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The map label for this gene is copA [H]

Identifier: 114331397

GI number: 114331397

Start: 1478164

End: 1479225

Strand: Reverse

Name: copA [H]

Synonym: Neut_1406

Alternate gene names: 114331397

Gene position: 1479225-1478164 (Counterclockwise)

Preceding gene: 114331399

Following gene: 114331396

Centisome position: 55.59

GC content: 45.39

Gene sequence:

>1062_bases
ATGAGAAATTCAAATTCGATATTTTCGCATTACCGATTCATCATCAGCATCGTTATTGGACTGTATGCACTGGTGATGAT
TCCTGCAACAAGCTGGGCCGAAAAACGTGAATTCGATATGTCAATCGAAGACACCCGGATCGTTCTAGTCGGCAAGAGAG
ATTTTCACACATTTGCCTTCAATGGCCAGGTTCCAGCGCCGCTTATTCACGTCAAGGAAGGCGATGACGTTGTAGTAAAT
GTAACCAACATGACCACGCTGCCGCATACCATCCACTGGCACGGCATGCTTCAGCGCGGTACCTGGCAGAACGATGGTGT
GCCTCACGCCACTCAGCATGCGATAGAGCCCGGTGATACGTTTACTTACAAATTCAAGGCTGAACCTTCCGGCACCATGT
GGTACCACTGTCACGTCAATGTGAACGAACACGTCACCATGCGCGGCATGTGGGGGCCACTCATTGTGGAGCCGAAGAAT
CCTCTTCCAATCGAGAAAACAGTAACCAAAGAATACATCATGATGCTTTCTGATTGGGTATCAGCTTGGGCGAACAAACC
GGGTGAGGGCGGTATTCCGGGAGATGTATTCGATTATTACACGATTAACGCCAAATCTTTTCCTGAAACGCAACCTATAC
GAGTCAAAAAAGGAGATGTCATAAGGCTGCGCATCTTTGGTGCAGGTGATCAAGTTCATTCCATTCATACTCATGGCCAC
ATCTCTAACATCGTATTCAAGGATGGTTTTCCTTTGGAAAGTCCAATTAAGGCCGACACTGTTCTTATTGGGCCGGGCGA
GCGTTATGACGTTATCATCAATATGGATAACCCTGGTTTATGGATGATACATGATCACGTTGATACGCATACTACCAATG
GAGATAAGCCTGACGGTGGAATTATGACAACCATCGAGTATGAGGAAGTCGGACTTGACCACGATTTCTATGTATGGAAA
GACAAAAAATTTGTACCTGATTTCTACTATGAAGAATCTCTGAAAAAAGACTTCGGAATGCATAATTCGAAAGTCTTCAA
AGGAGAACTCATCGAAGAATGA

Upstream 100 bases:

>100_bases
TCTATCAAGTGCTGATGAGGTATTAACACAGTATGTATCTAAAAGTAAGAGAGTTTTGTGCATCAAAGGCGTATTAAATA
TACACTAAAAGGACCGATTT

Downstream 100 bases:

>100_bases
TGTGTATGTGTAACACAACAACCAAAGGAGAAGAAATATGATGAAAGCCTATTTGCTTGCGGCGATGGTTGGTGCGGGTT
TTCTTGCATCATCGCTAACA

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MRNSNSIFSHYRFIISIVIGLYALVMIPATSWAEKREFDMSIEDTRIVLVGKRDFHTFAFNGQVPAPLIHVKEGDDVVVN
VTNMTTLPHTIHWHGMLQRGTWQNDGVPHATQHAIEPGDTFTYKFKAEPSGTMWYHCHVNVNEHVTMRGMWGPLIVEPKN
PLPIEKTVTKEYIMMLSDWVSAWANKPGEGGIPGDVFDYYTINAKSFPETQPIRVKKGDVIRLRIFGAGDQVHSIHTHGH
ISNIVFKDGFPLESPIKADTVLIGPGERYDVIINMDNPGLWMIHDHVDTHTTNGDKPDGGIMTTIEYEEVGLDHDFYVWK
DKKFVPDFYYEESLKKDFGMHNSKVFKGELIEE

Sequences:

>Translated_353_residues
MRNSNSIFSHYRFIISIVIGLYALVMIPATSWAEKREFDMSIEDTRIVLVGKRDFHTFAFNGQVPAPLIHVKEGDDVVVN
VTNMTTLPHTIHWHGMLQRGTWQNDGVPHATQHAIEPGDTFTYKFKAEPSGTMWYHCHVNVNEHVTMRGMWGPLIVEPKN
PLPIEKTVTKEYIMMLSDWVSAWANKPGEGGIPGDVFDYYTINAKSFPETQPIRVKKGDVIRLRIFGAGDQVHSIHTHGH
ISNIVFKDGFPLESPIKADTVLIGPGERYDVIINMDNPGLWMIHDHVDTHTTNGDKPDGGIMTTIEYEEVGLDHDFYVWK
DKKFVPDFYYEESLKKDFGMHNSKVFKGELIEE
>Mature_353_residues
MRNSNSIFSHYRFIISIVIGLYALVMIPATSWAEKREFDMSIEDTRIVLVGKRDFHTFAFNGQVPAPLIHVKEGDDVVVN
VTNMTTLPHTIHWHGMLQRGTWQNDGVPHATQHAIEPGDTFTYKFKAEPSGTMWYHCHVNVNEHVTMRGMWGPLIVEPKN
PLPIEKTVTKEYIMMLSDWVSAWANKPGEGGIPGDVFDYYTINAKSFPETQPIRVKKGDVIRLRIFGAGDQVHSIHTHGH
ISNIVFKDGFPLESPIKADTVLIGPGERYDVIINMDNPGLWMIHDHVDTHTTNGDKPDGGIMTTIEYEEVGLDHDFYVWK
DKKFVPDFYYEESLKKDFGMHNSKVFKGELIEE

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557485, Length=265, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539950, Length=265, Percent_Identity=27.1698113207547, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323703, Length=275, Percent_Identity=28.3636363636364, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321067, Length=246, Percent_Identity=28.4552845528455, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859919, Length=225, Percent_Identity=32.4444444444444, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221330000, Length=296, Percent_Identity=28.3783783783784, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281360167, Length=296, Percent_Identity=28.3783783783784, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585842, Length=296, Percent_Identity=28.3783783783784, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI221329998, Length=296, Percent_Identity=28.3783783783784, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574104, Length=125, Percent_Identity=39.2, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24650186, Length=82, Percent_Identity=43.9024390243902, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 40265; Mature: 40265

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNSNSIFSHYRFIISIVIGLYALVMIPATSWAEKREFDMSIEDTRIVLVGKRDFHTFAF
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEEEECCCCEEEEE
NGQVPAPLIHVKEGDDVVVNVTNMTTLPHTIHWHGMLQRGTWQNDGVPHATQHAIEPGDT
CCCCCCCEEEEECCCEEEEEEECCEECCCEEEEEEEEECCCCCCCCCCCHHHHCCCCCCE
FTYKFKAEPSGTMWYHCHVNVNEHVTMRGMWGPLIVEPKNPLPIEKTVTKEYIMMLSDWV
EEEEEEECCCCEEEEEEEEECCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
SAWANKPGEGGIPGDVFDYYTINAKSFPETQPIRVKKGDVIRLRIFGAGDQVHSIHTHGH
HHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCEEEEEEEECCCCEEEEECCCC
ISNIVFKDGFPLESPIKADTVLIGPGERYDVIINMDNPGLWMIHDHVDTHTTNGDKPDGG
EEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCC
IMTTIEYEEVGLDHDFYVWKDKKFVPDFYYEESLKKDFGMHNSKVFKGELIEE
EEEEEEHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCC
>Mature Secondary Structure
MRNSNSIFSHYRFIISIVIGLYALVMIPATSWAEKREFDMSIEDTRIVLVGKRDFHTFAF
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEEEECCCCEEEEE
NGQVPAPLIHVKEGDDVVVNVTNMTTLPHTIHWHGMLQRGTWQNDGVPHATQHAIEPGDT
CCCCCCCEEEEECCCEEEEEEECCEECCCEEEEEEEEECCCCCCCCCCCHHHHCCCCCCE
FTYKFKAEPSGTMWYHCHVNVNEHVTMRGMWGPLIVEPKNPLPIEKTVTKEYIMMLSDWV
EEEEEEECCCCEEEEEEEEECCCEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHH
SAWANKPGEGGIPGDVFDYYTINAKSFPETQPIRVKKGDVIRLRIFGAGDQVHSIHTHGH
HHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCEEEEEEEECCCCEEEEECCCC
ISNIVFKDGFPLESPIKADTVLIGPGERYDVIINMDNPGLWMIHDHVDTHTTNGDKPDGG
EEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCCC
IMTTIEYEEVGLDHDFYVWKDKKFVPDFYYEESLKKDFGMHNSKVFKGELIEE
EEEEEEHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]