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The map label for this gene is panF [H]

Identifier: 113476431

GI number: 113476431

Start: 4425850

End: 4427274

Strand: Reverse

Name: panF [H]

Synonym: Tery_2845

Alternate gene names: 113476431

Gene position: 4427274-4425850 (Counterclockwise)

Preceding gene: 113476435

Following gene: 113476430

Centisome position: 57.13

GC content: 34.46

Gene sequence:

>1425_bases
ATGATCAAAAACCTAATTCCCTACTTATTTATTAGTGCATATTTACTCCTGACTTTAGTCATCGGAATTATTGGTTATCG
TAGCCAAAAAAATACACCAGAAGATTACTTTCTAGCAGAGCGAAAAATCGGTTCCATAGTTCTATTTTTTACCCTCATTG
CTACCAACTTTAGTGCCTTTGCTTTTCTCGGACTTTCTGGTGCTGGTTATCGTATTGGTATAAGTTATTATCCGATGATA
GGATTTGGTACGGCCCTTGTCGGAATTACATTTTATTTTATCGGTTATAAAGTTTGGCTTTTAGGTAAAGAAAAAGGTTT
AATTACTCCCTCAGAATTAATCGCAAATTGCCTCCCAAGTCAACCACTAAAACTAATATTTTTAGCCGTGATGGTAATTT
TTACCATACCTTATTTAACCCTACAACCAATTGGTGGGGGTTATATGATTGAAAATTTAACTAATGGGCAAATTCCCTAT
TTTTGGGGAGCAGCTTTTTTAACTTTCATCATTGTTTTATATGTGTTTATCGGGGGAATGAAAAGTGTAGCTTTAACCGA
TGTTTTACAAGGAGTATTAATGTTGATTTTAATGATAGTTGCAGTAGTGACTATTTCCCAAAGTCTCGGTGGCTTGACTG
AAGCTAATCAAACTGTTCATAAACTCAAACCAGAGCTTTTTTCTCGTTCTGGTACCAATGATTTTTTCACTCCCCACAAA
TGGTTTAGTTATATGTTGCTTTGGGGTTTAAGTGTACCGATGTTCCCCCAAATGTTTATGCGCTTTTATACTCCTAAAAA
TCCTAATTCCCTCAAACTTTCTGCTAGTTTATATCCATTAATTACTTGCATAATGTTTATTTGCCCTGTTTTAATTGGAA
TGTGGGGTCATATTAATTTTCCTGATTTAGTTGGAAAAGAAGCAGATAAAATTTTTCCCATGATGTTAGCTGAATATACC
TCAACTACCATGGCTTCATTAGTAATGGTAGGAGCTTTAGCAGCGTTTATGTCAACCCTTGATTCTCAACTTTTAGCATT
AAGTTCTATGATTACTAGGGATATTTATATTGTTTATATTCGCCCCCAAGCAACCCTGACAGAACAAACTTTTGTGGGCA
AAATTTTAATTGTTATTTTAGCAATAATTGGTTTGATTTTAGCAGCAAATCCTCCGGCAACAATTGCAGCGATCGCTACT
CAAGCTTTTACAGGTTTAGCAGTATTATTTCCCACAGTTATTGCCGCTTTATATGGGAAAAATATTTCACCTTTGAGTTG
TATAATTTCCATTATTTTTGGAGAAATAGCAGTTATTGGTTTTCAGGTAAATATTATTCCTAAAAGTTGGGCTTTAGGAT
TTCTGCCAGTAGTGCCGATAGTGTTAATTTGTAGTTTAATTATTGTCGTTTTTTTGAGGAAGTAG

Upstream 100 bases:

>100_bases
GGGTTTTCTACTTTATTACTTTGCAAATTATCCTCGCCTGTGCTCTTTTTATCTTCTCTCAAACTTTCTGGAAATCTGAA
ACTGAAGAGGAAAATTAATC

Downstream 100 bases:

>100_bases
AGACCTGACATCTAACGCCGTTATTAATAGTAATTCGGGTTTTAGGAAATATAATTTGCTCAATTAAAGTATGATATTAT
AAAAGTTGCGATCGCTCTCA

Product: Na+/solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MIKNLIPYLFISAYLLLTLVIGIIGYRSQKNTPEDYFLAERKIGSIVLFFTLIATNFSAFAFLGLSGAGYRIGISYYPMI
GFGTALVGITFYFIGYKVWLLGKEKGLITPSELIANCLPSQPLKLIFLAVMVIFTIPYLTLQPIGGGYMIENLTNGQIPY
FWGAAFLTFIIVLYVFIGGMKSVALTDVLQGVLMLILMIVAVVTISQSLGGLTEANQTVHKLKPELFSRSGTNDFFTPHK
WFSYMLLWGLSVPMFPQMFMRFYTPKNPNSLKLSASLYPLITCIMFICPVLIGMWGHINFPDLVGKEADKIFPMMLAEYT
STTMASLVMVGALAAFMSTLDSQLLALSSMITRDIYIVYIRPQATLTEQTFVGKILIVILAIIGLILAANPPATIAAIAT
QAFTGLAVLFPTVIAALYGKNISPLSCIISIIFGEIAVIGFQVNIIPKSWALGFLPVVPIVLICSLIIVVFLRK

Sequences:

>Translated_474_residues
MIKNLIPYLFISAYLLLTLVIGIIGYRSQKNTPEDYFLAERKIGSIVLFFTLIATNFSAFAFLGLSGAGYRIGISYYPMI
GFGTALVGITFYFIGYKVWLLGKEKGLITPSELIANCLPSQPLKLIFLAVMVIFTIPYLTLQPIGGGYMIENLTNGQIPY
FWGAAFLTFIIVLYVFIGGMKSVALTDVLQGVLMLILMIVAVVTISQSLGGLTEANQTVHKLKPELFSRSGTNDFFTPHK
WFSYMLLWGLSVPMFPQMFMRFYTPKNPNSLKLSASLYPLITCIMFICPVLIGMWGHINFPDLVGKEADKIFPMMLAEYT
STTMASLVMVGALAAFMSTLDSQLLALSSMITRDIYIVYIRPQATLTEQTFVGKILIVILAIIGLILAANPPATIAAIAT
QAFTGLAVLFPTVIAALYGKNISPLSCIISIIFGEIAVIGFQVNIIPKSWALGFLPVVPIVLICSLIIVVFLRK
>Mature_474_residues
MIKNLIPYLFISAYLLLTLVIGIIGYRSQKNTPEDYFLAERKIGSIVLFFTLIATNFSAFAFLGLSGAGYRIGISYYPMI
GFGTALVGITFYFIGYKVWLLGKEKGLITPSELIANCLPSQPLKLIFLAVMVIFTIPYLTLQPIGGGYMIENLTNGQIPY
FWGAAFLTFIIVLYVFIGGMKSVALTDVLQGVLMLILMIVAVVTISQSLGGLTEANQTVHKLKPELFSRSGTNDFFTPHK
WFSYMLLWGLSVPMFPQMFMRFYTPKNPNSLKLSASLYPLITCIMFICPVLIGMWGHINFPDLVGKEADKIFPMMLAEYT
STTMASLVMVGALAAFMSTLDSQLLALSSMITRDIYIVYIRPQATLTEQTFVGKILIVILAIIGLILAANPPATIAAIAT
QAFTGLAVLFPTVIAALYGKNISPLSCIISIIFGEIAVIGFQVNIIPKSWALGFLPVVPIVLICSLIIVVFLRK

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=450, Percent_Identity=28.4444444444444, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI87082237, Length=456, Percent_Identity=28.5087719298246, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1787251, Length=481, Percent_Identity=26.1954261954262, Blast_Score=108, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 52096; Mature: 52096

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKNLIPYLFISAYLLLTLVIGIIGYRSQKNTPEDYFLAERKIGSIVLFFTLIATNFSAF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHH
AFLGLSGAGYRIGISYYPMIGFGTALVGITFYFIGYKVWLLGKEKGLITPSELIANCLPS
HHEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHCCCC
QPLKLIFLAVMVIFTIPYLTLQPIGGGYMIENLTNGQIPYFWGAAFLTFIIVLYVFIGGM
CCHHHHHHHHHHHHHCCHHEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
KSVALTDVLQGVLMLILMIVAVVTISQSLGGLTEANQTVHKLKPELFSRSGTNDFFTPHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHCCCCCCCCCCHHH
WFSYMLLWGLSVPMFPQMFMRFYTPKNPNSLKLSASLYPLITCIMFICPVLIGMWGHINF
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCC
PDLVGKEADKIFPMMLAEYTSTTMASLVMVGALAAFMSTLDSQLLALSSMITRDIYIVYI
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
RPQATLTEQTFVGKILIVILAIIGLILAANPPATIAAIATQAFTGLAVLFPTVIAALYGK
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NISPLSCIISIIFGEIAVIGFQVNIIPKSWALGFLPVVPIVLICSLIIVVFLRK
CCCHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIKNLIPYLFISAYLLLTLVIGIIGYRSQKNTPEDYFLAERKIGSIVLFFTLIATNFSAF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHH
AFLGLSGAGYRIGISYYPMIGFGTALVGITFYFIGYKVWLLGKEKGLITPSELIANCLPS
HHEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHCCCC
QPLKLIFLAVMVIFTIPYLTLQPIGGGYMIENLTNGQIPYFWGAAFLTFIIVLYVFIGGM
CCHHHHHHHHHHHHHCCHHEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
KSVALTDVLQGVLMLILMIVAVVTISQSLGGLTEANQTVHKLKPELFSRSGTNDFFTPHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHCCCCCCCCCCHHH
WFSYMLLWGLSVPMFPQMFMRFYTPKNPNSLKLSASLYPLITCIMFICPVLIGMWGHINF
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCC
PDLVGKEADKIFPMMLAEYTSTTMASLVMVGALAAFMSTLDSQLLALSSMITRDIYIVYI
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
RPQATLTEQTFVGKILIVILAIIGLILAANPPATIAAIATQAFTGLAVLFPTVIAALYGK
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NISPLSCIISIIFGEIAVIGFQVNIIPKSWALGFLPVVPIVLICSLIIVVFLRK
CCCHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]