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The map label for this gene is uvrC

Identifier: 114798753

GI number: 114798753

Start: 3122104

End: 3123948

Strand: Reverse

Name: uvrC

Synonym: HNE_2966

Alternate gene names: 114798753

Gene position: 3123948-3122104 (Counterclockwise)

Preceding gene: 114797434

Following gene: 114798412

Centisome position: 84.32

GC content: 63.25

Gene sequence:

>1845_bases
GTGCGCGGGGTAGATGTCATCAAAGAGAATCTGAAACACCTGCCGTCCCGGCCGGGCGTCTACCGTATGTTCGGTGAGGC
GGGCGAAGTGCTGTATGTCGGTAAGGCGCGCGACCTGAAGGCCCGTGTCTCCAATTACACCCGGATGGGCGGGCACACGC
AGCGCATCGCCCGGATGATCTCGCTGACCCGCGCGATGGAATTCGTGGTCACCGAGACCGAGACCGAGGCGCTGCTGCTG
GAAGCCAGCCTCGTCAAATCGCTCAAGCCTCGCTTCAACGTGCTGCTGCGCGACGACAAATCGTTCCCCTACATCCTGAT
CCGGCGCAATCATGAGGCGCCGCAGATCAAGAAATATCGCGGCTCCAAGCAGGATGAGGGGGATTATTTCGGCCCCTTCG
CCAATGCGGGCGCGGTGATGCGCACCCTCGACACGTTGCAGAAGGCGTTCCTGCTGCGCACCTGCGAGGATAGTGTCTAT
TCAGCGCGCACGCGCCCCTGCATGCTCCACCAGATCAAACGCTGCGCTGCGCCTTGCGTCGGTCTCGTCTCGAAGGAGGA
TTACACCGCCCTCGCTGATGAAGCGGCGGACTTCCTGCGCGGCAAGGCAGGCGAGCTCCAGAAACGCCTCGCCTCGGAAA
TGGAAGCGGCTTCTGAAGCGATGGAGTTCGAGACCGCCGCGCGCCTGCGCGACCGTATCCGCGCCATCGCCCATGTTCGC
TCCACCCAGGACGTGAACCCCGACGGGATCGAGGAAGCCGACGTTTTCGCCATCGCCATGGACGGCGGCGTTTCCTGCGT
ACAGGTTTTCTTCATCCGGGCCGGCCAGAACTGGGGCGCCAGCGCGCACTTTCCCCGCCACGAGAAGGACCAGACAGCGC
CAGAGATTCTCGCCGCTTTCCTCGTCCAGTTCTATGACAAGCGCCCGCCGCCCAAACTCATCCTCGTCAGCGAGCCGCCC
GATCAGGCTGACCTGATCGAAGAGGCGCTGGCGCTGAAAGCGGGCCGCCGAATCGAGCTGCGCCGTCCCGAGCGTGGCAC
CAAGCGCGACCTGCTCACTCAGGCCGAACGCAATGCCAGCGAGGCGCTCTCCCGCAAGCTCGCCGAATCCGCCAGCCAGG
AGCGGTTGCTCACCGAAGTGCAAAAGGTCTTCGACCTTGCCGAGGCGCCGCAACGGATTGAGGTCTATGACAACTCCCAC
ATCCAGGGGACGAACGCGGTCGGCGGCATGATCGTCGCCGGGCCGGAGGGCTTCCGCAAGCAGGCCTACCGGAAGTTCAA
CATCAAGGACACCGAGATCACGCCGGGCGATGATTACGGCATGATGCGTGAGGTGATGCGGCGGCGCTTTGCGCGCGCTA
TGAAGGAGAAAGTGGCCGGGAATGTCTCGGATTGGCCGGATCTTGTCCTGATCGATGGCGGGCTGGGGCAGTTGAATGCC
ACGCTGGAAACACTGGCGGAGCTTGGATTGACGCCGGATGACGTGACGTTGGTGTCCATTGCCAAGGGCGTTGACCGCAA
TGCCGGGCGCGAGCAGTTTTTCCGCCCCGGAAAAGCCCCTTTCAAATTACCCGAAAACGCGCCTGTGCTTTACTATCTCC
AGCGCCTACGCGACGAAGCCCACCGCTGGGCCATCGGCGCTCACCGTCAGAAGCGCGCCGCTGAAGCGGCCCGTTCGCCG
CTGGACGAAATCGAGGGCATCGGCCCTACACGGAAGAAAGCACTGCTCCACCATTTCGGCTCAGCGCGCGGTGTTTCCCG
TGCCAAGGTGGCCGATCTGATGGAGGTGGACGGGGTAAACGAGGCCCTCGCCATCCGCATCTATGGGCATTTCAACAGCG
GCTGA

Upstream 100 bases:

>100_bases
GGGCGCATTTCCTTCTGACGCGCAGCCCTTTGGCTTTCCGTGGGCGCCGGTCTCCATTATCTCTGCGCGTATGAGCGACG
CAGCCCCCGGCGCTGCCCCG

Downstream 100 bases:

>100_bases
ATTCAGGCGGAGGCCCGTTCTGCGCGCAAGGCTAGAGCGCCCATATAGCTCTCGATCAGCAATACCAGCTCGTCCTCCAG
AGCCGTGGGATCAAGTTCCA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MRGVDVIKENLKHLPSRPGVYRMFGEAGEVLYVGKARDLKARVSNYTRMGGHTQRIARMISLTRAMEFVVTETETEALLL
EASLVKSLKPRFNVLLRDDKSFPYILIRRNHEAPQIKKYRGSKQDEGDYFGPFANAGAVMRTLDTLQKAFLLRTCEDSVY
SARTRPCMLHQIKRCAAPCVGLVSKEDYTALADEAADFLRGKAGELQKRLASEMEAASEAMEFETAARLRDRIRAIAHVR
STQDVNPDGIEEADVFAIAMDGGVSCVQVFFIRAGQNWGASAHFPRHEKDQTAPEILAAFLVQFYDKRPPPKLILVSEPP
DQADLIEEALALKAGRRIELRRPERGTKRDLLTQAERNASEALSRKLAESASQERLLTEVQKVFDLAEAPQRIEVYDNSH
IQGTNAVGGMIVAGPEGFRKQAYRKFNIKDTEITPGDDYGMMREVMRRRFARAMKEKVAGNVSDWPDLVLIDGGLGQLNA
TLETLAELGLTPDDVTLVSIAKGVDRNAGREQFFRPGKAPFKLPENAPVLYYLQRLRDEAHRWAIGAHRQKRAAEAARSP
LDEIEGIGPTRKKALLHHFGSARGVSRAKVADLMEVDGVNEALAIRIYGHFNSG

Sequences:

>Translated_614_residues
MRGVDVIKENLKHLPSRPGVYRMFGEAGEVLYVGKARDLKARVSNYTRMGGHTQRIARMISLTRAMEFVVTETETEALLL
EASLVKSLKPRFNVLLRDDKSFPYILIRRNHEAPQIKKYRGSKQDEGDYFGPFANAGAVMRTLDTLQKAFLLRTCEDSVY
SARTRPCMLHQIKRCAAPCVGLVSKEDYTALADEAADFLRGKAGELQKRLASEMEAASEAMEFETAARLRDRIRAIAHVR
STQDVNPDGIEEADVFAIAMDGGVSCVQVFFIRAGQNWGASAHFPRHEKDQTAPEILAAFLVQFYDKRPPPKLILVSEPP
DQADLIEEALALKAGRRIELRRPERGTKRDLLTQAERNASEALSRKLAESASQERLLTEVQKVFDLAEAPQRIEVYDNSH
IQGTNAVGGMIVAGPEGFRKQAYRKFNIKDTEITPGDDYGMMREVMRRRFARAMKEKVAGNVSDWPDLVLIDGGLGQLNA
TLETLAELGLTPDDVTLVSIAKGVDRNAGREQFFRPGKAPFKLPENAPVLYYLQRLRDEAHRWAIGAHRQKRAAEAARSP
LDEIEGIGPTRKKALLHHFGSARGVSRAKVADLMEVDGVNEALAIRIYGHFNSG
>Mature_614_residues
MRGVDVIKENLKHLPSRPGVYRMFGEAGEVLYVGKARDLKARVSNYTRMGGHTQRIARMISLTRAMEFVVTETETEALLL
EASLVKSLKPRFNVLLRDDKSFPYILIRRNHEAPQIKKYRGSKQDEGDYFGPFANAGAVMRTLDTLQKAFLLRTCEDSVY
SARTRPCMLHQIKRCAAPCVGLVSKEDYTALADEAADFLRGKAGELQKRLASEMEAASEAMEFETAARLRDRIRAIAHVR
STQDVNPDGIEEADVFAIAMDGGVSCVQVFFIRAGQNWGASAHFPRHEKDQTAPEILAAFLVQFYDKRPPPKLILVSEPP
DQADLIEEALALKAGRRIELRRPERGTKRDLLTQAERNASEALSRKLAESASQERLLTEVQKVFDLAEAPQRIEVYDNSH
IQGTNAVGGMIVAGPEGFRKQAYRKFNIKDTEITPGDDYGMMREVMRRRFARAMKEKVAGNVSDWPDLVLIDGGLGQLNA
TLETLAELGLTPDDVTLVSIAKGVDRNAGREQFFRPGKAPFKLPENAPVLYYLQRLRDEAHRWAIGAHRQKRAAEAARSP
LDEIEGIGPTRKKALLHHFGSARGVSRAKVADLMEVDGVNEALAIRIYGHFNSG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=41.2151067323481, Blast_Score=457, Evalue=1e-129,
Organism=Escherichia coli, GI1788037, Length=200, Percent_Identity=32, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_HYPNA (Q0BY00)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761643.1
- ProteinModelPortal:   Q0BY00
- STRING:   Q0BY00
- GeneID:   4287988
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2966
- NMPDR:   fig|228405.5.peg.2842
- TIGR:   HNE_2966
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q0BY00
- ProtClustDB:   PRK00558
- BioCyc:   HNEP81032:HNE_2966-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68538; Mature: 68538

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGVDVIKENLKHLPSRPGVYRMFGEAGEVLYVGKARDLKARVSNYTRMGGHTQRIARMI
CCCHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHH
SLTRAMEFVVTETETEALLLEASLVKSLKPRFNVLLRDDKSFPYILIRRNHEAPQIKKYR
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHEEEEECCCCCCEEEEECCCCCCHHHHHC
GSKQDEGDYFGPFANAGAVMRTLDTLQKAFLLRTCEDSVYSARTRPCMLHQIKRCAAPCV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GLVSKEDYTALADEAADFLRGKAGELQKRLASEMEAASEAMEFETAARLRDRIRAIAHVR
HHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STQDVNPDGIEEADVFAIAMDGGVSCVQVFFIRAGQNWGASAHFPRHEKDQTAPEILAAF
HCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
LVQFYDKRPPPKLILVSEPPDQADLIEEALALKAGRRIELRRPERGTKRDLLTQAERNAS
HHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCHH
EALSRKLAESASQERLLTEVQKVFDLAEAPQRIEVYDNSHIQGTNAVGGMIVAGPEGFRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEECCHHHHH
QAYRKFNIKDTEITPGDDYGMMREVMRRRFARAMKEKVAGNVSDWPDLVLIDGGLGQLNA
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHH
TLETLAELGLTPDDVTLVSIAKGVDRNAGREQFFRPGKAPFKLPENAPVLYYLQRLRDEA
HHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
HRWAIGAHRQKRAAEAARSPLDEIEGIGPTRKKALLHHFGSARGVSRAKVADLMEVDGVN
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
EALAIRIYGHFNSG
CEEEEEEEEECCCC
>Mature Secondary Structure
MRGVDVIKENLKHLPSRPGVYRMFGEAGEVLYVGKARDLKARVSNYTRMGGHTQRIARMI
CCCHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHH
SLTRAMEFVVTETETEALLLEASLVKSLKPRFNVLLRDDKSFPYILIRRNHEAPQIKKYR
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHEEEEECCCCCCEEEEECCCCCCHHHHHC
GSKQDEGDYFGPFANAGAVMRTLDTLQKAFLLRTCEDSVYSARTRPCMLHQIKRCAAPCV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GLVSKEDYTALADEAADFLRGKAGELQKRLASEMEAASEAMEFETAARLRDRIRAIAHVR
HHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STQDVNPDGIEEADVFAIAMDGGVSCVQVFFIRAGQNWGASAHFPRHEKDQTAPEILAAF
HCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
LVQFYDKRPPPKLILVSEPPDQADLIEEALALKAGRRIELRRPERGTKRDLLTQAERNAS
HHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCHH
EALSRKLAESASQERLLTEVQKVFDLAEAPQRIEVYDNSHIQGTNAVGGMIVAGPEGFRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEECCHHHHH
QAYRKFNIKDTEITPGDDYGMMREVMRRRFARAMKEKVAGNVSDWPDLVLIDGGLGQLNA
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHH
TLETLAELGLTPDDVTLVSIAKGVDRNAGREQFFRPGKAPFKLPENAPVLYYLQRLRDEA
HHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
HRWAIGAHRQKRAAEAARSPLDEIEGIGPTRKKALLHHFGSARGVSRAKVADLMEVDGVN
HHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
EALAIRIYGHFNSG
CEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA