGTGACGTGACGCCCGAAGCCGTCATGCCCCTGTTCGAGAAAACCATCGAAGGCTTCTCCGTCAT
CTTCCACATGGTCAGCTATCAGAGCGTCGGCCTCTCAACGCTTCAATCGCGCGCCGTCGCGGGCCTTGCCAACTCCACCT
TCATCTTCTGCCTGCCCGGCTCCACCGGCGCGGTGAAAGATGGCTGGGATAAAGTCATCTCCTTCCAGCTCGACAGCCGC
CACAAGCCCTGCAACCTGGTCGAGCTGATGCCCCGCCTGGCGGAGATCTGA

Upstream 100 bases:

>100_bases
AAAAGAAGTGACCGAGGCGGGCGACCAATGGATCGAACCGCGCCCCGAAGATTACACCGACGCTGCCCGCTGGGCAGGTC
CGCAGGAGAGTTGAACACGC

Downstream 100 bases:

>100_bases
GCTGATGGCAGACCTCACCCATATCGGCCCCGATGGCCGCGCCCGTATGGTGGACATCTCCGCCAAGGCCGACACCGAAC
GTGAAGCGATCGCAACCGGC

Product: molybdenum cofactor biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MHGINESLPFKPVRISILIVSDTRTEETDTSGHTLSERIRAAGHEVAHHLIVPDDKAAIRNTVSAWIAAPDVDVVITSGG
TGLTGRDVTPEAVMPLFEKTIEGFSVIFHMVSYQSVGLSTLQSRAVAGLANSTFIFCLPGSTGAVKDGWDKVISFQLDSR
HKPCNLVELMPRLAEI

Sequences:

>Translated_176_residues
MHGINESLPFKPVRISILIVSDTRTEETDTSGHTLSERIRAAGHEVAHHLIVPDDKAAIRNTVSAWIAAPDVDVVITSGG
TGLTGRDVTPEAVMPLFEKTIEGFSVIFHMVSYQSVGLSTLQSRAVAGLANSTFIFCLPGSTGAVKDGWDKVISFQLDSR
HKPCNLVELMPRLAEI
>Mature_176_residues
MHGINESLPFKPVRISILIVSDTRTEETDTSGHTLSERIRAAGHEVAHHLIVPDDKAAIRNTVSAWIAAPDVDVVITSGG
TGLTGRDVTPEAVMPLFEKTIEGFSVIFHMVSYQSVGLSTLQSRAVAGLANSTFIFCLPGSTGAVKDGWDKVISFQLDSR
HKPCNLVELMPRLAEI

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=150, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI10880983, Length=150, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1787000, Length=160, Percent_Identity=53.75, Blast_Score=183, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17564954, Length=145, Percent_Identity=34.4827586206897, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136978, Length=144, Percent_Identity=36.8055555555556, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24638841, Length=144, Percent_Identity=36.8055555555556, Blast_Score=83, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 19006; Mature: 19006

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGINESLPFKPVRISILIVSDTRTEETDTSGHTLSERIRAAGHEVAHHLIVPDDKAAIR
CCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCHHHHH
NTVSAWIAAPDVDVVITSGGTGLTGRDVTPEAVMPLFEKTIEGFSVIFHMVSYQSVGLST
HHHHHHEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LQSRAVAGLANSTFIFCLPGSTGAVKDGWDKVISFQLDSRHKPCNLVELMPRLAEI
HHHHHHHCCCCCEEEEEECCCCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MHGINESLPFKPVRISILIVSDTRTEETDTSGHTLSERIRAAGHEVAHHLIVPDDKAAIR
CCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCHHHHH
NTVSAWIAAPDVDVVITSGGTGLTGRDVTPEAVMPLFEKTIEGFSVIFHMVSYQSVGLST
HHHHHHEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LQSRAVAGLANSTFIFCLPGSTGAVKDGWDKVISFQLDSRHKPCNLVELMPRLAEI
HHHHHHHCCCCCEEEEEECCCCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]