Click here to switch to the map view.

The map label for this gene is ilvD2 [H]

Identifier: 110835173

GI number: 110835173

Start: 2637631

End: 2639634

Strand: Direct

Name: ilvD2 [H]

Synonym: ABO_2312

Alternate gene names: 110835173

Gene position: 2637631-2639634 (Clockwise)

Preceding gene: 162139945

Following gene: 110835174

Centisome position: 84.54

GC content: 60.43

Gene sequence:

>2004_bases
GTGCGAGTGAAGGGCAGCTCTGGTTCTATGCAGGTTAGCTTCTGCATTACCGGAGCGCCTGAGCCCTTTCGCCGTGCGAG
CAAGGCTCCAACAGTGTGGGTCTGTGGGTTACAATGCCGTCCCTATGTCCCGCTATTGACCATTAACGAGGTTCCCATGC
CGCAGTATCGCTCCCGCACCACCACCCATGGCCGCAATATGGCTGGCGCCCGTGCCCTGTGGCGCGCCACGGGCATGAAG
GACGGGGACTTCGGTAAACCGATTATTGCCATCGCCAACTCCTTTACCCAGTTCGTACCGGGGCATGTGCACCTGAAGGA
CATGGGCCAGCTGGTGGCCGGTGAAGTCGAGAAGGCCGGCGGCATCGCCAAGGAATTCAATACCATTGCGGTGGATGACG
GCATCGCCATGGGCCACGACGGCATGCTCTATTCTTTGCCCAGCCGCGACATCATTGCGGATTCCGTGGAGTACATGGTT
AACGCCCACTGCGCCGACGCCCTTGTCTGCATCTCTAACTGCGACAAGATCACTCCTGGCATGCTGATGGCATCCATGCG
CCTGAATATTCCGGTGATCTTCGTGTCCGGTGGCCCCATGGAAGCGGGCAAAACCAAGCTGGCCGAGGGCAAGCTGGACC
TGGTAGACGCCATGGTGATGGCCGCCGATGACAGCGTGGACGAAGAAACCCTGAACGAAGTGGAGCGTTCCGCCTGCCCC
ACCTGCGGCTCGTGCTCCGGCATGTTCACCGCCAATTCCATGAACTGCCTAACCGAGGCACTGGGCCTGTCGTTGCCCGG
TAACGGCTCACTGCTGGCTACCCACGCGGACCGCCGCGAACTGTTCCTGGAAGCGGGCCGGCGCATCGTGGACGTTACCC
GACGCTACTACGAGCAGGACGAAGAGGCCTTGCTGCCGCGCAATATCGCTTCAGTGAAAGCGTTCGAAAACGCCATGAGC
TTGGACATCGCCATGGGCGGCTCCACTAACACCGTGCTGCACTTGCTAGCCGCAGCACTGGAAGGCGAAGTGGACTTCAC
CATGGAAGACATCGACCGCCTAAGCCGTAAGGTGCCGTGCTTGTCGAAAGTGGCCCCCGCCACCCAGAAATACCATATGG
AAGATGTGCACCGTGCCGGTGGTGTGATGGGCATTCTCGGCGAACTGGACCGGGCTGGCCTGCTCAACCGCGACATTCCC
ATGGTGCACTCGGCCTCTGTGGCCGAAGCCCTGGAGCATTACGACATCATGCGCACCCAGGATGAAGGCGTGAAAAAGAT
GTTCACCGCCGGCCCGGCAGGCATCCCCACCCAGACGGCCTTTAGCCAGGAAACGCGCTGGGAAAGCCTGGATGACGACC
GCGAAAACGGCTGTATCCGCAATTACGAAAATGCCTACAGTAAGGACGGCGGCCTAGCCGTGTTGTACGGCAACATCGCC
GAGCGCGGTTGCATCGTGAAAACCGCCGGGGTGGATGATTCCATTCTCACCTTCACCGGCCGCGCCCGAGTATTCGAATC
CCAGGATTCAGCGGTTCGCGCCATCCTCGGTGATCAGATCGTTGCCGGCGATGTGGTGGTAATTCGCTACGAAGGCCCCA
AAGGCGGCCCGGGCATGCAGGAAATGCTCTACCCCACCAGCTACTTGAAATCCAAAGGGCTGGGCAAGGAATGTGCGCTG
CTCACCGATGGCCGTTTCTCCGGCGGCACCTCCGGCCTGTCCATTGGCCACGCGTCCCCGGAAGCCGCAGAGGGCGGCGC
CATTGCCCTGGTGAATGAAGGCGACACTATCAATATCGATATTCCCAACCGCACCATCCATCTGGATATCAGCGATGAAG
AGCTGGCGCACCGCCGCACTCACATGGAAAACCGAGGCAAGCTGGCCTACAAGCCCAAGGAAATTCGCCCACGCCGTGTT
TCCACCGCCCTGAAAGCCTACGCCGCACTCACCACCAGTGCAGACCGCGGCGCAGTGCGTGACTTGAGCCAAATCGGCGA
ATAA

Upstream 100 bases:

>100_bases
GAAAACCCCATTTCTCAGCTCTTCGTGCTTAACGGAAAAATTCACTCTATCTCAGCAATTTATAAAAATATGTAAGCCAT
ATCCTACATTTCCAACTGGC

Downstream 100 bases:

>100_bases
GCTAAATCATCAAGGCGACCATCAGGTCGCCTTTTTTAGGCCTCTTCGTCACGGCCCTACACAATAAGACAAACGGGTTA
CATCCCTCTTTGAGGGCCTG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MRVKGSSGSMQVSFCITGAPEPFRRASKAPTVWVCGLQCRPYVPLLTINEVPMPQYRSRTTTHGRNMAGARALWRATGMK
DGDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAGEVEKAGGIAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMV
NAHCADALVCISNCDKITPGMLMASMRLNIPVIFVSGGPMEAGKTKLAEGKLDLVDAMVMAADDSVDEETLNEVERSACP
TCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRRELFLEAGRRIVDVTRRYYEQDEEALLPRNIASVKAFENAMS
LDIAMGGSTNTVLHLLAAALEGEVDFTMEDIDRLSRKVPCLSKVAPATQKYHMEDVHRAGGVMGILGELDRAGLLNRDIP
MVHSASVAEALEHYDIMRTQDEGVKKMFTAGPAGIPTQTAFSQETRWESLDDDRENGCIRNYENAYSKDGGLAVLYGNIA
ERGCIVKTAGVDDSILTFTGRARVFESQDSAVRAILGDQIVAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGKECAL
LTDGRFSGGTSGLSIGHASPEAAEGGAIALVNEGDTINIDIPNRTIHLDISDEELAHRRTHMENRGKLAYKPKEIRPRRV
STALKAYAALTTSADRGAVRDLSQIGE

Sequences:

>Translated_667_residues
MRVKGSSGSMQVSFCITGAPEPFRRASKAPTVWVCGLQCRPYVPLLTINEVPMPQYRSRTTTHGRNMAGARALWRATGMK
DGDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAGEVEKAGGIAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMV
NAHCADALVCISNCDKITPGMLMASMRLNIPVIFVSGGPMEAGKTKLAEGKLDLVDAMVMAADDSVDEETLNEVERSACP
TCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRRELFLEAGRRIVDVTRRYYEQDEEALLPRNIASVKAFENAMS
LDIAMGGSTNTVLHLLAAALEGEVDFTMEDIDRLSRKVPCLSKVAPATQKYHMEDVHRAGGVMGILGELDRAGLLNRDIP
MVHSASVAEALEHYDIMRTQDEGVKKMFTAGPAGIPTQTAFSQETRWESLDDDRENGCIRNYENAYSKDGGLAVLYGNIA
ERGCIVKTAGVDDSILTFTGRARVFESQDSAVRAILGDQIVAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGKECAL
LTDGRFSGGTSGLSIGHASPEAAEGGAIALVNEGDTINIDIPNRTIHLDISDEELAHRRTHMENRGKLAYKPKEIRPRRV
STALKAYAALTTSADRGAVRDLSQIGE
>Mature_667_residues
MRVKGSSGSMQVSFCITGAPEPFRRASKAPTVWVCGLQCRPYVPLLTINEVPMPQYRSRTTTHGRNMAGARALWRATGMK
DGDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAGEVEKAGGIAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMV
NAHCADALVCISNCDKITPGMLMASMRLNIPVIFVSGGPMEAGKTKLAEGKLDLVDAMVMAADDSVDEETLNEVERSACP
TCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRRELFLEAGRRIVDVTRRYYEQDEEALLPRNIASVKAFENAMS
LDIAMGGSTNTVLHLLAAALEGEVDFTMEDIDRLSRKVPCLSKVAPATQKYHMEDVHRAGGVMGILGELDRAGLLNRDIP
MVHSASVAEALEHYDIMRTQDEGVKKMFTAGPAGIPTQTAFSQETRWESLDDDRENGCIRNYENAYSKDGGLAVLYGNIA
ERGCIVKTAGVDDSILTFTGRARVFESQDSAVRAILGDQIVAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGKECAL
LTDGRFSGGTSGLSIGHASPEAAEGGAIALVNEGDTINIDIPNRTIHLDISDEELAHRRTHMENRGKLAYKPKEIRPRRV
STALKAYAALTTSADRGAVRDLSQIGE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=77.2727272727273, Blast_Score=990, Evalue=0.0,
Organism=Escherichia coli, GI1786464, Length=576, Percent_Identity=30.9027777777778, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI2367371, Length=564, Percent_Identity=30.1418439716312, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1788157, Length=579, Percent_Identity=27.8065630397237, Blast_Score=182, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=613, Percent_Identity=36.7047308319739, Blast_Score=340, Evalue=6e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 71818; Mature: 71818

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVKGSSGSMQVSFCITGAPEPFRRASKAPTVWVCGLQCRPYVPLLTINEVPMPQYRSRT
CCCCCCCCCEEEEEEEECCCHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCHHHCCC
TTHGRNMAGARALWRATGMKDGDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAGEVEKAG
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHC
GIAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADALVCISNCDKITPG
CCHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
MLMASMRLNIPVIFVSGGPMEAGKTKLAEGKLDLVDAMVMAADDSVDEETLNEVERSACP
HHHHHEECCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
TCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRRELFLEAGRRIVDVTRRYYEQD
CCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHCHHHHHHHHHHHCCC
EEALLPRNIASVKAFENAMSLDIAMGGSTNTVLHLLAAALEGEVDFTMEDIDRLSRKVPC
CHHHCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCH
LSKVAPATQKYHMEDVHRAGGVMGILGELDRAGLLNRDIPMVHSASVAEALEHYDIMRTQ
HHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHCCC
DEGVKKMFTAGPAGIPTQTAFSQETRWESLDDDRENGCIRNYENAYSKDGGLAVLYGNIA
HHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCCC
ERGCIVKTAGVDDSILTFTGRARVFESQDSAVRAILGDQIVAGDVVVIRYEGPKGGPGMQ
CCCCEEEECCCCCCEEEEECCEEEECCCCHHHHHHHCCCEEECCEEEEEECCCCCCCCHH
EMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAEGGAIALVNEGDTINID
HHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEE
IPNRTIHLDISDEELAHRRTHMENRGKLAYKPKEIRPRRVSTALKAYAALTTSADRGAVR
CCCEEEEEECCHHHHHHHHHHHCCCCCEEECCHHCCCHHHHHHHHHHHHHHCCCCCHHHH
DLSQIGE
HHHHHCC
>Mature Secondary Structure
MRVKGSSGSMQVSFCITGAPEPFRRASKAPTVWVCGLQCRPYVPLLTINEVPMPQYRSRT
CCCCCCCCCEEEEEEEECCCHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCHHHCCC
TTHGRNMAGARALWRATGMKDGDFGKPIIAIANSFTQFVPGHVHLKDMGQLVAGEVEKAG
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHC
GIAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADALVCISNCDKITPG
CCHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
MLMASMRLNIPVIFVSGGPMEAGKTKLAEGKLDLVDAMVMAADDSVDEETLNEVERSACP
HHHHHEECCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
TCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRRELFLEAGRRIVDVTRRYYEQD
CCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHCHHHHHHHHHHHCCC
EEALLPRNIASVKAFENAMSLDIAMGGSTNTVLHLLAAALEGEVDFTMEDIDRLSRKVPC
CHHHCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCH
LSKVAPATQKYHMEDVHRAGGVMGILGELDRAGLLNRDIPMVHSASVAEALEHYDIMRTQ
HHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHCCC
DEGVKKMFTAGPAGIPTQTAFSQETRWESLDDDRENGCIRNYENAYSKDGGLAVLYGNIA
HHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCCC
ERGCIVKTAGVDDSILTFTGRARVFESQDSAVRAILGDQIVAGDVVVIRYEGPKGGPGMQ
CCCCEEEECCCCCCEEEEECCEEEECCCCHHHHHHHCCCEEECCEEEEEECCCCCCCCHH
EMLYPTSYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAEGGAIALVNEGDTINID
HHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEE
IPNRTIHLDISDEELAHRRTHMENRGKLAYKPKEIRPRRVSTALKAYAALTTSADRGAVR
CCCEEEEEECCHHHHHHHHHHHCCCCCEEECCHHCCCHHHHHHHHHHHHHHCCCCCHHHH
DLSQIGE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA