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The map label for this gene is metE

Identifier: 113474669

GI number: 113474669

Start: 1341178

End: 1343412

Strand: Reverse

Name: metE

Synonym: Tery_0847

Alternate gene names: 113474669

Gene position: 1343412-1341178 (Counterclockwise)

Preceding gene: 113474670

Following gene: 113474668

Centisome position: 17.33

GC content: 37.54

Gene sequence:

>2235_bases
ATGTCAATATCAACATCAACTTTGGGATATCCCCGCATAGGGAAAAACCGCGAAGTTAAAAAAGCACTCGAATCATTTTG
GCAACAAAAAATTAGTGCTGATGAATTGCTAAAAATTGTCCGAGAAATTGAAGAGGCAAGTTGGCAAACCCAAACTAAAG
CAGGTATAGAACGAATTGGTATTGGTGATGCTACTCTCTACGACCAAATATTAGATTGGAGTTTTCGTTTCGGAATAATT
CCCAAGCGTTTTCAACAATTCCAAAATTTAGAATGCTACTTTGCAATGGCACGAGGAAAAGATGGTATTCTAGCATTAGA
AATGACTAAATGGTTTGATACAAACTATCACTATTTAGTGCCAGAAATTACACCAGATATTACTCCCAAAGCAGATTTTT
CTGATTTCTTAGAAACTGTGAAACGCGCGAAAAAAATAATAGGCAAAAGTGCAGTTCCTATTATTATCAGCCCTATTACT
TTTATCCGTTTAAGTCGTTTAGAATCTGTAGAATTTGACAATATTCTCGCTCAACTATTGCCGCTATACAGCGACCTATT
AACTAAACTAAAAAAGTTAGGAATTTCGGAAATACAATTACACGAACCTGCTTTAGTTTTTGGCGATTCTTCTAATCTTA
AAAAACAGTTCGAGATGGCTTATGCTGAATTAGCAAAAGTGGGATTAAATATTCATCTTGTCACCTACTTTGATGACCTG
GGAGAAACCTATCCTTGGGTGATGAAATTGCCAGTAACATCTATTAGTCTCGACTTGACTCGCGGTCAAAATTTAGAACT
AATTAAAAGTTATGGTTTTCCAGCAGATAAAACTCTAGGTGCTGGTGTAGTTGATGCTCGAAATATTTGGCGAATTCGTA
CTCAAGAAGTAACATCTTTATTAGAGGAATTAAAGGGGATTATTCCTAATATTTCTGTACAGCCTTCTGCTTCTTTACAA
TTTGTGCCTTATGATGTTAGACGTGAGGTAAAACTCCCAGAAGCACTGCGAAATGTATTAAGTTTTGCCGAGCAAAAACT
AGAAGAGACAGTTTTATTATCTAAAGCATTGACTGGAAAAAGTAATAAGTCAGAGATAGAAAATATCGAAATCTACTGGC
AAGAATTTTATAAATTTAGCCCTGCCAATGAAAAAGTAAAAAGTCAAATTAAAGCACTGAAAGAAACAGACTTTAGGCGA
AGCATGTCTTATTTAGAAAGATTAGACAATCAAATAAAATTACCTGCTTTTCCCACTACAACTATCGGCTCATTTCCCCA
GACTAAACAAGTTAGAAAATTACGAGCACGTTATAAAAAAGGCGAGCTGACTCAAGCTGAATATTTAGCACAAATTGATG
CTAATATTGCCTACTGTATTGGTCTACAAGAAGGGATGGGAATGGATGTTTTAGTCCATGGAGAATTTGAACGTTCTGAC
ATGGTGGAATACTTCGGTGAACAGTTAGATGGTTATACTTTTACTACTCATGGTTGGGTACAAAGTTATGGCAGTCGTTA
TGTACGCCCGCCAATTATTTTTGGTGATATTTATCGCCCTCATGCAATGACAATTCGGGAATTTGAAGTTGCTCAATCTT
TAACTGAAAAACCAGTAAAAGGAATGTTAACTGGACCAGTAACCATGTTGAATTGGTCTTATCCCCGGACCGATATTTCT
CGCCAAGAACAGGCATTCCAATTAGCATTAGCTATTCGCGAAGAACTGAAAGATTTAGAAAAGGCAGGTGCTGCTTTTAT
TCAAGTAGATGAACCAGCAATGCGGGAAGGTTTGCCACTAAAACAACAGCGTTGGCACGAATATTTGAATTGGGCAGTTG
ATGCTTTTCGTTTATCGACGGCGATCGCTCGACCAGAAACTCAGGTACATACTCATATGTGTTACTCTGAGTTCGGCGAC
ATTATGGAATCTATTAAGCAATTGGATGCTGACGTAATTTCTATTGAGGATAGTCGTAGTAATAATGAGACTTTAATGCA
ACTGACTGATGCTGATTATCCTGCTCAGGTTGGACCAGGAGTTTATGACGTTCACTCTCCGAGTATTCCTACTACTGAAT
ATTTGAGGGAAAGTTTGTATAAGTGTATTCAGTATCTGCCTGTAACTCAAATTTGGGTTAATCCCGACTGTGGTTTGAAA
ACTCGTCGTTGGGAAGAGGCAATTCCGGCAACTCGGAATATGGTACAAGCTGCTATTAGTTTGCGACAGGAGTAG

Upstream 100 bases:

>100_bases
CTTTTGACTTTTAACTTTTAATTTTCCCAATCTGAGGAAGTCTTCACAGACGCTTTACCTCAGATAAATTAACCCAATTT
ACTGGAAATAAATAAAAACT

Downstream 100 bases:

>100_bases
TTGTTGTTTTTGTCCATAAGCTGAAAATTGCCTAATTTTAGATAATTTGGCATTGAGGGGGTAAACAAACATTTTTCTAT
CTCCCTCAAAATACAGCAGT

Product: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase

Products: NA

Alternate protein names: Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MSISTSTLGYPRIGKNREVKKALESFWQQKISADELLKIVREIEEASWQTQTKAGIERIGIGDATLYDQILDWSFRFGII
PKRFQQFQNLECYFAMARGKDGILALEMTKWFDTNYHYLVPEITPDITPKADFSDFLETVKRAKKIIGKSAVPIIISPIT
FIRLSRLESVEFDNILAQLLPLYSDLLTKLKKLGISEIQLHEPALVFGDSSNLKKQFEMAYAELAKVGLNIHLVTYFDDL
GETYPWVMKLPVTSISLDLTRGQNLELIKSYGFPADKTLGAGVVDARNIWRIRTQEVTSLLEELKGIIPNISVQPSASLQ
FVPYDVRREVKLPEALRNVLSFAEQKLEETVLLSKALTGKSNKSEIENIEIYWQEFYKFSPANEKVKSQIKALKETDFRR
SMSYLERLDNQIKLPAFPTTTIGSFPQTKQVRKLRARYKKGELTQAEYLAQIDANIAYCIGLQEGMGMDVLVHGEFERSD
MVEYFGEQLDGYTFTTHGWVQSYGSRYVRPPIIFGDIYRPHAMTIREFEVAQSLTEKPVKGMLTGPVTMLNWSYPRTDIS
RQEQAFQLALAIREELKDLEKAGAAFIQVDEPAMREGLPLKQQRWHEYLNWAVDAFRLSTAIARPETQVHTHMCYSEFGD
IMESIKQLDADVISIEDSRSNNETLMQLTDADYPAQVGPGVYDVHSPSIPTTEYLRESLYKCIQYLPVTQIWVNPDCGLK
TRRWEEAIPATRNMVQAAISLRQE

Sequences:

>Translated_744_residues
MSISTSTLGYPRIGKNREVKKALESFWQQKISADELLKIVREIEEASWQTQTKAGIERIGIGDATLYDQILDWSFRFGII
PKRFQQFQNLECYFAMARGKDGILALEMTKWFDTNYHYLVPEITPDITPKADFSDFLETVKRAKKIIGKSAVPIIISPIT
FIRLSRLESVEFDNILAQLLPLYSDLLTKLKKLGISEIQLHEPALVFGDSSNLKKQFEMAYAELAKVGLNIHLVTYFDDL
GETYPWVMKLPVTSISLDLTRGQNLELIKSYGFPADKTLGAGVVDARNIWRIRTQEVTSLLEELKGIIPNISVQPSASLQ
FVPYDVRREVKLPEALRNVLSFAEQKLEETVLLSKALTGKSNKSEIENIEIYWQEFYKFSPANEKVKSQIKALKETDFRR
SMSYLERLDNQIKLPAFPTTTIGSFPQTKQVRKLRARYKKGELTQAEYLAQIDANIAYCIGLQEGMGMDVLVHGEFERSD
MVEYFGEQLDGYTFTTHGWVQSYGSRYVRPPIIFGDIYRPHAMTIREFEVAQSLTEKPVKGMLTGPVTMLNWSYPRTDIS
RQEQAFQLALAIREELKDLEKAGAAFIQVDEPAMREGLPLKQQRWHEYLNWAVDAFRLSTAIARPETQVHTHMCYSEFGD
IMESIKQLDADVISIEDSRSNNETLMQLTDADYPAQVGPGVYDVHSPSIPTTEYLRESLYKCIQYLPVTQIWVNPDCGLK
TRRWEEAIPATRNMVQAAISLRQE
>Mature_743_residues
SISTSTLGYPRIGKNREVKKALESFWQQKISADELLKIVREIEEASWQTQTKAGIERIGIGDATLYDQILDWSFRFGIIP
KRFQQFQNLECYFAMARGKDGILALEMTKWFDTNYHYLVPEITPDITPKADFSDFLETVKRAKKIIGKSAVPIIISPITF
IRLSRLESVEFDNILAQLLPLYSDLLTKLKKLGISEIQLHEPALVFGDSSNLKKQFEMAYAELAKVGLNIHLVTYFDDLG
ETYPWVMKLPVTSISLDLTRGQNLELIKSYGFPADKTLGAGVVDARNIWRIRTQEVTSLLEELKGIIPNISVQPSASLQF
VPYDVRREVKLPEALRNVLSFAEQKLEETVLLSKALTGKSNKSEIENIEIYWQEFYKFSPANEKVKSQIKALKETDFRRS
MSYLERLDNQIKLPAFPTTTIGSFPQTKQVRKLRARYKKGELTQAEYLAQIDANIAYCIGLQEGMGMDVLVHGEFERSDM
VEYFGEQLDGYTFTTHGWVQSYGSRYVRPPIIFGDIYRPHAMTIREFEVAQSLTEKPVKGMLTGPVTMLNWSYPRTDISR
QEQAFQLALAIREELKDLEKAGAAFIQVDEPAMREGLPLKQQRWHEYLNWAVDAFRLSTAIARPETQVHTHMCYSEFGDI
MESIKQLDADVISIEDSRSNNETLMQLTDADYPAQVGPGVYDVHSPSIPTTEYLRESLYKCIQYLPVTQIWVNPDCGLKT
RRWEEAIPATRNMVQAAISLRQE

Specific function: Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation

COG id: COG0620

COG function: function code E; Methionine synthase II (cobalamin-independent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the vitamin-B12 independent methionine synthase family

Homologues:

Organism=Escherichia coli, GI2367304, Length=757, Percent_Identity=43.4610303830911, Blast_Score=624, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6320936, Length=772, Percent_Identity=39.5077720207254, Blast_Score=563, Evalue=1e-161,

Paralogues:

None

Copy number: 45,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): METE_TRIEI (Q117R7)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720730.1
- ProteinModelPortal:   Q117R7
- SMR:   Q117R7
- STRING:   Q117R7
- GeneID:   4245664
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0847
- NMPDR:   fig|203124.1.peg.2279
- eggNOG:   COG0620
- HOGENOM:   HBG287495
- OMA:   RFGWVQS
- PhylomeDB:   Q117R7
- ProtClustDB:   PRK05222
- BioCyc:   TERY203124:TERY_0847-MONOMER
- HAMAP:   MF_00172
- InterPro:   IPR013215
- InterPro:   IPR006276
- InterPro:   IPR002629
- PIRSF:   PIRSF000382

Pfam domain/function: PF08267 Meth_synt_1; PF01717 Meth_synt_2

EC number: =2.1.1.14

Molecular weight: Translated: 85148; Mature: 85016

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISTSTLGYPRIGKNREVKKALESFWQQKISADELLKIVREIEEASWQTQTKAGIERIG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHCC
IGDATLYDQILDWSFRFGIIPKRFQQFQNLECYFAMARGKDGILALEMTKWFDTNYHYLV
CCCHHHHHHHHCCHHHCCCCHHHHHHHCCCEEEEEEECCCCCEEEEEEHHHHCCCCEEEC
PEITPDITPKADFSDFLETVKRAKKIIGKSAVPIIISPITFIRLSRLESVEFDNILAQLL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCHHHHHHHHH
PLYSDLLTKLKKLGISEIQLHEPALVFGDSSNLKKQFEMAYAELAKVGLNIHLVTYFDDL
HHHHHHHHHHHHCCCCCEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEHHC
GETYPWVMKLPVTSISLDLTRGQNLELIKSYGFPADKTLGAGVVDARNIWRIRTQEVTSL
CCCCCEEEEECCEEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LEELKGIIPNISVQPSASLQFVPYDVRREVKLPEALRNVLSFAEQKLEETVLLSKALTGK
HHHHHHHCCCCCCCCCCCEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SNKSEIENIEIYWQEFYKFSPANEKVKSQIKALKETDFRRSMSYLERLDNQIKLPAFPTT
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
TIGSFPQTKQVRKLRARYKKGELTQAEYLAQIDANIAYCIGLQEGMGMDVLVHGEFERSD
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCHHH
MVEYFGEQLDGYTFTTHGWVQSYGSRYVRPPIIFGDIYRPHAMTIREFEVAQSLTEKPVK
HHHHHHHHHCCCEEEEHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCC
GMLTGPVTMLNWSYPRTDISRQEQAFQLALAIREELKDLEKAGAAFIQVDEPAMREGLPL
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCC
KQQRWHEYLNWAVDAFRLSTAIARPETQVHTHMCYSEFGDIMESIKQLDADVISIEDSRS
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
NNETLMQLTDADYPAQVGPGVYDVHSPSIPTTEYLRESLYKCIQYLPVTQIWVNPDCGLK
CCCEEEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
TRRWEEAIPATRNMVQAAISLRQE
CHHHHHHCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SISTSTLGYPRIGKNREVKKALESFWQQKISADELLKIVREIEEASWQTQTKAGIERIG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHCC
IGDATLYDQILDWSFRFGIIPKRFQQFQNLECYFAMARGKDGILALEMTKWFDTNYHYLV
CCCHHHHHHHHCCHHHCCCCHHHHHHHCCCEEEEEEECCCCCEEEEEEHHHHCCCCEEEC
PEITPDITPKADFSDFLETVKRAKKIIGKSAVPIIISPITFIRLSRLESVEFDNILAQLL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCHHHHHHHHH
PLYSDLLTKLKKLGISEIQLHEPALVFGDSSNLKKQFEMAYAELAKVGLNIHLVTYFDDL
HHHHHHHHHHHHCCCCCEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEHHC
GETYPWVMKLPVTSISLDLTRGQNLELIKSYGFPADKTLGAGVVDARNIWRIRTQEVTSL
CCCCCEEEEECCEEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LEELKGIIPNISVQPSASLQFVPYDVRREVKLPEALRNVLSFAEQKLEETVLLSKALTGK
HHHHHHHCCCCCCCCCCCEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SNKSEIENIEIYWQEFYKFSPANEKVKSQIKALKETDFRRSMSYLERLDNQIKLPAFPTT
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
TIGSFPQTKQVRKLRARYKKGELTQAEYLAQIDANIAYCIGLQEGMGMDVLVHGEFERSD
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCHHH
MVEYFGEQLDGYTFTTHGWVQSYGSRYVRPPIIFGDIYRPHAMTIREFEVAQSLTEKPVK
HHHHHHHHHCCCEEEEHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCC
GMLTGPVTMLNWSYPRTDISRQEQAFQLALAIREELKDLEKAGAAFIQVDEPAMREGLPL
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCC
KQQRWHEYLNWAVDAFRLSTAIARPETQVHTHMCYSEFGDIMESIKQLDADVISIEDSRS
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
NNETLMQLTDADYPAQVGPGVYDVHSPSIPTTEYLRESLYKCIQYLPVTQIWVNPDCGLK
CCCEEEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
TRRWEEAIPATRNMVQAAISLRQE
CHHHHHHCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA