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The map label for this gene is xseA

Identifier: 114331498

GI number: 114331498

Start: 1581688

End: 1583034

Strand: Direct

Name: xseA

Synonym: Neut_1510

Alternate gene names: 114331498

Gene position: 1581688-1583034 (Clockwise)

Preceding gene: 114331493

Following gene: 114331499

Centisome position: 59.44

GC content: 48.18

Gene sequence:

>1347_bases
ATGACTGATAACAACCTTTTTCCTGAGCCAAAGAAAATAGTGTGGCGGGTCAGTGAATTAAACCGGCATGTGCGTGTAAT
ACTCGAACAGACTTTTCCATTGTTATGGGTAAGTGGAGAAATTTCCAATCTGAAACGTTATCCATCGGGACACTGGTATT
TTTCGCTCAAGGATGACAATGCTCAGGTACGATGTGTTATGTTCCGCCATAAAAATATGTACCTGGATTGGATGCCGCAG
GATGGTGCTCAAGTGGAAGCCCAGGCACTGATTACGCTCTATGAAGCACGTGGAGAGTTTCAACTGACAATTGAGCGGCT
TCGCCGCGCTGGACTAGGTGTTTTGTTTGAAACGTTTGAGCGGCTCAAAACCAGACTTCAACAAGAAGGGCTGTTCAATC
CCGAATACAAGCAACTGATTCCTCCTTACCCTCAACAAATCGGAATCATTACTTCAACCAATACTGCTGCGCTGAGAGAT
GTACTCACGACACTGCAACGGCGTTTACCCTCGCTACCTGTCGTTATTTACCCCGCACCGGTACAAGGTAAAGAAGCTGC
CTCAGCAATTGTGACTGCGCTACAAATCGCCACACAGCGAAGTGAATGCGATGTACTGATCCTGTGTCGTGGAGGAGGTT
CAATAGAAGATTTATGGGCGTTCAATGAAGAAATCGTTGCGCGAGCGATTGCTGCCTGCCCAATTCCAATTGTAACCGGT
ATCGGCCATGAAACCGACTTCACCATTGCTGATTTTGTAGCAGATATGCGCGCACCGACACCTACCGGTGCCGCTCAGTT
AGCAGCCCCGGACAGACAAGATATTCTGCATCGCCTGCAGTACTGGCAGCATCGATTGCAGCAGGCGATAGAACGAAATA
TTGAACGTCGCATGCAAACGACCGATTTGCTTGCTCACCGTCTGGTTCACCCTGGAGAGAGAATCCGCTACCAGTTAATC
CATTTGTCGCAATTACACAACCGTTTACTACATGCATGGAGCAGACAACTGGAAGTTTGCAAATGGCGAATCGAAGCATT
CAGGCGACGTATACAATTCACCAAACCCGATATCAATACGGGGAAAAGATATCAGCAAGAACTGGCTGCGCGGCTGCAAC
GAGCGATGGTGTACCGACTGGAAAGCTTGCAGGTTCAACTTATCCGACAGCAACAGCATCTCGCTCATCTCGACCCGAAA
GCAGTGCTGGAACGTGGTTACAGTATCACCTATACTGCCGGGGGTGAAATTCTGCAAGACAGTCAGCAGATTCACACTGG
CGATAACGTACAGATAGTCTTTGCCAAGGGATCGGCCAAGGCAAATATCACTGAAACAAACAAATGA

Upstream 100 bases:

>100_bases
TTTTTAAAAACAAATGTTTATTTTAAACCATTGTTATCGTACAAACTTTTCTATTCATAATGTAATAACCAAATGTCATT
GTGGATGATTATAAACCGGC

Downstream 100 bases:

>100_bases
CTCAGATCAGTTTTCTTATCCTCATTCTTATCACGCTTCACTTTAACCAGGAGTTTAACCAATAATGTCCAGAATCTTTC
TTGCGTTGGGGGCATTGAAT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTDNNLFPEPKKIVWRVSELNRHVRVILEQTFPLLWVSGEISNLKRYPSGHWYFSLKDDNAQVRCVMFRHKNMYLDWMPQ
DGAQVEAQALITLYEARGEFQLTIERLRRAGLGVLFETFERLKTRLQQEGLFNPEYKQLIPPYPQQIGIITSTNTAALRD
VLTTLQRRLPSLPVVIYPAPVQGKEAASAIVTALQIATQRSECDVLILCRGGGSIEDLWAFNEEIVARAIAACPIPIVTG
IGHETDFTIADFVADMRAPTPTGAAQLAAPDRQDILHRLQYWQHRLQQAIERNIERRMQTTDLLAHRLVHPGERIRYQLI
HLSQLHNRLLHAWSRQLEVCKWRIEAFRRRIQFTKPDINTGKRYQQELAARLQRAMVYRLESLQVQLIRQQQHLAHLDPK
AVLERGYSITYTAGGEILQDSQQIHTGDNVQIVFAKGSAKANITETNK

Sequences:

>Translated_448_residues
MTDNNLFPEPKKIVWRVSELNRHVRVILEQTFPLLWVSGEISNLKRYPSGHWYFSLKDDNAQVRCVMFRHKNMYLDWMPQ
DGAQVEAQALITLYEARGEFQLTIERLRRAGLGVLFETFERLKTRLQQEGLFNPEYKQLIPPYPQQIGIITSTNTAALRD
VLTTLQRRLPSLPVVIYPAPVQGKEAASAIVTALQIATQRSECDVLILCRGGGSIEDLWAFNEEIVARAIAACPIPIVTG
IGHETDFTIADFVADMRAPTPTGAAQLAAPDRQDILHRLQYWQHRLQQAIERNIERRMQTTDLLAHRLVHPGERIRYQLI
HLSQLHNRLLHAWSRQLEVCKWRIEAFRRRIQFTKPDINTGKRYQQELAARLQRAMVYRLESLQVQLIRQQQHLAHLDPK
AVLERGYSITYTAGGEILQDSQQIHTGDNVQIVFAKGSAKANITETNK
>Mature_447_residues
TDNNLFPEPKKIVWRVSELNRHVRVILEQTFPLLWVSGEISNLKRYPSGHWYFSLKDDNAQVRCVMFRHKNMYLDWMPQD
GAQVEAQALITLYEARGEFQLTIERLRRAGLGVLFETFERLKTRLQQEGLFNPEYKQLIPPYPQQIGIITSTNTAALRDV
LTTLQRRLPSLPVVIYPAPVQGKEAASAIVTALQIATQRSECDVLILCRGGGSIEDLWAFNEEIVARAIAACPIPIVTGI
GHETDFTIADFVADMRAPTPTGAAQLAAPDRQDILHRLQYWQHRLQQAIERNIERRMQTTDLLAHRLVHPGERIRYQLIH
LSQLHNRLLHAWSRQLEVCKWRIEAFRRRIQFTKPDINTGKRYQQELAARLQRAMVYRLESLQVQLIRQQQHLAHLDPKA
VLERGYSITYTAGGEILQDSQQIHTGDNVQIVFAKGSAKANITETNK

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=427, Percent_Identity=43.3255269320843, Blast_Score=354, Evalue=6e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_NITEC (Q0AFX7)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747720.1
- STRING:   Q0AFX7
- GeneID:   4274363
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1510
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   EISNFTR
- PhylomeDB:   Q0AFX7
- ProtClustDB:   PRK00286
- BioCyc:   NEUT335283:NEUT_1510-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 51542; Mature: 51411

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNNLFPEPKKIVWRVSELNRHVRVILEQTFPLLWVSGEISNLKRYPSGHWYFSLKDDN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCCCCEEEEEECCC
AQVRCVMFRHKNMYLDWMPQDGAQVEAQALITLYEARGEFQLTIERLRRAGLGVLFETFE
CEEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHH
RLKTRLQQEGLFNPEYKQLIPPYPQQIGIITSTNTAALRDVLTTLQRRLPSLPVVIYPAP
HHHHHHHHCCCCCCCHHHCCCCCCHHEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECC
VQGKEAASAIVTALQIATQRSECDVLILCRGGGSIEDLWAFNEEIVARAIAACPIPIVTG
CCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHEEC
IGHETDFTIADFVADMRAPTPTGAAQLAAPDRQDILHRLQYWQHRLQQAIERNIERRMQT
CCCCCCCHHHHHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDLLAHRLVHPGERIRYQLIHLSQLHNRLLHAWSRQLEVCKWRIEAFRRRIQFTKPDINT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GKRYQQELAARLQRAMVYRLESLQVQLIRQQQHLAHLDPKAVLERGYSITYTAGGEILQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCHHHHC
SQQIHTGDNVQIVFAKGSAKANITETNK
CHHCCCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TDNNLFPEPKKIVWRVSELNRHVRVILEQTFPLLWVSGEISNLKRYPSGHWYFSLKDDN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCCCCEEEEEECCC
AQVRCVMFRHKNMYLDWMPQDGAQVEAQALITLYEARGEFQLTIERLRRAGLGVLFETFE
CEEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHH
RLKTRLQQEGLFNPEYKQLIPPYPQQIGIITSTNTAALRDVLTTLQRRLPSLPVVIYPAP
HHHHHHHHCCCCCCCHHHCCCCCCHHEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECC
VQGKEAASAIVTALQIATQRSECDVLILCRGGGSIEDLWAFNEEIVARAIAACPIPIVTG
CCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHEEC
IGHETDFTIADFVADMRAPTPTGAAQLAAPDRQDILHRLQYWQHRLQQAIERNIERRMQT
CCCCCCCHHHHHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDLLAHRLVHPGERIRYQLIHLSQLHNRLLHAWSRQLEVCKWRIEAFRRRIQFTKPDINT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GKRYQQELAARLQRAMVYRLESLQVQLIRQQQHLAHLDPKAVLERGYSITYTAGGEILQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCHHHHC
SQQIHTGDNVQIVFAKGSAKANITETNK
CHHCCCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA