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The map label for this gene is lktA [H]

Identifier: 113474282

GI number: 113474282

Start: 634051

End: 636180

Strand: Reverse

Name: lktA [H]

Synonym: Tery_0405

Alternate gene names: 113474282

Gene position: 636180-634051 (Counterclockwise)

Preceding gene: 113474285

Following gene: 113474275

Centisome position: 8.21

GC content: 37.79

Gene sequence:

>2130_bases
ATGGCTTTTTATCAGGGTACCAATAAAAAAGACAATCTCAAAGGAACTGCTAAAAAAGACACCATTAACGGTAAGGGTGG
TAACGATAAAATTGATGGTAGAGGTGGCAATGACAAACTCAACGGTGGTGCGGGTAAAGATACCTTAAACGGTGGTGCGG
GTAAAGATACCTTAAACGGTGGCGGTGGCAATGATCAAATAAATGGTGGAGGCAGCAATGACAAACTCAACGGTGGTGCG
GGTAAAGATACTTTAAATGGTAGCGGTGGCAATGATCAAATAAATGGTGGAGGCAGCAATGACAAACTCAACGGTGGTGC
GGGTAAAGATACTTTAAACGGTGGCAACGCTCAAGATAATTTAATTGGTGGTTCTGGTAACGATTTTTTAGACGGTGGAA
ACGGTAATGATGTGCTTACTGGCAATGATGGTAATGATGTTCTAGTCGGCAATTTTGGCAAAGATATTTTAACTGGTGGT
GCAGGAGATGACGTATTTTTCTTAAAACAAAACAGTGCAGTTAATAACAACTCGGCTGCCGACATGATCACAGATTTTCA
GCCAAATTTTGATACCATTGGCTTAGATAGCGGTCTTACTGAGAATGATCTGAATTTACAGTTATCTGGCAACTCGACTG
TAATTAAAATCAAAAAAACAGGTAAAATTTTGGGAGTAGTACAAGGTGTTCAGCCTCAAGAACTCAAATGGAATTTTACA
TCTGTAGATGGCAAACCTAATGTCATTGAAAATTTAGTAACTTTTGATGCTCCCACCGTTGAACAAAAATCTTCTGACAC
CTATGAAATGAAGTTAACTGGTAGTGACAAAAGTGATTTTGTTATTAACATCAAAAAAACTGATACAGGAACACACCAGG
AGTCATTACGATACACACCATCTCCTTCAGAACAACGGAAGGGTAATAAACCTTTTACTGCTAAAGTTAATTCAGAAGGA
ACTCGAATTGAGTTACAGTTTGATGACTCCCCAACTGTTTACATATTTGACAACCAAAGAGATGAAAACACTGTAGATCT
GATCAAGAAAACAGCTACAGGAGAAACCAAAATAGCAGAAGTTCCTGTTGATCTAGAAATGAAGTCAAATATAGAGCAAT
CTATTTCTCAAGGGACTTTATGTGAAGCAGGTCAAAACATTTGTAAAAGTGTAGAAATTCTCGATAATGTCGCTAGTGGT
TTAGCAGCAGTAACTGCTCTTACTGGTGTCGGAACAGTAGCATCAGGACCATTGGGGGCTGTGGCTCTTGGAGCTAAAGT
TTTTGGATATGGTTGTTTAGTTTTGTACGGTGATGACACTGATCTGGTTAATAATTTAATAGGTGAAGTAGCTGGAAATG
TTTTCAGCCAAATAGGAAGTAAATTATTTAAAGCTGTTGCCAGTCCAACTCGCAAGCTGGTTAGCAAAATAATCGGGAAC
AAATATGATCAAGAAATTTTTAAGCCTCTTGGAGATGAGTCTTTTAAACAGATGGAAGATTTTTATCTTGGCAAAAAAGG
TGAAGAATTAGGAAAAAATACTTATGATTTCATTGCTTCAATTCTCAAAACCTCAGAAGTAATTACTAATAAGAATCAAA
ACAGTAAAAGTTCTGATGGTCTGATGCAAAAAATTCGTGAGGGTCTAGGTATTAATTGGTGCAATGAAAAAGACGAAAAA
GATGAAAAAGATGAAAAAAAGGAGGTAAGAGTCTATTTTCAGCCCCAGGGAAATCCTTGGGCTATCAGTAAGTTGTACCT
AGTTTCACCAGAAGAAAAGTTTATTGGTACTGCCCCAAATAGTTTCGTCAGTGTTAATAATGATGCTTTCAAGTGGAAAT
CCATAGGAACATTCCCTATAGGTACTGAACTTGAGTTTGAAACTCGTGTGGAAGGGCCTCTAGAACTCAGTGGATCGACT
AATCTTGTAGGCGGCTTGACCTTGAGTTCAAAAGCTTCTGAGGCGGCTTCCATAAAAACTAACTTTTTGGGTATGAATTT
GCTAGGATTTGAAGATGGTTCTAGTGGAAAATTGCTGGGGGTAGAAGTTGAGAAGCCAAACGACTTTAACGACACTTTAG
TTAAAATTGAGAATATAATATTTGAAGGAAACAACATTTTTGTTGGCTAA

Upstream 100 bases:

>100_bases
ATGTCAAGATAAATTCAAGCTAAACTTAACTTTTTTGCACTAGCTTTAGTTTTATGTATATGGGAAAATCTGAAAACTAT
CGACTACAAGGAAAATAATT

Downstream 100 bases:

>100_bases
AATTGTACCTTCAACGATGGCAAAGCGATCGCCCTTCCACAAAAGCATATTGTCAAACTTTATTGTTGAGGCGATCGCCA
CTCCGAAAATTGCTACTTTA

Product: hemolysin-type calcium-binding protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 709; Mature: 708

Protein sequence:

>709_residues
MAFYQGTNKKDNLKGTAKKDTINGKGGNDKIDGRGGNDKLNGGAGKDTLNGGAGKDTLNGGGGNDQINGGGSNDKLNGGA
GKDTLNGSGGNDQINGGGSNDKLNGGAGKDTLNGGNAQDNLIGGSGNDFLDGGNGNDVLTGNDGNDVLVGNFGKDILTGG
AGDDVFFLKQNSAVNNNSAADMITDFQPNFDTIGLDSGLTENDLNLQLSGNSTVIKIKKTGKILGVVQGVQPQELKWNFT
SVDGKPNVIENLVTFDAPTVEQKSSDTYEMKLTGSDKSDFVINIKKTDTGTHQESLRYTPSPSEQRKGNKPFTAKVNSEG
TRIELQFDDSPTVYIFDNQRDENTVDLIKKTATGETKIAEVPVDLEMKSNIEQSISQGTLCEAGQNICKSVEILDNVASG
LAAVTALTGVGTVASGPLGAVALGAKVFGYGCLVLYGDDTDLVNNLIGEVAGNVFSQIGSKLFKAVASPTRKLVSKIIGN
KYDQEIFKPLGDESFKQMEDFYLGKKGEELGKNTYDFIASILKTSEVITNKNQNSKSSDGLMQKIREGLGINWCNEKDEK
DEKDEKKEVRVYFQPQGNPWAISKLYLVSPEEKFIGTAPNSFVSVNNDAFKWKSIGTFPIGTELEFETRVEGPLELSGST
NLVGGLTLSSKASEAASIKTNFLGMNLLGFEDGSSGKLLGVEVEKPNDFNDTLVKIENIIFEGNNIFVG

Sequences:

>Translated_709_residues
MAFYQGTNKKDNLKGTAKKDTINGKGGNDKIDGRGGNDKLNGGAGKDTLNGGAGKDTLNGGGGNDQINGGGSNDKLNGGA
GKDTLNGSGGNDQINGGGSNDKLNGGAGKDTLNGGNAQDNLIGGSGNDFLDGGNGNDVLTGNDGNDVLVGNFGKDILTGG
AGDDVFFLKQNSAVNNNSAADMITDFQPNFDTIGLDSGLTENDLNLQLSGNSTVIKIKKTGKILGVVQGVQPQELKWNFT
SVDGKPNVIENLVTFDAPTVEQKSSDTYEMKLTGSDKSDFVINIKKTDTGTHQESLRYTPSPSEQRKGNKPFTAKVNSEG
TRIELQFDDSPTVYIFDNQRDENTVDLIKKTATGETKIAEVPVDLEMKSNIEQSISQGTLCEAGQNICKSVEILDNVASG
LAAVTALTGVGTVASGPLGAVALGAKVFGYGCLVLYGDDTDLVNNLIGEVAGNVFSQIGSKLFKAVASPTRKLVSKIIGN
KYDQEIFKPLGDESFKQMEDFYLGKKGEELGKNTYDFIASILKTSEVITNKNQNSKSSDGLMQKIREGLGINWCNEKDEK
DEKDEKKEVRVYFQPQGNPWAISKLYLVSPEEKFIGTAPNSFVSVNNDAFKWKSIGTFPIGTELEFETRVEGPLELSGST
NLVGGLTLSSKASEAASIKTNFLGMNLLGFEDGSSGKLLGVEVEKPNDFNDTLVKIENIIFEGNNIFVG
>Mature_708_residues
AFYQGTNKKDNLKGTAKKDTINGKGGNDKIDGRGGNDKLNGGAGKDTLNGGAGKDTLNGGGGNDQINGGGSNDKLNGGAG
KDTLNGSGGNDQINGGGSNDKLNGGAGKDTLNGGNAQDNLIGGSGNDFLDGGNGNDVLTGNDGNDVLVGNFGKDILTGGA
GDDVFFLKQNSAVNNNSAADMITDFQPNFDTIGLDSGLTENDLNLQLSGNSTVIKIKKTGKILGVVQGVQPQELKWNFTS
VDGKPNVIENLVTFDAPTVEQKSSDTYEMKLTGSDKSDFVINIKKTDTGTHQESLRYTPSPSEQRKGNKPFTAKVNSEGT
RIELQFDDSPTVYIFDNQRDENTVDLIKKTATGETKIAEVPVDLEMKSNIEQSISQGTLCEAGQNICKSVEILDNVASGL
AAVTALTGVGTVASGPLGAVALGAKVFGYGCLVLYGDDTDLVNNLIGEVAGNVFSQIGSKLFKAVASPTRKLVSKIIGNK
YDQEIFKPLGDESFKQMEDFYLGKKGEELGKNTYDFIASILKTSEVITNKNQNSKSSDGLMQKIREGLGINWCNEKDEKD
EKDEKKEVRVYFQPQGNPWAISKLYLVSPEEKFIGTAPNSFVSVNNDAFKWKSIGTFPIGTELEFETRVEGPLELSGSTN
LVGGLTLSSKASEAASIKTNFLGMNLLGFEDGSSGKLLGVEVEKPNDFNDTLVKIENIIFEGNNIFVG

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 75204; Mature: 75073

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFYQGTNKKDNLKGTAKKDTINGKGGNDKIDGRGGNDKLNGGAGKDTLNGGAGKDTLNG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGGNDQINGGGSNDKLNGGAGKDTLNGSGGNDQINGGGSNDKLNGGAGKDTLNGGNAQDN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LIGGSGNDFLDGGNGNDVLTGNDGNDVLVGNFGKDILTGGAGDDVFFLKQNSAVNNNSAA
CCCCCCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHCCCCCCCEEEEECCCCCCCCCHH
DMITDFQPNFDTIGLDSGLTENDLNLQLSGNSTVIKIKKTGKILGVVQGVQPQELKWNFT
HHHCCCCCCCCEEECCCCCCCCCCEEEECCCCEEEEEECCCCEEEEECCCCCCCEEEEEE
SVDGKPNVIENLVTFDAPTVEQKSSDTYEMKLTGSDKSDFVINIKKTDTGTHQESLRYTP
ECCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCHHHCCCCC
SPSEQRKGNKPFTAKVNSEGTRIELQFDDSPTVYIFDNQRDENTVDLIKKTATGETKIAE
CCHHHHCCCCCEEEEECCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEE
VPVDLEMKSNIEQSISQGTLCEAGQNICKSVEILDNVASGLAAVTALTGVGTVASGPLGA
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
VALGAKVFGYGCLVLYGDDTDLVNNLIGEVAGNVFSQIGSKLFKAVASPTRKLVSKIIGN
HHHHHHEECEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KYDQEIFKPLGDESFKQMEDFYLGKKGEELGKNTYDFIASILKTSEVITNKNQNSKSSDG
HHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
LMQKIREGLGINWCNEKDEKDEKDEKKEVRVYFQPQGNPWAISKLYLVSPEEKFIGTAPN
HHHHHHHCCCCCCCCCCCCCCHHCCCEEEEEEECCCCCCEEEEEEEEECCCHHHCCCCCC
SFVSVNNDAFKWKSIGTFPIGTELEFETRVEGPLELSGSTNLVGGLTLSSKASEAASIKT
CEEEECCCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCEEEEEEECCCCCHHHHEEE
NFLGMNLLGFEDGSSGKLLGVEVEKPNDFNDTLVKIENIIFEGNNIFVG
EEEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHEEEEEEEECCEEEEC
>Mature Secondary Structure 
AFYQGTNKKDNLKGTAKKDTINGKGGNDKIDGRGGNDKLNGGAGKDTLNGGAGKDTLNG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGGNDQINGGGSNDKLNGGAGKDTLNGSGGNDQINGGGSNDKLNGGAGKDTLNGGNAQDN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LIGGSGNDFLDGGNGNDVLTGNDGNDVLVGNFGKDILTGGAGDDVFFLKQNSAVNNNSAA
CCCCCCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHCCCCCCCEEEEECCCCCCCCCHH
DMITDFQPNFDTIGLDSGLTENDLNLQLSGNSTVIKIKKTGKILGVVQGVQPQELKWNFT
HHHCCCCCCCCEEECCCCCCCCCCEEEECCCCEEEEEECCCCEEEEECCCCCCCEEEEEE
SVDGKPNVIENLVTFDAPTVEQKSSDTYEMKLTGSDKSDFVINIKKTDTGTHQESLRYTP
ECCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCHHHCCCCC
SPSEQRKGNKPFTAKVNSEGTRIELQFDDSPTVYIFDNQRDENTVDLIKKTATGETKIAE
CCHHHHCCCCCEEEEECCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEE
VPVDLEMKSNIEQSISQGTLCEAGQNICKSVEILDNVASGLAAVTALTGVGTVASGPLGA
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
VALGAKVFGYGCLVLYGDDTDLVNNLIGEVAGNVFSQIGSKLFKAVASPTRKLVSKIIGN
HHHHHHEECEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KYDQEIFKPLGDESFKQMEDFYLGKKGEELGKNTYDFIASILKTSEVITNKNQNSKSSDG
HHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
LMQKIREGLGINWCNEKDEKDEKDEKKEVRVYFQPQGNPWAISKLYLVSPEEKFIGTAPN
HHHHHHHCCCCCCCCCCCCCCHHCCCEEEEEEECCCCCCEEEEEEEEECCCHHHCCCCCC
SFVSVNNDAFKWKSIGTFPIGTELEFETRVEGPLELSGSTNLVGGLTLSSKASEAASIKT
CEEEECCCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCEEEEEEECCCCCHHHHEEE
NFLGMNLLGFEDGSSGKLLGVEVEKPNDFNDTLVKIENIIFEGNNIFVG
EEEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHEEEEEEEECCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]