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The map label for this gene is uvrC

Identifier: 114331403

GI number: 114331403

Start: 1486703

End: 1488517

Strand: Direct

Name: uvrC

Synonym: Neut_1412

Alternate gene names: 114331403

Gene position: 1486703-1488517 (Clockwise)

Preceding gene: 114331402

Following gene: 114331405

Centisome position: 55.87

GC content: 50.52

Gene sequence:

>1815_bases
TTGCCGGATTCCTCTTTCGACGGTAAAGCGTTTGTTCTGACGCTCCCTTCTCAACCGGGCGTATATCGCATGCTGAATGC
GGCCGGCGATGTGATTTATGTAGGCAAAGCCATTGATCTGCGGAAAAGGGTGTCATCCTATTTTCAAAAATCGAATCTGT
CACCGCGTATTCAACTCATGGTATCGCAGATTACAGGGATTGAGACGACAGTCACCCGCTCCGAAGCGGAAGCGTTGCTG
CTTGAAAACAACCTGATCAAAAGCCTTGCACCCCGCTACAACATCCTGTTCCGGGATGACAAATCCTACCCTTACCTGCT
ACTGACGAATCATGCTTTTCCCAGGCTGGCGTTTTATCGCGGTGCACTGGATAACCGTCATCAGTATTTTGGCCCATTTC
CCAATGCAGGCGTGGTCAAATCCAGCATTCAGCTGCTGCAGAAAGTTTTTCGCCTGCGCACCTGTGAAAATTCGGTGTTT
AATAATCGTACACGGCCATGCCTGCTTCACCAGATCAAGCGCTGCAGCGCACCATGCGTTAATCTGATCACCCCGGAAGC
GTACCGGGAAGATGTCAACAGTGCAGCCCTGTTTCTGCAAGGCAAACAGGACGAAGTATTAAAAACCATAGAACAGAAAA
TGTTTGAGGCATCGGATCGACAAGCGTATGAACAGGCAGTACTGTTCCGTGACCAAATGCAGGCTTTACGCATGATTCAG
GAAAAACAGTTTGTCGACAGCAGCAGAGCACTGGATGCTGATGTTATCGCCTGCACAACCGGGACAGACAAACATACTGT
TGCGGTCAACCTGGTCATGATTCGCAGCGGACGACATCTGGGTGACAAAACCTTTTTCCCGCAGAACACACATGAAGACA
GTATCAGCACGGTGCTGGAAGCTTTTGTCAGCCAACATTACCTGAATCGCAGCGTTCCACCACTGATCATCCTGGGTAAA
AAAATCCGGGTGACACTCCTGCAAAAATTGCTATCTGAACAGGCTGGTCATAAAGTCACCCTGACGATCAATCCAATTGG
AGAACGACGCAAGTGGCTGGACATGGCAACCGAAAATGCGCAACTGGCGCTACGGCAAAAACAGATCCAGCAAGCCAGCC
AGGAAGATCGGTTGCAGGCACTGCAGGAGGTTTTGAATCTGCCAGGTCTGGCACGTATCGAATGTTTTGACATCAGCCAT
ACCATGGGAGAAGCAACGATGGCCTCCTGCGTGGTGTATGACCATTATGCCATGCGTAACGGCGAATATCGGCGTTATAA
CATTACCGGCATCACGCCGGGAGATGACTATGCAGCGATGCGTGATGTACTACAACGACGCTACGCAAAGATAGCCATGG
AAGAAGGCAAGCTACCCGATCTGATCCTGATTGATGGTGGCAAAGGGCAAATAGGCGTTGCCAGCGAAGTAATGATAGAA
CTGGGGCTCAATGATATTCCATTGGTAGGTGTGGCAAAAGGCGAAGCACGCAAGCCAGGACTGGAACAGCTGATCCTCCC
CTGGCAGGAAGAAACCTTGCATCTGCCGAATGACCATCCGGCTCTACACCTTATCCAACAGATTCGTGATGAAGCGCACC
GTTTTGCCATCCAGGGACATCGGGCAAAACGTGCCAAGACCCGTAAAACCTCCTCTCTTGAACAGATTGCCGGCATCGGC
AGCAAACGCCGCCAGAATCTGCTCACCCGCTTTGGCGGACTTAAAGGCGTAAAAAATGCCAGTATCGAAGAATTACAGCA
GACAGAAGGTGTCAGTCGGGCGCTGGCTGAAAAAATTTACCGGGAATTACGCTGA

Upstream 100 bases:

>100_bases
CCTAAATCTTACGTTTATATTGCCTTTGATGAAATGCCGCATGAAAGCTGGGCAATCGGCGGCCGGCTGCTGGGCAGCGA
TAAGTAACAAGGTACCTGTC

Downstream 100 bases:

>100_bases
CAAGGCGACTTAAACCCAGAAACTGCATCACCAACAGAAAGTTATTCTCGATGAAGTCGCACACGCCATTGCCAATAACC
TAAGCTCTGATAAGGCCCTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MPDSSFDGKAFVLTLPSQPGVYRMLNAAGDVIYVGKAIDLRKRVSSYFQKSNLSPRIQLMVSQITGIETTVTRSEAEALL
LENNLIKSLAPRYNILFRDDKSYPYLLLTNHAFPRLAFYRGALDNRHQYFGPFPNAGVVKSSIQLLQKVFRLRTCENSVF
NNRTRPCLLHQIKRCSAPCVNLITPEAYREDVNSAALFLQGKQDEVLKTIEQKMFEASDRQAYEQAVLFRDQMQALRMIQ
EKQFVDSSRALDADVIACTTGTDKHTVAVNLVMIRSGRHLGDKTFFPQNTHEDSISTVLEAFVSQHYLNRSVPPLIILGK
KIRVTLLQKLLSEQAGHKVTLTINPIGERRKWLDMATENAQLALRQKQIQQASQEDRLQALQEVLNLPGLARIECFDISH
TMGEATMASCVVYDHYAMRNGEYRRYNITGITPGDDYAAMRDVLQRRYAKIAMEEGKLPDLILIDGGKGQIGVASEVMIE
LGLNDIPLVGVAKGEARKPGLEQLILPWQEETLHLPNDHPALHLIQQIRDEAHRFAIQGHRAKRAKTRKTSSLEQIAGIG
SKRRQNLLTRFGGLKGVKNASIEELQQTEGVSRALAEKIYRELR

Sequences:

>Translated_604_residues
MPDSSFDGKAFVLTLPSQPGVYRMLNAAGDVIYVGKAIDLRKRVSSYFQKSNLSPRIQLMVSQITGIETTVTRSEAEALL
LENNLIKSLAPRYNILFRDDKSYPYLLLTNHAFPRLAFYRGALDNRHQYFGPFPNAGVVKSSIQLLQKVFRLRTCENSVF
NNRTRPCLLHQIKRCSAPCVNLITPEAYREDVNSAALFLQGKQDEVLKTIEQKMFEASDRQAYEQAVLFRDQMQALRMIQ
EKQFVDSSRALDADVIACTTGTDKHTVAVNLVMIRSGRHLGDKTFFPQNTHEDSISTVLEAFVSQHYLNRSVPPLIILGK
KIRVTLLQKLLSEQAGHKVTLTINPIGERRKWLDMATENAQLALRQKQIQQASQEDRLQALQEVLNLPGLARIECFDISH
TMGEATMASCVVYDHYAMRNGEYRRYNITGITPGDDYAAMRDVLQRRYAKIAMEEGKLPDLILIDGGKGQIGVASEVMIE
LGLNDIPLVGVAKGEARKPGLEQLILPWQEETLHLPNDHPALHLIQQIRDEAHRFAIQGHRAKRAKTRKTSSLEQIAGIG
SKRRQNLLTRFGGLKGVKNASIEELQQTEGVSRALAEKIYRELR
>Mature_603_residues
PDSSFDGKAFVLTLPSQPGVYRMLNAAGDVIYVGKAIDLRKRVSSYFQKSNLSPRIQLMVSQITGIETTVTRSEAEALLL
ENNLIKSLAPRYNILFRDDKSYPYLLLTNHAFPRLAFYRGALDNRHQYFGPFPNAGVVKSSIQLLQKVFRLRTCENSVFN
NRTRPCLLHQIKRCSAPCVNLITPEAYREDVNSAALFLQGKQDEVLKTIEQKMFEASDRQAYEQAVLFRDQMQALRMIQE
KQFVDSSRALDADVIACTTGTDKHTVAVNLVMIRSGRHLGDKTFFPQNTHEDSISTVLEAFVSQHYLNRSVPPLIILGKK
IRVTLLQKLLSEQAGHKVTLTINPIGERRKWLDMATENAQLALRQKQIQQASQEDRLQALQEVLNLPGLARIECFDISHT
MGEATMASCVVYDHYAMRNGEYRRYNITGITPGDDYAAMRDVLQRRYAKIAMEEGKLPDLILIDGGKGQIGVASEVMIEL
GLNDIPLVGVAKGEARKPGLEQLILPWQEETLHLPNDHPALHLIQQIRDEAHRFAIQGHRAKRAKTRKTSSLEQIAGIGS
KRRQNLLTRFGGLKGVKNASIEELQQTEGVSRALAEKIYRELR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=51.3957307060755, Blast_Score=594, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_NITEC (Q0AG72)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747625.1
- ProteinModelPortal:   Q0AG72
- STRING:   Q0AG72
- GeneID:   4274211
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1412
- NMPDR:   fig|335283.3.peg.564
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q0AG72
- ProtClustDB:   PRK00558
- BioCyc:   NEUT335283:NEUT_1412-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68174; Mature: 68043

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSSFDGKAFVLTLPSQPGVYRMLNAAGDVIYVGKAIDLRKRVSSYFQKSNLSPRIQLM
CCCCCCCCCEEEEECCCCCCHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHH
VSQITGIETTVTRSEAEALLLENNLIKSLAPRYNILFRDDKSYPYLLLTNHAFPRLAFYR
HHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCHHHHHHH
GALDNRHQYFGPFPNAGVVKSSIQLLQKVFRLRTCENSVFNNRTRPCLLHQIKRCSAPCV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
NLITPEAYREDVNSAALFLQGKQDEVLKTIEQKMFEASDRQAYEQAVLFRDQMQALRMIQ
HCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKQFVDSSRALDADVIACTTGTDKHTVAVNLVMIRSGRHLGDKTFFPQNTHEDSISTVLE
HHHHHHHCCCCCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
AFVSQHYLNRSVPPLIILGKKIRVTLLQKLLSEQAGHKVTLTINPIGERRKWLDMATENA
HHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCH
QLALRQKQIQQASQEDRLQALQEVLNLPGLARIECFDISHTMGEATMASCVVYDHYAMRN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHCHHHHHHHHHHHHHHHCC
GEYRRYNITGITPGDDYAAMRDVLQRRYAKIAMEEGKLPDLILIDGGKGQIGVASEVMIE
CCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHH
LGLNDIPLVGVAKGEARKPGLEQLILPWQEETLHLPNDHPALHLIQQIRDEAHRFAIQGH
CCCCCCCEEEECCCCCCCCCHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCC
RAKRAKTRKTSSLEQIAGIGSKRRQNLLTRFGGLKGVKNASIEELQQTEGVSRALAEKIY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RELR
HHCC
>Mature Secondary Structure 
PDSSFDGKAFVLTLPSQPGVYRMLNAAGDVIYVGKAIDLRKRVSSYFQKSNLSPRIQLM
CCCCCCCCEEEEECCCCCCHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHH
VSQITGIETTVTRSEAEALLLENNLIKSLAPRYNILFRDDKSYPYLLLTNHAFPRLAFYR
HHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCHHHHHHH
GALDNRHQYFGPFPNAGVVKSSIQLLQKVFRLRTCENSVFNNRTRPCLLHQIKRCSAPCV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHH
NLITPEAYREDVNSAALFLQGKQDEVLKTIEQKMFEASDRQAYEQAVLFRDQMQALRMIQ
HCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKQFVDSSRALDADVIACTTGTDKHTVAVNLVMIRSGRHLGDKTFFPQNTHEDSISTVLE
HHHHHHHCCCCCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
AFVSQHYLNRSVPPLIILGKKIRVTLLQKLLSEQAGHKVTLTINPIGERRKWLDMATENA
HHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCH
QLALRQKQIQQASQEDRLQALQEVLNLPGLARIECFDISHTMGEATMASCVVYDHYAMRN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHCHHHHHHHHHHHHHHHCC
GEYRRYNITGITPGDDYAAMRDVLQRRYAKIAMEEGKLPDLILIDGGKGQIGVASEVMIE
CCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHH
LGLNDIPLVGVAKGEARKPGLEQLILPWQEETLHLPNDHPALHLIQQIRDEAHRFAIQGH
CCCCCCCEEEECCCCCCCCCHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCC
RAKRAKTRKTSSLEQIAGIGSKRRQNLLTRFGGLKGVKNASIEELQQTEGVSRALAEKIY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RELR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA