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The map label for this gene is vipA [H]

Identifier: 113475907

GI number: 113475907

Start: 3528353

End: 3529612

Strand: Reverse

Name: vipA [H]

Synonym: Tery_2267

Alternate gene names: 113475907

Gene position: 3529612-3528353 (Counterclockwise)

Preceding gene: 113475908

Following gene: 113475906

Centisome position: 45.54

GC content: 38.89

Gene sequence:

>1260_bases
ATGCAGAACATTAAAATAGCTGTGATTGGTTTAGGATATGTTGGTTTACCCCTTGCGGTTGAATTTGCTCAAAAGTTTCC
AACCCTTGGGTTTGACATTTCACAAACGCGAGTTGAACAACTGAATCAAGGATTTGATAGCACCCTCGAAGTTGACAACG
ATTATTTAGCTTCAGTTATATCTGAAACAGGATTTCGCGTCACCACCTCTATTGAGGATATTGCTAATTGCAATATTTAT
ATTGTAACTGTACCAACTCCGATTGACCGACACAAACAACCAAATTTAGTTCCTTTAATTCAAGCCAGCGAAGCAGTTGG
TAAAATTCTTAAAAAGGATGATATAGTCATTTATGAATCTACTGTTTATCCGGGCACAACAGAGGAAGAATGCGTTCCTG
TGTTAGAAAAGATTTCAGGTTTAAAATTTAACCAAGACTTTTTCTGTGGTTACTCCCCTGAGCGCATTAATCCTGGTGAC
AAGATACACACAGTTACCAAAGTTAAAAAAGTCACTTCAGGTTCGACGCCTGAAATAGCTCAAAAAGTTGATGCACTCTA
TAATACGATTGTCATAGCTGGAACCCATTTAGCATCTTCTATAAGAGTTGCTGAGGCAGCTAAAGTAATTGAAAACTCTC
AACGAGATATTAATATTGCTTTTGTCAATGAGTTGGCGATTATTTTTAATAAAATGGGGATCAAAACTAGGGAAGTGTTA
GAGGCAGCCGCTACTAAATGGAATTTCTTGCCTTTTCAACCAGGACTGGTGGGGGGACACTGTATCGGAGTAGATCCATA
CTATTTAACGTACAAGGCCCAGGAACTAGGCTATCACCCAGAAATTATTCTTGCAGGACGACGCCTCAATGATAATATGG
GAATTTATGTTGCTAAGCAGGTTGTTAAGCTCGCGATTAAAAAGGGGCAAAAAGTTGAGGGTGCTGCTGTTCTAATTTTG
GGTATTACTTTTAAGGAAAATTGTTCGGATATTCGTAATTCTAAAGTAATAGATTTAATTCGTGAATTAGAAGATTTTGG
TTGTGTTGTAGATGTTTATGACCCTTGGGCATTGCCAGAGGAGGTTAAGCAGGAGCATGATATTGATATTTTAAGCGATC
TACCAAAACTTGCTAGCTATCAGGCAATTGTACTGGCTGTTGCCCACGATGAATTTAAACAGCTTCCTTTGGCTAAGAAT
GACGGGCAAGTTATTTTTGACGTCAAGTCCTTTTTGCCCTCGGCGGATGCAACGCTTTAG

Upstream 100 bases:

>100_bases
TACTTTAAAAAATTTCCAACAGATGCAACCTTTTTTGAAAGCTGGTCTGTTGATTAATTTTTGTGCAAAAAAATAAAGTA
TATTTTTCATCAAATAAAAA

Downstream 100 bases:

>100_bases
AGATTGTGGCTACACAACTTAGATTAAATAGGGCTTTGTTGCATGAAAGTGACGACAAAAGTCAAAACCCAGGTAATTTT
TTAGGACTTAAAAAGGCTAA

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MQNIKIAVIGLGYVGLPLAVEFAQKFPTLGFDISQTRVEQLNQGFDSTLEVDNDYLASVISETGFRVTTSIEDIANCNIY
IVTVPTPIDRHKQPNLVPLIQASEAVGKILKKDDIVIYESTVYPGTTEEECVPVLEKISGLKFNQDFFCGYSPERINPGD
KIHTVTKVKKVTSGSTPEIAQKVDALYNTIVIAGTHLASSIRVAEAAKVIENSQRDINIAFVNELAIIFNKMGIKTREVL
EAAATKWNFLPFQPGLVGGHCIGVDPYYLTYKAQELGYHPEIILAGRRLNDNMGIYVAKQVVKLAIKKGQKVEGAAVLIL
GITFKENCSDIRNSKVIDLIRELEDFGCVVDVYDPWALPEEVKQEHDIDILSDLPKLASYQAIVLAVAHDEFKQLPLAKN
DGQVIFDVKSFLPSADATL

Sequences:

>Translated_419_residues
MQNIKIAVIGLGYVGLPLAVEFAQKFPTLGFDISQTRVEQLNQGFDSTLEVDNDYLASVISETGFRVTTSIEDIANCNIY
IVTVPTPIDRHKQPNLVPLIQASEAVGKILKKDDIVIYESTVYPGTTEEECVPVLEKISGLKFNQDFFCGYSPERINPGD
KIHTVTKVKKVTSGSTPEIAQKVDALYNTIVIAGTHLASSIRVAEAAKVIENSQRDINIAFVNELAIIFNKMGIKTREVL
EAAATKWNFLPFQPGLVGGHCIGVDPYYLTYKAQELGYHPEIILAGRRLNDNMGIYVAKQVVKLAIKKGQKVEGAAVLIL
GITFKENCSDIRNSKVIDLIRELEDFGCVVDVYDPWALPEEVKQEHDIDILSDLPKLASYQAIVLAVAHDEFKQLPLAKN
DGQVIFDVKSFLPSADATL
>Mature_419_residues
MQNIKIAVIGLGYVGLPLAVEFAQKFPTLGFDISQTRVEQLNQGFDSTLEVDNDYLASVISETGFRVTTSIEDIANCNIY
IVTVPTPIDRHKQPNLVPLIQASEAVGKILKKDDIVIYESTVYPGTTEEECVPVLEKISGLKFNQDFFCGYSPERINPGD
KIHTVTKVKKVTSGSTPEIAQKVDALYNTIVIAGTHLASSIRVAEAAKVIENSQRDINIAFVNELAIIFNKMGIKTREVL
EAAATKWNFLPFQPGLVGGHCIGVDPYYLTYKAQELGYHPEIILAGRRLNDNMGIYVAKQVVKLAIKKGQKVEGAAVLIL
GITFKENCSDIRNSKVIDLIRELEDFGCVVDVYDPWALPEEVKQEHDIDILSDLPKLASYQAIVLAVAHDEFKQLPLAKN
DGQVIFDVKSFLPSADATL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=430, Percent_Identity=31.3953488372093, Blast_Score=168, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17560350, Length=466, Percent_Identity=23.175965665236, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17136908, Length=430, Percent_Identity=24.4186046511628, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46211; Mature: 46211

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNIKIAVIGLGYVGLPLAVEFAQKFPTLGFDISQTRVEQLNQGFDSTLEVDNDYLASVI
CCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEECCHHHHHHHH
SETGFRVTTSIEDIANCNIYIVTVPTPIDRHKQPNLVPLIQASEAVGKILKKDDIVIYES
HHCCCEEEECHHHHHCCCEEEEECCCCCCCCCCCCEEEEEECHHHHHHHHCCCCEEEEEE
TVYPGTTEEECVPVLEKISGLKFNQDFFCGYSPERINPGDKIHTVTKVKKVTSGSTPEIA
EECCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
QKVDALYNTIVIAGTHLASSIRVAEAAKVIENSQRDINIAFVNELAIIFNKMGIKTREVL
HHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCHHHHH
EAAATKWNFLPFQPGLVGGHCIGVDPYYLTYKAQELGYHPEIILAGRRLNDNMGIYVAKQ
HHHHHCCCCCCCCCCCCCCEEECCCCEEEEEEHHHCCCCCEEEEECCEECCCCCHHHHHH
VVKLAIKKGQKVEGAAVLILGITFKENCSDIRNSKVIDLIRELEDFGCVVDVYDPWALPE
HHHHHHHCCCCCCCEEEEEEEEEEHHHHHHHHCHHHHHHHHHHHHCCCEEEECCCCCCCH
EVKQEHDIDILSDLPKLASYQAIVLAVAHDEFKQLPLAKNDGQVIFDVKSFLPSADATL
HHHHHCCCHHHHHCHHHHCCEEEEEEEECHHHHHCCCCCCCCCEEEEHHHHCCCCCCCC
>Mature Secondary Structure
MQNIKIAVIGLGYVGLPLAVEFAQKFPTLGFDISQTRVEQLNQGFDSTLEVDNDYLASVI
CCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEECCHHHHHHHH
SETGFRVTTSIEDIANCNIYIVTVPTPIDRHKQPNLVPLIQASEAVGKILKKDDIVIYES
HHCCCEEEECHHHHHCCCEEEEECCCCCCCCCCCCEEEEEECHHHHHHHHCCCCEEEEEE
TVYPGTTEEECVPVLEKISGLKFNQDFFCGYSPERINPGDKIHTVTKVKKVTSGSTPEIA
EECCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
QKVDALYNTIVIAGTHLASSIRVAEAAKVIENSQRDINIAFVNELAIIFNKMGIKTREVL
HHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCHHHHH
EAAATKWNFLPFQPGLVGGHCIGVDPYYLTYKAQELGYHPEIILAGRRLNDNMGIYVAKQ
HHHHHCCCCCCCCCCCCCCEEECCCCEEEEEEHHHCCCCCEEEEECCEECCCCCHHHHHH
VVKLAIKKGQKVEGAAVLILGITFKENCSDIRNSKVIDLIRELEDFGCVVDVYDPWALPE
HHHHHHHCCCCCCCEEEEEEEEEEHHHHHHHHCHHHHHHHHHHHHCCCEEEECCCCCCCH
EVKQEHDIDILSDLPKLASYQAIVLAVAHDEFKQLPLAKNDGQVIFDVKSFLPSADATL
HHHHHCCCHHHHHCHHHHCCEEEEEEEECHHHHHCCCCCCCCCEEEEHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]