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The map label for this gene is tuaD [H]

Identifier: 113476098

GI number: 113476098

Start: 3810957

End: 3812372

Strand: Reverse

Name: tuaD [H]

Synonym: Tery_2477

Alternate gene names: 113476098

Gene position: 3812372-3810957 (Counterclockwise)

Preceding gene: 113476099

Following gene: 113476097

Centisome position: 49.19

GC content: 39.69

Gene sequence:

>1416_bases
ATGAAAATATTTTTTCTTTCTGTTGTTAAAATTTTAGAGGATATAAATATGCGTGTTTGTGTTATTGGTACTGGTTACGT
TGGTTTAGTGACGGGAGTTTGTTTGTCTTATATAGGACACCATGTAATTTGCATAGACAACAATGAAGAAAAAGTTAAGT
TGTTAAAATCAGGACAGTCTCCAATATACGAACCAGGACTGTCTGAGTTGATGCAAAGTAGTACTAAAACTGGTTTGCTA
GAGTTTACATCTGACTTGAAAGTGGGGGTCGAGCATGGTGATATTTTATTTATCGCTGTTGGTACTCCTCCACTGCCGAC
AGGAGAAAGTGATACTCGTTATGTGGAGGCAGTAGCAAAGGGTATAGGTGCTCATATGATTAAAGGTTACAAAGTAATTG
TTAATAAATCAACTGTACCTATTGGATCTGGTGACTGGGTACGGAGAATTGTTTTGGATGGTGTTGAGGAACATAAAAAA
GAAGAAGGGGGAACTCGTACAGAGATTGAAGTAGAGTTTGATGTAGTTAGTAACCCAGAGTTTTTGCGTGAAGGTTCGGC
TATCTTTGATACTTTTAACCCAGATAGAATTGTGTTGGGAAGTAATAGTCAAAAGGCATTAGATATGATGCAGGAACTTT
ATAGGCCTTTAGTAACACGCAAGTATGGTGATGAACAGTCTCTGCCACCAGTGCCAGTGGTAATTACAGATTTGAGCTCT
GCAGAAATGATTAAGTATGCTGCTAATTCTTTTTTGGCAACTAAGATTAGTTTTGTGAATGAGATTGCTAATATATGCGA
TCGCGTAGGTGCAGATGTGACTCAGGTTGCTAAGGGTATCGGATTAGATTCTCGTATTGGTAATAAGTTTTTACAGGCTG
GTCTTGGTTGGGGTGGTTCCTGTTTCCCGAAAGATATCTCTGCTTTGGTTCATACTGCTGATGACTATGGTTGTGAAGCA
CATTTGTTGAAAGCAGCAGTTGAGGTGAACAGGCGTCAACGGATGATAGTGGTGGATAAGTTACAGCAGTATTTGAAAAT
TCTCAAGGGTAAGACTATTGGGTTATTGGGTTTGACTTTTAAACCTGATACTGATGATATGCGGGATGCACCTTCTCTAG
ATTTGATTCAAGAGTTGAATAGGTTGGGGGCAAAGGTGAAGGCTTATGATCCAATTATTTCTCAGTCTGGTATACGTGAT
GGTTTAACAGGTGTACTTGTGGAGACTGACTCAGAAAGGCTTGCTGATACTTGTGATGCTTTGGTTTTGGTGACGGACTG
GGCACAGTTTCAAAAGTTAGACTATGGGAAGATGGTGAAGTCGATGGAGCATAATTTGTTTGTTGATGGTCGGAATTTCT
GCGATCGTAAACAGTTGGAAGCTGCTGGTTTTCAGTATGTGGGAATTGGGCATTAA

Upstream 100 bases:

>100_bases
TGTTACCTGTAGTAATTTTCAGTTATCTTTTTTGTGCTACTAGTTGGCAAAATTAAGTTAGATCTCAATAAACAAGAAAG
AATATTACAGTTTAATCTTT

Downstream 100 bases:

>100_bases
TTTTGTGGTTGAAACTTGAGAATTTTTGTCATGCTATAATGTAGGAATATTTTATAAATTTCCCTACATTTTATTGTTAA
GTCAAGCAATAGAAATTAAT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKIFFLSVVKILEDINMRVCVIGTGYVGLVTGVCLSYIGHHVICIDNNEEKVKLLKSGQSPIYEPGLSELMQSSTKTGLL
EFTSDLKVGVEHGDILFIAVGTPPLPTGESDTRYVEAVAKGIGAHMIKGYKVIVNKSTVPIGSGDWVRRIVLDGVEEHKK
EEGGTRTEIEVEFDVVSNPEFLREGSAIFDTFNPDRIVLGSNSQKALDMMQELYRPLVTRKYGDEQSLPPVPVVITDLSS
AEMIKYAANSFLATKISFVNEIANICDRVGADVTQVAKGIGLDSRIGNKFLQAGLGWGGSCFPKDISALVHTADDYGCEA
HLLKAAVEVNRRQRMIVVDKLQQYLKILKGKTIGLLGLTFKPDTDDMRDAPSLDLIQELNRLGAKVKAYDPIISQSGIRD
GLTGVLVETDSERLADTCDALVLVTDWAQFQKLDYGKMVKSMEHNLFVDGRNFCDRKQLEAAGFQYVGIGH

Sequences:

>Translated_471_residues
MKIFFLSVVKILEDINMRVCVIGTGYVGLVTGVCLSYIGHHVICIDNNEEKVKLLKSGQSPIYEPGLSELMQSSTKTGLL
EFTSDLKVGVEHGDILFIAVGTPPLPTGESDTRYVEAVAKGIGAHMIKGYKVIVNKSTVPIGSGDWVRRIVLDGVEEHKK
EEGGTRTEIEVEFDVVSNPEFLREGSAIFDTFNPDRIVLGSNSQKALDMMQELYRPLVTRKYGDEQSLPPVPVVITDLSS
AEMIKYAANSFLATKISFVNEIANICDRVGADVTQVAKGIGLDSRIGNKFLQAGLGWGGSCFPKDISALVHTADDYGCEA
HLLKAAVEVNRRQRMIVVDKLQQYLKILKGKTIGLLGLTFKPDTDDMRDAPSLDLIQELNRLGAKVKAYDPIISQSGIRD
GLTGVLVETDSERLADTCDALVLVTDWAQFQKLDYGKMVKSMEHNLFVDGRNFCDRKQLEAAGFQYVGIGH
>Mature_471_residues
MKIFFLSVVKILEDINMRVCVIGTGYVGLVTGVCLSYIGHHVICIDNNEEKVKLLKSGQSPIYEPGLSELMQSSTKTGLL
EFTSDLKVGVEHGDILFIAVGTPPLPTGESDTRYVEAVAKGIGAHMIKGYKVIVNKSTVPIGSGDWVRRIVLDGVEEHKK
EEGGTRTEIEVEFDVVSNPEFLREGSAIFDTFNPDRIVLGSNSQKALDMMQELYRPLVTRKYGDEQSLPPVPVVITDLSS
AEMIKYAANSFLATKISFVNEIANICDRVGADVTQVAKGIGLDSRIGNKFLQAGLGWGGSCFPKDISALVHTADDYGCEA
HLLKAAVEVNRRQRMIVVDKLQQYLKILKGKTIGLLGLTFKPDTDDMRDAPSLDLIQELNRLGAKVKAYDPIISQSGIRD
GLTGVLVETDSERLADTCDALVLVTDWAQFQKLDYGKMVKSMEHNLFVDGRNFCDRKQLEAAGFQYVGIGH

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=490, Percent_Identity=33.8775510204082, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI296040438, Length=388, Percent_Identity=34.7938144329897, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI296040443, Length=323, Percent_Identity=35.2941176470588, Blast_Score=178, Evalue=1e-44,
Organism=Escherichia coli, GI1788340, Length=409, Percent_Identity=27.8728606356968, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI48994968, Length=429, Percent_Identity=27.039627039627, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17560350, Length=475, Percent_Identity=33.8947368421053, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17136908, Length=482, Percent_Identity=31.9502074688797, Blast_Score=258, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51709; Mature: 51709

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIFFLSVVKILEDINMRVCVIGTGYVGLVTGVCLSYIGHHVICIDNNEEKVKLLKSGQS
CEEHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCC
PIYEPGLSELMQSSTKTGLLEFTSDLKVGVEHGDILFIAVGTPPLPTGESDTRYVEAVAK
CCCCCCHHHHHHCCCCCCHHEECCCCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHH
GIGAHMIKGYKVIVNKSTVPIGSGDWVRRIVLDGVEEHKKEEGGTRTEIEVEFDVVSNPE
HHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHCCCCEEEEEEEEEECCCHH
FLREGSAIFDTFNPDRIVLGSNSQKALDMMQELYRPLVTRKYGDEQSLPPVPVVITDLSS
HHHCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCH
AEMIKYAANSFLATKISFVNEIANICDRVGADVTQVAKGIGLDSRIGNKFLQAGLGWGGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCC
CFPKDISALVHTADDYGCEAHLLKAAVEVNRRQRMIVVDKLQQYLKILKGKTIGLLGLTF
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEE
KPDTDDMRDAPSLDLIQELNRLGAKVKAYDPIISQSGIRDGLTGVLVETDSERLADTCDA
CCCCCCCCCCCCHHHHHHHHHHCCEEECCCCHHHCCCCCCCCCEEEEECCCHHHHHHHCE
LVLVTDWAQFQKLDYGKMVKSMEHNLFVDGRNFCDRKQLEAAGFQYVGIGH
EEEEECHHHHHHCCHHHHHHHHCCCEEECCCCCCCHHHHHHCCEEEEECCC
>Mature Secondary Structure
MKIFFLSVVKILEDINMRVCVIGTGYVGLVTGVCLSYIGHHVICIDNNEEKVKLLKSGQS
CEEHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCC
PIYEPGLSELMQSSTKTGLLEFTSDLKVGVEHGDILFIAVGTPPLPTGESDTRYVEAVAK
CCCCCCHHHHHHCCCCCCHHEECCCCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHH
GIGAHMIKGYKVIVNKSTVPIGSGDWVRRIVLDGVEEHKKEEGGTRTEIEVEFDVVSNPE
HHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHCCCCEEEEEEEEEECCCHH
FLREGSAIFDTFNPDRIVLGSNSQKALDMMQELYRPLVTRKYGDEQSLPPVPVVITDLSS
HHHCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCH
AEMIKYAANSFLATKISFVNEIANICDRVGADVTQVAKGIGLDSRIGNKFLQAGLGWGGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCC
CFPKDISALVHTADDYGCEAHLLKAAVEVNRRQRMIVVDKLQQYLKILKGKTIGLLGLTF
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEE
KPDTDDMRDAPSLDLIQELNRLGAKVKAYDPIISQSGIRDGLTGVLVETDSERLADTCDA
CCCCCCCCCCCCHHHHHHHHHHCCEEECCCCHHHCCCCCCCCCEEEEECCCHHHHHHHCE
LVLVTDWAQFQKLDYGKMVKSMEHNLFVDGRNFCDRKQLEAAGFQYVGIGH
EEEEECHHHHHHCCHHHHHHHHCCCEEECCCCCCCHHHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]