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The map label for this gene is mtaP [H]

Identifier: 114798898

GI number: 114798898

Start: 346771

End: 347649

Strand: Direct

Name: mtaP [H]

Synonym: HNE_0354

Alternate gene names: 114798898

Gene position: 346771-347649 (Clockwise)

Preceding gene: 114799462

Following gene: 114797053

Centisome position: 9.36

GC content: 66.33

Gene sequence:

>879_bases
ATGAGCGGCTGGAAACTCGGGATCATCGGCGGCTCCGGCCTCTACGCGCTGGACGGTCTGGAAGACCGGCGCGAGCATAC
CGTTGAAACCCCTTGGGGGCCCCCGTCTGATGCCCTCGTCTCCGGCCGCATCGGCGAGGTCGAGCTTGTCTTCCTCCCCC
GTCACGGCAAGGGCCACCGCCTCACGCCCACCGACGTGCCCTACCGCGCCAATATCGCCGCCCTGAAAATGGCCGGCGTC
ACCGATGTCCTCTCCATCTCCGCCTGCGGCTCGCTGCAGGAGCAGTATGCCCCCGGCGAGGTCGTCGCCGCTGACCAGTT
CATCGACCGGACCGTCAGCCGCGAGAAAACCTTCTTCGGCGCCGGGCTCGTCGGCCATGTCTCGATGGCTGAGCCCGTCT
GCGCCCGGCTCTCGGCCCTCGCGGCCAATGCGATGGAAGCGGTCGGCGGCAAGGTCCACCGCGGCGGAACCTATCTCGCG
ATGGAAGGCCCGCAATTCTCGTCGCTCGCCGAAAGCCGCCTCTACCGCCAATGGGGCTGCGATGTGATCGGCATGACCAA
CATGCCCGAAGCCAAGCTCGCCCGCGAGGCAGAGCTGCCCTACGCCACCCTCGCCATGGTCACCGATTATGACTGCTGGC
GCGCCGACACGGACGCGGTCACGGTCACCAATGTGCTCGAAATCATGGCGCAGAACACCGCGCTTGCCCGCCGCGCCATC
CTCCAGCTCGCCCACAGCCTGAACGGTACGCCGCGTACACTCTCGCCGCAGGGCATTGAAACCTGTCTGGATTTTGCCCT
GATTACGGCGCCAGACCTACGCGATCCTGTCATGATTGATAAGCTGCGGGCGATTGCAGGGCGCGCGCTCGGCGTTTAG

Upstream 100 bases:

>100_bases
TTGCCGAAGATGTCGAGCTGACAACCCATAACCCCCTCTCGCCCCCGCCCACCGGCATGCGAAAGTGGTTTATAGAACAC
CCAACACCAAAGGAGCGCGC

Downstream 100 bases:

>100_bases
AAGTCGGTAACGTCTGGCGTTTGCCCGGCGCGGGCGGGCACGTTTCGGGTCCAGCCTGAGGGGGACTCAGAATGAGCGAA
GCACAGTTTCATACCTTCCT

Product: methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSGWKLGIIGGSGLYALDGLEDRREHTVETPWGPPSDALVSGRIGEVELVFLPRHGKGHRLTPTDVPYRANIAALKMAGV
TDVLSISACGSLQEQYAPGEVVAADQFIDRTVSREKTFFGAGLVGHVSMAEPVCARLSALAANAMEAVGGKVHRGGTYLA
MEGPQFSSLAESRLYRQWGCDVIGMTNMPEAKLAREAELPYATLAMVTDYDCWRADTDAVTVTNVLEIMAQNTALARRAI
LQLAHSLNGTPRTLSPQGIETCLDFALITAPDLRDPVMIDKLRAIAGRALGV

Sequences:

>Translated_292_residues
MSGWKLGIIGGSGLYALDGLEDRREHTVETPWGPPSDALVSGRIGEVELVFLPRHGKGHRLTPTDVPYRANIAALKMAGV
TDVLSISACGSLQEQYAPGEVVAADQFIDRTVSREKTFFGAGLVGHVSMAEPVCARLSALAANAMEAVGGKVHRGGTYLA
MEGPQFSSLAESRLYRQWGCDVIGMTNMPEAKLAREAELPYATLAMVTDYDCWRADTDAVTVTNVLEIMAQNTALARRAI
LQLAHSLNGTPRTLSPQGIETCLDFALITAPDLRDPVMIDKLRAIAGRALGV
>Mature_291_residues
SGWKLGIIGGSGLYALDGLEDRREHTVETPWGPPSDALVSGRIGEVELVFLPRHGKGHRLTPTDVPYRANIAALKMAGVT
DVLSISACGSLQEQYAPGEVVAADQFIDRTVSREKTFFGAGLVGHVSMAEPVCARLSALAANAMEAVGGKVHRGGTYLAM
EGPQFSSLAESRLYRQWGCDVIGMTNMPEAKLAREAELPYATLAMVTDYDCWRADTDAVTVTNVLEIMAQNTALARRAIL
QLAHSLNGTPRTLSPQGIETCLDFALITAPDLRDPVMIDKLRAIAGRALGV

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=269, Percent_Identity=42.7509293680297, Blast_Score=231, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI71980569, Length=279, Percent_Identity=36.9175627240143, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6323045, Length=301, Percent_Identity=37.5415282392027, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20130079, Length=243, Percent_Identity=43.6213991769547, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221459247, Length=242, Percent_Identity=35.1239669421488, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 31277; Mature: 31146

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGWKLGIIGGSGLYALDGLEDRREHTVETPWGPPSDALVSGRIGEVELVFLPRHGKGHR
CCCEEEEEEECCCEEEECCCHHHHHCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCC
LTPTDVPYRANIAALKMAGVTDVLSISACGSLQEQYAPGEVVAADQFIDRTVSREKTFFG
CCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCC
AGLVGHVSMAEPVCARLSALAANAMEAVGGKVHRGGTYLAMEGPQFSSLAESRLYRQWGC
CCHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEECCCCHHHHHHHHHHHHHCC
DVIGMTNMPEAKLAREAELPYATLAMVTDYDCWRADTDAVTVTNVLEIMAQNTALARRAI
CEEECCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LQLAHSLNGTPRTLSPQGIETCLDFALITAPDLRDPVMIDKLRAIAGRALGV
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGWKLGIIGGSGLYALDGLEDRREHTVETPWGPPSDALVSGRIGEVELVFLPRHGKGHR
CCEEEEEEECCCEEEECCCHHHHHCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCC
LTPTDVPYRANIAALKMAGVTDVLSISACGSLQEQYAPGEVVAADQFIDRTVSREKTFFG
CCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCC
AGLVGHVSMAEPVCARLSALAANAMEAVGGKVHRGGTYLAMEGPQFSSLAESRLYRQWGC
CCHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEECCCCHHHHHHHHHHHHHCC
DVIGMTNMPEAKLAREAELPYATLAMVTDYDCWRADTDAVTVTNVLEIMAQNTALARRAI
CEEECCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LQLAHSLNGTPRTLSPQGIETCLDFALITAPDLRDPVMIDKLRAIAGRALGV
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA