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The map label for this gene is serA [H]

Identifier: 113477612

GI number: 113477612

Start: 6475318

End: 6476901

Strand: Reverse

Name: serA [H]

Synonym: Tery_4196

Alternate gene names: 113477612

Gene position: 6476901-6475318 (Counterclockwise)

Preceding gene: 113477615

Following gene: 113477611

Centisome position: 83.57

GC content: 38.76

Gene sequence:

>1584_bases
ATGCCAAAAGTTCTTGTATCTGATTCAATCGATCAAAATGGAATAAATATTCTCTCCCAAGTAGCTCAGGTAGATATAAA
AATAGGTCTACCAGTAGAAGAACTAGTAAAAATTATACCAGAATATGATGGTTTAATGATTCGCTCTGGTACCAAAGTTA
CCAAAGAAATAATAGAAGCTGCCGATAAACTAAAAATTATTGGTCGTGCTGGAGTGGGTGTAGATAATGTAGACGTACAA
GCAGCAACCCGTAAAGGTATTGTGGTAGTCAACTCACCAGAAGGAAATACAATTGCTGCAGCAGAACACGCTTTGGCAAT
GATGTTATCTATGTCGCGCCACGTTCCAGAAGCTAACCAATCAATTATCAATGCTCAATGGGACCGCAAAAAGTTTGTCG
GGGTCGAGGTCTACAAAAAAACTCTCGGTGTTGTTGGTTTAGGTAAAATTGGCTCCCATGTAGCTAAGGTAGCAAAAGCT
ATGGGAATGAAAATTTTGGCTTATGATCCATTTATTTCTGAAGAAAGAGCAGAACAATTGGGTTGTAGTTTGGTAGATCT
GGATCTTTTAGTCCAAGAGTCTGATTATATTACTCTCCATATACCCAAAACTGACGAAACTTATCACTCAATTAATGCTG
AAACTTTTGCCAAAATGAAACCCACAGCTCGGATTATTAATTGTTCTAGAGGTGGCATTATTGATGAAGTTGCTTTATCC
AAAGCTCTAAAAGAAGGAAAAATTGCTGGAGCTGCTTTAGATGTATATGAAAATGAGCCTCTAGAAGTTGAGTCCCCACT
ACGAGATTTGGGACAAAAAATTGTGATGACTCCTCATTTGGGTGCTTCTACTGCTGAAGCTCAAGTGAATGTAGCAATAG
ATGTTGCTGAACAAATTCGAGATGTATTGTTAGGGCTGCCTGCCAGATCGGCAGTGAATATCCCTGGTATGTATCCTGAT
ACTTTAAAAAAACTGAAGCCCTATTTACGATTGGCCGAAACTCTTGGTAATTTGGTAAGTCAGTTAGCCGGTGGGCGTAT
TGATTTTCTCAATGTTCGTCTTGAAGGAGATTTGGCCGGTGGAGATAGTAAACCTGTAGTAGTAGGAGCTTTAAAGGGAT
TACTTTCTCAAGCTTTGCGAGAGCGCGTCAATTATGTAAATGCTTTTATTGAAGCTAAAGAACGAGGTATTCGAGTAGTG
GAAACTAGAGATGATTCAGTACGAGATTATACTGGTTCATTACATCTAGAAGCAAAAGGGTCTCTGGGTGAACATAATGT
TCGAGGTTCTTTGCTGGGAAAAGATGAGATTCGGATTACTAATATTGATGGGTTTCCAATTAATGTCCCTCCTAGCCCAT
ATATGTTATTGACTCTCCACCGAGATATGCCGGGAATTATTGGTAAAATTGGTTCACTTCTGGGGAGTTTTAATGTCAAT
ATTGCTAGTATGCAGGTGGGACGTAAAATTGTTAGAGGTGATGCTGTAATGGTATTAAGTGTTGATGACCCATTACCAGA
AGAAATATTAACTGAAATTCTTAAAGAACCAGGAATTAGGAATGCTTATACAGTTGCTCTTTGA

Upstream 100 bases:

>100_bases
GAAGAGTATAGTTGTTATTTAAGGCACAAAAAAATTAAACTGAAGCAGAAGTTTCAGTAAGAAAAATAATCAAATAACCC
AATTATTTAACTAACTTCCT

Downstream 100 bases:

>100_bases
AGTACTGTTATACCTAAAAGCCCCGATATTTTGTTAATATTAAATTCGGTAGTGTCAACTATAAATAAAGTATAAAAAGT
CGATCAAACCGGGTTGAGCT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MPKVLVSDSIDQNGINILSQVAQVDIKIGLPVEELVKIIPEYDGLMIRSGTKVTKEIIEAADKLKIIGRAGVGVDNVDVQ
AATRKGIVVVNSPEGNTIAAAEHALAMMLSMSRHVPEANQSIINAQWDRKKFVGVEVYKKTLGVVGLGKIGSHVAKVAKA
MGMKILAYDPFISEERAEQLGCSLVDLDLLVQESDYITLHIPKTDETYHSINAETFAKMKPTARIINCSRGGIIDEVALS
KALKEGKIAGAALDVYENEPLEVESPLRDLGQKIVMTPHLGASTAEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGMYPD
TLKKLKPYLRLAETLGNLVSQLAGGRIDFLNVRLEGDLAGGDSKPVVVGALKGLLSQALRERVNYVNAFIEAKERGIRVV
ETRDDSVRDYTGSLHLEAKGSLGEHNVRGSLLGKDEIRITNIDGFPINVPPSPYMLLTLHRDMPGIIGKIGSLLGSFNVN
IASMQVGRKIVRGDAVMVLSVDDPLPEEILTEILKEPGIRNAYTVAL

Sequences:

>Translated_527_residues
MPKVLVSDSIDQNGINILSQVAQVDIKIGLPVEELVKIIPEYDGLMIRSGTKVTKEIIEAADKLKIIGRAGVGVDNVDVQ
AATRKGIVVVNSPEGNTIAAAEHALAMMLSMSRHVPEANQSIINAQWDRKKFVGVEVYKKTLGVVGLGKIGSHVAKVAKA
MGMKILAYDPFISEERAEQLGCSLVDLDLLVQESDYITLHIPKTDETYHSINAETFAKMKPTARIINCSRGGIIDEVALS
KALKEGKIAGAALDVYENEPLEVESPLRDLGQKIVMTPHLGASTAEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGMYPD
TLKKLKPYLRLAETLGNLVSQLAGGRIDFLNVRLEGDLAGGDSKPVVVGALKGLLSQALRERVNYVNAFIEAKERGIRVV
ETRDDSVRDYTGSLHLEAKGSLGEHNVRGSLLGKDEIRITNIDGFPINVPPSPYMLLTLHRDMPGIIGKIGSLLGSFNVN
IASMQVGRKIVRGDAVMVLSVDDPLPEEILTEILKEPGIRNAYTVAL
>Mature_526_residues
PKVLVSDSIDQNGINILSQVAQVDIKIGLPVEELVKIIPEYDGLMIRSGTKVTKEIIEAADKLKIIGRAGVGVDNVDVQA
ATRKGIVVVNSPEGNTIAAAEHALAMMLSMSRHVPEANQSIINAQWDRKKFVGVEVYKKTLGVVGLGKIGSHVAKVAKAM
GMKILAYDPFISEERAEQLGCSLVDLDLLVQESDYITLHIPKTDETYHSINAETFAKMKPTARIINCSRGGIIDEVALSK
ALKEGKIAGAALDVYENEPLEVESPLRDLGQKIVMTPHLGASTAEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGMYPDT
LKKLKPYLRLAETLGNLVSQLAGGRIDFLNVRLEGDLAGGDSKPVVVGALKGLLSQALRERVNYVNAFIEAKERGIRVVE
TRDDSVRDYTGSLHLEAKGSLGEHNVRGSLLGKDEIRITNIDGFPINVPPSPYMLLTLHRDMPGIIGKIGSLLGSFNVNI
ASMQVGRKIVRGDAVMVLSVDDPLPEEILTEILKEPGIRNAYTVAL

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=407, Percent_Identity=41.5233415233415, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI4557497, Length=319, Percent_Identity=33.5423197492163, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI61743967, Length=319, Percent_Identity=33.5423197492163, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI145580578, Length=301, Percent_Identity=32.890365448505, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4557499, Length=301, Percent_Identity=32.890365448505, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI145580575, Length=301, Percent_Identity=32.890365448505, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI6912396, Length=324, Percent_Identity=31.4814814814815, Blast_Score=140, Evalue=4e-33,
Organism=Escherichia coli, GI87082289, Length=286, Percent_Identity=37.4125874125874, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1789279, Length=320, Percent_Identity=33.125, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1787645, Length=241, Percent_Identity=38.5892116182573, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1788660, Length=301, Percent_Identity=29.9003322259136, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081824, Length=272, Percent_Identity=25.3676470588235, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=44.0993788819876, Blast_Score=264, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI25147481, Length=300, Percent_Identity=33, Blast_Score=136, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=328, Percent_Identity=36.5853658536585, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=35.7798165137615, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=30.8641975308642, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=264, Percent_Identity=29.5454545454545, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325144, Length=177, Percent_Identity=29.3785310734463, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=155, Percent_Identity=32.258064516129, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=46, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24646446, Length=323, Percent_Identity=34.0557275541796, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24646448, Length=323, Percent_Identity=34.0557275541796, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24646452, Length=323, Percent_Identity=34.0557275541796, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24646450, Length=323, Percent_Identity=34.0557275541796, Blast_Score=155, Evalue=8e-38,
Organism=Drosophila melanogaster, GI62472511, Length=323, Percent_Identity=34.0557275541796, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28571528, Length=304, Percent_Identity=31.9078947368421, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28574284, Length=317, Percent_Identity=29.9684542586751, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574286, Length=314, Percent_Identity=31.5286624203822, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45551003, Length=317, Percent_Identity=29.9684542586751, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24585514, Length=317, Percent_Identity=29.9684542586751, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI28574282, Length=317, Percent_Identity=29.9684542586751, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45552429, Length=317, Percent_Identity=29.9684542586751, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24585516, Length=279, Percent_Identity=26.5232974910394, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56895; Mature: 56764

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS00287 CYSTATIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVLVSDSIDQNGINILSQVAQVDIKIGLPVEELVKIIPEYDGLMIRSGTKVTKEIIEA
CCCEEECCCCCCCHHHHHHHHHHEEEEECCCHHHHHHHCCCCCCEEEECCCHHHHHHHHH
ADKLKIIGRAGVGVDNVDVQAATRKGIVVVNSPEGNTIAAAEHALAMMLSMSRHVPEANQ
HHHEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCH
SIINAQWDRKKFVGVEVYKKTLGVVGLGKIGSHVAKVAKAMGMKILAYDPFISEERAEQL
HHHCCCCCCHHHHHHHHHHHHHCEEECHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GCSLVDLDLLVQESDYITLHIPKTDETYHSINAETFAKMKPTARIINCSRGGIIDEVALS
CCEEEEEEEEEECCCEEEEEECCCCCHHHHCCHHHHHHCCCCEEEEECCCCCCHHHHHHH
KALKEGKIAGAALDVYENEPLEVESPLRDLGQKIVMTPHLGASTAEAQVNVAIDVAEQIR
HHHHCCCCCCEEEEECCCCCCCCHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEHHHHHH
DVLLGLPARSAVNIPGMYPDTLKKLKPYLRLAETLGNLVSQLAGGRIDFLNVRLEGDLAG
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECC
GDSKPVVVGALKGLLSQALRERVNYVNAFIEAKERGIRVVETRDDSVRDYTGSLHLEAKG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEECC
SLGEHNVRGSLLGKDEIRITNIDGFPINVPPSPYMLLTLHRDMPGIIGKIGSLLGSFNVN
CCCCCCCCCCEECCCCEEEEECCCEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCE
IASMQVGRKIVRGDAVMVLSVDDPLPEEILTEILKEPGIRNAYTVAL
EEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
PKVLVSDSIDQNGINILSQVAQVDIKIGLPVEELVKIIPEYDGLMIRSGTKVTKEIIEA
CCEEECCCCCCCHHHHHHHHHHEEEEECCCHHHHHHHCCCCCCEEEECCCHHHHHHHHH
ADKLKIIGRAGVGVDNVDVQAATRKGIVVVNSPEGNTIAAAEHALAMMLSMSRHVPEANQ
HHHEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCH
SIINAQWDRKKFVGVEVYKKTLGVVGLGKIGSHVAKVAKAMGMKILAYDPFISEERAEQL
HHHCCCCCCHHHHHHHHHHHHHCEEECHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
GCSLVDLDLLVQESDYITLHIPKTDETYHSINAETFAKMKPTARIINCSRGGIIDEVALS
CCEEEEEEEEEECCCEEEEEECCCCCHHHHCCHHHHHHCCCCEEEEECCCCCCHHHHHHH
KALKEGKIAGAALDVYENEPLEVESPLRDLGQKIVMTPHLGASTAEAQVNVAIDVAEQIR
HHHHCCCCCCEEEEECCCCCCCCHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEHHHHHH
DVLLGLPARSAVNIPGMYPDTLKKLKPYLRLAETLGNLVSQLAGGRIDFLNVRLEGDLAG
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECC
GDSKPVVVGALKGLLSQALRERVNYVNAFIEAKERGIRVVETRDDSVRDYTGSLHLEAKG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEECC
SLGEHNVRGSLLGKDEIRITNIDGFPINVPPSPYMLLTLHRDMPGIIGKIGSLLGSFNVN
CCCCCCCCCCEECCCCEEEEECCCEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCE
IASMQVGRKIVRGDAVMVLSVDDPLPEEILTEILKEPGIRNAYTVAL
EEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]