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The map label for this gene is uppS1 [H]

Identifier: 113476060

GI number: 113476060

Start: 3747453

End: 3748199

Strand: Reverse

Name: uppS1 [H]

Synonym: Tery_2432

Alternate gene names: 113476060

Gene position: 3748199-3747453 (Counterclockwise)

Preceding gene: 113476061

Following gene: 113476054

Centisome position: 48.36

GC content: 38.42

Gene sequence:

>747_bases
ATGAATCAAGGAACTTGCTTACAAGATTTACCTGTCGATCTGGAACCAGAAAGGTTACCTCATCATGTGGCTGTGATTAT
GGATGGTAATGGTCGTTGGGCTCAAAGTCGTGGTTTACCTCGAATTATGGGCCATAGAAAGGGAGTGGAAACACTTAAGG
ACTTACTGCGATGTTGTAGAGATTGGGGTCTAGAAGCTTTAACAGCTTACGCTTTTTCTAGTGAAAATTGGGGAAGACCA
CTAGAAGAAGTGAATTTTCTGATGACTTTGTTTGAAAAAGTTTTGCGCCAAGAACTGCAAGAGATAGTCGCAGAAGATGT
TCAAATTAGATTTGTGGGTAATTTAAGTTCTTTGCCTGTATCTTTACAAGCTGAGATTAAACACTCAATGGAGATGACTC
GGCCAAATCAGGGAATTAAATTTACTGTCGCTACTAATTATGGAGGACGCCAGGAAATTGTACACGCTTGTAAGGCGATC
GGCACCCAAATACAAAAAGGTTTGCTTAAGCCAGAAGAAATTAATGAAGGACTTTTTGAAAAATACCTTTATACTGCTGG
TATTTCTCACCCAGATTTATTAATTCGTACTAGTGGGGAAATGCGTATTAGTAATTTTTTACTATGGCAAATGGCTTATT
CAGAAATTTATGTCACTCAGACACTTTGGCCTGACTTTAATCGTTATGAATTTCATCGGGCTTTGTGTGCTTATCAGAAG
CGTGAACGTAGATTTGGTAAAATTTAA

Upstream 100 bases:

>100_bases
CACTTCCTTTAGTTAATATTGGACGTCAAATAGGATCAAAAGGATCACAATTAATTTCATGGGTACTTCATCAAAGTCCA
TCAGGTCCTCGAAAGAAAAG

Downstream 100 bases:

>100_bases
TTAACTCTAGTCCAACTAGGGGCCGGAAAAAATAGCTTCTTCAATATCCCGGCGACTTAAGGAATATGTAAAAGAGCGTT
GAATATCACTACCATCAACA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1 [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MNQGTCLQDLPVDLEPERLPHHVAVIMDGNGRWAQSRGLPRIMGHRKGVETLKDLLRCCRDWGLEALTAYAFSSENWGRP
LEEVNFLMTLFEKVLRQELQEIVAEDVQIRFVGNLSSLPVSLQAEIKHSMEMTRPNQGIKFTVATNYGGRQEIVHACKAI
GTQIQKGLLKPEEINEGLFEKYLYTAGISHPDLLIRTSGEMRISNFLLWQMAYSEIYVTQTLWPDFNRYEFHRALCAYQK
RERRFGKI

Sequences:

>Translated_248_residues
MNQGTCLQDLPVDLEPERLPHHVAVIMDGNGRWAQSRGLPRIMGHRKGVETLKDLLRCCRDWGLEALTAYAFSSENWGRP
LEEVNFLMTLFEKVLRQELQEIVAEDVQIRFVGNLSSLPVSLQAEIKHSMEMTRPNQGIKFTVATNYGGRQEIVHACKAI
GTQIQKGLLKPEEINEGLFEKYLYTAGISHPDLLIRTSGEMRISNFLLWQMAYSEIYVTQTLWPDFNRYEFHRALCAYQK
RERRFGKI
>Mature_248_residues
MNQGTCLQDLPVDLEPERLPHHVAVIMDGNGRWAQSRGLPRIMGHRKGVETLKDLLRCCRDWGLEALTAYAFSSENWGRP
LEEVNFLMTLFEKVLRQELQEIVAEDVQIRFVGNLSSLPVSLQAEIKHSMEMTRPNQGIKFTVATNYGGRQEIVHACKAI
GTQIQKGLLKPEEINEGLFEKYLYTAGISHPDLLIRTSGEMRISNFLLWQMAYSEIYVTQTLWPDFNRYEFHRALCAYQK
RERRFGKI

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=37.7777777777778, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=37.9464285714286, Blast_Score=159, Evalue=2e-39,
Organism=Escherichia coli, GI1786371, Length=234, Percent_Identity=44.4444444444444, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=36.283185840708, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=237, Percent_Identity=35.8649789029536, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=224, Percent_Identity=35.2678571428571, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=39.9122807017544, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28644; Mature: 28644

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQGTCLQDLPVDLEPERLPHHVAVIMDGNGRWAQSRGLPRIMGHRKGVETLKDLLRCCR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCHHHHHCCCCHHHHHHHHHHHH
DWGLEALTAYAFSSENWGRPLEEVNFLMTLFEKVLRQELQEIVAEDVQIRFVGNLSSLPV
HHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCC
SLQAEIKHSMEMTRPNQGIKFTVATNYGGRQEIVHACKAIGTQIQKGLLKPEEINEGLFE
HHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KYLYTAGISHPDLLIRTSGEMRISNFLLWQMAYSEIYVTQTLWPDFNRYEFHRALCAYQK
HHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHEEEHHCCCCCCHHHHHHHHHHHHH
RERRFGKI
HHHHCCCC
>Mature Secondary Structure
MNQGTCLQDLPVDLEPERLPHHVAVIMDGNGRWAQSRGLPRIMGHRKGVETLKDLLRCCR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCHHHHHCCCCHHHHHHHHHHHH
DWGLEALTAYAFSSENWGRPLEEVNFLMTLFEKVLRQELQEIVAEDVQIRFVGNLSSLPV
HHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCC
SLQAEIKHSMEMTRPNQGIKFTVATNYGGRQEIVHACKAIGTQIQKGLLKPEEINEGLFE
HHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KYLYTAGISHPDLLIRTSGEMRISNFLLWQMAYSEIYVTQTLWPDFNRYEFHRALCAYQK
HHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHEEEHHCCCCCCHHHHHHHHHHHHH
RERRFGKI
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]