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The map label for this gene is argH

Identifier: 110835186

GI number: 110835186

Start: 2652773

End: 2654167

Strand: Direct

Name: argH

Synonym: ABO_2325

Alternate gene names: 110835186

Gene position: 2652773-2654167 (Clockwise)

Preceding gene: 110835179

Following gene: 110835188

Centisome position: 85.02

GC content: 59.35

Gene sequence:

>1395_bases
ATGACTGACAAGCAGCAGAACAAACTCTGGGGCGGCCGCTTCAGCGAGTCCACCGACCAGTTCGTGCAAGAATTCACTGC
CAGTGTGAACTTCGACCGGCGCATGTACCGTCAGGACATCTACGGCTCTCAGGCTCATGCAACCATGCTTGCGGAAGTGG
GCGTGCTCACCGATGAAGAGCGCGACGCCATTATTGTGGGCCTGCGTGAAATCCAGCTGGAAATCGAAAACGGCGAGTTC
CAGTGGTCCGTAGCACTGGAAGATGTGCACATGAACATCGAAGCCCGGCTCACCGACAAGATCGGCATCACCGGCAAGAA
GCTGCACACCGGTCGTTCGCGTAACGACCAAGTGGCCACCGACATTCGCCTGTGGCTACGTGACGAATTGCTGATTCTGG
AAGAACAGTTCCTGCACCTCATGCAAGGCCTGCTTAACCTGGCCGAGCGCGAAGCCGCCACCATCATGCCTGGCTTCACC
CACCTGCAGACAGCCCAGCCGGTGACCTTCGGGCATCACCTGCTAGCGTGGTTCGAAATGCTCAAACGCGACCGGGAACG
TCTGCTGGACTGCAAGAAGCGGGTTAACCGTATGCCGCTGGGGGCCGCCGCCTTGGCCGGCACCACCTACCCGATTAACC
GGGAGCGCACCTGCGAGCTTCTCGGTTTTGACGGCGTCTGCGAAAACTCCCTGGATGCAGTGAGCGACCGGGATTTCGCC
ATTGAATTCTGCGCGATGGCGGCACTGACCATGACTCACTTGTCACGGATCAGCGAAGAGCTTGTGCTGTGGACCAGCGC
CCAGTTCAACTTTATCAACCTGCCCGACCGCTTCTGCACCGGCAGCTCCATCATGCCGCAGAAGAAAAACCCGGACGTGC
CTGAACTAGTGCGAGGCAAGACCGGCCGCGTTAATGGCCACCTGATCAGCCTGCTAACCCTGATGAAGAGCCAGCCGCTG
GCCTACAACAAGGACAACCAGGAAGACAAAGAGCCGCTGTACGATGCCGTGGATACTCTCAAAGGCAGCCTGCGCGCCTT
CGGTGACATGATCCCTGCGTTGGAACCCAACCGTGAAGTGATGCGCGAAGCGGCCCGTCGCGGTTTCGCCACGGCCACCG
ATCTGGCGGATTACTTGGTACGCAAAGGCATCGCCTTCCGCGACTCCCACGAGATCGTCGGCAAGGCGGTGGCTTATGGC
GTAGAGAAAAAGAAGGATTTGGGCGACATGTCCTTGTCGGAACTGAAGCAATTCAGCGACCAAATCGAAGACAACGTGTT
CGAAGTATTGACTCTGGAAGGCTCCGTGAGCGCCCGTAACCACATCGGCGGCACCGCCCCCGACCAGGTCCGCGCCGCTG
TGGCCCGTGCCCGCGAGGCGCTGGACAACACCTAA

Upstream 100 bases:

>100_bases
TAATTATGAATATGTTATACCTGAATGAACCGCCACTCCCAAGAAATACTCTCCCCCTGCTATACTTGCGCCCCCGCAAA
CCAAGCGTTGAGCAAGTACG

Downstream 100 bases:

>100_bases
GCCGGGCAACAGCAAGGCGGGAGCTTCAGTCTTTCCGCCTTGCTGTTGAGCTGGTGGCTAGGGCCGAGTTATTCGCCGCC
CAGGTCCTCACCATTGGCTT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTDKQQNKLWGGRFSESTDQFVQEFTASVNFDRRMYRQDIYGSQAHATMLAEVGVLTDEERDAIIVGLREIQLEIENGEF
QWSVALEDVHMNIEARLTDKIGITGKKLHTGRSRNDQVATDIRLWLRDELLILEEQFLHLMQGLLNLAEREAATIMPGFT
HLQTAQPVTFGHHLLAWFEMLKRDRERLLDCKKRVNRMPLGAAALAGTTYPINRERTCELLGFDGVCENSLDAVSDRDFA
IEFCAMAALTMTHLSRISEELVLWTSAQFNFINLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVNGHLISLLTLMKSQPL
AYNKDNQEDKEPLYDAVDTLKGSLRAFGDMIPALEPNREVMREAARRGFATATDLADYLVRKGIAFRDSHEIVGKAVAYG
VEKKKDLGDMSLSELKQFSDQIEDNVFEVLTLEGSVSARNHIGGTAPDQVRAAVARAREALDNT

Sequences:

>Translated_464_residues
MTDKQQNKLWGGRFSESTDQFVQEFTASVNFDRRMYRQDIYGSQAHATMLAEVGVLTDEERDAIIVGLREIQLEIENGEF
QWSVALEDVHMNIEARLTDKIGITGKKLHTGRSRNDQVATDIRLWLRDELLILEEQFLHLMQGLLNLAEREAATIMPGFT
HLQTAQPVTFGHHLLAWFEMLKRDRERLLDCKKRVNRMPLGAAALAGTTYPINRERTCELLGFDGVCENSLDAVSDRDFA
IEFCAMAALTMTHLSRISEELVLWTSAQFNFINLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVNGHLISLLTLMKSQPL
AYNKDNQEDKEPLYDAVDTLKGSLRAFGDMIPALEPNREVMREAARRGFATATDLADYLVRKGIAFRDSHEIVGKAVAYG
VEKKKDLGDMSLSELKQFSDQIEDNVFEVLTLEGSVSARNHIGGTAPDQVRAAVARAREALDNT
>Mature_463_residues
TDKQQNKLWGGRFSESTDQFVQEFTASVNFDRRMYRQDIYGSQAHATMLAEVGVLTDEERDAIIVGLREIQLEIENGEFQ
WSVALEDVHMNIEARLTDKIGITGKKLHTGRSRNDQVATDIRLWLRDELLILEEQFLHLMQGLLNLAEREAATIMPGFTH
LQTAQPVTFGHHLLAWFEMLKRDRERLLDCKKRVNRMPLGAAALAGTTYPINRERTCELLGFDGVCENSLDAVSDRDFAI
EFCAMAALTMTHLSRISEELVLWTSAQFNFINLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVNGHLISLLTLMKSQPLA
YNKDNQEDKEPLYDAVDTLKGSLRAFGDMIPALEPNREVMREAARRGFATATDLADYLVRKGIAFRDSHEIVGKAVAYGV
EKKKDLGDMSLSELKQFSDQIEDNVFEVLTLEGSVSARNHIGGTAPDQVRAAVARAREALDNT

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=457, Percent_Identity=42.6695842450766, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303542, Length=457, Percent_Identity=42.6695842450766, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303547, Length=457, Percent_Identity=40.7002188183807, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI68303549, Length=457, Percent_Identity=39.8249452954048, Blast_Score=324, Evalue=1e-88,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=47.0459518599562, Blast_Score=412, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321806, Length=463, Percent_Identity=42.9805615550756, Blast_Score=345, Evalue=1e-95,
Organism=Drosophila melanogaster, GI221473854, Length=447, Percent_Identity=38.0313199105145, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI78706858, Length=447, Percent_Identity=38.0313199105145, Blast_Score=320, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_ALCBS (Q0VM25)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_694045.1
- ProteinModelPortal:   Q0VM25
- SMR:   Q0VM25
- STRING:   Q0VM25
- GeneID:   4213482
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2325
- NMPDR:   fig|393595.12.peg.2326
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- PhylomeDB:   Q0VM25
- ProtClustDB:   PRK00855
- BioCyc:   ABOR393595:ABO_2325-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52248; Mature: 52117

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKQQNKLWGGRFSESTDQFVQEFTASVNFDRRMYRQDIYGSQAHATMLAEVGVLTDEE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
RDAIIVGLREIQLEIENGEFQWSVALEDVHMNIEARLTDKIGITGKKLHTGRSRNDQVAT
CCEEEEEEEEEEEEEECCEEEEEEEEEEEEECEEEEEECCCCCCCCCCCCCCCCCCHHHH
DIRLWLRDELLILEEQFLHLMQGLLNLAEREAATIMPGFTHLQTAQPVTFGHHLLAWFEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHH
LKRDRERLLDCKKRVNRMPLGAAALAGTTYPINRERTCELLGFDGVCENSLDAVSDRDFA
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHCCCCHHH
IEFCAMAALTMTHLSRISEELVLWTSAQFNFINLPDRFCTGSSIMPQKKNPDVPELVRGK
HHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCHHHCCCCCCCCCCCCCCCHHHHCCC
TGRVNGHLISLLTLMKSQPLAYNKDNQEDKEPLYDAVDTLKGSLRAFGDMIPALEPNREV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
MREAARRGFATATDLADYLVRKGIAFRDSHEIVGKAVAYGVEKKKDLGDMSLSELKQFSD
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHH
QIEDNVFEVLTLEGSVSARNHIGGTAPDQVRAAVARAREALDNT
HHHCCCEEEEEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDKQQNKLWGGRFSESTDQFVQEFTASVNFDRRMYRQDIYGSQAHATMLAEVGVLTDEE
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
RDAIIVGLREIQLEIENGEFQWSVALEDVHMNIEARLTDKIGITGKKLHTGRSRNDQVAT
CCEEEEEEEEEEEEEECCEEEEEEEEEEEEECEEEEEECCCCCCCCCCCCCCCCCCHHHH
DIRLWLRDELLILEEQFLHLMQGLLNLAEREAATIMPGFTHLQTAQPVTFGHHLLAWFEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHH
LKRDRERLLDCKKRVNRMPLGAAALAGTTYPINRERTCELLGFDGVCENSLDAVSDRDFA
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHCCCCHHH
IEFCAMAALTMTHLSRISEELVLWTSAQFNFINLPDRFCTGSSIMPQKKNPDVPELVRGK
HHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCHHHCCCCCCCCCCCCCCCHHHHCCC
TGRVNGHLISLLTLMKSQPLAYNKDNQEDKEPLYDAVDTLKGSLRAFGDMIPALEPNREV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
MREAARRGFATATDLADYLVRKGIAFRDSHEIVGKAVAYGVEKKKDLGDMSLSELKQFSD
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHH
QIEDNVFEVLTLEGSVSARNHIGGTAPDQVRAAVARAREALDNT
HHHCCCEEEEEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA