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The map label for this gene is lpd [H]

Identifier: 114331618

GI number: 114331618

Start: 1716877

End: 1718295

Strand: Reverse

Name: lpd [H]

Synonym: Neut_1632

Alternate gene names: 114331618

Gene position: 1718295-1716877 (Counterclockwise)

Preceding gene: 114331620

Following gene: 114331617

Centisome position: 64.57

GC content: 45.81

Gene sequence:

>1419_bases
ATGCATAAATTTGATGTGATAATCATTGGTGCGGGAAGTGCTGGTTTATCTGCCTTGCGTGAGGTAAGAAAACGAACTGA
TAATTTTGTACTGATCAACGATGGTCCGTGGGGTACTACCTGTGCACGGGTCGGGTGTATGCCTTCTAAGTTATTGATTG
AAGCAGCCAATGCTTTTCATCGACGGTTCAATTTTGGTGAGTTCGGGATTATGGGCGCAGATCAACTGGAACTGGATGGC
AAAAAGGTTCTGCAACGTCTACGCAGGCTACGTGATGATTTTGTTACCAGCACCCTTAAAATAACCAATGATTTGGGTGA
ACGTGCAATATCGGGGCGTGCCCGTATTCTGTCGCCAGATCAAGTAATGGTCAATGGAGAGAAACTCAGCGCTCATAAAA
TCATTATTGCAACGGGTTCCCGGCCTGTTGTGCCCAAGAACTGGCTGAATCTTGGCAAACGTTTGCTGACGACGGATACT
TTGTTTGAGCTGGATACGTTGCCAAAAAGTATTGCTGTCATCGGCATGGGTCCAGTTGGTCTGGAAATGATCCAGGCATT
ATCCAGGCTTGGTGTACATGTAACAGGCTTTGGATTTCGCAGCTCAGTAGGGGGGATAAGTGATCCATTCATTAATCAGA
CAGCAGTGAAGCTGTTGTCAGAAGAATTTCCACTCTATCTTGGTAGCAAAGCGAGTGTCGCCATAAATCCGGATAATAAT
GTGCTTACTGTCCGTGCAGAGAATATCGAAATTGAGGTAGACAGTGTACTAGCCGCATTGGGGAGGCAACCAAATATCGA
TGATATTGGTCTCGATACACTGGATGTGCCGCTTGATGAAAAAGGGCTACCATCAGTAAATCCAATTACCCTGCAGATTG
CAGATTTACCAGTATTTCTGGCAGGAGATGCAAATCAGCGTCTTCCTCTGCTGCATGAGGCTGCAGATGATGGGCATATT
GCCGGTTTAAATACAACAAGTGAAGAATTAATTTACTTTAAGCGCCGAGTACCACTAGCTATCGTATTTGCTGATCCTAA
TATTGCCGTAGTTGGTCAATCCTTTCATTCACTCGAACACGAAAATATTCAAATAGGTGAAGTCTCTTTCTCTAACCAGG
GAAGGGCACGTTCGGCCCAGTCTAATCGTGGTGCCTTACGTGTGTATGCTGCGGCAAATGATGGCCGATTGCTAGGTGCA
GAAATGTGTGCACCAGCCGGGGAGCATTTCGCACATTTGCTTGCTTTGGCAATCGATCAATCTCTAAGTGTGTGGGATTT
ATTGCGAATACCGTTTTATCATCCGGTGCTGGAAGAAGGTTTGCGTACAGCATTACGTAATCTGGCATCCAAGCTTCCAG
CGTGCAGTAAGTCAGATCTAGCGGCTTGCGACTCTTTTAATTCCGAGGCGCTTGATTGA

Upstream 100 bases:

>100_bases
GATTTTTATATTAAGGATTAGAATAACAAACTGATTGGACCCATAAATCGTAATGTGTTTACTTATTTATTATACAAATT
GACTGGGGACTCGAATACTG

Downstream 100 bases:

>100_bases
GCGTAACCTGGAACTTCTATCTCATCAGATAAATCAGGATGATCACAACTGGCTGTGTTGTATATTACGAAAGCAAGTCA
TTAAGCAGATGATTTTTAAT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MHKFDVIIIGAGSAGLSALREVRKRTDNFVLINDGPWGTTCARVGCMPSKLLIEAANAFHRRFNFGEFGIMGADQLELDG
KKVLQRLRRLRDDFVTSTLKITNDLGERAISGRARILSPDQVMVNGEKLSAHKIIIATGSRPVVPKNWLNLGKRLLTTDT
LFELDTLPKSIAVIGMGPVGLEMIQALSRLGVHVTGFGFRSSVGGISDPFINQTAVKLLSEEFPLYLGSKASVAINPDNN
VLTVRAENIEIEVDSVLAALGRQPNIDDIGLDTLDVPLDEKGLPSVNPITLQIADLPVFLAGDANQRLPLLHEAADDGHI
AGLNTTSEELIYFKRRVPLAIVFADPNIAVVGQSFHSLEHENIQIGEVSFSNQGRARSAQSNRGALRVYAAANDGRLLGA
EMCAPAGEHFAHLLALAIDQSLSVWDLLRIPFYHPVLEEGLRTALRNLASKLPACSKSDLAACDSFNSEALD

Sequences:

>Translated_472_residues
MHKFDVIIIGAGSAGLSALREVRKRTDNFVLINDGPWGTTCARVGCMPSKLLIEAANAFHRRFNFGEFGIMGADQLELDG
KKVLQRLRRLRDDFVTSTLKITNDLGERAISGRARILSPDQVMVNGEKLSAHKIIIATGSRPVVPKNWLNLGKRLLTTDT
LFELDTLPKSIAVIGMGPVGLEMIQALSRLGVHVTGFGFRSSVGGISDPFINQTAVKLLSEEFPLYLGSKASVAINPDNN
VLTVRAENIEIEVDSVLAALGRQPNIDDIGLDTLDVPLDEKGLPSVNPITLQIADLPVFLAGDANQRLPLLHEAADDGHI
AGLNTTSEELIYFKRRVPLAIVFADPNIAVVGQSFHSLEHENIQIGEVSFSNQGRARSAQSNRGALRVYAAANDGRLLGA
EMCAPAGEHFAHLLALAIDQSLSVWDLLRIPFYHPVLEEGLRTALRNLASKLPACSKSDLAACDSFNSEALD
>Mature_472_residues
MHKFDVIIIGAGSAGLSALREVRKRTDNFVLINDGPWGTTCARVGCMPSKLLIEAANAFHRRFNFGEFGIMGADQLELDG
KKVLQRLRRLRDDFVTSTLKITNDLGERAISGRARILSPDQVMVNGEKLSAHKIIIATGSRPVVPKNWLNLGKRLLTTDT
LFELDTLPKSIAVIGMGPVGLEMIQALSRLGVHVTGFGFRSSVGGISDPFINQTAVKLLSEEFPLYLGSKASVAINPDNN
VLTVRAENIEIEVDSVLAALGRQPNIDDIGLDTLDVPLDEKGLPSVNPITLQIADLPVFLAGDANQRLPLLHEAADDGHI
AGLNTTSEELIYFKRRVPLAIVFADPNIAVVGQSFHSLEHENIQIGEVSFSNQGRARSAQSNRGALRVYAAANDGRLLGA
EMCAPAGEHFAHLLALAIDQSLSVWDLLRIPFYHPVLEEGLRTALRNLASKLPACSKSDLAACDSFNSEALD

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=468, Percent_Identity=25.8547008547009, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI50301238, Length=470, Percent_Identity=24.468085106383, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI291045266, Length=315, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI291045268, Length=315, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1786307, Length=470, Percent_Identity=24.2553191489362, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789915, Length=424, Percent_Identity=23.8207547169811, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87082354, Length=480, Percent_Identity=22.2916666666667, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=22.707423580786, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI32565766, Length=474, Percent_Identity=26.7932489451477, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17557007, Length=480, Percent_Identity=25.4166666666667, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71983419, Length=466, Percent_Identity=23.8197424892704, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71983429, Length=466, Percent_Identity=23.8197424892704, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321091, Length=480, Percent_Identity=27.7083333333333, Blast_Score=123, Evalue=8e-29,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=27.3706896551724, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24640551, Length=331, Percent_Identity=24.773413897281, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24640549, Length=331, Percent_Identity=24.773413897281, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24640553, Length=331, Percent_Identity=24.773413897281, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 51114; Mature: 51114

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKFDVIIIGAGSAGLSALREVRKRTDNFVLINDGPWGTTCARVGCMPSKLLIEAANAFH
CCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHH
RRFNFGEFGIMGADQLELDGKKVLQRLRRLRDDFVTSTLKITNDLGERAISGRARILSPD
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
QVMVNGEKLSAHKIIIATGSRPVVPKNWLNLGKRLLTTDTLFELDTLPKSIAVIGMGPVG
EEEEECCEECEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHH
LEMIQALSRLGVHVTGFGFRSSVGGISDPFINQTAVKLLSEEFPLYLGSKASVAINPDNN
HHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCEEEEECCCCC
VLTVRAENIEIEVDSVLAALGRQPNIDDIGLDTLDVPLDEKGLPSVNPITLQIADLPVFL
EEEEEECCEEEEHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCEEE
AGDANQRLPLLHEAADDGHIAGLNTTSEELIYFKRRVPLAIVFADPNIAVVGQSFHSLEH
ECCCCCCCCHHHHCCCCCEEEECCCCHHHHHEEEECCCEEEEEECCCEEEEECHHHCCCC
ENIQIGEVSFSNQGRARSAQSNRGALRVYAAANDGRLLGAEMCAPAGEHFAHLLALAIDQ
CCEEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEEEHHHCCCCHHHHHHHHHHHHCC
SLSVWDLLRIPFYHPVLEEGLRTALRNLASKLPACSKSDLAACDSFNSEALD
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure
MHKFDVIIIGAGSAGLSALREVRKRTDNFVLINDGPWGTTCARVGCMPSKLLIEAANAFH
CCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHH
RRFNFGEFGIMGADQLELDGKKVLQRLRRLRDDFVTSTLKITNDLGERAISGRARILSPD
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
QVMVNGEKLSAHKIIIATGSRPVVPKNWLNLGKRLLTTDTLFELDTLPKSIAVIGMGPVG
EEEEECCEECEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHH
LEMIQALSRLGVHVTGFGFRSSVGGISDPFINQTAVKLLSEEFPLYLGSKASVAINPDNN
HHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCEEEEECCCCC
VLTVRAENIEIEVDSVLAALGRQPNIDDIGLDTLDVPLDEKGLPSVNPITLQIADLPVFL
EEEEEECCEEEEHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCEEE
AGDANQRLPLLHEAADDGHIAGLNTTSEELIYFKRRVPLAIVFADPNIAVVGQSFHSLEH
ECCCCCCCCHHHHCCCCCEEEECCCCHHHHHEEEECCCEEEEEECCCEEEEECHHHCCCC
ENIQIGEVSFSNQGRARSAQSNRGALRVYAAANDGRLLGAEMCAPAGEHFAHLLALAIDQ
CCEEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEEEHHHCCCCHHHHHHHHHHHHCC
SLSVWDLLRIPFYHPVLEEGLRTALRNLASKLPACSKSDLAACDSFNSEALD
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA