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The map label for this gene is mmgC [H]

Identifier: 114799086

GI number: 114799086

Start: 674093

End: 675268

Strand: Direct

Name: mmgC [H]

Synonym: HNE_0669

Alternate gene names: 114799086

Gene position: 674093-675268 (Clockwise)

Preceding gene: 114800213

Following gene: 114798681

Centisome position: 18.19

GC content: 60.03

Gene sequence:

>1176_bases
ATGCATGAGAGCCCCCTGAACGTCCCCAAATCCGCCTGGCGCCAGGACGAAGAGCTCGAAATCTTCGCCGATGCCGTGGG
CCAGTTCTTCGAGAAGGAATGTGCCCCGCATGTGCCCGCCTGGCGCAAGGCCGGCATCGTGCCGCGCGAGATCTGGAAGA
AGGCGGGCGAAATGGGCCTGCTGGGCGCCTCGGTTCCCGAAGAGTATGGCGGCGCGGGCGGCGATTTCCGCCATGAGGCC
ATCATCATCGAACAGCAGCAATGGAAGGGTATCGACGGTTTCGGCATCACCCTGCACAACGCCATCATCGCCCCCTACAT
CACCGCCTATGGCACCGAGGAACAGAAGCAGCGCTGGCTGCCAAAAATCTGCTCCGGCGATCTTGTCACCGCCATCGCGA
TGACCGAGCCCGGTGCAGGTTCTGACCTCCAGGGCATGAAGACCACCGCAAAGCTTGATGGCGATCATTATGTCATCAAC
GGCTCGAAGACCTTCATCTCCAATGGCCAGACCGCTGACCTCATTCTCCTTTGCGTCAAGACGGACCCGACCAAGGGCGC
CAAGGGCATCTCTATCATCTGTGTCGAGACAGAAGCCGTTGAAGGCGCAGGCGGCTTCCGCCGTGGCCGCAACCTCGACA
AGGTCGGCCAGCATGCCGCCGACACGTCCGAGCTGTTCTTTGATGATGTCCGCGTGCCCGCCGCCCACCTCCTCGGCGGG
GAAGCCGGGAAGGGGTTCGTCCAGCTCATGCAGAAACTCCCGCAGGAGCGCCACATCATCGGCCTCCAGGGCGTCGGCAT
GATCGAGCGCGCGATCCATGAGACGGTCAATTATGTCAAAGGCCGCAAGGCGTTCGGCCAGACCATCTTCGATTTCCAGA
ACACCCAGTTCAAGCTCGCCGAAGCCAAGACCGAGGCAACTGTCGCAAAAGTGTTCGCCGATCACTGTACAGAGCTTCTT
CTGAAGGAAGAGCTTGATGCGTCCACGGCCTCCATGTCGAAATACTGGATCTCCGATCTGCAGTGCAAGATCATCGATGA
ATGTCTCCAGCTGCATGGCGGCTTCGGCTATATGGACGAATATCCCATCGCCCAGATGTATGCCGACGCCCGCGTCCAGC
GCATCTATGGCGGCGCCAATGAAGTGATGAAAATGCTGATCGCGAGGACGCTGTAG

Upstream 100 bases:

>100_bases
GACGCGGCGGCACGGCTGGAGAATCCGGGTCGCCGCGCTTACATGCTTACGTGAACGTAAGCGGCAACTTTACGCCGCGA
CAAGGATGTGGAGATTACCG

Downstream 100 bases:

>100_bases
AGGTATCATGCCCGATCGCCACCTGCTCCGCGAAGTCTTCCCTACGCCTGCGCGCAGCTCGCTGTCCCTCGGCTTTGAGA
TCATTGAACTGGACGCGAAG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MHESPLNVPKSAWRQDEELEIFADAVGQFFEKECAPHVPAWRKAGIVPREIWKKAGEMGLLGASVPEEYGGAGGDFRHEA
IIIEQQQWKGIDGFGITLHNAIIAPYITAYGTEEQKQRWLPKICSGDLVTAIAMTEPGAGSDLQGMKTTAKLDGDHYVIN
GSKTFISNGQTADLILLCVKTDPTKGAKGISIICVETEAVEGAGGFRRGRNLDKVGQHAADTSELFFDDVRVPAAHLLGG
EAGKGFVQLMQKLPQERHIIGLQGVGMIERAIHETVNYVKGRKAFGQTIFDFQNTQFKLAEAKTEATVAKVFADHCTELL
LKEELDASTASMSKYWISDLQCKIIDECLQLHGGFGYMDEYPIAQMYADARVQRIYGGANEVMKMLIARTL

Sequences:

>Translated_391_residues
MHESPLNVPKSAWRQDEELEIFADAVGQFFEKECAPHVPAWRKAGIVPREIWKKAGEMGLLGASVPEEYGGAGGDFRHEA
IIIEQQQWKGIDGFGITLHNAIIAPYITAYGTEEQKQRWLPKICSGDLVTAIAMTEPGAGSDLQGMKTTAKLDGDHYVIN
GSKTFISNGQTADLILLCVKTDPTKGAKGISIICVETEAVEGAGGFRRGRNLDKVGQHAADTSELFFDDVRVPAAHLLGG
EAGKGFVQLMQKLPQERHIIGLQGVGMIERAIHETVNYVKGRKAFGQTIFDFQNTQFKLAEAKTEATVAKVFADHCTELL
LKEELDASTASMSKYWISDLQCKIIDECLQLHGGFGYMDEYPIAQMYADARVQRIYGGANEVMKMLIARTL
>Mature_391_residues
MHESPLNVPKSAWRQDEELEIFADAVGQFFEKECAPHVPAWRKAGIVPREIWKKAGEMGLLGASVPEEYGGAGGDFRHEA
IIIEQQQWKGIDGFGITLHNAIIAPYITAYGTEEQKQRWLPKICSGDLVTAIAMTEPGAGSDLQGMKTTAKLDGDHYVIN
GSKTFISNGQTADLILLCVKTDPTKGAKGISIICVETEAVEGAGGFRRGRNLDKVGQHAADTSELFFDDVRVPAAHLLGG
EAGKGFVQLMQKLPQERHIIGLQGVGMIERAIHETVNYVKGRKAFGQTIFDFQNTQFKLAEAKTEATVAKVFADHCTELL
LKEELDASTASMSKYWISDLQCKIIDECLQLHGGFGYMDEYPIAQMYADARVQRIYGGANEVMKMLIARTL

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=49.7340425531915, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI7656849, Length=393, Percent_Identity=32.3155216284987, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=30.9711286089239, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=32.3699421965318, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4501859, Length=390, Percent_Identity=31.7948717948718, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4557233, Length=389, Percent_Identity=33.6760925449871, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=30.1587301587302, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=30.1587301587302, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI76496475, Length=383, Percent_Identity=33.9425587467363, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI4557235, Length=383, Percent_Identity=33.9425587467363, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI21361497, Length=392, Percent_Identity=32.3979591836735, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI4503943, Length=380, Percent_Identity=25.5263157894737, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI7669494, Length=374, Percent_Identity=26.2032085561497, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI48976061, Length=292, Percent_Identity=29.4520547945205, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI211971008, Length=292, Percent_Identity=29.4520547945205, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI87081958, Length=356, Percent_Identity=28.6516853932584, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=24.4094488188976, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87081702, Length=363, Percent_Identity=24.5179063360882, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=32.9758713136729, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17538396, Length=385, Percent_Identity=32.4675324675325, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17551932, Length=381, Percent_Identity=32.0209973753281, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=33.245382585752, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=33.9522546419098, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17508101, Length=387, Percent_Identity=31.0077519379845, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17569725, Length=374, Percent_Identity=31.5508021390374, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=31.2335958005249, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71990804, Length=283, Percent_Identity=38.5159010600707, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17570075, Length=375, Percent_Identity=32.2666666666667, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=33.5211267605634, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=235, Percent_Identity=37.4468085106383, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=280, Percent_Identity=32.8571428571429, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=311, Percent_Identity=33.4405144694534, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=28.0487804878049, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17534353, Length=380, Percent_Identity=26.0526315789474, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562446, Length=294, Percent_Identity=29.2517006802721, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355753, Length=388, Percent_Identity=33.7628865979381, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24666513, Length=385, Percent_Identity=30.1298701298701, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24660351, Length=369, Percent_Identity=31.4363143631436, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24646207, Length=377, Percent_Identity=31.5649867374005, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=28.8359788359788, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=32.2946175637394, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI19920834, Length=397, Percent_Identity=27.2040302267003, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42953; Mature: 42953

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHESPLNVPKSAWRQDEELEIFADAVGQFFEKECAPHVPAWRKAGIVPREIWKKAGEMGL
CCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHCCCCCE
LGASVPEEYGGAGGDFRHEAIIIEQQQWKGIDGFGITLHNAIIAPYITAYGTEEQKQRWL
ECCCCCHHHCCCCCCCCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
PKICSGDLVTAIAMTEPGAGSDLQGMKTTAKLDGDHYVINGSKTFISNGQTADLILLCVK
HHHHCCCCEEEEEEECCCCCCCCCCCCCEEEECCCEEEECCCEEEECCCCCEEEEEEEEE
TDPTKGAKGISIICVETEAVEGAGGFRRGRNLDKVGQHAADTSELFFDDVRVPAAHLLGG
CCCCCCCCCEEEEEEECCCCCCCCCHHCCCCHHHHHHHCCCHHHHHHHHHCCCHHHHHCC
EAGKGFVQLMQKLPQERHIIGLQGVGMIERAIHETVNYVKGRKAFGQTIFDFQNTQFKLA
CCCHHHHHHHHHCCHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEH
EAKTEATVAKVFADHCTELLLKEELDASTASMSKYWISDLQCKIIDECLQLHGGFGYMDE
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YPIAQMYADARVQRIYGGANEVMKMLIARTL
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MHESPLNVPKSAWRQDEELEIFADAVGQFFEKECAPHVPAWRKAGIVPREIWKKAGEMGL
CCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHCCCCCE
LGASVPEEYGGAGGDFRHEAIIIEQQQWKGIDGFGITLHNAIIAPYITAYGTEEQKQRWL
ECCCCCHHHCCCCCCCCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
PKICSGDLVTAIAMTEPGAGSDLQGMKTTAKLDGDHYVINGSKTFISNGQTADLILLCVK
HHHHCCCCEEEEEEECCCCCCCCCCCCCEEEECCCEEEECCCEEEECCCCCEEEEEEEEE
TDPTKGAKGISIICVETEAVEGAGGFRRGRNLDKVGQHAADTSELFFDDVRVPAAHLLGG
CCCCCCCCCEEEEEEECCCCCCCCCHHCCCCHHHHHHHCCCHHHHHHHHHCCCHHHHHCC
EAGKGFVQLMQKLPQERHIIGLQGVGMIERAIHETVNYVKGRKAFGQTIFDFQNTQFKLA
CCCHHHHHHHHHCCHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEH
EAKTEATVAKVFADHCTELLLKEELDASTASMSKYWISDLQCKIIDECLQLHGGFGYMDE
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YPIAQMYADARVQRIYGGANEVMKMLIARTL
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]