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The map label for this gene is hmuU [H]

Identifier: 110835230

GI number: 110835230

Start: 2693231

End: 2694247

Strand: Reverse

Name: hmuU [H]

Synonym: ABO_2369

Alternate gene names: 110835230

Gene position: 2694247-2693231 (Counterclockwise)

Preceding gene: 110835231

Following gene: 110835229

Centisome position: 86.35

GC content: 62.14

Gene sequence:

>1017_bases
GTGCCCGCGCCCTGTGTCGGCATTTGGAAAGTGCCCGTGCTCGCCATTAAGTCGCCGACGCTTGCTACCTTATTCGCGCT
GACGGCCCTGGGGCTGTTGGCGTTATTACTGTCGGTGGCGGTGGGCAGTGTATCGATTTCACTGCAGGATCTGTGGGCTG
TGGCGAGCGGTGGCGGTAGTGACCTGCATCGGGAACTGATTATGTCGTTGCGCGCGCCCCGTGCGCTGGCGGCGTTCTCC
ACGGGGGGGCTGCTAGCCCTGGCCGGGGCGCTGATGCAGGTGTTGTTGCGTAATCCGCTGGCGGACCCCTATGTGCTGGG
TATTTCCGGGGGGGCTGCGGTGGGCGCGCTGGGTGCCATGTTGATTGGTGGCGGCTTGGCGTTAGTGTCCGGCTCGGCGT
TTGCCGGTGCTTTGCTATCTACCTTGTTGGTGTTTGGTTTGGCGCAAGGCGGGGGCGGCTGGACCCCGACCAGACTGTTG
CTGACGGGCGTTGTGGTGGCCGCCGGTTGGGGCGCGGTAATTACCTTTATGTTGACCATGAGCCCTGCGGATCGGTTGCC
GGGCATGCTGTATTGGTTAATGGGAGACTTGAGCTACGCCCGCGCTCCTTACGCAGCCTGGTTAGTGATGATTATCGCGG
TGCTGCTGACCCTGCCACTGGGGCGTAGCCTGAATGTGTTGGCGAGGGGGCCGTTACAGGCCGCGGCCTTGGGTATTGCG
GTGAAGCCGTTGGAGTGGCTGGTGTATGTCTTGGCCAGTCTGTTGACGGCGGTGGCGGTGACCACGGCCGGGAGTGTGGG
GTTTGTCGGCCTGATTGTGCCGCATATGCTGCGGCTACAGTTGGGTAATGATCAGCGCATTATCTTGCCCGCCAGTGTTT
TGGCGGGGGGTACCTTGCTGACCGTGGCCGATACTCTGGCGCGTACGGTGATGGCTCCTGAGCAGCTGCCTGTGGGGGTA
ATTACGGCCCTATTGGGGGTGCCCACTTTCCTGTTCTTGTTGCATCGCAATCGCTGA

Upstream 100 bases:

>100_bases
CCGTGGCGGCAGTTTGCCAGCTTACGGGCGGTAAAAAACGATAATTTGTTTTTTGTTGCGCCGTCCACATTGCAGCGGCC
TACCCCGCAAATGCTGATCG

Downstream 100 bases:

>100_bases
TTGATTGGGGACGGCATCGCCCGGAACCTGTGTCACCGAAACGGAGAGCGCCATGGCGGTGCTGGACATTGAACATCTGG
TTATCGACATCCCCGGTCGC

Product: Fe3+-siderophore ABC transporter permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MPAPCVGIWKVPVLAIKSPTLATLFALTALGLLALLLSVAVGSVSISLQDLWAVASGGGSDLHRELIMSLRAPRALAAFS
TGGLLALAGALMQVLLRNPLADPYVLGISGGAAVGALGAMLIGGGLALVSGSAFAGALLSTLLVFGLAQGGGGWTPTRLL
LTGVVVAAGWGAVITFMLTMSPADRLPGMLYWLMGDLSYARAPYAAWLVMIIAVLLTLPLGRSLNVLARGPLQAAALGIA
VKPLEWLVYVLASLLTAVAVTTAGSVGFVGLIVPHMLRLQLGNDQRIILPASVLAGGTLLTVADTLARTVMAPEQLPVGV
ITALLGVPTFLFLLHRNR

Sequences:

>Translated_338_residues
MPAPCVGIWKVPVLAIKSPTLATLFALTALGLLALLLSVAVGSVSISLQDLWAVASGGGSDLHRELIMSLRAPRALAAFS
TGGLLALAGALMQVLLRNPLADPYVLGISGGAAVGALGAMLIGGGLALVSGSAFAGALLSTLLVFGLAQGGGGWTPTRLL
LTGVVVAAGWGAVITFMLTMSPADRLPGMLYWLMGDLSYARAPYAAWLVMIIAVLLTLPLGRSLNVLARGPLQAAALGIA
VKPLEWLVYVLASLLTAVAVTTAGSVGFVGLIVPHMLRLQLGNDQRIILPASVLAGGTLLTVADTLARTVMAPEQLPVGV
ITALLGVPTFLFLLHRNR
>Mature_337_residues
PAPCVGIWKVPVLAIKSPTLATLFALTALGLLALLLSVAVGSVSISLQDLWAVASGGGSDLHRELIMSLRAPRALAAFST
GGLLALAGALMQVLLRNPLADPYVLGISGGAAVGALGAMLIGGGLALVSGSAFAGALLSTLLVFGLAQGGGGWTPTRLLL
TGVVVAAGWGAVITFMLTMSPADRLPGMLYWLMGDLSYARAPYAAWLVMIIAVLLTLPLGRSLNVLARGPLQAAALGIAV
KPLEWLVYVLASLLTAVAVTTAGSVGFVGLIVPHMLRLQLGNDQRIILPASVLAGGTLLTVADTLARTVMAPEQLPVGVI
TALLGVPTFLFLLHRNR

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=310, Percent_Identity=36.1290322580645, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1788004, Length=278, Percent_Identity=37.0503597122302, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1790741, Length=333, Percent_Identity=34.8348348348348, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786347, Length=283, Percent_Identity=36.3957597173145, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1786805, Length=306, Percent_Identity=37.2549019607843, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786804, Length=302, Percent_Identity=32.4503311258278, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34525; Mature: 34394

Theoretical pI: Translated: 10.57; Mature: 10.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPCVGIWKVPVLAIKSPTLATLFALTALGLLALLLSVAVGSVSISLQDLWAVASGGGS
CCCCCCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCCH
DLHRELIMSLRAPRALAAFSTGGLLALAGALMQVLLRNPLADPYVLGISGGAAVGALGAM
HHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHH
LIGGGLALVSGSAFAGALLSTLLVFGLAQGGGGWTPTRLLLTGVVVAAGWGAVITFMLTM
HHCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
SPADRLPGMLYWLMGDLSYARAPYAAWLVMIIAVLLTLPLGRSLNVLARGPLQAAALGIA
CCHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHH
VKPLEWLVYVLASLLTAVAVTTAGSVGFVGLIVPHMLRLQLGNDQRIILPASVLAGGTLL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCHHH
TVADTLARTVMAPEQLPVGVITALLGVPTFLFLLHRNR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAPCVGIWKVPVLAIKSPTLATLFALTALGLLALLLSVAVGSVSISLQDLWAVASGGGS
CCCCCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCCH
DLHRELIMSLRAPRALAAFSTGGLLALAGALMQVLLRNPLADPYVLGISGGAAVGALGAM
HHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHH
LIGGGLALVSGSAFAGALLSTLLVFGLAQGGGGWTPTRLLLTGVVVAAGWGAVITFMLTM
HHCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
SPADRLPGMLYWLMGDLSYARAPYAAWLVMIIAVLLTLPLGRSLNVLARGPLQAAALGIA
CCHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHH
VKPLEWLVYVLASLLTAVAVTTAGSVGFVGLIVPHMLRLQLGNDQRIILPASVLAGGTLL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCHHH
TVADTLARTVMAPEQLPVGVITALLGVPTFLFLLHRNR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]