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The map label for this gene is tktA [H]

Identifier: 110835476

GI number: 110835476

Start: 2958029

End: 2960029

Strand: Reverse

Name: tktA [H]

Synonym: ABO_2615

Alternate gene names: 110835476

Gene position: 2960029-2958029 (Counterclockwise)

Preceding gene: 110835484

Following gene: 110835475

Centisome position: 94.87

GC content: 59.17

Gene sequence:

>2001_bases
ATGTCCAGTGCACCCGCCCGCCGTGAACTCGCCAACGCTATCCGTGCCCTGAGCATGGATGCGGTACAGAAAGCCAACTC
CGGGCACCCCGGTGCGCCCATGGGCATGGCGGATATCGCCGAAGTTTTGTGGCGCGATTTCATGCGACACAACCCGGCGG
ACCCAACCTGGGCCGACCGCGACCGCTTTGTGCTCTCCAATGGCCATGGCTCCATGCTGCTTTACAGCCTTCTGCATTTG
ACCGGTTACGGTGTCAGCCTGGATGACATCAAAAACTTTCGCCAGTTGGGTAGCCCCACTGCCGGACACCCAGAATATGG
TGACGCTCCGGGCATCGAAACCACCACTGGCCCGCTGGGGCAGGGGATTGCCAATGCGGTAGGCATGGCGCTGGCTGAGA
AGATGCTAGCGGGGCAGTTCAATCGTGATGGGCACACCATTGTTGATCACAACACCTATTGCTTCCTGGGTGATGGCTGC
ATGATGGAAGGGATCTCCCACGAAGTGGCATCCCTGGCAGGCACCTTGGGCTTGGGTAAACTGGTGGCCTTCTACGACGA
CAATGGCATTTCCATTGACGGTGAAGTGGAAGGCTGGTTCACCGACGATACCGTAGAGCGTTTCCGCGCCTACGGTTGGC
AGGTGATTCCTAATGTCGACGGCCACAACGCGGAAGAAATAATGGTGGCGGTGGAAAATGCCCGCGCCAACACCTCCCAG
CCTACGCTGATCTGCTGCAAAACCATTATCGGTTTCGGTAGCCCGAATAAGCAGGGCAAGGAAGATTCCCATGGTGCCGC
CCTGGGCGAAGACGAAATCACTCTGACCCGTAAAGCGCTGGGCTGGGAGTACGGCCCGTTCGAGATCCCCGCGGACATTA
AGAGTGCCTGGGATGCCAAAGAGGCGGGTGCCAAAGCGCAGAGTGAGTGGCAGCAGCGTTTCGATGCTTATCAGGCTGCG
TACCCGGAGCTGGCCGCTGAGTTTACGCGCCGCATGGCTAGCGAGCTGCCGGCGGATTTTGCCGAGCAAGCGGATGCCTA
TATCCGTGAGTGTCAGGAAAAAGGCGAAAAGGTGGCGACCCGCAAGGCCAGCCAGAATACGTTGGACGCTTTCGGCCCGC
TGTTGCCAGAATTGGCTGGCGGCTCTGCCGACCTGGCCGGTTCCAACAACACCATTTGGAAAGGCTGCAAATCGGTTACC
GCAGACGATGCCAGCGGCAACTATATTCACTACGGCGTGCGCGAATTTGGTATGACCGCCATCCAGAACGGCCTGTGCCT
GCACGGCGGCCTACGCCCCTACGGCGGCACCTTCCTGGTCTTTATGGAGTACGCCCGCAACGCGGTGCGCATGGCGGCGA
TCATGCACCAGCCGAACATTTTGGTTTATACCCACGATTCCATTGGCCTGGGCGAAGATGGCCCAACTCACCAGCCCATT
GAGCAATTGGCCAACTTGCGCCTGACCCCGAACATGCGCACCTGGCGTCCTTGTGACACGGTGGAGTCGGCGGTGTCCTG
GAAGCAGGCTGTATTGCGTCAGGATGGTCCGTCTGCGCTGATTTTCTCTCGTCAGGGGCTGCCCTGCATGGAGCGTGGCA
GCGAACAGCTGGCTGAGATCGAAAAGGGTGGCTACACCTTGCTGCAAACGGGTGAAGACACTCCGGACGCGATCATCATT
GCCACCGGTTCTGAAGTGGAGCTGGCGGTGATTGCGGCTAGAGCGCTCACCGGTAAGAATATTCGCGTGGTGTCCATGCC
CTGTGTGGAAGAATTTCTGGCCCAGGACAAGGCGTACCAGGACAGCGTGTTGCCAGGCGACGTGCGCGCCCGGGTCGCGG
TAGAAGCCGCCATTGCCGATTACTGGTTCCGCTTTGTGGGCCTGGACGGCAAGGTGATTGGCATGAACAGCTTTGGCGCT
TCCGCTCCGGCGGGGGATTTGTTCAAGCACTTCAATATCACCGCTGAAGCCGTACAGGAAGCAGTGGAGTCGTTGTTGTA
A

Upstream 100 bases:

>100_bases
ACTAGGCAGCGGCGAGCTCTGGGGCGTGCGGCTTGTAGGCGTTATCGGCTTGAGGGACAATAGCGCCCCTTTTCAGCCAC
CAGCCAGTTTGGAGCCCTGC

Downstream 100 bases:

>100_bases
TGAAACGCCGGACGCCTGGTGCTGGGCACGTGACGCTGCTGCGGAGCGCTGTCTAATGCGCATCGCCATTAATGGCTATG
GCCGTATTGGGCGTTCTTTT

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSSAPARRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDFMRHNPADPTWADRDRFVLSNGHGSMLLYSLLHL
TGYGVSLDDIKNFRQLGSPTAGHPEYGDAPGIETTTGPLGQGIANAVGMALAEKMLAGQFNRDGHTIVDHNTYCFLGDGC
MMEGISHEVASLAGTLGLGKLVAFYDDNGISIDGEVEGWFTDDTVERFRAYGWQVIPNVDGHNAEEIMVAVENARANTSQ
PTLICCKTIIGFGSPNKQGKEDSHGAALGEDEITLTRKALGWEYGPFEIPADIKSAWDAKEAGAKAQSEWQQRFDAYQAA
YPELAAEFTRRMASELPADFAEQADAYIRECQEKGEKVATRKASQNTLDAFGPLLPELAGGSADLAGSNNTIWKGCKSVT
ADDASGNYIHYGVREFGMTAIQNGLCLHGGLRPYGGTFLVFMEYARNAVRMAAIMHQPNILVYTHDSIGLGEDGPTHQPI
EQLANLRLTPNMRTWRPCDTVESAVSWKQAVLRQDGPSALIFSRQGLPCMERGSEQLAEIEKGGYTLLQTGEDTPDAIII
ATGSEVELAVIAARALTGKNIRVVSMPCVEEFLAQDKAYQDSVLPGDVRARVAVEAAIADYWFRFVGLDGKVIGMNSFGA
SAPAGDLFKHFNITAEAVQEAVESLL

Sequences:

>Translated_666_residues
MSSAPARRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDFMRHNPADPTWADRDRFVLSNGHGSMLLYSLLHL
TGYGVSLDDIKNFRQLGSPTAGHPEYGDAPGIETTTGPLGQGIANAVGMALAEKMLAGQFNRDGHTIVDHNTYCFLGDGC
MMEGISHEVASLAGTLGLGKLVAFYDDNGISIDGEVEGWFTDDTVERFRAYGWQVIPNVDGHNAEEIMVAVENARANTSQ
PTLICCKTIIGFGSPNKQGKEDSHGAALGEDEITLTRKALGWEYGPFEIPADIKSAWDAKEAGAKAQSEWQQRFDAYQAA
YPELAAEFTRRMASELPADFAEQADAYIRECQEKGEKVATRKASQNTLDAFGPLLPELAGGSADLAGSNNTIWKGCKSVT
ADDASGNYIHYGVREFGMTAIQNGLCLHGGLRPYGGTFLVFMEYARNAVRMAAIMHQPNILVYTHDSIGLGEDGPTHQPI
EQLANLRLTPNMRTWRPCDTVESAVSWKQAVLRQDGPSALIFSRQGLPCMERGSEQLAEIEKGGYTLLQTGEDTPDAIII
ATGSEVELAVIAARALTGKNIRVVSMPCVEEFLAQDKAYQDSVLPGDVRARVAVEAAIADYWFRFVGLDGKVIGMNSFGA
SAPAGDLFKHFNITAEAVQEAVESLL
>Mature_665_residues
SSAPARRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDFMRHNPADPTWADRDRFVLSNGHGSMLLYSLLHLT
GYGVSLDDIKNFRQLGSPTAGHPEYGDAPGIETTTGPLGQGIANAVGMALAEKMLAGQFNRDGHTIVDHNTYCFLGDGCM
MEGISHEVASLAGTLGLGKLVAFYDDNGISIDGEVEGWFTDDTVERFRAYGWQVIPNVDGHNAEEIMVAVENARANTSQP
TLICCKTIIGFGSPNKQGKEDSHGAALGEDEITLTRKALGWEYGPFEIPADIKSAWDAKEAGAKAQSEWQQRFDAYQAAY
PELAAEFTRRMASELPADFAEQADAYIRECQEKGEKVATRKASQNTLDAFGPLLPELAGGSADLAGSNNTIWKGCKSVTA
DDASGNYIHYGVREFGMTAIQNGLCLHGGLRPYGGTFLVFMEYARNAVRMAAIMHQPNILVYTHDSIGLGEDGPTHQPIE
QLANLRLTPNMRTWRPCDTVESAVSWKQAVLRQDGPSALIFSRQGLPCMERGSEQLAEIEKGGYTLLQTGEDTPDAIIIA
TGSEVELAVIAARALTGKNIRVVSMPCVEEFLAQDKAYQDSVLPGDVRARVAVEAAIADYWFRFVGLDGKVIGMNSFGAS
APAGDLFKHFNITAEAVQEAVESLL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=677, Percent_Identity=26.5878877400295, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI4507521, Length=677, Percent_Identity=26.5878877400295, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI133778974, Length=526, Percent_Identity=27.1863117870722, Blast_Score=128, Evalue=2e-29,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=67.7224736048265, Blast_Score=940, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=64.4042232277526, Blast_Score=903, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=535, Percent_Identity=26.9158878504673, Blast_Score=165, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=46.1883408071749, Blast_Score=554, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=43.2190760059613, Blast_Score=515, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45551847, Length=588, Percent_Identity=25.6802721088435, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45550715, Length=588, Percent_Identity=25.6802721088435, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24645119, Length=554, Percent_Identity=25.0902527075812, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24666278, Length=266, Percent_Identity=31.5789473684211, Blast_Score=115, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71964; Mature: 71832

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAPARRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDFMRHNPADPTWADR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
DRFVLSNGHGSMLLYSLLHLTGYGVSLDDIKNFRQLGSPTAGHPEYGDAPGIETTTGPLG
CCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
QGIANAVGMALAEKMLAGQFNRDGHTIVDHNTYCFLGDGCMMEGISHEVASLAGTLGLGK
HHHHHHHHHHHHHHHHHCCCCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHHCHHC
LVAFYDDNGISIDGEVEGWFTDDTVERFRAYGWQVIPNVDGHNAEEIMVAVENARANTSQ
EEEEECCCCEEECCCCCCEECHHHHHHHHHCCCEEECCCCCCCHHEEEEEEECCCCCCCC
PTLICCKTIIGFGSPNKQGKEDSHGAALGEDEITLTRKALGWEYGPFEIPADIKSAWDAK
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCCCEECCHHHHHHCCHH
EAGAKAQSEWQQRFDAYQAAYPELAAEFTRRMASELPADFAEQADAYIRECQEKGEKVAT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RKASQNTLDAFGPLLPELAGGSADLAGSNNTIWKGCKSVTADDASGNYIHYGVREFGMTA
HHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEECHHHHHHHH
IQNGLCLHGGLRPYGGTFLVFMEYARNAVRMAAIMHQPNILVYTHDSIGLGEDGPTHQPI
HHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHH
EQLANLRLTPNMRTWRPCDTVESAVSWKQAVLRQDGPSALIFSRQGLPCMERGSEQLAEI
HHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCHHHHHHH
EKGGYTLLQTGEDTPDAIIIATGSEVELAVIAARALTGKNIRVVSMPCVEEFLAQDKAYQ
HCCCEEEEECCCCCCCEEEEEECCCEEEEEEEHHHHCCCCEEEEECHHHHHHHHHCHHHH
DSVLPGDVRARVAVEAAIADYWFRFVGLDGKVIGMNSFGASAPAGDLFKHFNITAEAVQE
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHH
AVESLL
HHHHHC
>Mature Secondary Structure 
SSAPARRELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDFMRHNPADPTWADR
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
DRFVLSNGHGSMLLYSLLHLTGYGVSLDDIKNFRQLGSPTAGHPEYGDAPGIETTTGPLG
CCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
QGIANAVGMALAEKMLAGQFNRDGHTIVDHNTYCFLGDGCMMEGISHEVASLAGTLGLGK
HHHHHHHHHHHHHHHHHCCCCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHHCHHC
LVAFYDDNGISIDGEVEGWFTDDTVERFRAYGWQVIPNVDGHNAEEIMVAVENARANTSQ
EEEEECCCCEEECCCCCCEECHHHHHHHHHCCCEEECCCCCCCHHEEEEEEECCCCCCCC
PTLICCKTIIGFGSPNKQGKEDSHGAALGEDEITLTRKALGWEYGPFEIPADIKSAWDAK
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCCCEECCHHHHHHCCHH
EAGAKAQSEWQQRFDAYQAAYPELAAEFTRRMASELPADFAEQADAYIRECQEKGEKVAT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RKASQNTLDAFGPLLPELAGGSADLAGSNNTIWKGCKSVTADDASGNYIHYGVREFGMTA
HHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEECHHHHHHHH
IQNGLCLHGGLRPYGGTFLVFMEYARNAVRMAAIMHQPNILVYTHDSIGLGEDGPTHQPI
HHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHH
EQLANLRLTPNMRTWRPCDTVESAVSWKQAVLRQDGPSALIFSRQGLPCMERGSEQLAEI
HHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHCHHHHHHH
EKGGYTLLQTGEDTPDAIIIATGSEVELAVIAARALTGKNIRVVSMPCVEEFLAQDKAYQ
HCCCEEEEECCCCCCCEEEEEECCCEEEEEEEHHHHCCCCEEEEECHHHHHHHHHCHHHH
DSVLPGDVRARVAVEAAIADYWFRFVGLDGKVIGMNSFGASAPAGDLFKHFNITAEAVQE
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHH
AVESLL
HHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]