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The map label for this gene is ald [H]

Identifier: 114797819

GI number: 114797819

Start: 985203

End: 986324

Strand: Reverse

Name: ald [H]

Synonym: HNE_0971

Alternate gene names: 114797819

Gene position: 986324-985203 (Counterclockwise)

Preceding gene: 114799574

Following gene: 114797659

Centisome position: 26.62

GC content: 64.8

Gene sequence:

>1122_bases
ATGCGAATTGGTGTTCCAACTGAAATCAAAAAGCAGGAATCCCGTGTCGGTCTGACACCTGAGAGCGCTGGCGAACTGGT
ACGCGCCGGCCATCAGGTGAACATCCAGGCCGGTGCGGGAATTGCGTCCGGCTTTGCCGATGAAACCTACACCGCCATTG
GCGCCGCCATCCTGCCGGACGCCGAGGCCCTCTTCGCCCAAAGCGACCTGATCGTGAAGGTGAAGGAGCCCCAGCCGGAA
GAAACCGCGCGCCTCACCAAAGACCACACCCTCTTCACCTATCTCCATCTCGCGCCAGACCCTGTGCAGGCCAAAGGCCT
TATGAACTCCGGTTGCCTCGCCATCGCCTATGAAACCGTCACCGACGCCCATGGCGGCCTCCCCCTCCTGCGCCCGATGA
GCCAGGTCGCCGGGCGCATGTCGATGCAGGTCGCCGCCGGCGCCCTGATGCGCACCAAGGGCCGGGGCCGGGGCATCCTG
CTCGGCGGCGTGCCGGGCGTTGCGCCCGCCAAGGTCGTCATCATCGGCGGCGGTGTCTCCGGCACCCATGCCGCCGAGAT
CGCGGTCGGCATGCGCGCCGATGTCTGGGTCTTCGACCGCAACAATGAGCGCCTCGGCGAACTCGACGAACAGTTCCGCG
GCACCATCAACACGATGTATTCGACCGCCCATTCCCTCGCCGAAGCCATCAAGGACGCTGACCTCGTGATCGGCGCCGTG
CTGATCCCCGGCGCCTCAGCGCCCAAGCTCGTCAGCCGCGCCCAGCTCTCGACCATGCAACCGGGCTCGGTGCTCGTTGA
CATCGCCATCGACCAGGGCGGCTGCTTCGAGACAAGCCGTCCGACCACGCATGATGATCCGATCTATGAGGTGGATGGTA
TCCTGCACTATTGCGTCGCCAACATGCCCGGCGCCGTACCGCGCACCTCCACCTACGCGCTGAACAACGCCACCCTGCCC
TTCGTCATGCAGATCGCCAATCTCGGCGCCCGCAACGCCATCAATGCCAACAAGCATCTCGCCAATGGCCTGACGGCCGA
CCAGGGCACCATCGCCCACAAACTCGTCGCGCGGGATCTGGGCGAAAAGTATGTGCGCCCGGACTGGCTGACGGTCGTGT
AA

Upstream 100 bases:

>100_bases
TGTTTCCCGCACGCGGTTTTCTTTTTCCCGCTTTCGTGGCGGGGGTGGAACCGCCTCAAAAGGCGGTTTATAGGCATGAT
CTTTCCCTAAGGAGAGGCGC

Downstream 100 bases:

>100_bases
TATAATCCGCTGGCGGATAGCGGCCCACGCCGCTGCCCTTGAACCCCTCTCCTCCTCCGGGGGAGAGGGCCAGGGGTGAG
GGGGCGAGGCCGGATAAGAC

Product: alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MRIGVPTEIKKQESRVGLTPESAGELVRAGHQVNIQAGAGIASGFADETYTAIGAAILPDAEALFAQSDLIVKVKEPQPE
ETARLTKDHTLFTYLHLAPDPVQAKGLMNSGCLAIAYETVTDAHGGLPLLRPMSQVAGRMSMQVAAGALMRTKGRGRGIL
LGGVPGVAPAKVVIIGGGVSGTHAAEIAVGMRADVWVFDRNNERLGELDEQFRGTINTMYSTAHSLAEAIKDADLVIGAV
LIPGASAPKLVSRAQLSTMQPGSVLVDIAIDQGGCFETSRPTTHDDPIYEVDGILHYCVANMPGAVPRTSTYALNNATLP
FVMQIANLGARNAINANKHLANGLTADQGTIAHKLVARDLGEKYVRPDWLTVV

Sequences:

>Translated_373_residues
MRIGVPTEIKKQESRVGLTPESAGELVRAGHQVNIQAGAGIASGFADETYTAIGAAILPDAEALFAQSDLIVKVKEPQPE
ETARLTKDHTLFTYLHLAPDPVQAKGLMNSGCLAIAYETVTDAHGGLPLLRPMSQVAGRMSMQVAAGALMRTKGRGRGIL
LGGVPGVAPAKVVIIGGGVSGTHAAEIAVGMRADVWVFDRNNERLGELDEQFRGTINTMYSTAHSLAEAIKDADLVIGAV
LIPGASAPKLVSRAQLSTMQPGSVLVDIAIDQGGCFETSRPTTHDDPIYEVDGILHYCVANMPGAVPRTSTYALNNATLP
FVMQIANLGARNAINANKHLANGLTADQGTIAHKLVARDLGEKYVRPDWLTVV
>Mature_373_residues
MRIGVPTEIKKQESRVGLTPESAGELVRAGHQVNIQAGAGIASGFADETYTAIGAAILPDAEALFAQSDLIVKVKEPQPE
ETARLTKDHTLFTYLHLAPDPVQAKGLMNSGCLAIAYETVTDAHGGLPLLRPMSQVAGRMSMQVAAGALMRTKGRGRGIL
LGGVPGVAPAKVVIIGGGVSGTHAAEIAVGMRADVWVFDRNNERLGELDEQFRGTINTMYSTAHSLAEAIKDADLVIGAV
LIPGASAPKLVSRAQLSTMQPGSVLVDIAIDQGGCFETSRPTTHDDPIYEVDGILHYCVANMPGAVPRTSTYALNNATLP
FVMQIANLGARNAINANKHLANGLTADQGTIAHKLVARDLGEKYVRPDWLTVV

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=348, Percent_Identity=32.7586206896552, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI122939153, Length=348, Percent_Identity=32.7586206896552, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1787887, Length=333, Percent_Identity=29.7297297297297, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17550456, Length=358, Percent_Identity=30.1675977653631, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39310; Mature: 39310

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGVPTEIKKQESRVGLTPESAGELVRAGHQVNIQAGAGIASGFADETYTAIGAAILPD
CCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCC
AEALFAQSDLIVKVKEPQPEETARLTKDHTLFTYLHLAPDPVQAKGLMNSGCLAIAYETV
HHHHHCCCCEEEEECCCCCHHHHHHCCCCEEEEEEEECCCCHHHCCCCCCCEEEEEEEHH
TDAHGGLPLLRPMSQVAGRMSMQVAAGALMRTKGRGRGILLGGVPGVAPAKVVIIGGGVS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCC
GTHAAEIAVGMRADVWVFDRNNERLGELDEQFRGTINTMYSTAHSLAEAIKDADLVIGAV
CCCHHHEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
LIPGASAPKLVSRAQLSTMQPGSVLVDIAIDQGGCFETSRPTTHDDPIYEVDGILHYCVA
EECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
NMPGAVPRTSTYALNNATLPFVMQIANLGARNAINANKHLANGLTADQGTIAHKLVARDL
CCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHH
GEKYVRPDWLTVV
HHHHCCCCEEEEC
>Mature Secondary Structure
MRIGVPTEIKKQESRVGLTPESAGELVRAGHQVNIQAGAGIASGFADETYTAIGAAILPD
CCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCC
AEALFAQSDLIVKVKEPQPEETARLTKDHTLFTYLHLAPDPVQAKGLMNSGCLAIAYETV
HHHHHCCCCEEEEECCCCCHHHHHHCCCCEEEEEEEECCCCHHHCCCCCCCEEEEEEEHH
TDAHGGLPLLRPMSQVAGRMSMQVAAGALMRTKGRGRGILLGGVPGVAPAKVVIIGGGVS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCC
GTHAAEIAVGMRADVWVFDRNNERLGELDEQFRGTINTMYSTAHSLAEAIKDADLVIGAV
CCCHHHEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
LIPGASAPKLVSRAQLSTMQPGSVLVDIAIDQGGCFETSRPTTHDDPIYEVDGILHYCVA
EECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
NMPGAVPRTSTYALNNATLPFVMQIANLGARNAINANKHLANGLTADQGTIAHKLVARDL
CCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHH
GEKYVRPDWLTVV
HHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]