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The map label for this gene is lktA [H]

Identifier: 113475708

GI number: 113475708

Start: 3204998

End: 3206956

Strand: Reverse

Name: lktA [H]

Synonym: Tery_2055

Alternate gene names: 113475708

Gene position: 3206956-3204998 (Counterclockwise)

Preceding gene: 113475716

Following gene: 113475705

Centisome position: 41.38

GC content: 39.46

Gene sequence:

>1959_bases
ATGGCTCGTTATTCATTTGACAAATTTTTTTTTGGACCTTCTTTATTTATCTCAGAACAACAGGAAGTTCCACCTGTAGA
AGATAGTCCAGCTGTAGGGGGTTTTACTGCATTATTACTTGATAATATATTATTAATAGATGGCAAATTTAAGGAGCTAT
CAAGTCCTCTACTTCCTTTAGGAGGAGTAGACTCAGAGGAAAATATTGAAAGCCCCATTCATCTTCATCAGGGTGAAATA
GGTCAGAATGGAGGTATTGTCCGCAACTTAAATAGATTTGAAATTGATGATCGTTCTGGTAGATTTAATGGAGCTTTTAC
CCTCACAGATCCAGAGCTAGAAACAGCAAAAGCAGACGCGTTTTATATAAATCTCCACACAGAAAATAACCCAAGTGGAG
AACTACGGGGACAGGTAAATTTTTTAGATGGTTTACAAATATCATTTGGCCTTGGGTTGCCCATGTCAGAATCTTTTGAA
GTACCCCCAGTAGCAGATAGTCCCGCTGAAGGAATAATAAATGCGACTCTGGATGATAATACACTGATAATACAAGGAAC
TTTTTCAGGTTTATCAAGCGATTTATTTTCGGTGGGAGGTACAGACTTAGAGGGAAATGCTGAAAGTTCTGTTCACTTGC
ATCAGGGATTAGCTAATTCTACTGGTGGAATTGCCCGTAATTTCAATGTCACTGATAATGGTGACGGTTCAGGTGGATTT
TTGGGATCCTTTTCTTTGAGTGATGATGAGGTCGTAGCTGCAAAGTCAGGGAACTTTTATGTGAATTTGCACACAGAAAA
TAATCTGGGTGGTGAGTTACGCGCACAAGTTCTTGTCAACGAGACAGCTCCAGGGAACGATGCTCTAGTAGGATTTTTAC
CAATGTTAGAATCTCAAGTCGTTGACTTAGATTCAAATACCCAGGCTGGAGGAGTCTTTTCTAGTGAACTTTTGGGCAAT
AATTTTAATATATTTGGACGTTTTTTTGGGCTGTCGAGTGACTTATTTAATGTCGGACCAGAGCAGGACTCAGAGGGAAA
TTCTCAAAGCTCGGCTCAACTTTATTTGGGAGAAATTGGCGAGAATGGTGCATTTTTACGCAACTTAACTGTATTTGAAA
CTGATGGTAACTCTGGTTTCTTCTCTGGTAACTTTACTTTGGATGAGACTGAAGTGGCTGCAGTAGAGTCAGGAGGAGTT
TATATTAACCTGCATACACAAAATAATCAGAGTGGTGAGTTGCGCGGACAGGTTATCTTAGAAAATATGAATACTGTAAT
TCCTGTTGAGAATGTGGTTTTCAATGGAGATAAACGGGATAACAATATTCAAGCAGGTTTTGCTGACGATAAGGTAAGGG
GTTTTGCTGGAGATGATCGCCTAAATGGACTGGCAGGCAATGACCGAATTCTTGGTGATGATGGTAATGACACTCTGATA
GGCGCCAGGGGTAATGATACTCTTTTGGGTCAGGATGGTGATGATTTTTTACAAGGTCGTCCAGGGTTTGATATATTGCT
TGGAGGAAGGGGTGATGATACTCTTAATGGTGGTCAAGGTCGCGATCGCCTGAATGGTGGTCCTGGAGACGATGAATTAA
CTGGTGGAGCCAGTATAGATAGATTTATCTTTAACACCAATAAAGAATTTAATTCTCAGGATATAGGTACAGATAGAATT
ACTGATTTTAATATTGGTCAAGATAGAATCTTGCTTGACTTGGATACTTTTACTGCTCTAGATAGTTCTGCTGATGCTGG
TTTATCTGAAGATGATTTTGCTACTGTCTCTAGTGAAAGTGATGCCGAAACTGCTGAAGCTGCTATTGTTTACAACTCTG
TTAGCGGAGCGTTATATTATAATACTAACGGCAGTGAAGATGGTTTTGGTATTGGAGCTGAGTTTGCTAATTTAGATAAT
AGTCCAGTTTTAGCTACTAGTAATTTTCAACTTAGGTAG

Upstream 100 bases:

>100_bases
CAGTAAAAGCAAGAGATGTTGCATGTAATGTCTGTACACATCAATTTTTTACCGAATTTAAAGCTTTGTATTAGTTTTAC
AACTAGAAAGGAGATTTATA

Downstream 100 bases:

>100_bases
AAGCTTGAAAGCAAATTTGCTTTTTAGAAGAGTTGTTTATTTTTCCTCAACAGCTCTTCAGAATAATTGAAGTAGTAAGT
GCCAATTCTATCTTTTTTAA

Product: hemolysin-type calcium-binding protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MARYSFDKFFFGPSLFISEQQEVPPVEDSPAVGGFTALLLDNILLIDGKFKELSSPLLPLGGVDSEENIESPIHLHQGEI
GQNGGIVRNLNRFEIDDRSGRFNGAFTLTDPELETAKADAFYINLHTENNPSGELRGQVNFLDGLQISFGLGLPMSESFE
VPPVADSPAEGIINATLDDNTLIIQGTFSGLSSDLFSVGGTDLEGNAESSVHLHQGLANSTGGIARNFNVTDNGDGSGGF
LGSFSLSDDEVVAAKSGNFYVNLHTENNLGGELRAQVLVNETAPGNDALVGFLPMLESQVVDLDSNTQAGGVFSSELLGN
NFNIFGRFFGLSSDLFNVGPEQDSEGNSQSSAQLYLGEIGENGAFLRNLTVFETDGNSGFFSGNFTLDETEVAAVESGGV
YINLHTQNNQSGELRGQVILENMNTVIPVENVVFNGDKRDNNIQAGFADDKVRGFAGDDRLNGLAGNDRILGDDGNDTLI
GARGNDTLLGQDGDDFLQGRPGFDILLGGRGDDTLNGGQGRDRLNGGPGDDELTGGASIDRFIFNTNKEFNSQDIGTDRI
TDFNIGQDRILLDLDTFTALDSSADAGLSEDDFATVSSESDAETAEAAIVYNSVSGALYYNTNGSEDGFGIGAEFANLDN
SPVLATSNFQLR

Sequences:

>Translated_652_residues
MARYSFDKFFFGPSLFISEQQEVPPVEDSPAVGGFTALLLDNILLIDGKFKELSSPLLPLGGVDSEENIESPIHLHQGEI
GQNGGIVRNLNRFEIDDRSGRFNGAFTLTDPELETAKADAFYINLHTENNPSGELRGQVNFLDGLQISFGLGLPMSESFE
VPPVADSPAEGIINATLDDNTLIIQGTFSGLSSDLFSVGGTDLEGNAESSVHLHQGLANSTGGIARNFNVTDNGDGSGGF
LGSFSLSDDEVVAAKSGNFYVNLHTENNLGGELRAQVLVNETAPGNDALVGFLPMLESQVVDLDSNTQAGGVFSSELLGN
NFNIFGRFFGLSSDLFNVGPEQDSEGNSQSSAQLYLGEIGENGAFLRNLTVFETDGNSGFFSGNFTLDETEVAAVESGGV
YINLHTQNNQSGELRGQVILENMNTVIPVENVVFNGDKRDNNIQAGFADDKVRGFAGDDRLNGLAGNDRILGDDGNDTLI
GARGNDTLLGQDGDDFLQGRPGFDILLGGRGDDTLNGGQGRDRLNGGPGDDELTGGASIDRFIFNTNKEFNSQDIGTDRI
TDFNIGQDRILLDLDTFTALDSSADAGLSEDDFATVSSESDAETAEAAIVYNSVSGALYYNTNGSEDGFGIGAEFANLDN
SPVLATSNFQLR
>Mature_651_residues
ARYSFDKFFFGPSLFISEQQEVPPVEDSPAVGGFTALLLDNILLIDGKFKELSSPLLPLGGVDSEENIESPIHLHQGEIG
QNGGIVRNLNRFEIDDRSGRFNGAFTLTDPELETAKADAFYINLHTENNPSGELRGQVNFLDGLQISFGLGLPMSESFEV
PPVADSPAEGIINATLDDNTLIIQGTFSGLSSDLFSVGGTDLEGNAESSVHLHQGLANSTGGIARNFNVTDNGDGSGGFL
GSFSLSDDEVVAAKSGNFYVNLHTENNLGGELRAQVLVNETAPGNDALVGFLPMLESQVVDLDSNTQAGGVFSSELLGNN
FNIFGRFFGLSSDLFNVGPEQDSEGNSQSSAQLYLGEIGENGAFLRNLTVFETDGNSGFFSGNFTLDETEVAAVESGGVY
INLHTQNNQSGELRGQVILENMNTVIPVENVVFNGDKRDNNIQAGFADDKVRGFAGDDRLNGLAGNDRILGDDGNDTLIG
ARGNDTLLGQDGDDFLQGRPGFDILLGGRGDDTLNGGQGRDRLNGGPGDDELTGGASIDRFIFNTNKEFNSQDIGTDRIT
DFNIGQDRILLDLDTFTALDSSADAGLSEDDFATVSSESDAETAEAAIVYNSVSGALYYNTNGSEDGFGIGAEFANLDNS
PVLATSNFQLR

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 69230; Mature: 69099

Theoretical pI: Translated: 3.77; Mature: 3.77

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARYSFDKFFFGPSLFISEQQEVPPVEDSPAVGGFTALLLDNILLIDGKFKELSSPLLPL
CCCCCCCCEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHCCEEEECCCHHHHCCCCCCC
GGVDSEENIESPIHLHQGEIGQNGGIVRNLNRFEIDDRSGRFNGAFTLTDPELETAKADA
CCCCCHHCCCCCEEEECCCCCCCCCEEECCCEEEECCCCCCCCCEEEEECCCCCCCCCCE
FYINLHTENNPSGELRGQVNFLDGLQISFGLGLPMSESFEVPPVADSPAEGIINATLDDN
EEEEEECCCCCCCCEEEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCC
TLIIQGTFSGLSSDLFSVGGTDLEGNAESSVHLHQGLANSTGGIARNFNVTDNGDGSGGF
EEEEEEECCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCCCE
LGSFSLSDDEVVAAKSGNFYVNLHTENNLGGELRAQVLVNETAPGNDALVGFLPMLESQV
EEEECCCCCCEEEEECCCEEEEEEECCCCCCEEEEEEEEECCCCCCCCEEEEHHHHCCEE
VDLDSNTQAGGVFSSELLGNNFNIFGRFFGLSSDLFNVGPEQDSEGNSQSSAQLYLGEIG
EECCCCCCCCCEEEHHHHCCCCEEEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEEECC
ENGAFLRNLTVFETDGNSGFFSGNFTLDETEVAAVESGGVYINLHTQNNQSGELRGQVIL
CCCEEEEEEEEEEECCCCCEEECCEEECCCEEEEEECCCEEEEEEECCCCCCCEEEEEEE
ENMNTVIPVENVVFNGDKRDNNIQAGFADDKVRGFAGDDRLNGLAGNDRILGDDGNDTLI
ECCCCEEEECCEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCEE
GARGNDTLLGQDGDDFLQGRPGFDILLGGRGDDTLNGGQGRDRLNGGPGDDELTGGASID
EECCCCEEECCCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
RFIFNTNKEFNSQDIGTDRITDFNIGQDRILLDLDTFTALDSSADAGLSEDDFATVSSES
EEEEECCCCCCCCCCCCCCEEECCCCCCEEEEEECHHHCCCCCCCCCCCCCCCEEECCCC
DAETAEAAIVYNSVSGALYYNTNGSEDGFGIGAEFANLDNSPVLATSNFQLR
CCCCCEEEEEEECCCCEEEECCCCCCCCCCCCHHHHCCCCCCEEEECCCEEC
>Mature Secondary Structure 
ARYSFDKFFFGPSLFISEQQEVPPVEDSPAVGGFTALLLDNILLIDGKFKELSSPLLPL
CCCCCCCEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHCCEEEECCCHHHHCCCCCCC
GGVDSEENIESPIHLHQGEIGQNGGIVRNLNRFEIDDRSGRFNGAFTLTDPELETAKADA
CCCCCHHCCCCCEEEECCCCCCCCCEEECCCEEEECCCCCCCCCEEEEECCCCCCCCCCE
FYINLHTENNPSGELRGQVNFLDGLQISFGLGLPMSESFEVPPVADSPAEGIINATLDDN
EEEEEECCCCCCCCEEEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCC
TLIIQGTFSGLSSDLFSVGGTDLEGNAESSVHLHQGLANSTGGIARNFNVTDNGDGSGGF
EEEEEEECCCCCHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCCCE
LGSFSLSDDEVVAAKSGNFYVNLHTENNLGGELRAQVLVNETAPGNDALVGFLPMLESQV
EEEECCCCCCEEEEECCCEEEEEEECCCCCCEEEEEEEEECCCCCCCCEEEEHHHHCCEE
VDLDSNTQAGGVFSSELLGNNFNIFGRFFGLSSDLFNVGPEQDSEGNSQSSAQLYLGEIG
EECCCCCCCCCEEEHHHHCCCCEEEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEEECC
ENGAFLRNLTVFETDGNSGFFSGNFTLDETEVAAVESGGVYINLHTQNNQSGELRGQVIL
CCCEEEEEEEEEEECCCCCEEECCEEECCCEEEEEECCCEEEEEEECCCCCCCEEEEEEE
ENMNTVIPVENVVFNGDKRDNNIQAGFADDKVRGFAGDDRLNGLAGNDRILGDDGNDTLI
ECCCCEEEECCEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCEE
GARGNDTLLGQDGDDFLQGRPGFDILLGGRGDDTLNGGQGRDRLNGGPGDDELTGGASID
EECCCCEEECCCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
RFIFNTNKEFNSQDIGTDRITDFNIGQDRILLDLDTFTALDSSADAGLSEDDFATVSSES
EEEEECCCCCCCCCCCCCCEEECCCCCCEEEEEECHHHCCCCCCCCCCCCCCCEEECCCC
DAETAEAAIVYNSVSGALYYNTNGSEDGFGIGAEFANLDNSPVLATSNFQLR
CCCCCEEEEEEECCCCEEEECCCCCCCCCCCCHHHHCCCCCCEEEECCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]