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The map label for this gene is sphR [H]

Identifier: 113474524

GI number: 113474524

Start: 1105112

End: 1105870

Strand: Reverse

Name: sphR [H]

Synonym: Tery_0675

Alternate gene names: 113474524

Gene position: 1105870-1105112 (Counterclockwise)

Preceding gene: 113474526

Following gene: 113474520

Centisome position: 14.27

GC content: 37.15

Gene sequence:

>759_bases
GTGGGAGATGCTTGTATTTTAATTGTAGAGGGTAATGTGCATCTGCGCTCCTTACTTGCTTGGCATTTGCAGCAATCAAA
ACACTTGGTTCATCAGTCAGCAGATGTTGATCATGCAAAAAAATTAATATACGCTCATTGCCCAAGTCTCGTAATTCTGG
AAACTGATCTACCAGATGGAAATAGTTTTGAGTTTTGCCAATGGCTTCAGCAACAGCAACAGTGTTTAATTTTAATGTTA
TCCTCACGCAAAACTGAAGCTGATATTGTGGCAGGCTTAAAGTCAGGAGCGGATGACTATATTACAAAGCCTTTTGGTAT
GCAAGAGTTTATGGCTAGGATAGAAGCACTACTACGTCGTCGCAGAAGTATTAGTTCTACCCCACCCATTAGTTTAGATT
ATGGTGATTTGATTATTGATTTGGTACACCGTAGAGTTATCTTCAAGGGTAATTTGATTGATTTAACTCCACAAGAATTT
AATCTTCTTTATGTGTTAGCTCAAGCAGAAGGAATACCCCTAAGTCGTTCAGAATTACTGCACAGAGGATGGCCAGATTC
TATAGATAATCCTCGTACTATAGATACTCATGTACTATCTCTGCGGAAAAAAATTGAAATTGACCCCCGTCAACCTAGTC
TAATTCAGACAGTTAGAAATGTTGGTTATAGATTTAATAGAGAAATTTTAACTATAGATCAATGGAATAATAATTATCAG
AAGAGCTATCAACAACCTCAAAAAGTTGCACCAGCTTAA

Upstream 100 bases:

>100_bases
GCATGATTTTTAGTAGCTTCTGTTACAAAAGCGCCACAATAATTTATGTTATTTTTATACTTAGTAATATTCAAGAAGAA
TCTATTAGGAAATTATTTAA

Downstream 100 bases:

>100_bases
TATTCTATCAACTTTTAGCTCAGTTAGCCTTTTGGGTCGAAACTGGGTTAATAGCTTTGAGCTACTTTGGGTAAAAATAT
ACCGCTGTTGCCACTAATGT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MGDACILIVEGNVHLRSLLAWHLQQSKHLVHQSADVDHAKKLIYAHCPSLVILETDLPDGNSFEFCQWLQQQQQCLILML
SSRKTEADIVAGLKSGADDYITKPFGMQEFMARIEALLRRRRSISSTPPISLDYGDLIIDLVHRRVIFKGNLIDLTPQEF
NLLYVLAQAEGIPLSRSELLHRGWPDSIDNPRTIDTHVLSLRKKIEIDPRQPSLIQTVRNVGYRFNREILTIDQWNNNYQ
KSYQQPQKVAPA

Sequences:

>Translated_252_residues
MGDACILIVEGNVHLRSLLAWHLQQSKHLVHQSADVDHAKKLIYAHCPSLVILETDLPDGNSFEFCQWLQQQQQCLILML
SSRKTEADIVAGLKSGADDYITKPFGMQEFMARIEALLRRRRSISSTPPISLDYGDLIIDLVHRRVIFKGNLIDLTPQEF
NLLYVLAQAEGIPLSRSELLHRGWPDSIDNPRTIDTHVLSLRKKIEIDPRQPSLIQTVRNVGYRFNREILTIDQWNNNYQ
KSYQQPQKVAPA
>Mature_251_residues
GDACILIVEGNVHLRSLLAWHLQQSKHLVHQSADVDHAKKLIYAHCPSLVILETDLPDGNSFEFCQWLQQQQQCLILMLS
SRKTEADIVAGLKSGADDYITKPFGMQEFMARIEALLRRRRSISSTPPISLDYGDLIIDLVHRRVIFKGNLIDLTPQEFN
LLYVLAQAEGIPLSRSELLHRGWPDSIDNPRTIDTHVLSLRKKIEIDPRQPSLIQTVRNVGYRFNREILTIDQWNNNYQK
SYQQPQKVAPA

Specific function: Member of the two-component regulatory system sphR/sphS. Response regulator. Involved in inducible production of alkaline phosphatase in response to phosphate limitation as it is directly involved in the regulation of phoA transcription in response to pho

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=34.6846846846847, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32.8888888888889, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=33.1858407079646, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.0396475770925, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=33.1858407079646, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=35, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=34.2342342342342, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=31.6742081447964, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=32.7510917030568, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=29.7413793103448, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=30.2222222222222, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI2367329, Length=176, Percent_Identity=34.0909090909091, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.9012875536481, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787229, Length=209, Percent_Identity=26.7942583732057, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28887; Mature: 28755

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDACILIVEGNVHLRSLLAWHLQQSKHLVHQSADVDHAKKLIYAHCPSLVILETDLPDG
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCC
NSFEFCQWLQQQQQCLILMLSSRKTEADIVAGLKSGADDYITKPFGMQEFMARIEALLRR
CCHHHHHHHHHHHHHEEHHCCCCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
RRSISSTPPISLDYGDLIIDLVHRRVIFKGNLIDLTPQEFNLLYVLAQAEGIPLSRSELL
HHCCCCCCCCEECHHHHHHHHHHHHHHEECCEEEECCCCCEEEEEEEECCCCCCCHHHHH
HRGWPDSIDNPRTIDTHVLSLRKKIEIDPRQPSLIQTVRNVGYRFNREILTIDQWNNNYQ
HCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEECCEEEEEECCCCHHH
KSYQQPQKVAPA
HHHCCCHHCCCC
>Mature Secondary Structure 
GDACILIVEGNVHLRSLLAWHLQQSKHLVHQSADVDHAKKLIYAHCPSLVILETDLPDG
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCC
NSFEFCQWLQQQQQCLILMLSSRKTEADIVAGLKSGADDYITKPFGMQEFMARIEALLRR
CCHHHHHHHHHHHHHEEHHCCCCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
RRSISSTPPISLDYGDLIIDLVHRRVIFKGNLIDLTPQEFNLLYVLAQAEGIPLSRSELL
HHCCCCCCCCEECHHHHHHHHHHHHHHEECCEEEECCCCCEEEEEEEECCCCCCCHHHHH
HRGWPDSIDNPRTIDTHVLSLRKKIEIDPRQPSLIQTVRNVGYRFNREILTIDQWNNNYQ
HCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEECCEEEEEECCCCHHH
KSYQQPQKVAPA
HHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8497200; 8157591 [H]