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The map label for this gene is panC

Identifier: 114798508

GI number: 114798508

Start: 1137984

End: 1138865

Strand: Reverse

Name: panC

Synonym: HNE_1126

Alternate gene names: 114798508

Gene position: 1138865-1137984 (Counterclockwise)

Preceding gene: 114798957

Following gene: 114797423

Centisome position: 30.74

GC content: 62.81

Gene sequence:

>882_bases
GTGAATTCCACGAAAGAAAACCCGGTCGAAATAATCCGTACCCGAAACGAGCTGCAAGCCCGTGTACGCGCGTGGAAACA
GGCCGGTGAAACCGTTGGTTTCGTCCCCACCATGGGGGCGCTGCATGAAGGGCATCTCTCGCTCATTGAAAAAGCTCAGG
AAAAGGTCACGCGCACCGTGGCGAGCATTTTCGTTAACCCGGCGCAGTTCGCCCCTGGCGAGGATTTCGACACCTATCCG
CGCCGCGAGGGCGAAGACATTGCCAAGCTGGCGAGCGTAAACTGTGACGCGGTTTACCTGCCCACTGTTGCAGAAATGTA
TCCCGAAGGATCGGTCACGAATGTGCGGGTCGAATCGCTGTCGGACCTGCTGGACGGGATTTACCGGCCGCACTTCTTCT
ATGGAGTGGCGACGGTGGTGGCGCGCCTCTTCCTGCATGCGCAGCCGGACGTGGCCGTATTCGGCGAGAAGGATTACCAG
CAGCTGCAGGTGATCCGCCGGATGGTGCGGGATCTGGGATTCCCGATCGAGATCATCGGCGGGGCAACCCGGCGGGACGC
CGACGGGCTGGCCCAGTCTTCCCGCAATCTTTATCTTTCCCCGGACGAACGCAGGGCGGCGGGCGCGATCTATTCGGCCA
TGCACCGCGCCGCCAGCCGCATGGCGCTTGGCACCCTCCCCTCAGAGGCGCTGAAGGAGGCGGAGGGCTACATCCTCACC
GCCGGCTTCCGGAAGATCGACTATGTGACGCTGGTGGACCCGGCAACGCTACAGGCCCTGCCCGCAGATACGCCGCTAGA
AGACGGCGCAGCCGCGCGGCTGCTGGCAGCGGCATGGATCGGCAAGACGCGGCTGATCGACAATATCAGCGTGACGCGGT
GA

Upstream 100 bases:

>100_bases
CGAGCGGAGAGTGGTCAGGATGCGCTGGGTCATGTCTGTAAAATTCCCGCTTATGGGTTAACAACGCATTAACTTCATCA
AGAAGCAGGGCATCTGAAAA

Downstream 100 bases:

>100_bases
AGGCTTTCAGGGCGTCCAGGAAACGCTGATTGTCGTCTGCGCTGCCCACCGAGATACGCAGCTTGGTGGGCAGGCCATAA
CCGCCGATGGCGCGCACGAG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNSTKENPVEIIRTRNELQARVRAWKQAGETVGFVPTMGALHEGHLSLIEKAQEKVTRTVASIFVNPAQFAPGEDFDTYP
RREGEDIAKLASVNCDAVYLPTVAEMYPEGSVTNVRVESLSDLLDGIYRPHFFYGVATVVARLFLHAQPDVAVFGEKDYQ
QLQVIRRMVRDLGFPIEIIGGATRRDADGLAQSSRNLYLSPDERRAAGAIYSAMHRAASRMALGTLPSEALKEAEGYILT
AGFRKIDYVTLVDPATLQALPADTPLEDGAAARLLAAAWIGKTRLIDNISVTR

Sequences:

>Translated_293_residues
MNSTKENPVEIIRTRNELQARVRAWKQAGETVGFVPTMGALHEGHLSLIEKAQEKVTRTVASIFVNPAQFAPGEDFDTYP
RREGEDIAKLASVNCDAVYLPTVAEMYPEGSVTNVRVESLSDLLDGIYRPHFFYGVATVVARLFLHAQPDVAVFGEKDYQ
QLQVIRRMVRDLGFPIEIIGGATRRDADGLAQSSRNLYLSPDERRAAGAIYSAMHRAASRMALGTLPSEALKEAEGYILT
AGFRKIDYVTLVDPATLQALPADTPLEDGAAARLLAAAWIGKTRLIDNISVTR
>Mature_293_residues
MNSTKENPVEIIRTRNELQARVRAWKQAGETVGFVPTMGALHEGHLSLIEKAQEKVTRTVASIFVNPAQFAPGEDFDTYP
RREGEDIAKLASVNCDAVYLPTVAEMYPEGSVTNVRVESLSDLLDGIYRPHFFYGVATVVARLFLHAQPDVAVFGEKDYQ
QLQVIRRMVRDLGFPIEIIGGATRRDADGLAQSSRNLYLSPDERRAAGAIYSAMHRAASRMALGTLPSEALKEAEGYILT
AGFRKIDYVTLVDPATLQALPADTPLEDGAAARLLAAAWIGKTRLIDNISVTR

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=284, Percent_Identity=42.6056338028169, Blast_Score=213, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6322046, Length=303, Percent_Identity=37.953795379538, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_HYPNA (Q0C347)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759846.1
- STRING:   Q0C347
- GeneID:   4287761
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1126
- NMPDR:   fig|228405.5.peg.1096
- TIGR:   HNE_1126
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   EDFGSYP
- PhylomeDB:   Q0C347
- ProtClustDB:   PRK00380
- BioCyc:   HNEP81032:HNE_1126-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32189; Mature: 32189

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: ACT_SITE 45-45 BINDING 69-69 BINDING 69-69 BINDING 161-161

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTKENPVEIIRTRNELQARVRAWKQAGETVGFVPTMGALHEGHLSLIEKAQEKVTRTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASIFVNPAQFAPGEDFDTYPRREGEDIAKLASVNCDAVYLPTVAEMYPEGSVTNVRVESL
HHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCHHHHHCCCCCCCEEEHHHH
SDLLDGIYRPHFFYGVATVVARLFLHAQPDVAVFGEKDYQQLQVIRRMVRDLGFPIEIIG
HHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEC
GATRRDADGLAQSSRNLYLSPDERRAAGAIYSAMHRAASRMALGTLPSEALKEAEGYILT
CCCCCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCEEEE
AGFRKIDYVTLVDPATLQALPADTPLEDGAAARLLAAAWIGKTRLIDNISVTR
CCCCEEEEEEEECCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNSTKENPVEIIRTRNELQARVRAWKQAGETVGFVPTMGALHEGHLSLIEKAQEKVTRTV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASIFVNPAQFAPGEDFDTYPRREGEDIAKLASVNCDAVYLPTVAEMYPEGSVTNVRVESL
HHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCHHHHHCCCCCCCEEEHHHH
SDLLDGIYRPHFFYGVATVVARLFLHAQPDVAVFGEKDYQQLQVIRRMVRDLGFPIEIIG
HHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEC
GATRRDADGLAQSSRNLYLSPDERRAAGAIYSAMHRAASRMALGTLPSEALKEAEGYILT
CCCCCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCEEEE
AGFRKIDYVTLVDPATLQALPADTPLEDGAAARLLAAAWIGKTRLIDNISVTR
CCCCEEEEEEEECCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA