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The map label for this gene is rhmD [H]

Identifier: 114799021

GI number: 114799021

Start: 2217511

End: 2218815

Strand: Direct

Name: rhmD [H]

Synonym: HNE_2133

Alternate gene names: 114799021

Gene position: 2217511-2218815 (Clockwise)

Preceding gene: 114798458

Following gene: 114797082

Centisome position: 59.85

GC content: 61.0

Gene sequence:

>1305_bases
ATGATTGACAGTATCGAAGCGCGCGACATCCGCTTCCCCACATCGCGGGACAGCCACGGCTCCGACGCGATGAATCCGGA
CCCGGACTATTCCTGCGCCTATGTCACGCTGAAAATGCGCGGCGGTGATCCGGCCGGCAATGGTCTCACCTTCACCATCG
GGCGCGGCAATGATCTCTGCGTCGCCGCCATCGAAGGGCTCGGAAAACATCTCATCGGCCGCAGCCTGGACGAGTTTGAA
GCCGACCTCGGCCTCGCCTCCCGCCTGTTGCTGAACGATAGCCAGTATCGCTGGCTTGGGCCGGAAAAAGGCGTCGTGCA
TCTTGCCGCCGCTGCGCTCATCAACGCCGTCTGGGACGCGCTGGCGAAACGCGCCAAAAAACCGCTCTGGCGCTATGTGG
CCGATATGTCTCCCGAACAGATCGTCTCGGCCATCGATTTCCGCCATATCAGCGATTTCCTCAGTAAGGAGGAAGCCCTG
CACCGCCTGACACAGCAGGCGCCGGGCAAGGCTGCGCGCATCGAATTCCTTACGCGAGAAGGCTATCCGGCCTACACGAC
CTCCGCGGGCTGGATCGGATATTCCGATGCCCAGATCGTCCAGCTCCTCAAAGGGGCGTATGCGGAAGGCTGGCGCCACT
TCAAGATCAAGGTGGGCGGTGATCTTGCGACCGATGTGCGCCGCTGCGCCCTGTTCCGCGAAACCTTGGGCAAGGATGTG
AAGCTCAGCGTCGACGCCAATCAGGTCTGGAACATCGACCAGGCCGTCGCCGCGATCAAGGCCATCGCGCCCTACAACAT
TTATTGGGTGGAAGAACCTACGAGCCCGGACGATGTGCTCGGCCACAAGGAGATCGCCCGCCAGGTCGCGCCCATTCAGC
TGGCCACCGGCGAACACGCGCACAACAAGGTGATGTTCAAACAATTCCTGCAGGCGCAGGCCATCGGCTTCTGCCAGATC
GATTCCTGCCGTCTTGCGGGCGTCAATGAAGTCATCGCTGTCATGCTGATGGCCGACAAGGCCGGTATCCCTGTCTGTCC
CCATGCCGGCGGCGTCGGCCTCTGCGAATATGTTCAACACCTCTCGATGATCGATTTCGTCTGCATTTCCGGCACGATGG
AAAACCGCGTGATCGAGCACGCCGCGCACCTGCACCAGCATTTCCGCAATCCCATCGAGATCCGCAACGGGCGCTATCTG
GTACCCAGCGCGCCGGGATATTCGGTCGACCTCTGGCCACAGAGCATGGCCGATCATGAATTTCCCCATGGCAAAGTCTG
GGCGGAGGAAACCGTCGCTTCATGA

Upstream 100 bases:

>100_bases
GCGCAGGCTGTGACCCGTCCCCAGCGATGGCAGGGCCAGGATCAGATGTGCAACTGCCCCACCGCATTTCCCTTACCATC
GCCAGCCTGGAGCCCACGGC

Downstream 100 bases:

>100_bases
TTTCAGAGCCCCCCGCATTGATATTGCCGGAATTCGGCCTCGGTGCGGCGGGGCTCGGAAATCTGTATACGGCTATTTCT
GATGAGACGGCGCGGGAAAC

Product: mandelate racemase/muconate lactonizing enzyme family protein

Products: NA

Alternate protein names: RhamD [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MIDSIEARDIRFPTSRDSHGSDAMNPDPDYSCAYVTLKMRGGDPAGNGLTFTIGRGNDLCVAAIEGLGKHLIGRSLDEFE
ADLGLASRLLLNDSQYRWLGPEKGVVHLAAAALINAVWDALAKRAKKPLWRYVADMSPEQIVSAIDFRHISDFLSKEEAL
HRLTQQAPGKAARIEFLTREGYPAYTTSAGWIGYSDAQIVQLLKGAYAEGWRHFKIKVGGDLATDVRRCALFRETLGKDV
KLSVDANQVWNIDQAVAAIKAIAPYNIYWVEEPTSPDDVLGHKEIARQVAPIQLATGEHAHNKVMFKQFLQAQAIGFCQI
DSCRLAGVNEVIAVMLMADKAGIPVCPHAGGVGLCEYVQHLSMIDFVCISGTMENRVIEHAAHLHQHFRNPIEIRNGRYL
VPSAPGYSVDLWPQSMADHEFPHGKVWAEETVAS

Sequences:

>Translated_434_residues
MIDSIEARDIRFPTSRDSHGSDAMNPDPDYSCAYVTLKMRGGDPAGNGLTFTIGRGNDLCVAAIEGLGKHLIGRSLDEFE
ADLGLASRLLLNDSQYRWLGPEKGVVHLAAAALINAVWDALAKRAKKPLWRYVADMSPEQIVSAIDFRHISDFLSKEEAL
HRLTQQAPGKAARIEFLTREGYPAYTTSAGWIGYSDAQIVQLLKGAYAEGWRHFKIKVGGDLATDVRRCALFRETLGKDV
KLSVDANQVWNIDQAVAAIKAIAPYNIYWVEEPTSPDDVLGHKEIARQVAPIQLATGEHAHNKVMFKQFLQAQAIGFCQI
DSCRLAGVNEVIAVMLMADKAGIPVCPHAGGVGLCEYVQHLSMIDFVCISGTMENRVIEHAAHLHQHFRNPIEIRNGRYL
VPSAPGYSVDLWPQSMADHEFPHGKVWAEETVAS
>Mature_434_residues
MIDSIEARDIRFPTSRDSHGSDAMNPDPDYSCAYVTLKMRGGDPAGNGLTFTIGRGNDLCVAAIEGLGKHLIGRSLDEFE
ADLGLASRLLLNDSQYRWLGPEKGVVHLAAAALINAVWDALAKRAKKPLWRYVADMSPEQIVSAIDFRHISDFLSKEEAL
HRLTQQAPGKAARIEFLTREGYPAYTTSAGWIGYSDAQIVQLLKGAYAEGWRHFKIKVGGDLATDVRRCALFRETLGKDV
KLSVDANQVWNIDQAVAAIKAIAPYNIYWVEEPTSPDDVLGHKEIARQVAPIQLATGEHAHNKVMFKQFLQAQAIGFCQI
DSCRLAGVNEVIAVMLMADKAGIPVCPHAGGVGLCEYVQHLSMIDFVCISGTMENRVIEHAAHLHQHFRNPIEIRNGRYL
VPSAPGYSVDLWPQSMADHEFPHGKVWAEETVAS

Specific function: Catalyzes the dehydration of L-rhamnonate to 2-keto-3- deoxy-L-rhamnonate (KDR) [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=431, Percent_Identity=48.9559164733179, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI42544117, Length=411, Percent_Identity=47.4452554744526, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI186972148, Length=341, Percent_Identity=50.1466275659824, Blast_Score=378, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.90 [H]

Molecular weight: Translated: 47837; Mature: 47837

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00018 EF_HAND_1 ; PS00909 MR_MLE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSIEARDIRFPTSRDSHGSDAMNPDPDYSCAYVTLKMRGGDPAGNGLTFTIGRGNDLC
CCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEECCCCEE
VAAIEGLGKHLIGRSLDEFEADLGLASRLLLNDSQYRWLGPEKGVVHLAAAALINAVWDA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHH
LAKRAKKPLWRYVADMSPEQIVSAIDFRHISDFLSKEEALHRLTQQAPGKAARIEFLTRE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GYPAYTTSAGWIGYSDAQIVQLLKGAYAEGWRHFKIKVGGDLATDVRRCALFRETLGKDV
CCCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCE
KLSVDANQVWNIDQAVAAIKAIAPYNIYWVEEPTSPDDVLGHKEIARQVAPIQLATGEHA
EEEECCHHHCCHHHHHHHHHHHCCCEEEEEECCCCHHHHCCHHHHHHHHCCEEEECCCCH
HNKVMFKQFLQAQAIGFCQIDSCRLAGVNEVIAVMLMADKAGIPVCPHAGGVGLCEYVQH
HHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
LSMIDFVCISGTMENRVIEHAAHLHQHFRNPIEIRNGRYLVPSAPGYSVDLWPQSMADHE
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCEEEECCCCCCEEECCCHHHCCCC
FPHGKVWAEETVAS
CCCCCEEHHHHCCC
>Mature Secondary Structure
MIDSIEARDIRFPTSRDSHGSDAMNPDPDYSCAYVTLKMRGGDPAGNGLTFTIGRGNDLC
CCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEECCCCEE
VAAIEGLGKHLIGRSLDEFEADLGLASRLLLNDSQYRWLGPEKGVVHLAAAALINAVWDA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHH
LAKRAKKPLWRYVADMSPEQIVSAIDFRHISDFLSKEEALHRLTQQAPGKAARIEFLTRE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GYPAYTTSAGWIGYSDAQIVQLLKGAYAEGWRHFKIKVGGDLATDVRRCALFRETLGKDV
CCCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCE
KLSVDANQVWNIDQAVAAIKAIAPYNIYWVEEPTSPDDVLGHKEIARQVAPIQLATGEHA
EEEECCHHHCCHHHHHHHHHHHCCCEEEEEECCCCHHHHCCHHHHHHHHCCEEEECCCCH
HNKVMFKQFLQAQAIGFCQIDSCRLAGVNEVIAVMLMADKAGIPVCPHAGGVGLCEYVQH
HHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
LSMIDFVCISGTMENRVIEHAAHLHQHFRNPIEIRNGRYLVPSAPGYSVDLWPQSMADHE
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCEEEECCCCCCEEECCCHHHCCCC
FPHGKVWAEETVAS
CCCCCEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA