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The map label for this gene is rnr [H]

Identifier: 114331605

GI number: 114331605

Start: 1700597

End: 1702801

Strand: Reverse

Name: rnr [H]

Synonym: Neut_1619

Alternate gene names: 114331605

Gene position: 1702801-1700597 (Counterclockwise)

Preceding gene: 114331608

Following gene: 114331604

Centisome position: 63.99

GC content: 46.49

Gene sequence:

>2205_bases
TTGTCAATCAAGAGAAAAAGAAATAAGAAAAATCAGCTTCGCGAGCTTGATCCTTTTCTTAAGCGTGAGCAGACACGTTA
CGGGTTAGCGCTTCCCAGTCGAGAATTTATCCTGGAAGTATTGGATAAACAGGGAGTGCCAATCAGCGAGCCCAAGTTGC
TTGAGTTGCTGGATATTACTGCTGAAGAATCTGAATTTTTTCATCGCAGGCTGTCTGCGATGATACGTGACGGGCAGATT
ATCTGTAATCGCAAGGGTGATATTTGTGTAACAGACAAGCTGGAACTCGTAAAAGGAACCGTGCAGGGGCATAGTGATGG
TTTCGGTTTTTTGATTCCAGATGATGGCGGTACTGATCTGTTCCTGACCCCAAAAGAGATGCATAAAGTGCTGCATGGTG
ATCGCGTAATTGCCAGGCTTACCAATGACGTGGATCGGCGGGGGCGGCGGGAATGCAGAATCGTCAGGGTACTGGAGAGT
GTTAATACGCACTTGGTTGGCAGGTTATATGAAGACCACGGTATTTTTTTTATTGTGGCTGAAGATAAACGTATTAACCA
GGATATTCTTGTCCCAAAGGAAAATATCATGAATGCGCATGCTGGGCAGGTGGTGATGGCGAACATTATTCAGCAGCCAG
GCCAACACGCTCAGCCTATTGGCCATATCGTTGAGATTCTGGGGGATTATGCAGCTCCAGGAATGGAGATTGAAATTGCA
TTGCGCAAATTCGATTTGCCCCATGAGTTTTCGCCAGAAATCATTTCCACCAAGTTTCCCAAGAAGGTTCTGAAGAAAGA
GTTTGCCAAGCGAGAAGATATTCGCCATTTACCGCTGGTAACAATAGACAGTGAAACGGCCAAAGACTTTGACGATGCTG
TTTATTGTCGCCAGGAAGGCAAGGATTTCAGATTGTTTGTTGCCATCGCCGATGTCAGCCATTATGTGCGCGATCAGGAT
GCGCTGGATAAAGAAGCATTTGATCGCGGCAATTCGGTTTATTTCCCGAGACGAGTTATTCCAATGTTGCCGGAAGTGCT
TTCAAATGGGTTGTGCTCGCTCAATCCGCAGGTCGATCGGCTGTGCATGGTGTGTGAAATGCTGTGGACTGCCAAGGGGG
AGCTGAGCGAATATCGTTTTTATCCAGCGGTGATGCTTTCCCATGCGCGCTTGACTTATAACATTGTTGCCGAGTTGCTG
GATCAGCCCAAAGGGAATACCGCAACAGAATATACACAACTGCTACCGCATATTCAATTATTGTACCGGTTGTTCAAGGT
GTTGCATAAATCCCGCAGAAAACGGGGAGCGATTGATTTTGAGACCATTGAAACAGAAATGGTTTTCAATAATCAGGGCA
AGATTGAAAGAATATGCCCAGTAGAGCGTAATGATGCTCATCGCTTGATTGAGGAGTGTATGCTGGCGGCCAATGTGTGT
GCTGCTGATTTTCTGGAGAAACACCAACAGCCCGTTTTATACCGGGTTCATGAAGGGCCGTCCGATGAAAAACTGGTGGC
ATTGCGAGATTTCCTGAAAGAATTCGGCTTGCAGTTACGTGGTGGCGATAAGCCCAGCGCTAAGGATTATGCCAGGACAC
TTGACCATATCCGGGAACGGACTGACGCACAATTGCTGCAAACAGTGATGCTAAGGTCTCTTAGTCAGGCAATGTACAGT
CCGGATAATGCCGGGCACTTTGGTCTGGCCTATGAAATGTATACCCATTTTACTTCACCCATTCGGCGTTACCCGGATCT
GCTGGTACATCGTGCCATCAAGGCAGTGCTTGCCGGCAAGCACTATGACCCTGGCGACTGGCATGAGATTGGAAAACATT
GCTCACAAACTGAGCGCCGTGCTGATGAAGCTACGCGGGAAGTTGAATCTTGGCTCAAGTGTTTTTATATGCAGGATAAA
ATTAATGATTGCTTTGATGGCGTTATCACCGGGGTAACTGCATTCGGGTTGTTTGTTACCCTGAACACTATTTATGTTGA
AGGTCTGGTTTATATTTCAGAATTACCCAGTGATTATTTTCGGCATGATTCGGTCAAGCATGTATTACGTGGTGAACGTA
GCGGAATTAGTTTCCGGTTAGGTGACAGCTTGCGAGTAAAACTTGTCCGGGTCGATCTGGCCACCCGCAAGATAGATTTT
GTCCTTGCAGACAATAACAATGCACGCAAGAAATCAAGCAAATAA

Upstream 100 bases:

>100_bases
GCATTATTTTGATTATTGCTGTGTTGCTGGTTGGTTTTGTGAAAACCAGGCAGGTATAAACAACACATGAAGACCGCAAA
TTCTATAGGAAACCTTCGAT

Downstream 100 bases:

>100_bases
TATTCTTCTTCATTTCTCATCGCCATCATGTCTCATTCCCAGTATATTTTTGGCTTCCATGCCATTACCAGCCGTTTACG
GCAACATCCGGACAGCATCA

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 734; Mature: 733

Protein sequence:

>734_residues
MSIKRKRNKKNQLRELDPFLKREQTRYGLALPSREFILEVLDKQGVPISEPKLLELLDITAEESEFFHRRLSAMIRDGQI
ICNRKGDICVTDKLELVKGTVQGHSDGFGFLIPDDGGTDLFLTPKEMHKVLHGDRVIARLTNDVDRRGRRECRIVRVLES
VNTHLVGRLYEDHGIFFIVAEDKRINQDILVPKENIMNAHAGQVVMANIIQQPGQHAQPIGHIVEILGDYAAPGMEIEIA
LRKFDLPHEFSPEIISTKFPKKVLKKEFAKREDIRHLPLVTIDSETAKDFDDAVYCRQEGKDFRLFVAIADVSHYVRDQD
ALDKEAFDRGNSVYFPRRVIPMLPEVLSNGLCSLNPQVDRLCMVCEMLWTAKGELSEYRFYPAVMLSHARLTYNIVAELL
DQPKGNTATEYTQLLPHIQLLYRLFKVLHKSRRKRGAIDFETIETEMVFNNQGKIERICPVERNDAHRLIEECMLAANVC
AADFLEKHQQPVLYRVHEGPSDEKLVALRDFLKEFGLQLRGGDKPSAKDYARTLDHIRERTDAQLLQTVMLRSLSQAMYS
PDNAGHFGLAYEMYTHFTSPIRRYPDLLVHRAIKAVLAGKHYDPGDWHEIGKHCSQTERRADEATREVESWLKCFYMQDK
INDCFDGVITGVTAFGLFVTLNTIYVEGLVYISELPSDYFRHDSVKHVLRGERSGISFRLGDSLRVKLVRVDLATRKIDF
VLADNNNARKKSSK

Sequences:

>Translated_734_residues
MSIKRKRNKKNQLRELDPFLKREQTRYGLALPSREFILEVLDKQGVPISEPKLLELLDITAEESEFFHRRLSAMIRDGQI
ICNRKGDICVTDKLELVKGTVQGHSDGFGFLIPDDGGTDLFLTPKEMHKVLHGDRVIARLTNDVDRRGRRECRIVRVLES
VNTHLVGRLYEDHGIFFIVAEDKRINQDILVPKENIMNAHAGQVVMANIIQQPGQHAQPIGHIVEILGDYAAPGMEIEIA
LRKFDLPHEFSPEIISTKFPKKVLKKEFAKREDIRHLPLVTIDSETAKDFDDAVYCRQEGKDFRLFVAIADVSHYVRDQD
ALDKEAFDRGNSVYFPRRVIPMLPEVLSNGLCSLNPQVDRLCMVCEMLWTAKGELSEYRFYPAVMLSHARLTYNIVAELL
DQPKGNTATEYTQLLPHIQLLYRLFKVLHKSRRKRGAIDFETIETEMVFNNQGKIERICPVERNDAHRLIEECMLAANVC
AADFLEKHQQPVLYRVHEGPSDEKLVALRDFLKEFGLQLRGGDKPSAKDYARTLDHIRERTDAQLLQTVMLRSLSQAMYS
PDNAGHFGLAYEMYTHFTSPIRRYPDLLVHRAIKAVLAGKHYDPGDWHEIGKHCSQTERRADEATREVESWLKCFYMQDK
INDCFDGVITGVTAFGLFVTLNTIYVEGLVYISELPSDYFRHDSVKHVLRGERSGISFRLGDSLRVKLVRVDLATRKIDF
VLADNNNARKKSSK
>Mature_733_residues
SIKRKRNKKNQLRELDPFLKREQTRYGLALPSREFILEVLDKQGVPISEPKLLELLDITAEESEFFHRRLSAMIRDGQII
CNRKGDICVTDKLELVKGTVQGHSDGFGFLIPDDGGTDLFLTPKEMHKVLHGDRVIARLTNDVDRRGRRECRIVRVLESV
NTHLVGRLYEDHGIFFIVAEDKRINQDILVPKENIMNAHAGQVVMANIIQQPGQHAQPIGHIVEILGDYAAPGMEIEIAL
RKFDLPHEFSPEIISTKFPKKVLKKEFAKREDIRHLPLVTIDSETAKDFDDAVYCRQEGKDFRLFVAIADVSHYVRDQDA
LDKEAFDRGNSVYFPRRVIPMLPEVLSNGLCSLNPQVDRLCMVCEMLWTAKGELSEYRFYPAVMLSHARLTYNIVAELLD
QPKGNTATEYTQLLPHIQLLYRLFKVLHKSRRKRGAIDFETIETEMVFNNQGKIERICPVERNDAHRLIEECMLAANVCA
ADFLEKHQQPVLYRVHEGPSDEKLVALRDFLKEFGLQLRGGDKPSAKDYARTLDHIRERTDAQLLQTVMLRSLSQAMYSP
DNAGHFGLAYEMYTHFTSPIRRYPDLLVHRAIKAVLAGKHYDPGDWHEIGKHCSQTERRADEATREVESWLKCFYMQDKI
NDCFDGVITGVTAFGLFVTLNTIYVEGLVYISELPSDYFRHDSVKHVLRGERSGISFRLGDSLRVKLVRVDLATRKIDFV
LADNNNARKKSSK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=539, Percent_Identity=30.6122448979592, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI190014625, Length=539, Percent_Identity=30.6122448979592, Blast_Score=201, Evalue=3e-51,
Organism=Homo sapiens, GI19115966, Length=538, Percent_Identity=27.5092936802974, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI219521928, Length=538, Percent_Identity=27.5092936802974, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI134288890, Length=494, Percent_Identity=27.7327935222672, Blast_Score=164, Evalue=4e-40,
Organism=Homo sapiens, GI156105695, Length=192, Percent_Identity=31.25, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI156105693, Length=192, Percent_Identity=31.25, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI87082383, Length=736, Percent_Identity=49.1847826086957, Blast_Score=714, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=579, Percent_Identity=28.6701208981002, Blast_Score=190, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI212645896, Length=512, Percent_Identity=29.296875, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17553506, Length=550, Percent_Identity=28.7272727272727, Blast_Score=182, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6324552, Length=537, Percent_Identity=26.8156424581006, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24649634, Length=485, Percent_Identity=28.8659793814433, Blast_Score=179, Evalue=6e-45,
Organism=Drosophila melanogaster, GI19922976, Length=448, Percent_Identity=27.2321428571429, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24654597, Length=448, Percent_Identity=27.2321428571429, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24654592, Length=448, Percent_Identity=27.2321428571429, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 84269; Mature: 84138

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKRKRNKKNQLRELDPFLKREQTRYGLALPSREFILEVLDKQGVPISEPKLLELLDIT
CCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCC
AEESEFFHRRLSAMIRDGQIICNRKGDICVTDKLELVKGTVQGHSDGFGFLIPDDGGTDL
CHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCHHHHHHHHCCCCCCCEEEEECCCCCCE
FLTPKEMHKVLHGDRVIARLTNDVDRRGRRECRIVRVLESVNTHLVGRLYEDHGIFFIVA
EECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEE
EDKRINQDILVPKENIMNAHAGQVVMANIIQQPGQHAQPIGHIVEILGDYAAPGMEIEIA
CCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEE
LRKFDLPHEFSPEIISTKFPKKVLKKEFAKREDIRHLPLVTIDSETAKDFDDAVYCRQEG
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCC
KDFRLFVAIADVSHYVRDQDALDKEAFDRGNSVYFPRRVIPMLPEVLSNGLCSLNPQVDR
CCEEEEEEEHHHHHHHHCHHHHCHHHHHCCCCEECCHHHHHHHHHHHCCCCCCCCHHHHH
LCMVCEMLWTAKGELSEYRFYPAVMLSHARLTYNIVAELLDQPKGNTATEYTQLLPHIQL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LYRLFKVLHKSRRKRGAIDFETIETEMVFNNQGKIERICPVERNDAHRLIEECMLAANVC
HHHHHHHHHHHHHHCCCCCHHHHEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHH
AADFLEKHQQPVLYRVHEGPSDEKLVALRDFLKEFGLQLRGGDKPSAKDYARTLDHIRER
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHH
TDAQLLQTVMLRSLSQAMYSPDNAGHFGLAYEMYTHFTSPIRRYPDLLVHRAIKAVLAGK
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HYDPGDWHEIGKHCSQTERRADEATREVESWLKCFYMQDKINDCFDGVITGVTAFGLFVT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNTIYVEGLVYISELPSDYFRHDSVKHVLRGERSGISFRLGDSLRVKLVRVDLATRKIDF
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEEEEEEEEEEEE
VLADNNNARKKSSK
EEECCCCCCCCCCC
>Mature Secondary Structure 
SIKRKRNKKNQLRELDPFLKREQTRYGLALPSREFILEVLDKQGVPISEPKLLELLDIT
CCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCC
AEESEFFHRRLSAMIRDGQIICNRKGDICVTDKLELVKGTVQGHSDGFGFLIPDDGGTDL
CHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCHHHHHHHHCCCCCCCEEEEECCCCCCE
FLTPKEMHKVLHGDRVIARLTNDVDRRGRRECRIVRVLESVNTHLVGRLYEDHGIFFIVA
EECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEE
EDKRINQDILVPKENIMNAHAGQVVMANIIQQPGQHAQPIGHIVEILGDYAAPGMEIEIA
CCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEE
LRKFDLPHEFSPEIISTKFPKKVLKKEFAKREDIRHLPLVTIDSETAKDFDDAVYCRQEG
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCC
KDFRLFVAIADVSHYVRDQDALDKEAFDRGNSVYFPRRVIPMLPEVLSNGLCSLNPQVDR
CCEEEEEEEHHHHHHHHCHHHHCHHHHHCCCCEECCHHHHHHHHHHHCCCCCCCCHHHHH
LCMVCEMLWTAKGELSEYRFYPAVMLSHARLTYNIVAELLDQPKGNTATEYTQLLPHIQL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LYRLFKVLHKSRRKRGAIDFETIETEMVFNNQGKIERICPVERNDAHRLIEECMLAANVC
HHHHHHHHHHHHHHCCCCCHHHHEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHH
AADFLEKHQQPVLYRVHEGPSDEKLVALRDFLKEFGLQLRGGDKPSAKDYARTLDHIRER
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHH
TDAQLLQTVMLRSLSQAMYSPDNAGHFGLAYEMYTHFTSPIRRYPDLLVHRAIKAVLAGK
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HYDPGDWHEIGKHCSQTERRADEATREVESWLKCFYMQDKINDCFDGVITGVTAFGLFVT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNTIYVEGLVYISELPSDYFRHDSVKHVLRGERSGISFRLGDSLRVKLVRVDLATRKIDF
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEEEEEEEEEEEE
VLADNNNARKKSSK
EEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]