Click here to switch to the map view.

The map label for this gene is cobB1 [H]

Identifier: 114798782

GI number: 114798782

Start: 903504

End: 904253

Strand: Reverse

Name: cobB1 [H]

Synonym: HNE_0882

Alternate gene names: 114798782

Gene position: 904253-903504 (Counterclockwise)

Preceding gene: 114798046

Following gene: 114800285

Centisome position: 24.41

GC content: 62.8

Gene sequence:

>750_bases
ATGACCGAGACTGATGCAGACGACCTCGCCCACCTGATCCGCAATGCCCACCGCGTGGTGGTGTTCACCGGCGCGGGCAT
TTCGACCGAAAGCGGCATTCCCGATTTCCGCTCGCCCGGCGGCGTGTGGAGCAAGATGAAGCCGATCATGTTCCAGGACT
TCGTCGCCTCGCGCGATGCAAGGCGGGAAGCCTGGACGCGCGTGTTCAACCGCACCGCCGGCTGGACCGGGGCCTCTCCG
AACGCCGGGCATTATGCCGTGGCGCAGCTGGTCGAGGCGGGTAAGGTGACCAGCGTGATTACGCAGAATGTCGACAACCT
GCACCAGGATTCCGGCGTGCCCGACAGCAAGGTGATCGAGGTGCACGGCAATGCGAGCTATGCCAAATGCCTGACCTGCG
GGAAGCGGTATGAGCTGGAAGCGCTGCGCCATCACTGGGAAGCGGACGAAGACATCACCTGCATGTTCTGCACCGGTCTG
ATCAAGACCGCGACGATTTCCTTTGGCCAGGCGATGCCCGAAGACGAGATGGCGCGGGCGACCGAAGAGGCGCTGCTGGC
TGACCTGTTTCTGGTGCTCGGCTCATCGCTGGTCGTGTATCCGGCCGCCAGCCTGCCCCTTGTGGCCAAGAAGGCCGGAT
CAAATCTCGCCATCATCAATCGCGAGGCGACGGAGCAGGATCCTTATGCCGATCTTGTGCTGAATACGGACATCGGGCCG
TTGATGAGCGCGGTCATGGGGCGGCTTTAG

Upstream 100 bases:

>100_bases
GATGCTGTGCTGCCTGAAGGCGTTTCTGGAGCATGGCATTAATCTGCGCGAAGGCATGTTCCGCTAGAAGGCCGCGCGAA
ATCTGTGTAGCCTCAGCCCC

Downstream 100 bases:

>100_bases
GCGGGGCCGCGTTTCTGAATTTTCCAGATGCCCGGCCAGATGCCCGGCCAGATTCCCGGCCAGATTCCCGGAAAGAGCGA
AGCGGTTATCCGGGAGCCGG

Product: Sir2 family transcriptional regulator

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTETDADDLAHLIRNAHRVVVFTGAGISTESGIPDFRSPGGVWSKMKPIMFQDFVASRDARREAWTRVFNRTAGWTGASP
NAGHYAVAQLVEAGKVTSVITQNVDNLHQDSGVPDSKVIEVHGNASYAKCLTCGKRYELEALRHHWEADEDITCMFCTGL
IKTATISFGQAMPEDEMARATEEALLADLFLVLGSSLVVYPAASLPLVAKKAGSNLAIINREATEQDPYADLVLNTDIGP
LMSAVMGRL

Sequences:

>Translated_249_residues
MTETDADDLAHLIRNAHRVVVFTGAGISTESGIPDFRSPGGVWSKMKPIMFQDFVASRDARREAWTRVFNRTAGWTGASP
NAGHYAVAQLVEAGKVTSVITQNVDNLHQDSGVPDSKVIEVHGNASYAKCLTCGKRYELEALRHHWEADEDITCMFCTGL
IKTATISFGQAMPEDEMARATEEALLADLFLVLGSSLVVYPAASLPLVAKKAGSNLAIINREATEQDPYADLVLNTDIGP
LMSAVMGRL
>Mature_248_residues
TETDADDLAHLIRNAHRVVVFTGAGISTESGIPDFRSPGGVWSKMKPIMFQDFVASRDARREAWTRVFNRTAGWTGASPN
AGHYAVAQLVEAGKVTSVITQNVDNLHQDSGVPDSKVIEVHGNASYAKCLTCGKRYELEALRHHWEADEDITCMFCTGLI
KTATISFGQAMPEDEMARATEEALLADLFLVLGSSLVVYPAASLPLVAKKAGSNLAIINREATEQDPYADLVLNTDIGPL
MSAVMGRL

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300797577, Length=251, Percent_Identity=33.0677290836653, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI6912660, Length=231, Percent_Identity=35.0649350649351, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI6912662, Length=268, Percent_Identity=32.4626865671642, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI300797597, Length=242, Percent_Identity=33.0578512396694, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI63054862, Length=209, Percent_Identity=35.8851674641148, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI7706712, Length=261, Percent_Identity=31.8007662835249, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI300795542, Length=228, Percent_Identity=32.0175438596491, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI6912664, Length=248, Percent_Identity=30.241935483871, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI13787215, Length=248, Percent_Identity=30.241935483871, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI13775602, Length=222, Percent_Identity=28.8288288288288, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI13775600, Length=222, Percent_Identity=28.8288288288288, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI7657575, Length=229, Percent_Identity=28.3842794759825, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI308199517, Length=221, Percent_Identity=32.579185520362, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17567771, Length=279, Percent_Identity=30.1075268817204, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17541892, Length=222, Percent_Identity=31.5315315315315, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71990482, Length=278, Percent_Identity=29.4964028776978, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71990487, Length=280, Percent_Identity=29.2857142857143, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17505510, Length=240, Percent_Identity=27.0833333333333, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6325242, Length=223, Percent_Identity=30.4932735426009, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24645650, Length=254, Percent_Identity=30.3149606299213, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24648389, Length=224, Percent_Identity=31.6964285714286, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI28571445, Length=280, Percent_Identity=31.0714285714286, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17137536, Length=255, Percent_Identity=28.2352941176471, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24650933, Length=260, Percent_Identity=26.1538461538462, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571443, Length=225, Percent_Identity=27.5555555555556, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28571441, Length=225, Percent_Identity=27.5555555555556, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26967; Mature: 26836

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETDADDLAHLIRNAHRVVVFTGAGISTESGIPDFRSPGGVWSKMKPIMFQDFVASRDA
CCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCHH
RREAWTRVFNRTAGWTGASPNAGHYAVAQLVEAGKVTSVITQNVDNLHQDSGVPDSKVIE
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VHGNASYAKCLTCGKRYELEALRHHWEADEDITCMFCTGLIKTATISFGQAMPEDEMARA
EECCCCHHHHHHCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCCCCCHHHHHHH
TEEALLADLFLVLGSSLVVYPAASLPLVAKKAGSNLAIINREATEQDPYADLVLNTDIGP
HHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCCCCEEEEECCCCCCCCCEEEEEECCHHH
LMSAVMGRL
HHHHHHHCC
>Mature Secondary Structure 
TETDADDLAHLIRNAHRVVVFTGAGISTESGIPDFRSPGGVWSKMKPIMFQDFVASRDA
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCHH
RREAWTRVFNRTAGWTGASPNAGHYAVAQLVEAGKVTSVITQNVDNLHQDSGVPDSKVIE
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VHGNASYAKCLTCGKRYELEALRHHWEADEDITCMFCTGLIKTATISFGQAMPEDEMARA
EECCCCHHHHHHCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCCCCCHHHHHHH
TEEALLADLFLVLGSSLVVYPAASLPLVAKKAGSNLAIINREATEQDPYADLVLNTDIGP
HHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCCCCEEEEECCCCCCCCCEEEEEECCHHH
LMSAVMGRL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]