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The map label for this gene is penA [H]

Identifier: 114798338

GI number: 114798338

Start: 3200258

End: 3201901

Strand: Reverse

Name: penA [H]

Synonym: HNE_3030

Alternate gene names: 114798338

Gene position: 3201901-3200258 (Counterclockwise)

Preceding gene: 114797112

Following gene: 114798974

Centisome position: 86.42

GC content: 65.63

Gene sequence:

>1644_bases
ATGAGCGAAGCCTCCCGGGATCGTACACGGCTCGTCGGGCTGGCCATCGGCCTGCTCTTCGTGCTGATGGCGGGCCGGGG
CGGGTTTCTGGCGCTGTCGGATGCGCCGTCCAATGCCGCAGTATATCCCGTGGCAGCCTCTCTCGAAACGCGTGCGGACA
TTGTCGACCGGCATGGCGAATTGCTGGCGACCTCGGTCGTCTCCTGGTCACTCTGGGCCAATCCGAGCCTGATCTGGGAC
GGCGCGGACGCGGCAAGACAGCTGGCAGGCGTGTTGCCCGATCTCAGCGAGGCAGACCTCGGTGCCCGACTGTCTGATCC
TGACCGTAAATTTGTCTGGGTGAAGCGGGGACTGACGCCGCGCCAGCGCGAGCATGTCGTGGCGCTGGGCCTTGAGGGGC
TCGATTTCCGCGAGGAAGCGCGCCGGGCCTATCCGCGCGGTGTTCTGGCCGGACAGGTGCTGGGCTTCACCAATGTCGAC
GGCAAGGGCATCGCCGGCATCGAGCTGGCCCATGATGAAGCGCTGCAGGGCGGGGGAGACCCCGTTCGTCTGACGCTGGA
CATCGGCGCGCAGGCGGCGCTGGAGGCAGAGCTTGCGACGGCCGCCATGGATTATGACATGAAGGGCGGCGCGGCGATCC
TGATGGATACGCGCAGCGGCGAAATCCGCGGCATGGCCAGCTGGCCGCCTTTTGACCCCAACCGCGCCAGCGATACGCCT
GCGGATGATCCGGCCCGAACCAACCGGGCCATCAGCGCGGTCTATGAGCTGGGCTCGATCTTCAAGCCGTTCACCATTGC
CGCCGCGCTTGAGGTCGGGGCGATCACGCCGGAAGACCGGTTTCAGGTCGGCCAGCCCCTGCTCATTCAGGGGCGGCGGA
TTTCGGACACGCACTGGTTTGCCCGTGACGCGAATGTCTGGAAGATCCTCTCGGAAAGCTCCAATATCGGCACCGTTCAG
GTAAATTATGCGCTGGGCACGCAGCGCCAGCAGCAGTTCCTGGAGCGCGCGGGCCTGACGCGCCGGGCGCCGATCGATCT
GCCAGGATCGGCCGCGCCGCTGATGCCGGAGCGGTTTGATGAGGTGACGGCGGCGACGGTGTCCTACGGGCACGGTATCT
CCGTGACGCCGCTGGCGTTCCTGCTGGCCTTTTCGGCGTTCGGAAATGACGGCCTGATGATCGCGCCCGTGCTTGTCGAG
GCGGGGGCCGATGCGGGCGATATTGCCGCGCCGGCGCCCGTGCGTCTCTTCTCTGAGGAAACCACCCATCTGGTGACGCA
GATGATGCGTGACACCGTACTTCAGGGGACAGCCCGGCGCGCTGATGTTGCCGGATACCGGGTGGCCGGAAAGACCGGCA
CCGCCGAAAAGCCGATTGCGGGCGGATATGCCAAGGACCGGAACGTTTCGAGCTTTGCTGCTGTGTTTCCCGCAGACAGC
CCCCAATATGCCCTGATTGTGACGCTGGATGAGCCCAAGGCCATCGAGGACGGAACCATGACCGCCGCAGTGAATGCCGC
GCCGGTTGCCGGGCGCATCATTGAGCGCGTTGCGCCGTTGCTTGAGGTCGATCCGCGATTTGAGGATCTCCGGCCTGCCA
CAGCGCCGCCTCAGGCCCTCTCCCAGAACAGGAGCGAACTTTGA

Upstream 100 bases:

>100_bases
CGACGCTTCAGGCGCTGACGGTCTCCGAAGATGCAGTCTCCGAAGATGAAGAGGGCAGCGACGCTGCCTCACCGGCGCAA
ACGCCTGCGGAGGCGCCCAG

Downstream 100 bases:

>100_bases
AACTCTCGGACCTTTTCCCCCTCGCCGAGAATGGCGAGACCGAGATACTCGGTATGACGTCAGACAGCCGGAAGGTGCAG
CCTGGCTGGCTGTTTGCGGC

Product: putative penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MSEASRDRTRLVGLAIGLLFVLMAGRGGFLALSDAPSNAAVYPVAASLETRADIVDRHGELLATSVVSWSLWANPSLIWD
GADAARQLAGVLPDLSEADLGARLSDPDRKFVWVKRGLTPRQREHVVALGLEGLDFREEARRAYPRGVLAGQVLGFTNVD
GKGIAGIELAHDEALQGGGDPVRLTLDIGAQAALEAELATAAMDYDMKGGAAILMDTRSGEIRGMASWPPFDPNRASDTP
ADDPARTNRAISAVYELGSIFKPFTIAAALEVGAITPEDRFQVGQPLLIQGRRISDTHWFARDANVWKILSESSNIGTVQ
VNYALGTQRQQQFLERAGLTRRAPIDLPGSAAPLMPERFDEVTAATVSYGHGISVTPLAFLLAFSAFGNDGLMIAPVLVE
AGADAGDIAAPAPVRLFSEETTHLVTQMMRDTVLQGTARRADVAGYRVAGKTGTAEKPIAGGYAKDRNVSSFAAVFPADS
PQYALIVTLDEPKAIEDGTMTAAVNAAPVAGRIIERVAPLLEVDPRFEDLRPATAPPQALSQNRSEL

Sequences:

>Translated_547_residues
MSEASRDRTRLVGLAIGLLFVLMAGRGGFLALSDAPSNAAVYPVAASLETRADIVDRHGELLATSVVSWSLWANPSLIWD
GADAARQLAGVLPDLSEADLGARLSDPDRKFVWVKRGLTPRQREHVVALGLEGLDFREEARRAYPRGVLAGQVLGFTNVD
GKGIAGIELAHDEALQGGGDPVRLTLDIGAQAALEAELATAAMDYDMKGGAAILMDTRSGEIRGMASWPPFDPNRASDTP
ADDPARTNRAISAVYELGSIFKPFTIAAALEVGAITPEDRFQVGQPLLIQGRRISDTHWFARDANVWKILSESSNIGTVQ
VNYALGTQRQQQFLERAGLTRRAPIDLPGSAAPLMPERFDEVTAATVSYGHGISVTPLAFLLAFSAFGNDGLMIAPVLVE
AGADAGDIAAPAPVRLFSEETTHLVTQMMRDTVLQGTARRADVAGYRVAGKTGTAEKPIAGGYAKDRNVSSFAAVFPADS
PQYALIVTLDEPKAIEDGTMTAAVNAAPVAGRIIERVAPLLEVDPRFEDLRPATAPPQALSQNRSEL
>Mature_546_residues
SEASRDRTRLVGLAIGLLFVLMAGRGGFLALSDAPSNAAVYPVAASLETRADIVDRHGELLATSVVSWSLWANPSLIWDG
ADAARQLAGVLPDLSEADLGARLSDPDRKFVWVKRGLTPRQREHVVALGLEGLDFREEARRAYPRGVLAGQVLGFTNVDG
KGIAGIELAHDEALQGGGDPVRLTLDIGAQAALEAELATAAMDYDMKGGAAILMDTRSGEIRGMASWPPFDPNRASDTPA
DDPARTNRAISAVYELGSIFKPFTIAAALEVGAITPEDRFQVGQPLLIQGRRISDTHWFARDANVWKILSESSNIGTVQV
NYALGTQRQQQFLERAGLTRRAPIDLPGSAAPLMPERFDEVTAATVSYGHGISVTPLAFLLAFSAFGNDGLMIAPVLVEA
GADAGDIAAPAPVRLFSEETTHLVTQMMRDTVLQGTARRADVAGYRVAGKTGTAEKPIAGGYAKDRNVSSFAAVFPADSP
QYALIVTLDEPKAIEDGTMTAAVNAAPVAGRIIERVAPLLEVDPRFEDLRPATAPPQALSQNRSEL

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=511, Percent_Identity=30.7240704500978, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786854, Length=576, Percent_Identity=25, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 58192; Mature: 58061

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEASRDRTRLVGLAIGLLFVLMAGRGGFLALSDAPSNAAVYPVAASLETRADIVDRHGE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCC
LLATSVVSWSLWANPSLIWDGADAARQLAGVLPDLSEADLGARLSDPDRKFVWVKRGLTP
EEEHHHHEEEECCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCC
RQREHVVALGLEGLDFREEARRAYPRGVLAGQVLGFTNVDGKGIAGIELAHDEALQGGGD
CHHCCEEEECCCCCCHHHHHHHHCCCCCHHHHEEEEECCCCCCCEEEEECCHHHHCCCCC
PVRLTLDIGAQAALEAELATAAMDYDMKGGAAILMDTRSGEIRGMASWPPFDPNRASDTP
EEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCC
ADDPARTNRAISAVYELGSIFKPFTIAAALEVGAITPEDRFQVGQPLLIQGRRISDTHWF
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCCEEEECCEECCCEEE
ARDANVWKILSESSNIGTVQVNYALGTQRQQQFLERAGLTRRAPIDLPGSAAPLMPERFD
ECCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
EVTAATVSYGHGISVTPLAFLLAFSAFGNDGLMIAPVLVEAGADAGDIAAPAPVRLFSEE
HHHHHHEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEHEECCCCCCCCCCCCCCEEHHHH
TTHLVTQMMRDTVLQGTARRADVAGYRVAGKTGTAEKPIAGGYAKDRNVSSFAAVFPADS
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCC
PQYALIVTLDEPKAIEDGTMTAAVNAAPVAGRIIERVAPLLEVDPRFEDLRPATAPPQAL
CCEEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHH
SQNRSEL
HCCCCCC
>Mature Secondary Structure 
SEASRDRTRLVGLAIGLLFVLMAGRGGFLALSDAPSNAAVYPVAASLETRADIVDRHGE
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCC
LLATSVVSWSLWANPSLIWDGADAARQLAGVLPDLSEADLGARLSDPDRKFVWVKRGLTP
EEEHHHHEEEECCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCC
RQREHVVALGLEGLDFREEARRAYPRGVLAGQVLGFTNVDGKGIAGIELAHDEALQGGGD
CHHCCEEEECCCCCCHHHHHHHHCCCCCHHHHEEEEECCCCCCCEEEEECCHHHHCCCCC
PVRLTLDIGAQAALEAELATAAMDYDMKGGAAILMDTRSGEIRGMASWPPFDPNRASDTP
EEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCC
ADDPARTNRAISAVYELGSIFKPFTIAAALEVGAITPEDRFQVGQPLLIQGRRISDTHWF
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCCEEEECCEECCCEEE
ARDANVWKILSESSNIGTVQVNYALGTQRQQQFLERAGLTRRAPIDLPGSAAPLMPERFD
ECCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
EVTAATVSYGHGISVTPLAFLLAFSAFGNDGLMIAPVLVEAGADAGDIAAPAPVRLFSEE
HHHHHHEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEHEECCCCCCCCCCCCCCEEHHHH
TTHLVTQMMRDTVLQGTARRADVAGYRVAGKTGTAEKPIAGGYAKDRNVSSFAAVFPADS
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCC
PQYALIVTLDEPKAIEDGTMTAAVNAAPVAGRIIERVAPLLEVDPRFEDLRPATAPPQAL
CCEEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHH
SQNRSEL
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]