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The map label for this gene is upp [H]

Identifier: 113475833

GI number: 113475833

Start: 3417970

End: 3418620

Strand: Reverse

Name: upp [H]

Synonym: Tery_2191

Alternate gene names: 113475833

Gene position: 3418620-3417970 (Counterclockwise)

Preceding gene: 113475836

Following gene: 113475832

Centisome position: 44.11

GC content: 43.01

Gene sequence:

>651_bases
ATGGCTTTGCAACTTCGTGTTTATGTCCCACCCCATCCATTAGTCAAACATTGGTTAGGAGTAGCTCGTGACCTTAATAC
GCCTTCTCCTCTATTTCGTTCTGCCATAACAGAGTTAGGTAAATGGTTAACTTATGAAGCAATTCGAGATTGGTTACCTG
TCGTAGAAACAAATGTACAGACTCCTTTAGCTGAATGTTCGGCTACTTTTGTCCATCCTCAAGCTCCCATGGTAGTAATA
CCTATCCTCCGAGCCGGTCTAGGATTACTAGAAGGCGCTCAAACTGTCTTGCCCTTGGCATCTATCTATCATTTGGGAAT
GGTCAGGAATGAAGAAACTCTCGAAGCTAATTGTTATTTCAATAAGCTTCCCTCCCAATTTGACTCGAATGTTCGGGTTT
TGATTTGCGACCCAATGTTAGCTACTGGTGGCACAATTATGCAGGCAATGGCGGAATTAACTCATCGTGGAGTTGACCCT
GCTGCTATAAGAATTATTTCTGTAGTAGCTGCTAAACCTGCTCTACAAAAACTGGGTAGCACTTATCCTAGCTTGGCTAT
CTATACGGCAACTATTGATGAGATTGTAAATGATGTTGGTTATATTGTGCCGGGCCTTGGTGATGCGGGGGATCGATTTT
TTGGTACTTAG

Upstream 100 bases:

>100_bases
GGATTTATTGCTCTATATTGACTTTTTGTTCAACTCAGAAAGTTTTGTAGATTAAGTTTCTACATAAGTCCTAAAACTAA
TTTTTTTTACTTTTGTAATC

Downstream 100 bases:

>100_bases
TGATTGGCCACTAAGACTTACCTAATCTTAATTAAATTTTGACATTAAATTTCATAATCTGTTATTCTAGATATATAAAC
ATGTAATATAAGTAATTAGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MALQLRVYVPPHPLVKHWLGVARDLNTPSPLFRSAITELGKWLTYEAIRDWLPVVETNVQTPLAECSATFVHPQAPMVVI
PILRAGLGLLEGAQTVLPLASIYHLGMVRNEETLEANCYFNKLPSQFDSNVRVLICDPMLATGGTIMQAMAELTHRGVDP
AAIRIISVVAAKPALQKLGSTYPSLAIYTATIDEIVNDVGYIVPGLGDAGDRFFGT

Sequences:

>Translated_216_residues
MALQLRVYVPPHPLVKHWLGVARDLNTPSPLFRSAITELGKWLTYEAIRDWLPVVETNVQTPLAECSATFVHPQAPMVVI
PILRAGLGLLEGAQTVLPLASIYHLGMVRNEETLEANCYFNKLPSQFDSNVRVLICDPMLATGGTIMQAMAELTHRGVDP
AAIRIISVVAAKPALQKLGSTYPSLAIYTATIDEIVNDVGYIVPGLGDAGDRFFGT
>Mature_215_residues
ALQLRVYVPPHPLVKHWLGVARDLNTPSPLFRSAITELGKWLTYEAIRDWLPVVETNVQTPLAECSATFVHPQAPMVVIP
ILRAGLGLLEGAQTVLPLASIYHLGMVRNEETLEANCYFNKLPSQFDSNVRVLICDPMLATGGTIMQAMAELTHRGVDPA
AIRIISVVAAKPALQKLGSTYPSLAIYTATIDEIVNDVGYIVPGLGDAGDRFFGT

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=204, Percent_Identity=27.9411764705882, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI57863312, Length=204, Percent_Identity=27.9411764705882, Blast_Score=78, Evalue=6e-15,
Organism=Escherichia coli, GI87082118, Length=212, Percent_Identity=40.5660377358491, Blast_Score=154, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17539892, Length=143, Percent_Identity=25.1748251748252, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539894, Length=143, Percent_Identity=25.1748251748252, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321920, Length=205, Percent_Identity=30.7317073170732, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=26.6990291262136, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=26.6990291262136, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=26.6990291262136, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=26.6990291262136, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23490; Mature: 23358

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQLRVYVPPHPLVKHWLGVARDLNTPSPLFRSAITELGKWLTYEAIRDWLPVVETNVQ
CEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPLAECSATFVHPQAPMVVIPILRAGLGLLEGAQTVLPLASIYHLGMVRNEETLEANCYF
CCHHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHH
NKLPSQFDSNVRVLICDPMLATGGTIMQAMAELTHRGVDPAAIRIISVVAAKPALQKLGS
HHCCHHHCCCCEEEEECCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCC
TYPSLAIYTATIDEIVNDVGYIVPGLGDAGDRFFGT
CCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALQLRVYVPPHPLVKHWLGVARDLNTPSPLFRSAITELGKWLTYEAIRDWLPVVETNVQ
EEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPLAECSATFVHPQAPMVVIPILRAGLGLLEGAQTVLPLASIYHLGMVRNEETLEANCYF
CCHHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHH
NKLPSQFDSNVRVLICDPMLATGGTIMQAMAELTHRGVDPAAIRIISVVAAKPALQKLGS
HHCCHHHCCCCEEEEECCHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCC
TYPSLAIYTATIDEIVNDVGYIVPGLGDAGDRFFGT
CCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]